Chem & Bio Engineering最新文献

{"title":"Light-Controlled Adhesive Hydrogels for On-Demand Adhesion.","authors":"Song Yang, Chenxi Qin, Zhizhi Zhang, Ming Zhang, Bin Li, Yanfei Ma, Feng Zhou, Weimin Liu","doi":"10.1021/cbe.4c00177","DOIUrl":"https://doi.org/10.1021/cbe.4c00177","url":null,"abstract":"<p><p>The rapid and reversible adhesion between solids is of great significance, particularly in fields such as biomedicine, intelligent machines, and bioelectronic sensors. Hydrogels, as soft materials, play a vital role in reversible adhesion. To achieve a wider range of applications, it is essential to enhance the intelligence of hydrogels. However, the preparation of reversible adhesive hydrogels with remote control, reversible adhesion, rapid response, and no residue remains a challenge in the field. Herein, we developed a light-controlled reversible adhesive hydrogel by integrating temperature-controlled reversible adhesion with the photothermal response capabilities of Fe₃O₄. The hydrogel can adhere/desorb reversibly under temperature control and allows for remote adhesion control using infrared light. Under infrared light irradiation, surface water causes carboxylic acid groups to migrate to the surface, thereby shielding the catechol groups. This results in insufficient adhesive groups at the interface to form interactions with opposing surfaces. Without infrared light irradiation, the adhesive functional groups are exposed, allowing interaction forces to form between the surface with the adhesion groups and the opposing surfaces. This smart hydrogel holds significant potential for future applications in wound dressings, wearable devices, and soft robots.</p>","PeriodicalId":100230,"journal":{"name":"Chem & Bio Engineering","volume":"2 4","pages":"253-259"},"PeriodicalIF":0.0,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12035562/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144061263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Light-Controlled Adhesive Hydrogels for On-Demand Adhesion","authors":"Song Yang,&nbsp;Chenxi Qin,&nbsp;Zhizhi Zhang,&nbsp;Ming Zhang,&nbsp;Bin Li*,&nbsp;Yanfei Ma*,&nbsp;Feng Zhou* and Weimin Liu,&nbsp;","doi":"10.1021/cbe.4c0017710.1021/cbe.4c00177","DOIUrl":"https://doi.org/10.1021/cbe.4c00177https://doi.org/10.1021/cbe.4c00177","url":null,"abstract":"<p >The rapid and reversible adhesion between solids is of great significance, particularly in fields such as biomedicine, intelligent machines, and bioelectronic sensors. Hydrogels, as soft materials, play a vital role in reversible adhesion. To achieve a wider range of applications, it is essential to enhance the intelligence of hydrogels. However, the preparation of reversible adhesive hydrogels with remote control, reversible adhesion, rapid response, and no residue remains a challenge in the field. Herein, we developed a light-controlled reversible adhesive hydrogel by integrating temperature-controlled reversible adhesion with the photothermal response capabilities of Fe₃O₄. The hydrogel can adhere/desorb reversibly under temperature control and allows for remote adhesion control using infrared light. Under infrared light irradiation, surface water causes carboxylic acid groups to migrate to the surface, thereby shielding the catechol groups. This results in insufficient adhesive groups at the interface to form interactions with opposing surfaces. Without infrared light irradiation, the adhesive functional groups are exposed, allowing interaction forces to form between the surface with the adhesion groups and the opposing surfaces. This smart hydrogel holds significant potential for future applications in wound dressings, wearable devices, and soft robots.</p>","PeriodicalId":100230,"journal":{"name":"Chem & Bio Engineering","volume":"2 4","pages":"253–259 253–259"},"PeriodicalIF":0.0,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/cbe.4c00177","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143863102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Crystallization-Assisted Asymmetric Synthesis of Enantiopure Amines Using Membrane-Immobilized Transaminase.","authors":"Hippolyte Meersseman Arango, Neal Bachus, Xuan Dieu Linh Nguyen, Basile Bredun, Patricia Luis, Tom Leyssens, David Roura Padrosa, Francesca Paradisi, Damien P Debecker","doi":"10.1021/cbe.4c00186","DOIUrl":"https://doi.org/10.1021/cbe.4c00186","url":null,"abstract":"<p><p>The production of active pharmaceutical ingredients (APIs) requires enantiopure chiral