Chem & Bio Engineering最新文献_第4页

Chem & Bio Engineering Pub Date : 2025-05-22

Xiaofeng Li, Xi Shan, Jiadong Chen, Jun Zhu, Yang Chen, Xueyi Chen, Shahao Li, Mengze Lu, Yuhui Du, Panchao Yin, Tingjian Chen* and Taolin Sun*,

引用次数: 0

Polymer Network Architecture of Single Network and Semi-Interpenetrating Network Hydrogels Modulates Water Retention and Degradation in Soil Conditioning Applications 单网络和半互穿网络水凝胶的聚合物网络结构调节土壤调节应用中的保水和降解。

Chem & Bio Engineering Pub Date : 2025-05-19 DOI: 10.1021/cbe.5c00029

Berke Çalbaş, Fahed Albreiki, Zel Carey, Katharina Wang, Rachel Ford, Advaita Kamal Nair, Nhu Nguyen and Thaiesha A. Wright*,

{"title":"Polymer Network Architecture of Single Network and Semi-Interpenetrating Network Hydrogels Modulates Water Retention and Degradation in Soil Conditioning Applications","authors":"Berke Çalbaş, Fahed Albreiki, Zel Carey, Katharina Wang, Rachel Ford, Advaita Kamal Nair, Nhu Nguyen and Thaiesha A. Wright*, ","doi":"10.1021/cbe.5c00029","DOIUrl":"10.1021/cbe.5c00029","url":null,"abstract":"With the global population projected to reach 9.7 billion by 2050, agricultural systems must address challenges related to soil fertility, water retention, and sustainability. To address these issues, biobased hydrogels made from natural polymers, such as gelatin methacrylate (GelMA) and chitosan (CS), have shown promise as sustainable soil conditioners. This study investigates GelMA/CS-based semi-interpenetrating network (semi-IPN) hydrogels, evaluating their swelling capacity, water retention, mechanical properties, and degradation behavior compared to GelMA-only hydrogels. The results show that semi-IPNs with higher CS concentrations exhibit superior water retention and faster degradation rates, alongside enhanced mechanical strength. Scanning electron microscopy reveals smaller, uniform pores in semi-IPNs, contributing to improved water retention. These findings suggest that GelMA/CS semi-IPNs are promising, biodegradable alternatives for enhancing soil moisture retention, soil fertility, and environmental sustainability in agriculture.","PeriodicalId":100230,"journal":{"name":"Chem & Bio Engineering","volume":"2 7","pages":"423–430"},"PeriodicalIF":0.0,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12301938/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144746722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surface Defect-Induced Dispersion and Stabilization of Monolayer MoS2 Nanosheets in Polar Solvents 表面缺陷诱导的单层MoS2纳米片在极性溶剂中的分散和稳定。

Chem & Bio Engineering Pub Date : 2025-05-16 DOI: 10.1021/cbe.4c00183

Yuxin Zhang, Yishu Chen, Zhengqi Peng, Deliang Wang*, Chengzhi Fu and Pingwei Liu*,

{"title":"Surface Defect-Induced Dispersion and Stabilization of Monolayer MoS2 Nanosheets in Polar Solvents","authors":"Yuxin Zhang, Yishu Chen, Zhengqi Peng, Deliang Wang*, Chengzhi Fu and Pingwei Liu*, ","doi":"10.1021/cbe.4c00183","DOIUrl":"10.1021/cbe.4c00183","url":null,"abstract":"Effective dispersion of two-dimensional (2D) nanosheets in polar solvents is essential for their practical applications. However, ultrathin MoS2 nanosheets produced via mechanical exfoliation or liquid-phase exfoliation lack surface functionalities, posing a significant challenge for achieving a uniform dispersion and good colloidal stability. Here, we investigate the dispersion properties and stabilization mechanism of monolayer MoS2 colloids synthesized via a bottom-up strategy under nanoconfinement. The nanosheets achieve high dispersion concentrations of >1.6 g/L in polar solvents such as water, N-methylpyrrolidone, and 1,4-butanediol, with the highest concentration approaching 10.6 g/L in ethylene glycol, significantly higher than the previously reported concentrations of less than 0.8 g/L for the exfoliated MoS2 nanosheets. The surface free energy of our MoS2 nanosheets is determined to be 48.7 mJ/m2, from which their maximum stable dispersion concentrations in various solvents can be predicted precisely. The high surface free energy can be attributed to the presence of abundant surface defects on the nanosheets, which induce the formation of polar hydroxyl (−OH) groups and increase the negative charge density on the surface, thereby enhancing their dispersibility and colloidal stability. These findings hold significant implications for colloidal applications of 2D MoS2 nanosheets in various fields.","PeriodicalId":100230,"journal":{"name":"Chem & Bio Engineering","volume":"2 6","pages":"370–379"},"PeriodicalIF":0.0,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12207278/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144546764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combing Directed Enzyme Evolution with Metabolic Engineering to Develop Efficient Microbial Cell Factories 结合定向酶进化与代谢工程开发高效微生物细胞工厂

