Chem & Bio Engineering最新文献

{"title":"Self-Healable and Superrobust Supramolecular Elastomer-Bound Sulfide Electrolyte Films for Dendrite-Free All-Solid-State Lithium Batteries","authors":"Wanqing Jia,&nbsp;Jingyi Liu,&nbsp;Shiyu Yao,&nbsp;Xiaokong Liu,&nbsp;Fei Du","doi":"10.1021/cbe.6c00001","DOIUrl":"10.1021/cbe.6c00001","url":null,"abstract":"<p>The commercialization of all-solid-state lithium batteries(ASSLBs)is hindered by the lack of advanced binders for sulfide solid-stateelectrolyte (SSE) films, as current binders often fail to achievecohesion and adhesion balance, resulting in agglomeration or insufficientmechanical strength. Herein, we introduce a self-healable supramolecularpoly­(urethane-urea) (SPU) binder for sulfide SSE films, leveragingdynamic hydrogen bonds to achieve a balance between adhesion and cohesion.The SPU binder enables the fabrication of free-standing Li₆PS₅Cl (LPSCl) films at a low binder content of 3 wt %,achieving an ionic conductivity of 1.5 mS cm^–1 anda highly densified morphology. The resulting lithium symmetric cellexhibits a critical current density (CCD) of 1.8 mA cm^–2 and cycling stability over 3500 h at 0.1 mA cm^–2, and lithium dendrite growth is revealed to be largely mitigatedin the LPSCl film. Furthermore, ASSLBs incorporating SPU-bound LPSClfilms demonstrate enhanced rate capability (140.6 mAh g^–1 at 1C) and cycling performance (78.8% capacity retention after 400cycles). This work highlights the potential of self-healable bindersin addressing the mechanical and electrochemical challenges of sulfideSSE films, paving the way for scalable ASSLB development.</p>","PeriodicalId":100230,"journal":{"name":"Chem & Bio Engineering","volume":"3 3","pages":"418–427"},"PeriodicalIF":8.4,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147597292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structure-Dependent Formation of HFC-125a/CO2 Mixed Hydrates: Raman Evidence and Implications for Fire Suppression","authors":"Sai Kiran Burla,&nbsp;Seong Deok Seo,&nbsp;Ju Dong Lee","doi":"10.1021/cbe.5c00178","DOIUrl":"10.1021/cbe.5c00178","url":null,"abstract":"<p>Mixed gas hydrates containing 1,1,1,2,2-pentafluoroethane(HFC-125a)and carbon dioxide (CO₂) have emerged as promising candidatesfor next-generation fire suppression due to their combined coolingand capabilities. In this study, the formation behavior, hydrate yield,thermodynamic characteristics, and molecular-level guest occupancyof HFC-125a + CO₂ (20–80 mol %) mixed hydrates weresystematically investigated under isochoric conditions. Pressure–temperaturemeasurements revealed distinct differences between pure and mixedsystems, with the mixed hydrate exhibiting a two-stage nucleationbehavior. Primary nucleation was associated with rapid CO₂-driven hydrate formation, subsequent structural reorganization,and gas incorporation, while secondary nucleation occurred at lowertemperatures and pressures. Comparative hydrate yield analysis showedthat although the mixed system exhibits a lower overall water-to-hydrateconversion than that of pure HFC-125a, it provides improved structuralstability and controlled gas incorporation. Raman spectroscopic analysisconfirmed the encapsulation of CO₂ predominantly in structureI (sI) hydrates and HFC-125a in structure II (sII) hydrates, supportingthe coexistence of sI and sII phases in the mixed system. These findingsdemonstrate how guest-specific kinetics and cage affinity govern hydratestructure and formation pathways, providing critical insight intotailoring mixed hydrate systems toward efficient and controllablefire-suppression applications.</p>","PeriodicalId":100230,"journal":{"name":"Chem & Bio Engineering","volume":"3 3","pages":"396–405"},"PeriodicalIF":8.4,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147597379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Industrial Chemical Glycan Synthesis (ICGS): Process Intensification of Glycosylations","authors":"Chunjun Qin,&nbsp;Junjie Fu,&nbsp;Guangzong Tian,&nbsp;Xiaopeng Zou,&nbsp;Jing Hu,&nbsp;Peter H. Seeberger,&nbsp;Jian Yin","doi":"10.1021/cbe.5c00135","DOIUrl":"10.1021/cbe.5c00135","url":null,"abstract":"<p>The industrial production of biologicallyactive glycans is pivotalto the development and manufacture of glycan-based medicinal products.Chemical synthesis is critical to acquiring well-defined glycans forglycobiology investigations and the advancement of glycan-enabledapplications. Efforts toward industrial chemical glycan synthesis(ICGS) are hampered by unique challenges associated with their structuralcomplexity and diversity. The major bottleneck in ICGS are regio-and stereoselective glycosylations. In this Perspective, we reviewthe process intensification of glycosylations based on innovativemethodologies and devices, and highlight its contributions to ICGS.Five topics including optimization of glycan assembly sequence, modulationof glycosylation reactivity, adjustment of environmental parameters,development of an automated chemical glycan synthesizer, and applicationof artificial intelligence (AI) to glycan synthesis will be discussed.We also present prospects for accelerating ICGS through process intensificationof glycosylation, including the integration of AI techniques, thedevelopment of glycosylation-oriented special large-scale reactorsand flow chemistry platforms.