Chem & Bio Engineering最新文献_第4页

Modular Biosurface Engineering of Magnetotactic Bacteria for Multimodal Synergistic Cancer Therapy 多模态协同癌症治疗的趋磁细菌模块化生物表面工程。

IF 8.4

Chem & Bio Engineering Pub Date : 2026-05-28 Epub Date: 2026-03-30 DOI: 10.1021/cbe.5c00177

Qilong Li, Wangqing Li, Xuefei Sun, Feng Feng, Zhengdong Cheng, Wenchao Li, Li Yao, Xiuyu Wang

{"title":"Modular Biosurface Engineering of Magnetotactic Bacteria for Multimodal Synergistic Cancer Therapy","authors":"Qilong Li, Wangqing Li, Xuefei Sun, Feng Feng, Zhengdong Cheng, Wenchao Li, Li Yao, Xiuyu Wang","doi":"10.1021/cbe.5c00177","DOIUrl":"10.1021/cbe.5c00177","url":null,"abstract":"Bacterial-mediated cancer therapy shows therapeutic potentialyetremains constrained by bioavailability and biosafety challenges. Weintroduce a scalable, modular biosurface-engineering platform forfunctionalizing wild-type magnetotactic bacteria (Magnetospirillum magneticum, AMB-1), enabling the integration of diverse materials,including small molecules, polymers, nanoparticles, and metal–organicframeworks. As a proof-of-concept, AMB-1@Fe3+-PDA (polydopamine) exemplifies a bacteria-mediated therapeutic strategy thatmerges tumor-targeted delivery, immunosuppressive tumor microenvironment(TME) reprogramming, and innate immune activation with photothermal-chemodynamictherapy. The Fe3+-PDA coating counteracts deep-tissue immunosuppressionand primes adaptive immunity, while AMB-1 enhances penetration intoresistant TME niches. These mechanisms synergistically suppress aggressive4T1 breast tumor progression, metastasis, and recurrence while establishingimmunological memory. In murine models, two treatment cycles prolongedmedian survival from 45 to 67 days and elicited systemic antitumorimmunity, including abscopal effects targeting untreated distant tumors.This platform establishes a bridge between materials science and syntheticbiology, providing a generalizable blueprint for advancing the clinicaltranslation of engineered bacterial therapies.","PeriodicalId":100230,"journal":{"name":"Chem & Bio Engineering","volume":"3 5","pages":"524–534"},"PeriodicalIF":8.4,"publicationDate":"2026-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148152837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microfiltration of Selective Polysaccharides Using Inexpensive Fuller’s Earth-Based Ceramic Membranes 利用廉价的富勒土基陶瓷膜对选择性多糖进行微滤。

IF 8.4

Chem & Bio Engineering Pub Date : 2026-05-28 Epub Date: 2026-01-30 DOI: 10.1021/cbe.5c00123

Maddala Sree Kanth, Gourhari Chakraborty, Vijaykumar Sudarshana Deepa, Selvam Karuppasamy, Vinoth Kumar Raja

{"title":"Microfiltration of Selective Polysaccharides Using Inexpensive Fuller’s Earth-Based Ceramic Membranes","authors":"Maddala Sree Kanth, Gourhari Chakraborty, Vijaykumar Sudarshana Deepa, Selvam Karuppasamy, Vinoth Kumar Raja","doi":"10.1021/cbe.5c00123","DOIUrl":"10.1021/cbe.5c00123","url":null,"abstract":"This study presents a microfiltration approach for separatingpolysaccharidesusing an unprecedented ceramic membrane made from affordable Fuller’searth. The membrane was created through uniaxial hydraulic pressingand sintered at 850 °C, resulting in a pore size of 0.176 μm,39% porosity, and strong chemical and mechanical stability. Characterizedcomprehensively with Fourier transform infrared (FTIR) spectroscopy,optical microscopy, particle size analysis, and colorimetry, it effectivelyretained polysaccharides (cellulose and starch) while allowing thepassage of monosaccharides (glucose) and disaccharides (sucrose).Microfiltration experiments performed in a dead-end setup under differentpressures and concentrations showed flux rates from 212.18 to 225.97L m–2 h–1 for cellulose-glucosemixtures and 218.84 to 222.91 L m–2 h–1 for cellulose-sucrose mixtures, with flux increasing linearly withpressure. Fouling analysis using Hermia’s model identifiedcomplete pore blocking as the primary mechanism, except for starch-glucosemixtures, which followed the cake filtration model. These findingsdemonstrate the potential of locally sourced ceramic membranes forefficient, selective carbohydrate separation with promising applicationsin the food, pharmaceutical, and environmental industries.","PeriodicalId":100230,"journal":{"name":"Chem & Bio Engineering","volume":"3 5","pages":"513–523"},"PeriodicalIF":8.4,"publicationDate":"2026-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148152826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancing Diastereoselectivity of l-Threonine Aldolase by Strengthening Kinetic Control To Mitigate Thermodynamic Equilibrium 通过加强动力学控制来缓解热力学平衡，提高l -苏氨酸醛缩酶的非对映选择性。

