Chem & Bio Engineering最新文献

Bipolar Breakthrough: A Greener Path to Deuterated Chemicals. 双极突破：一条更环保的氘化化学品之路。

Chem & Bio Engineering Pub Date : 2025-08-20 eCollection Date: 2025-09-25 DOI: 10.1021/cbe.5c00081

Kaiqiang He, Huanting Wang

引用次数: 0

Synthetic Whole-Cell Bioelectronic Chemical Sensing with In Situ Genetic Computing. 原位遗传计算合成全细胞生物电子化学传感。

Chem & Bio Engineering Pub Date : 2025-08-07 eCollection Date: 2025-09-25 DOI: 10.1021/cbe.5c00015

Robert W Bradley, Estefania Nunez-Bajo, Firat Guder, Martin Buck, Baojun Wang

{"title":"Synthetic Whole-Cell Bioelectronic Chemical Sensing with In Situ Genetic Computing.","authors":"Robert W Bradley, Estefania Nunez-Bajo, Firat Guder, Martin Buck, Baojun Wang","doi":"10.1021/cbe.5c00015","DOIUrl":"10.1021/cbe.5c00015","url":null,"abstract":"Biosensors exploit the capabilities of biological systems to acquire a huge variety of chemical or physical information and convert molecular signals into actionable data. Here we took a bottom-up synthetic biology approach to combine the versatility and programmability of whole-cell bacterial biosensors with the sensitivity of electrochemical sensing devices. We built genetic modules to produce different phenazines and wired these to various sensing and information processing modules. A whole-cell bioelectronic sensor with a T7 RNAP-based signal amplifier was first constructed that detected mercury contaminants below the level of WHO safe limit for drinking water. We demonstrated the modularity and programmability of the sensor design by incorporating Boolean logic computation into a dual-input sensor. We subsequently engineered a sensor strain that can produce two phenazine types, giving a two-channel electrochemical output signal based on the detection of differentiated midpoint potentials. Our modular bioelectronic sensor therefore can be readily adapted for different applications and forms the basis for development of low-cost, field-deployable sensing devices.","PeriodicalId":100230,"journal":{"name":"Chem & Bio Engineering","volume":"2 9","pages":"501-510"},"PeriodicalIF":0.0,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12478552/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145202694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anisotropic Tactile Sensors: Constructive Designs, Challenges, and Emerging Applications. 各向异性触觉传感器：建设性设计，挑战和新兴应用。

Chem & Bio Engineering Pub Date : 2025-07-28 eCollection Date: 2025-09-25 DOI: 10.1021/cbe.5c00053

Jiaxing Zhang, Kaikai Zheng, Jingchen Ma, Mingfeng Chen, Xiuyu Wang, Fangle Chang, Shanshan Chen, Bin Ai, Zhengdong Cheng

{"title":"Anisotropic Tactile Sensors: Constructive Designs, Challenges, and Emerging Applications.","authors":"Jiaxing Zhang, Kaikai Zheng, Jingchen Ma, Mingfeng Chen, Xiuyu Wang, Fangle Chang, Shanshan Chen, Bin Ai, Zhengdong Cheng","doi":"10.1021/cbe.5c00053","DOIUrl":"10.1021/cbe.5c00053","url":null,"abstract":"Recent advancements in human-machine interaction technologies have driven significant interest in tactile sensors for health monitoring, movement detection, and the progression of intelligent robotics. However, most existing sensors rely on isotropic materials or structures, limiting their ability to detect stimuli from multiple directions simultaneously, which can be efficiently mitigated by incorporating anisotropic architectures. Despite their promising potential, the development of anisotropic tactile sensors remains nascent and necessitates more comprehensive synthesis and generalization of the current state. This review offers a thorough analysis of anisotropic tactile sensors, delving into their sensing mechanisms, performance metrics, materials, and structural designs. It also explores their applications in intelligent systems and critically evaluates the current developmental status and outlines the challenges to be addressed, providing essential insights and innovative solutions to propel advancements in this emerging research area.","PeriodicalId":100230,"journal":{"name":"Chem & Bio Engineering","volume":"2 9","pages":"530-566"},"PeriodicalIF":0.0,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12478554/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145202735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neutrophil-Inspired Film for Nonadhesive Capture of Tumor Cells through Synergistic Functionalization of Zwitterions and Aptamers 中性粒细胞激发膜通过中性离子和适体的协同功能捕获肿瘤细胞

Chem & Bio Engineering Pub Date : 2025-07-25 DOI: 10.1021/cbe.4c00189

Yangyang Li, Riyue Shu, Dan Lu, Cheng Zeng, Feng Qi, Shengfu Chen, Lin Zhang* and Zhe Tang*,

{"title":"Neutrophil-Inspired Film for Nonadhesive Capture of Tumor Cells through Synergistic Functionalization of Zwitterions and Aptamers","authors":"Yangyang Li, Riyue Shu, Dan Lu, Cheng Zeng, Feng Qi, Shengfu Chen, Lin Zhang* and Zhe Tang*, ","doi":"10.1021/cbe.4c00189","DOIUrl":"https://doi.org/10.1021/cbe.4c00189","url":null,"abstract":"The development of biomaterials capable of capturing nondestructively capturing tumor cells is critical for advancing cancer diagnostics and personalized therapies. However, designing specific capture materials for maintaining the structure of captured cells is still a challenge due to the undesirable nonspecific adhesion. Recent evidence showed that neutrophils possess the tumor cell targeting property via the binding of β-integrin on neutrophil membranes to VCAM-1 expressed on tumor cells and natural antiadhesion properties due to the phosphorylcholine on the cell membrane. Herein, we present a neutrophil-inspired nanofibrous film for the nondestructive capture of tumor cells. The polyurethane and polyacrylonitrile (PU–PAN) blend film was fabricated by electrospinning as a matrix. A tailored zwitterionic polymer of poly(sulfobetaine methacrylate-co-glycidyl methacrylate) (PScG), mimicking the phosphorylcholine on the cell membrane, was synthesized to graft onto the PU chain for preparing the PScG/PU–PAN film. Then, amino-modified aptamer (NH2-AS1411) targeting tumor cells, mimicking the β-integrin on neutrophil membranes, was further grafted onto hydrolyzed PAN surface to obtain the AS/PScG/PU–PAN film. The resulting AS/PScG/PU–PAN film demonstrates excellent specific capture ability of tumor cells, while maintaining the morphology of tumor cells, providing a promising solution for cancer therapy.","PeriodicalId":100230,"journal":{"name":"Chem & Bio Engineering","volume":"2 8","pages":"493–500"},"PeriodicalIF":0.0,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/cbe.4c00189","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144906698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0