</p>","PeriodicalId":100230,"journal":{"name":"Chem & Bio Engineering","volume":"3 3","pages":"361–372"},"PeriodicalIF":8.4,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147597369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Green Methanol from CO2 Hydrogenation at Industrial Scale: Progress, Challenges, and Perspectives","authors":"Huibin Wang,&nbsp;Jiaxin Ben,&nbsp;Shijing Zhang,&nbsp;Ke Wang,&nbsp;Pengfei Xie","doi":"10.1021/cbe.5c00113","DOIUrl":"10.1021/cbe.5c00113","url":null,"abstract":"<p>With the increasing global concernover climate change and energycrisis, green methanol (GM) from carbon dioxide (CO₂) hydrogenationhas received extensive research and attention as an effective wayto convert greenhouse gases into high value-added chemicals and fuels.However, GM from CO₂ at industrial scale still faces manychallenges in industrial applications, including catalyst stability,optimization of reaction conditions, cost of CO₂ captureand purification, hydrogen supply, high investment costs, and marketprice volatility. This paper reviews the background, importance, andresearch progress of CO₂ to GM, details the types and propertiesof catalysts, effects of reaction conditions, catalyst stability andlifetime, and challenges of industrial applications, analyzes thekey factors of success through case studies, and concludes by providingthe directions and outlooks for future research.</p>","PeriodicalId":100230,"journal":{"name":"Chem & Bio Engineering","volume":"3 2","pages":"159–178"},"PeriodicalIF":8.4,"publicationDate":"2026-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147350151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the Effect of NaCl Concentration on CO2 Hydrate Formation Kinetics: Experimental and Modeling Insights for CO2 Sequestration","authors":"Eti Pagar,&nbsp;Avinash V. Palodkar,&nbsp;Vimal Kumar,&nbsp;Hari Prakash Veluswamy","doi":"10.1021/cbe.5c00092","DOIUrl":"10.1021/cbe.5c00092","url":null,"abstract":"<p>Gas hydrate-based CO₂ sequestrationstandsout as apotential approach for the permanent storage of CO₂ inmarine sediments, leveraging its exceptional capacity for CO₂ storage along with long-term stability and safety. This study presentsa systematic investigation of the kinetics of CO₂ hydrateformation in a silica sand matrix over a wide range of NaCl concentrations(0–5.0 wt %). While gas hydrates are typically stable in freshwater-saturatedsilica sediments, the presence of NaCl (in seawater) poses significantchallenges by inhibiting hydrate growth, reducing thermodynamic stability,and lowering storage capacity. Previous studies often considered asingle salt concentration, limiting our understanding of the salinityeffect. This work provides a comprehensive kinetic analysis, supportedby a chemical potential-driven model, to elucidate the impact of varyingsalt content on CO₂ hydrate formation. The findings indicatethat higher NaCl concentrations (≥3 wt %) markedly hinder hydrateformation rates, reaffirming the suppressive effect of salt. To addressthis challenge, biodegradable amino acid <span>l</span>-leucine (LL) wasemployed as a kinetic hydrate promoter. In the presence of 5.0 wt% NaCl, incorporating 2.0 wt % LL boosted gas uptake by nearly 2.6times, highlighting its strong promotional impact. The proposed model,first of its kind, accurately represents the kinetics across diversesalinity levels and additive scenarios, providing actionable insightsfor advancing CO₂ hydrate-based sequestration.</p>","PeriodicalId":100230,"journal":{"name":"Chem & Bio Engineering","volume":"3 2","pages":"268–282"},"PeriodicalIF":8.4,"publicationDate":"2026-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147350134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual-Functional Lanthanum Doping: Stabilizing Cathodes by Simultaneously Mitigating Na+/Vacancy Ordering and Oxygen Release","authors":"Mingjie Dong,&nbsp;Jiale Chen,&nbsp;Wei Cao,&nbsp;Yingge Guo,&nbsp;Kejun Zhang,&nbsp;Jinhao Cao,&nbsp;Jun Wang,&nbsp;Xingxing Yin,&nbsp;Maolin Yang,&nbsp;Chunlin Yu,&nbsp;Yinguo Xiao,&nbsp;Ziwei Chen,&nbsp;Jun Chen","doi":"10.1021/cbe.5c00084","DOIUrl":"10.1021/cbe.5c00084","url":null,"abstract":"<p>P2-type Na_<em>x</em>Li_<em>y</em>Mn_{1–<em>y</em>}O₂ layeredoxides