IF 8.4

Chem & Bio Engineering Pub Date : 2026-05-28 Epub Date: 2026-04-28 DOI: 10.1021/cbe.6c00020

Wenlong Zheng, Sai Fang, Chennuo Zhu, Liu Yang, Yan Meng, Lirong Yang, Jianping Wu

{"title":"Enhancing Diastereoselectivity of l-Threonine Aldolase by Strengthening Kinetic Control To Mitigate Thermodynamic Equilibrium","authors":"Wenlong Zheng, Sai Fang, Chennuo Zhu, Liu Yang, Yan Meng, Lirong Yang, Jianping Wu","doi":"10.1021/cbe.6c00020","DOIUrl":"10.1021/cbe.6c00020","url":null,"abstract":"The reaction catalyzed by l-threonine aldolase(LTA) forthe formation of β-hydroxy-α-amino acids is governed byboth kinetic and thermodynamic control, causing the diastereoselectivityof LTA to gradually decrease as the reaction progresses. This hindersthe enzyme’s industrial application. To address this, we proposeda strategy to enhance kinetic control via substrate tunnel engineering,thereby mitigating the influence of thermodynamic equilibrium. Weinvestigated hotspot amino acid residues in the substrate tunnel usingthe VR-3M mutant from Bacillus nealsonii. As a result, we obtained mutant N6A/Q303K, which exhibited a diastereoselectivityof up to 99.0% at maximum conversion for the synthesis of (2S,3R)-3-[4-(methylsulfonyl)phenylserine].The kinetic control in this mutant was significantly enhanced, maintaininga diastereomeric excess (de) value above 95% until500 min─a 340 min delay over the original VR-3M, which dropsbelow 95% after 160 min while reaching only a 40.9% de value at 500min. Molecular dynamics simulations suggest that increases in activecenter volume and substrate tunnel reshaping are key factors enhancingthe kinetic control of diastereoselectivity. This study offers valuableinsights into the interplay between kinetic and thermodynamic controlin enzymatic catalysis.","PeriodicalId":100230,"journal":{"name":"Chem & Bio Engineering","volume":"3 5","pages":"546–554"},"PeriodicalIF":8.4,"publicationDate":"2026-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148152777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Photo and Thermal Stable Lignin-Based Sunscreen Microcapsules 光热稳定木质素基防晒微胶囊。

IF 8.4

Chem & Bio Engineering Pub Date : 2026-04-23 Epub Date: 2026-02-28 DOI: 10.1021/cbe.5c00141

Yuting Xiao, Xiaojing Li, Mingsong Zhou, Yong Qian

引用次数: 0

Ultrasound-Activated Prodrugs for Precision Cancer Therapy: From Mechanical and Cavitation Effects to Advanced Sonochemical Activation 用于精确癌症治疗的超声激活前药：从机械和空化效应到先进的声化学激活。

IF 8.4

Chem & Bio Engineering Pub Date : 2026-04-23 Epub Date: 2026-03-03 DOI: 10.1021/cbe.5c00185