amines, for which greener synthesis processes are needed. Transaminases (TAs) are enzymes that catalyze the enantioselective production of chiral amines from prochiral ketones through transamination under mild conditions. Yet, industrial applications of biocatalytic transamination remain currently hindered by the limited stability of soluble enzymes and by the unfavorable thermodynamic equilibrium of targeted asymmetric reactions. Enzyme immobilization can be applied to address stability, recoverability, and reusability issues. In the perspective of process intensification, we chose to immobilize TAs on polymeric (polypropylene) membranes. In the asymmetric synthesis of (R)-2-fluoro-α-methylbenzylamine ((R)-FMBA), such membrane-immobilized TAs exhibited superior specific activity and stability compared with soluble TAs; they also outperformed TAs immobilized on resins. The reaction yield remained, however, limited by thermodynamics. To further enhance the synthesis yield, the reaction was coupled with the <i>in situ</i> crystallization of (R)-FMBA with 3,3-diphenylpropionic acid (DPPA). By doing so, the theoretical equilibrium conversion was pushed from ∼44% to ∼83%. In fact, a 72% overall recovery yield of crystallized (R)-FMBA was demonstrated. The enantioselectivity of the reaction mixture was preserved. Importantly, purification was greatly facilitated since the target enantiopure amine was readily recovered as high-purity (R)-FMBA:DPPA crystals. The biocatalytic membranes were found to be fully reusable, performing successive high-yield asymmetric syntheses with only minor deactivation. Overall, the crystallization-assisted strategy proposed herein offers a greener path for the biocatalytic production of valuable chiral targets.</p>","PeriodicalId":100230,"journal":{"name":"Chem & Bio Engineering","volume":"2 4","pages":"272-282"},"PeriodicalIF":0.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12035565/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144016193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Crystallization-Assisted Asymmetric Synthesis of Enantiopure Amines Using Membrane-Immobilized Transaminase","authors":"Hippolyte Meersseman Arango,&nbsp;Neal Bachus,&nbsp;Xuan Dieu Linh Nguyen,&nbsp;Basile Bredun,&nbsp;Patricia Luis,&nbsp;Tom Leyssens,&nbsp;David Roura Padrosa,&nbsp;Francesca Paradisi and Damien P. Debecker*,&nbsp;","doi":"10.1021/cbe.4c0018610.1021/cbe.4c00186","DOIUrl":"https://doi.org/10.1021/cbe.4c00186https://doi.org/10.1021/cbe.4c00186","url":null,"abstract":"<p >The production of active pharmaceutical ingredients (APIs) requires enantiopure chiral amines, for which greener synthesis processes are needed. Transaminases (TAs) are enzymes that catalyze the enantioselective production of chiral amines from prochiral ketones through transamination under mild conditions. Yet, industrial applications of biocatalytic transamination remain currently hindered by the limited stability of soluble enzymes and by the unfavorable thermodynamic equilibrium of targeted asymmetric reactions. Enzyme immobilization can be applied to address stability, recoverability, and reusability issues. In the perspective of process intensification, we chose to immobilize TAs on polymeric (polypropylene) membranes. In the asymmetric synthesis of (R)-2-fluoro-α-methylbenzylamine ((R)-FMBA), such membrane-immobilized TAs exhibited superior specific activity and stability compared with soluble TAs; they also outperformed TAs immobilized on resins. The reaction yield remained, however, limited by thermodynamics. To further enhance the synthesis yield, the reaction was coupled with the <i>in situ</i> crystallization of (R)-FMBA with 3,3-diphenylpropionic acid (DPPA). By doing so, the theoretical equilibrium conversion was pushed from ∼44% to ∼83%. In fact, a 72% overall recovery yield of crystallized (R)-FMBA was demonstrated. The enantioselectivity of the reaction mixture was preserved. Importantly, purification was greatly facilitated since the target enantiopure amine was readily recovered as high-purity (R)-FMBA:DPPA crystals. The biocatalytic membranes were found to be fully reusable, performing successive high-yield asymmetric syntheses with only minor deactivation. Overall, the crystallization-assisted strategy proposed herein offers a greener path for the biocatalytic production of valuable chiral targets.