represent a promising class of cathode materials for sodium-ionbatteries, capable of delivering a high specific capacity by leveraginganionic redox reactions. However, their practical application is oftenhampered by issues such as Na⁺/vacancy ordering and irreversibleoxygen release, which significantly impair the rate capability andcycling stability. To address the aforementioned problem, this workdemonstrates that introducing trace La into P2–Na_0.6Li_0.2Mn_0.8O₂ fundamentally altersthe Na⁺ distribution between Na_e and Na_f sites in the sodium layer and suppresses Na⁺/vacancyordering. More importantly, the high bond energy of La–O significantlyenhances the stability of lattice oxygen, suppressing irreversibleoxygen release during cycling and thereby simultaneously improvingthe reversibility of redox reactions and structural integrity. Electrochemicaltests demonstrate that the optimized LM-La0.04 cathode delivers ahigh discharge capacity of 193.5 mAh g^–1 at 0.2C and retains a reversible capacity of 86.8 mAh g^–1 even at 10 C, highlighting its superior rate performance. Furthermore,the material exhibits remarkable capacity retention in long-term cycling.A combination of <em>in situ</em> and <em>ex situ</em> characterization techniques and theoretical calculations was employedto elucidate the charge compensation mechanism and structural evolutionof the La-doped system during electrochemical cycling. This work providesnew insights into the regulatory role of lanthanum in layered oxidesand offers a feasible doping strategy for developing anion-redox-basedcathode materials with a high energy density and long cycling stability.</p>","PeriodicalId":100230,"journal":{"name":"Chem & Bio Engineering","volume":"3 2","pages":"244–254"},"PeriodicalIF":8.4,"publicationDate":"2026-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147350018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Structural Design to Molecular Mechanisms: The Evolution of Solar Evaporators","authors":"Dong Wu,&nbsp;Jie Zhu,&nbsp;Qichen Zhang,&nbsp;Xiayun Huang,&nbsp;Zhihong Nie","doi":"10.1021/cbe.5c00110","DOIUrl":"10.1021/cbe.5c00110","url":null,"abstract":"<p>To address global water scarcity,solar-driven interfacial evaporationhas emerged as a promising solution that minimizes energy consumptionand environmental impact by harvesting solar energy directly at theair–water interface. Recent advances show that performancebreakthroughs depend on the synergistic interplay between macroscopicstructural designs and molecular-level mechanisms. This review tracesthe evolution of solar evaporators, from buoyancy-driven floatingarchitectures and enhanced water transport enabled by capillary andosmotic pressure differences, to state-of-the-art regulation of waterassociation states through hydrophobic interaction, hydrogen-bonding,and electrostatic interaction. These strategies accelerate mass transport,optimize solar energy utilization, lower evaporation enthalpy, andenhance long-term stability, achieving water transport rates up to0.091 g min^–1, evaporation rates up to 6.92 kg m^–2 h^–1 under 1 kW m^–2 illumination, and salt rejection efficiencies above 99.99%. Despitethese advances, challenges remain in achieving a precise mechanisticunderstanding of interfacial evaporation, scaling up fabrication,and standardized performance evaluation. This review highlights theseissues and outlines future research directions to accelerate the practicaldeployment of solar-driven interfacial evaporation technologies forsustainable desalination and water purification.</p>","PeriodicalId":100230,"journal":{"name":"Chem & Bio Engineering","volume":"3 2","pages":"148–158"},"PeriodicalIF":8.4,"publicationDate":"2026-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147350060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in the pH-Activity Profiles of Enzymes upon Immobilization on Polyelectrolyte-Containing Hydrogels","authors":"Nikita M. Ivanov,&nbsp;Anastasia T. Tsitsimeli,&nbsp;Wilhelm T. S. Huck","doi":"10.1021/cbe.5c00051","DOIUrl":"10.1021/cbe.5c00051","url":null,"abstract":"<p>Understanding changes in the physicochemical propertiesof enzymesupon immobilization is the key to optimizing their activities. Immobilizationon or modification with polyelectrolytes will induce shifts in thepH-activity profiles of enzymes, but a systematic study comparingvarious enzymes and polyelectrolyte supports is lacking. Here, wereport the pH-activity profiles of eight enzymes immobilized via covalentbonds within six different polyacrylamide-<em>co</em>-polyelectrolytehydrogel particles containing diverse ionic groups. Depending on theenzyme, shifts of the maximum activity toward either acidic or basicpH, as well as broadening of the pH-activity curves, were observed.While a general correlation of the direction of the shifts with thenature of the polyelectrolyte is not evident, we highlight that enzymestructural features, electrostatic factors, and local buffering areamong the determinants of the observed effects. Finally, we demonstrateexamples of unexpectedly large shifts that can be used to create biocatalystswith improved activities at unusual pHs.