Xitong Ren, Hui Zhang, Jingxuan Zhang, Na Shen, Zhaohui Tang

{"title":"Ultrasound-Activated Prodrugs for Precision Cancer Therapy: From Mechanical and Cavitation Effects to Advanced Sonochemical Activation","authors":"Xitong Ren, Hui Zhang, Jingxuan Zhang, Na Shen, Zhaohui Tang","doi":"10.1021/cbe.5c00185","DOIUrl":"10.1021/cbe.5c00185","url":null,"abstract":"Small-molecule drugs remain the mainstayof cancer therapy butare frequently compromised by poor tumor selectivity and dose-limitingsystemic toxicity. Prodrug strategies have therefore been widely developedto improve therapeutic indices; however, conventional prodrugs thatrely on endogenous biological stimuli often suffer from interpatientheterogeneity and unintended off-target activation. In this context,ultrasound (US) has emerged as a highly attractive exogenous triggerfor on-demand prodrug activation owing to its excellent safety profile,deep tissue penetration, and precise spatiotemporal controllability.In this review, we provide a comprehensive and systematic overviewof US-activated prodrugs for cancer therapy. We first summarize thefundamental physical principles of US and delineate four major US-inducedeffectsmechanical, cavitation, thermal, and chemicalhighlightinghow each effect can induce specific chemical bond cleavage and drugrelease. Particular emphasis is placed on the rapidly advancing fieldof sonochemistry, especially sonosensitizer-mediated electron transferand reactive oxygen species/radical generation, which enables highlyefficient and controllable chemical activation of prodrugs under clinicallyrelevant US conditions. By critically comparing activation mechanisms,chemical design strategies, and representative prodrug systems, thisreview clarifies the unique advantages and limitations of differentUS-responsive approaches. Importantly, we highlight recent advancesthat demonstrate the superiority of sonochemical activation in achievingprecise, deep-tissue, and minimally invasive drug activation. Collectively,this work aims to provide conceptual and practical guidance for therational design of next-generation US-activated prodrugs and to acceleratetheir translation toward safer and more effective precision cancertherapies.","PeriodicalId":100230,"journal":{"name":"Chem & Bio Engineering","volume":"3 4","pages":"448–469"},"PeriodicalIF":8.4,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147793861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

3D Aerohydrogel Scaffolds for Brain Tissue Engineering and In Vitro Neuroscience 用于脑组织工程和体外神经科学的3D气凝胶支架。

IF 8.4

Chem & Bio Engineering Pub Date : 2026-04-23 Epub Date: 2026-02-20 DOI: 10.1021/cbe.5c00104

Torge Hartig, Luise Schlotterose, Grace Atteh, Alexandrina Turcanu, Atharva Markale, Gabriel Chan, Margarethe Hauck, Thomas Strunskus, Ralph Lucius, Rainer Adelung, Fabian Schütt, Franz Faupel, Benjamin R. Freedman, Kirsten Hattermann, Stefan Schröder

{"title":"3D Aerohydrogel Scaffolds for Brain Tissue Engineering and In Vitro Neuroscience","authors":"Torge Hartig, Luise Schlotterose, Grace Atteh, Alexandrina Turcanu, Atharva Markale, Gabriel Chan, Margarethe Hauck, Thomas Strunskus, Ralph Lucius, Rainer Adelung, Fabian Schütt, Franz Faupel, Benjamin R. Freedman, Kirsten Hattermann, Stefan Schröder","doi":"10.1021/cbe.5c00104","DOIUrl":"10.1021/cbe.5c00104","url":null,"abstract":"The development of 3D scaffolds addresses a criticalgap in neuraltissue modeling by mimicking the physiological architecture in braincell culture. This is a key challenge to improve the reliability of in vitro assays and reduce animal testing, but also mandatoryfor the successful engineering of neural tissues in the future. Recentlyvarious types of applicable scaffolds have been applied for 3D cellcultures, which are typically porous hydrogels or fibrous mats producedby electrospinning. These scaffold materials oftentimes have a 3Dstructure limiting the ingrowth of cells and the diffusion of biophysicalfactors throughout the material. In this study, we show the capabilityof Aerohydrogels, fabricated via initiated chemical vapor deposition,to allow biophysical communication throughout the material in a spatiallydivided brain cell coculture of microglia and astrocytes. The recentlydeveloped Aerohydrogels have an ultralow density and mechanicallystable 3D hollow fibrous structure. The analysis of Interleukin inflammatorypathways shows the protective influence of astrocytes within the cocultureby intercellular communication. The findings support the great applicabilityof the newly applied Aerohydrogels in 3D brain cell coculture andrelevant analysis methods like live cell imaging, cell viability assays,or gene expression. This successful establishment allows more dedicatedfuture applications and optimization of Aerohydrogels in neural tissuemodeling.","PeriodicalId":100230,"journal":{"name":"Chem & Bio Engineering","volume":"3 4","pages":"487–495"},"PeriodicalIF":8.4,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147793894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Direct Regeneration of Spent LiNi0.8Co0.1Mn0.1O2 into Ce-Doped Single-Crystal Cathodes 废LiNi0.8Co0.1Mn0.1O2直接再生成掺铈单晶阴极

IF 8.4

Chem & Bio Engineering Pub Date : 2026-04-23 Epub Date: 2026-02-27 DOI: 10.1021/cbe.5c00155