Chem & Bio Engineering Pub Date : 2025-05-01 DOI: 10.1021/cbe.5c00002

Yuyao Ren, Ewelina Celińska, Peng Cai* and Yongjin J. Zhou*,

{"title":"Combing Directed Enzyme Evolution with Metabolic Engineering to Develop Efficient Microbial Cell Factories","authors":"Yuyao Ren, Ewelina Celińska, Peng Cai* and Yongjin J. Zhou*, ","doi":"10.1021/cbe.5c00002","DOIUrl":"https://doi.org/10.1021/cbe.5c00002","url":null,"abstract":"The booming field of synthetic biology and metabolic engineering provides promising approaches for sustainable manufacturing of chemicals from renewable feedstocks with microbial cell factories. Classical metabolic engineering strategies mainly focus on altering gene expression levels and enzyme concentrations to improve the metabolic fluxes of specific pathways. However, the impact and limitations of enzyme properties, which are usually ignored in classical metabolic engineering efforts, can hinder further optimization of microbial cell factories. Protein engineering and directed evolution are powerful tools for modifying proteins to achieve desirable properties, and they have been integrated into metabolic engineering efforts to build highly efficient metabolic pathways and optimal industrial chassis. In this review, we present traditional and data-driven strategies and techniques of directed evolution, including random library design, semirational design, smart library design, and in vivo continuous evolution. We also discuss how these directed evolution strategies have been applied in metabolic engineering toward superphenotypes that cannot be achieved through simple gene overexpression or knockout. Finally, we discuss the challenges of applying protein engineering in metabolic engineering and the prospects for accelerating the directed evolution workflow using the state-of-art technologies.","PeriodicalId":100230,"journal":{"name":"Chem & Bio Engineering","volume":"2 8","pages":"449–459"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/cbe.5c00002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144906680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Redoxable Deep Eutectic Solvent Boosts Recovery Efficiency of Neptunium 可还原的深度共熔溶剂提高了镎的回收率。

Chem & Bio Engineering Pub Date : 2025-04-30 DOI: 10.1021/cbe.5c00008

Qilong Tang, Shuang Liu, Huaixin Hao, Xue Dong, Yuxiao Guo, Yuexiang Lu, Zhipeng Wang* and Chao Xu*,

引用次数: 0

Chem & Bio Engineering Pub Date : 2025-04-24

Justin P. Edaugal, Difan Zhang*, Dupeng Liu*, Vassiliki-Alexandra Glezakou and Ning Sun*,

引用次数: 0

Chem & Bio Engineering Pub Date : 2025-04-24

Song Yang, Chenxi Qin, Zhizhi Zhang, Ming Zhang, Bin Li*, Yanfei Ma*, Feng Zhou* and Weimin Liu,

引用次数: 0

Chem & Bio Engineering Pub Date : 2025-04-24

引用次数: 0

Chem & Bio Engineering Pub Date : 2025-04-24

引用次数: 0

Programmable Cargo Release from Jet-Printed Microgel Particles via an In Situ Ionic Exchange Method 通过原位离子交换法从喷射打印的微凝胶颗粒中可编程释放货物

Chem & Bio Engineering Pub Date : 2025-04-24 DOI: 10.1021/cbe.5c0001710.1021/cbe.5c00017

Rong Ma, Jihpeng Sun, Sungwan Park, Fiona Nikolla and Albert Tianxiang Liu*,

{"title":"Programmable Cargo Release from Jet-Printed Microgel Particles via an In Situ Ionic Exchange Method","authors":"Rong Ma, Jihpeng Sun, Sungwan Park, Fiona Nikolla and Albert Tianxiang Liu*, ","doi":"10.1021/cbe.5c0001710.1021/cbe.5c00017","DOIUrl":"https://doi.org/10.1021/cbe.5c00017https://doi.org/10.1021/cbe.5c00017","url":null,"abstract":"Hydrogel-based drug delivery systems hold significant clinical potential by enabling precise spatial and temporal control over therapeutic release, ranging from metabolites, macromolecules to other cellular and subcellular constructs. However, achieving programmable release of payloads with diverse molecular weights at distinct rates typically requires complex polymer designs that can compromise the accessibility and biocompatibility of the delivery system. We present a scalable method for producing injectable, micrometer-scale alginate hydrogel particles (microgels) with precisely tuned microstructures for multiplexed, programmable cargo release. Our approach integrates an established jetting technique with a simple postsynthesis ion-exchange process to fine-tune the cross-linked microstructure of alginate microgels. By varying cation type (Ca2+, Mg2+, Na+) and concentration, we systematically modulate the microgels’ chemical and physical properties to control release rates of model compounds, including rhodamine B, methylene blue, and dextrans of various molecular weights. Additionally, a PEG-alginate composite microgel system is used to demonstrate the pre-programmed stepwise release of rhodamine B. These findings offer a straightforward strategy for postsynthetic manipulation of ionic microgels with controllable release performances, paving the way for advanced biomedical applications.","PeriodicalId":100230,"journal":{"name":"Chem & Bio Engineering","volume":"2 5","pages":"312–321 312–321"},"PeriodicalIF":0.0,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/cbe.5c00017","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144104893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0