</p>","PeriodicalId":100230,"journal":{"name":"Chem & Bio Engineering","volume":"3 2","pages":"179–187"},"PeriodicalIF":8.4,"publicationDate":"2026-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147350062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A New Framework for Medium- to Long-Term PM2.5 Predictions Using AI-Based High-Resolution Meteorological Forecasts","authors":"Haonan Gu,&nbsp;Yichao Xu,&nbsp;Hua Pan,&nbsp;Yao Shi,&nbsp;Chunlei Wei,&nbsp;Xiaoyong Cao,&nbsp;Yi He","doi":"10.1021/cbe.5c00074","DOIUrl":"10.1021/cbe.5c00074","url":null,"abstract":"<p>Accurate forecasting of PM_2.5 concentrationsis vitalfor effective air quality management and public health protection,particularly in the context of medium- to long-term planning. Suchforecasts are also essential for guiding emission control and timelyresponses in urban and regional environments. Reliable predictionover extended horizons critically depends on access to accurate, high-resolutionmeteorological fields. To address limitations in traditional approachesthat rely on short-term site-level observations or retrospective meteorologicalfields, this study proposes a deep learning framework that couplesAI-based gridded meteorological forecasts with a dynamic graph-basedarchitecture for PM_2.5 prediction. The model captures evolvingspatiotemporal patterns of pollutant transport and enables extended-rangeforecasts. By leveraging gridded meteorological forecasts, the proposedframework reduces 3-day RMSE and MAE of the prediction by 12% comparedto models without the gridded inputs. For seasonal 10-day forecasts,errors can be decreased by approximately 20% relative to the physics-basedWeather Research and Forecasting (WRF)-Community Multiscale Air Quality(CMAQ) system. Furthermore, interpretability analysis reveals theimportance of wind-driven spatial asymmetries and supports the designof boundary-aware graph construction. Additional evaluations usingIntegrated Forecasting System (IFS) and PanGu-Weather forecasts furtherdemonstrate that the model maintains high performance across differentgridded data sources without retraining, highlighting its flexibilityand potential to incorporate other AI-based meteorological modelsfor adaptable and effective air quality forecasting. These findingsunderscore the potential of the proposed framework to serve as a computationallyefficient and operationally feasible alternative to conventional chemicaltransport models in future air quality management systems, particularlyfor early warning systems and targeted emission control strategies.</p>","PeriodicalId":100230,"journal":{"name":"Chem & Bio Engineering","volume":"3 2","pages":"219–230"},"PeriodicalIF":8.4,"publicationDate":"2026-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147350082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Boron Nitride Dispersing Strategy to Engineer Edge B Active Sites to Promote Propane Oxidative Dehydrogenation","authors":"Xinping Zhang,&nbsp;Guoqiang Shen,&nbsp;Yangqiang Huang,&nbsp;Xiao Luo,&nbsp;Hao Chen","doi":"10.1021/cbe.5c00073","DOIUrl":"10.1021/cbe.5c00073","url":null,"abstract":"<p>Hexagonal boron nitride (h-BN) demonstrates high olefinselectivityin the oxidative dehydrogenation of propane (ODHP), outperformingmetal oxide catalysts prone to overoxidation. However, the catalyticefficiency of h-BN is limited by a stable structure that resists regulation,a low specific surface area, and scarce oxy/hydroxylated edge-activesites formed at edges and defects. In this study, we successfullytuned the edge B active site of h-BN by dispersing flake h-BN nanosheetson an h-BN support, forming an architecture with an increased surfacearea and dense edge sites. The optimized catalyst achieves a propaneconversion of 46.9%, an olefin yield of 32.2%, and a deactivation&lt;5% over 50 h, exhibiting activity more than 2.1 times that ofcommercial h-BN. Characterizations revealed that by optimizing thestructure and density of active sites through edge exposure, the contactefficiency between propane and reactive centers is enhanced, therebyestablishing an efficient ODHP catalytic system that integrates activity,selectivity, and stability.</p>","PeriodicalId":100230,"journal":{"name":"Chem & Bio Engineering","volume":"3 2","pages":"210–218"},"PeriodicalIF":8.4,"publicationDate":"2026-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147350033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}