Yudi Shao, Shuaipeng Hao, Fangyan Liu, Yuelin Kong, Haijin Ji, Zhangyating Xie, Yaqi Liao, Wei Liu, Yunhui Huang, Lixia Yuan

{"title":"Direct Regeneration of Spent LiNi0.8Co0.1Mn0.1O2 into Ce-Doped Single-Crystal Cathodes","authors":"Yudi Shao, Shuaipeng Hao, Fangyan Liu, Yuelin Kong, Haijin Ji, Zhangyating Xie, Yaqi Liao, Wei Liu, Yunhui Huang, Lixia Yuan","doi":"10.1021/cbe.5c00155","DOIUrl":"10.1021/cbe.5c00155","url":null,"abstract":"The widespread deployment of lithium-ionbatteries (LIBs)is drivinga steep rise in end-of-life batteries, heightening resource and environmentalburdens and underscoring the need for efficient recycling. Directregeneration, with its simplified processing, offers a practical alternativeto conventional pyrometallurgical and hydrometallurgical routes. Herein,we directly regenerate spent polycrystalline LiNi0.8Co0.1Mn0.1O2 (S-NCM811) into single-crystalcathodes with uniformly distributed Ce through mechanical deagglomeration-assistedeutectic molten salt regeneration. Lithium is replenished throughfast ionic transport in the molten salt, while the surface NiO rocksalt phase is relithiated and reconstructed into the layered structure.Notably, Ce doping expands the interlayer spacing and enhances thestructural stability of regenerated LiNi0.8Co0.1Mn0.1O2 (R-NCM811). In situ X-ray diffractionand electrochemical impedance spectroscopy confirm that Ce-doped single-crystalR-NCM811 alleviates H2→H3 lattice distortion and maintainslower charge-transfer resistance. As a result, R-NCM811 exhibits improvedelectrochemical performance, delivering 159.5 mAh g–1 at 5 C and retaining 88.17% of its capacity after 300 cycles at1 C. This work establishes a viable upcycling strategy for regeneratingsingle-crystal cathodes and provides a practical pathway toward moresustainable battery recycling.","PeriodicalId":100230,"journal":{"name":"Chem & Bio Engineering","volume":"3 4","pages":"470–477"},"PeriodicalIF":8.4,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147793882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mathematical Modeling of Biomass Pyrolysis in Fixed-Bed Reactors: A Systematic Review of Trends, Challenges, and Perspectives 固定床反应器中生物质热解的数学建模：趋势、挑战和前景的系统回顾。

IF 8.4

Chem & Bio Engineering Pub Date : 2026-04-23 Epub Date: 2026-03-17 DOI: 10.1021/cbe.6c00010

Vilmar Steffen, Maiquiel Schmidt de Oliveira, Edson Antonio da Silva

{"title":"Mathematical Modeling of Biomass Pyrolysis in Fixed-Bed Reactors: A Systematic Review of Trends, Challenges, and Perspectives","authors":"Vilmar Steffen, Maiquiel Schmidt de Oliveira, Edson Antonio da Silva","doi":"10.1021/cbe.6c00010","DOIUrl":"10.1021/cbe.6c00010","url":null,"abstract":"Accurate simulation of biomass pyrolysis in fixed-bedreactorsis crucial for optimizing this promising thermochemical conversionpathway. This review systematically consolidates and critically evaluatescontemporary mathematical models that describe the intrinsically coupledphenomena of heat transfer, reaction kinetics, and fluid dynamicswithin such systems. Employing an enhanced paper-ranking methodology(NIRP 2.0), a curated portfolio of 54 key studies was establishedand analyzed through integrated bibliometric and systematic contentanalysis. The synthesis delineates prevailing modeling paradigms,spanning from continuum approaches to advanced discrete particle-resolvedmethods like computational fluid dynamics-extended discrete elementmethod (CFD-XDEM), and provides a detailed discussion of their governingequations, submodel formulations, and numerical solution strategies.Particular emphasis is placed on scrutinizing common assumptions incritical subprocesses (drying, devolatilization, and char conversion)and on identifying persistent challenges in representing intraparticlegradients, bed shrinkage dynamics, and secondary reaction networks.The analysis reveals significant research gaps and emerging trends,underscoring the pressing need for more integrated, experimentallyvalidated multiscale models. Consequently, this review serves notonly as a comprehensive reference for current modeling practices butalso as a strategic roadmap for developing next-generation simulationtools to advance the design, scale-up, and operation of industrial-scalepyrolysis reactors.","PeriodicalId":100230,"journal":{"name":"Chem & Bio Engineering","volume":"3 4","pages":"428–447"},"PeriodicalIF":8.4,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147793879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Crystalline Porous Materials for Lithium Extraction 锂萃取用晶体多孔材料。