</p>","PeriodicalId":100230,"journal":{"name":"Chem & Bio Engineering","volume":"2 4","pages":"272–282 272–282"},"PeriodicalIF":0.0,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/cbe.4c00186","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143863097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Solvent Screening for Separation Processes Using Machine Learning and High-Throughput Technologies","authors":"Justin P. Edaugal,&nbsp;Difan Zhang*,&nbsp;Dupeng Liu*,&nbsp;Vassiliki-Alexandra Glezakou and Ning Sun*,&nbsp;","doi":"10.1021/cbe.4c0017010.1021/cbe.4c00170","DOIUrl":"https://doi.org/10.1021/cbe.4c00170https://doi.org/10.1021/cbe.4c00170","url":null,"abstract":"<p >As the chemical industry shifts toward sustainable practices, there is a growing initiative to replace conventional fossil-derived solvents with environmentally friendly alternatives such as ionic liquids (ILs) and deep eutectic solvents (DESs). Artificial intelligence (AI) plays a key role in the discovery and design of novel solvents and the development of green processes. This review explores the latest advancements in AI-assisted solvent screening with a specific focus on machine learning (ML) models for physicochemical property prediction and separation process design. Additionally, this paper highlights recent progress in the development of automated high-throughput (HT) platforms for solvent screening. Finally, this paper discusses the challenges and prospects of ML-driven HT strategies for green solvent design and optimization. To this end, this review provides key insights to advance solvent screening strategies for future chemical and separation processes.</p>","PeriodicalId":100230,"journal":{"name":"Chem & Bio Engineering","volume":"2 4","pages":"210–228 210–228"},"PeriodicalIF":0.0,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/cbe.4c00170","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143863226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Solvent Screening for Separation Processes Using Machine Learning and High-Throughput Technologies.","authors":"Justin P Edaugal, Difan Zhang, Dupeng Liu, Vassiliki-Alexandra Glezakou, Ning Sun","doi":"10.1021/cbe.4c00170","DOIUrl":"https://doi.org/10.1021/cbe.4c00170","url":null,"abstract":"<p><p>As the chemical industry shifts toward sustainable practices, there is a growing initiative to replace conventional fossil-derived solvents with environmentally friendly alternatives such as ionic liquids (ILs) and deep eutectic solvents (DESs). Artificial intelligence (AI) plays a key role in the discovery and design of novel solvents and the development of green processes. This review explores the latest advancements in AI-assisted solvent screening with a specific focus on machine learning (ML) models for physicochemical property prediction and separation process design. Additionally, this paper highlights recent progress in the development of automated high-throughput (HT) platforms for solvent screening. Finally, this paper discusses the challenges and prospects of ML-driven HT strategies for green solvent design and optimization. To this end, this review provides key insights to advance solvent screening strategies for future chemical and separation processes.</p>","PeriodicalId":100230,"journal":{"name":"Chem & Bio Engineering","volume":"2 4","pages":"210-228"},"PeriodicalIF":0.0,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12035567/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144016561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experimental Investigation into Dissociation Characteristics of Methane Hydrate in Sediments with Different Contents of Montmorillonite Clay","authors":"Chang Chen,&nbsp;Yu Zhang,&nbsp;Xiaosen Li*,&nbsp;Yuru Chen and Du Wang,&nbsp;","doi":"10.1021/cbe.4c0017410.1021/cbe.4c00174","DOIUrl":"https://doi.org/10.1021/cbe.4c00174https://doi.org/10.1021/cbe.4c00174","url":null,"abstract":"<p >The characteristics of gas production in sediments are crucial to the safe and efficient exploitation of gas hydrate resources. However, research on methane hydrate dissociation in these sediments, particularly in silty-clayey sediments, which are commonly found in nature, remains limited and contains significant gaps. To address this, a series of depressurization experiments were conducted to investigate the dissociation behavior of methane hydrate in silty-clayey sediments with montmorillonite contents ranging from 0 to 20 wt %. The results indicate that montmorillonite significantly inhibits methane hydrate dissociation. When the montmorillonite content increases from 10 to 20 wt %, the