Yuehua Xiao, Yinjie Wang, Chengtao Wang*, Wei Fang, Pei Liu, Yu Hui, Hangjie Li, Hang Zhou and Feng-Shou Xiao*,
{"title":"Tungsten Species on Beta Zeolite with Abundant Silanol Nests for Efficient Olefin Metathesis","authors":"Yuehua Xiao, Yinjie Wang, Chengtao Wang*, Wei Fang, Pei Liu, Yu Hui, Hangjie Li, Hang Zhou and Feng-Shou Xiao*, ","doi":"10.1021/cbe.5c00041","DOIUrl":"https://doi.org/10.1021/cbe.5c00041","url":null,"abstract":"<p >Tungstate-based catalysts for olefin metathesis generally suffer from insufficient reaction rates, which require relatively high temperatures for the satisfied activities. This issue is mainly due to the shortage of active WO<sub><i>x</i></sub> species related to intrinsic low adsorption and poor activation of olefin molecules. Herein, we found that the silanol nests in dealuminated Beta zeolite (DeAl-Beta) were favorable for high dispersion of tungsten species, forming active WO<sub><i>x</i></sub> species on the zeolite, which was helpful for the adsorption and activation of olefin molecules, thus facilitating the generation of metallocycle intermediates. As a result, the propene yield in the metathesis of ethene and 1-butene over WO<sub><i>x</i></sub>/DeAl-Beta was 2.3 times higher than that of the tungsten species supported on siliceous Beta zeolite with fewer silanol nests (WO<sub><i>x</i></sub>/Si-Beta) under the equivalent conditions. A propene yield as high as >50% was achieved by optimizing the silanol nests in the WO<sub><i>x</i></sub>/DeAl-Beta catalyst, outperforming those in the industrial silica supported tungsten species (W/SiO<sub>2</sub>) catalysts reported previously.</p>","PeriodicalId":100230,"journal":{"name":"Chem & Bio Engineering","volume":"2 8","pages":"485–492"},"PeriodicalIF":0.0,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/cbe.5c00041","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144906703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yuxin Zhang, Yishu Chen, Zhengqi Peng, Deliang Wang*, Chengzhi Fu and Pingwei Liu*,
{"title":"","authors":"Yuxin Zhang, Yishu Chen, Zhengqi Peng, Deliang Wang*, Chengzhi Fu and Pingwei Liu*, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":100230,"journal":{"name":"Chem & Bio Engineering","volume":"2 6","pages":"XXX-XXX 2305–2315"},"PeriodicalIF":0.0,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/cbe.4c00183","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144479824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chem & Bio EngineeringPub Date : 2025-06-26eCollection Date: 2025-09-25DOI: 10.1021/cbe.5c00025
Mengting Zhang, Ruxin Li, Jun Yu, Weili Dai
{"title":"Direct Conversion of the Biomass-Derived Acetone-Ethanol Mixture into Propene over Zr/Beta Zeolite.","authors":"Mengting Zhang, Ruxin Li, Jun Yu, Weili Dai","doi":"10.1021/cbe.5c00025","DOIUrl":"10.1021/cbe.5c00025","url":null,"abstract":"<p><p>The conversion of biomass fermentation liquor has garnered significant attention due to its potential for sustainable chemical production. Particularly, the transformation of an acetone-ethanol mixture, derived from the separation of high-value butanol, into other valuable compounds represents a critical advancement in biorefinery processes. Herein, we present a high-efficiency Zr/Beta zeolite catalyst for the conversion of an acetone-ethanol mixture into propene. Through systematic optimization, the optimal catalyst 5%Zr/Beta achieves a high propene yield (37.8%) with a propene selectivity of 67%. Spectroscopic results reveal that the conversion of acetone and ethanol primarily proceeds via the Meerwein-Ponndorf-Verley (MPV) reduction at Zr sites to form the isopropanol intermediate, followed by acid-catalyzed dehydration to propene facilitated by Si-OH groups. The high propene selectivity is due to the minor side reaction of converting acetone to isobutene, accompanied by the accumulation of cyclic unsaturated aldehydes/ketones and aromatic compounds deposited on the Zr active sites, leading to catalyst deactivation. Additionally, the Zr/Beta catalyst demonstrates good regenerability, which could recover to the initial state after a facile calcination process in air. This work offers a promising approach for the synthesis of propene from a biomass-derived acetone-ethanol mixture, contributing to the development of sustainable catalytic processes for biorefinery applications.</p>","PeriodicalId":100230,"journal":{"name":"Chem & Bio Engineering","volume":"2 9","pages":"520-529"},"PeriodicalIF":0.0,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12478550/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145202701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jiaqi Fan, Qi Wei, Pengcheng Yuan, Bing Xiao, Shasha Yao, Haoran Xu, Jiwei Liu, Ruoshui Li, Youqing Shen, Nigel K. H. Slater and Jianbin Tang*,
{"title":"Hydroxychloroquine-Derived Ionizable Lipid Facilitates Spleen-Tropic Transfection and Enhances Cancer Immunotherapy","authors":"Jiaqi Fan, Qi Wei, Pengcheng Yuan, Bing Xiao, Shasha Yao, Haoran Xu, Jiwei Liu, Ruoshui Li, Youqing Shen, Nigel K. H. Slater and Jianbin Tang*, ","doi":"10.1021/cbe.5c00031","DOIUrl":"10.1021/cbe.5c00031","url":null,"abstract":"<p >The success of SARS-CoV-2 mRNA vaccines has boosted their development against various diseases, especially tumors. However, their clinical application is hindered by limited therapeutic efficacy and non-negligible side effects. Many studies attempt to improve therapeutic effect against tumors by using spleen-tropism mRNA delivery systems. Herein, we develop lipid nanoparticles (LNPs) based on hydroxychloroquine (HCQ)-derived ionizable lipid as a spleen-tropism mRNA delivery system that simultaneously modulates the tumor immune-suppressive microenvironment. The screened HCQ LNPs exhibit high mRNA transfection efficiency both <i>in vitro</i> and <i>in vivo</i>. Surprisingly, the HCQ LNP can achieve spleen-tropic transfection after systemic administration, which is conducive to immune cells for antigen presentation. In addition, HCQ LNP passively targeted to tumors significantly repolarizes tumor-associated macrophages to the M1 phenotype, thereby modulating the tumor microenvironment. Therefore, compared to the commercial MC-3 LNP/mOVA, HCQ LNP/mOVA shows significantly improved prophylactic and therapeutic antitumor efficacy and antimetastatic effect. HCQ LNP/mOVA demonstrates a multifaceted strategy that enhances the therapeutic efficacy of mRNA tumor vaccines through functional mRNA delivery system design.</p>","PeriodicalId":100230,"journal":{"name":"Chem & Bio Engineering","volume":"2 7","pages":"437–448"},"PeriodicalIF":0.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12301932/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144746720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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