IF 8.4

Chem & Bio Engineering Pub Date : 2026-03-26 Epub Date: 2026-02-28 DOI: 10.1021/cbe.5c00145

Meng Sun, Xueyan Zhang, Yinfeng Han, Zixi Kang, Weidong Fan, Rongming Wang, Gangjun Chen, Daofeng Sun

{"title":"Crystalline Porous Materials for Lithium Extraction","authors":"Meng Sun, Xueyan Zhang, Yinfeng Han, Zixi Kang, Weidong Fan, Rongming Wang, Gangjun Chen, Daofeng Sun","doi":"10.1021/cbe.5c00145","DOIUrl":"10.1021/cbe.5c00145","url":null,"abstract":"The rapid transformation of the global energy structurehas promotedthe broad application of lithium-ion batteries. The efficient extractionof lithium, which is a core raw material for lithium-ion batteries,has become a crucial step in the new energy sector. Crystalline porousmaterials (CPMs) with distinct chemical properties and versatile topologicalstructures are promising for the separation of Li+ ions.Herein, we systematically review the structural features of CPMs,particularly metal–organic frameworks (MOFs) and covalent organicframeworks (COFs), for lithium-ion adsorption and separation, encompassingthe latest advancements in adsorption and membrane-based technologies.By analyzing the core mechanisms underlying lithium ions’ selectiverecognition and transport, such as ion exchange, chelation coordination,and sieving effects, this study reveals the structure-performancerelationship for Li+ ion separation. It is further elucidatedthat CPMs typically employ synergistic mechanisms, integrating multiplerecognition pathways to enhance performance. Research indicates thatthe structural flexibility of MOFs and the chemical stability of COFsenable them to exhibit both high selectivity and high capacity inLi+ ion adsorption. Functional modification and synthesisof composite materials help the adsorption and membrane separationprocess based on CPMs further overcome the limitations of traditionalseparation technologies. Finally, this review summarizes the challengesCPMs face in practical applications, outlines their future developmentdirections for sustainable lithium resource development, and providestheoretical and practical references for the next generation of efficientlithium separation materials.","PeriodicalId":100230,"journal":{"name":"Chem & Bio Engineering","volume":"3 3","pages":"373–395"},"PeriodicalIF":8.4,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147597350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aqueous Micellar-Catalyzed Thioetherification for the Synthesis of Aggregation-Induced Emission Molecules 水胶束催化硫醚反应合成聚集诱导发射分子。

IF 8.4

Chem & Bio Engineering Pub Date : 2026-03-26 Epub Date: 2026-03-04 DOI: 10.1021/cbe.6c00006

Zhike Qiu, Yulan Chen, Xiangyu Yin, Linxi Hou, Jianquan Hong, Xin Ge

{"title":"Aqueous Micellar-Catalyzed Thioetherification for the Synthesis of Aggregation-Induced Emission Molecules","authors":"Zhike Qiu, Yulan Chen, Xiangyu Yin, Linxi Hou, Jianquan Hong, Xin Ge","doi":"10.1021/cbe.6c00006","DOIUrl":"10.1021/cbe.6c00006","url":null,"abstract":"1,1-Diphenylvinyl sulfide (DPVS)exhibits aggregation-inducedemission(AIE) behavior by restricting intramolecular motion, making it a valuableaggregation-induced luminescent material. However, the synthesis ofsuch AIE molecules typically involves organic sulfur reagents andtoxic organic solvents, which limits their development in green synthesisconditions. In this study, we present a method for the multicomponentcross-coupling synthesis of DPVS in aqueous micellar conditions, utilizingiodine-mediated inorganic sulfur sources, such as elemental sulfur.The broad applicability of this method is demonstrated by the high-yieldsynthesis of over 20 different DPVS compounds using various inorganicsulfur sources. Furthermore, the glycosylated nonionic surfactantGluM can modify the coordination complexes formed by copper saltsand ligands, significantly enhancing the solubility of substrates.Notably, when emulsions are used as detection reagents, the accuracyof detecting nitroaromatic explosives improves significantly, witha quenching constant of 92.28 × 107. This advancementfacilitates the application of AIE molecules in chemical sensing.","PeriodicalId":100230,"journal":{"name":"Chem & Bio Engineering","volume":"3 3","pages":"406–417"},"PeriodicalIF":8.4,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147597331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0