average dissociation rate of methane hydrate decreases by approximately 47%–78% compared to sandy sediments. An excess temperature drop of around 0.13 to 0.40 K was observed in the depressurization process as the montmorillonite content increased from 10 to 20 wt %. Methane hydrate dissociates unevenly in montmorillonite clay-bearing sediments due to the nonuniform distribution of the methane hydrate, coupled with the low thermal conductivity and high-water absorption capacity of montmorillonite, which restrict the supply of extra heat. The electrical resistance changes further reveal that the increased bound water content in clayey sediments reduces the impact of water fluctuation on the resistivity changes. Consequently, the resistivity changes in sandy sediments are more pronounced compared to silty-clayey sediments. These findings provide valuable insights for optimizing methane hydrate production technology via depressurization.</p>","PeriodicalId":100230,"journal":{"name":"Chem & Bio Engineering","volume":"2 4","pages":"260–271 260–271"},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/cbe.4c00174","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143863222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experimental Investigation into Dissociation Characteristics of Methane Hydrate in Sediments with Different Contents of Montmorillonite Clay.","authors":"Chang Chen, Yu Zhang, Xiaosen Li, Yuru Chen, Du Wang","doi":"10.1021/cbe.4c00174","DOIUrl":"https://doi.org/10.1021/cbe.4c00174","url":null,"abstract":"<p><p>The characteristics of gas production in sediments are crucial to the safe and efficient exploitation of gas hydrate resources. However, research on methane hydrate dissociation in these sediments, particularly in silty-clayey sediments, which are commonly found in nature, remains limited and contains significant gaps. To address this, a series of depressurization experiments were conducted to investigate the dissociation behavior of methane hydrate in silty-clayey sediments with montmorillonite contents ranging from 0 to 20 wt %. The results indicate that montmorillonite significantly inhibits methane hydrate dissociation. When the montmorillonite content increases from 10 to 20 wt %, the average dissociation rate of methane hydrate decreases by approximately 47%-78% compared to sandy sediments. An excess temperature drop of around 0.13 to 0.40 K was observed in the depressurization process as the montmorillonite content increased from 10 to 20 wt %. Methane hydrate dissociates unevenly in montmorillonite clay-bearing sediments due to the nonuniform distribution of the methane hydrate, coupled with the low thermal conductivity and high-water absorption capacity of montmorillonite, which restrict the supply of extra heat. The electrical resistance changes further reveal that the increased bound water content in clayey sediments reduces the impact of water fluctuation on the resistivity changes. Consequently, the resistivity changes in sandy sediments are more pronounced compared to silty-clayey sediments. These findings provide valuable insights for optimizing methane hydrate production technology via depressurization.</p>","PeriodicalId":100230,"journal":{"name":"Chem & Bio Engineering","volume":"2 4","pages":"260-271"},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12035566/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144060919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advanced Separation Materials and Processes","authors":"Zongbi Bao*,&nbsp; and ,&nbsp;Banglin Chen*,&nbsp;","doi":"10.1021/cbe.5c0000910.1021/cbe.5c00009","DOIUrl":"https://doi.org/10.1021/cbe.5c00009https://doi.org/10.1021/cbe.5c00009","url":null,"abstract":"","PeriodicalId":100230,"journal":{"name":"Chem & Bio Engineering","volume":"2 2","pages":"68–70 68–70"},"PeriodicalIF":0.0,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/cbe.5c00009","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143496235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advanced Separation Materials and Processes.","authors":"Zongbi Bao, Banglin Chen","doi":"10.1021/cbe.5c00009","DOIUrl":"https://doi.org/10.1021/cbe.5c00009","url":null,"abstract":"","PeriodicalId":100230,"journal":{"name":"Chem & Bio Engineering","volume":"2 2","pages":"68-70"},"PeriodicalIF":0.0,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11873843/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143560532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}