Chem & Bio Engineering最新文献_第2页

Bioinspired DNA Plastics with Brick-and-Mortar Structure: Enhanced Toughness, Recyclability, and Degradability. 生物启发DNA塑料砖和砂浆结构：增强韧性，可回收性和可降解性。

Chem & Bio Engineering Pub Date : 2025-03-14 eCollection Date: 2025-05-22 DOI: 10.1021/cbe.4c00190

Xiaofeng Li, Xi Shan, Jiadong Chen, Jun Zhu, Yang Chen, Xueyi Chen, Shahao Li, Mengze Lu, Yuhui Du, Panchao Yin, Tingjian Chen, Taolin Sun

{"title":"Bioinspired DNA Plastics with Brick-and-Mortar Structure: Enhanced Toughness, Recyclability, and Degradability.","authors":"Xiaofeng Li, Xi Shan, Jiadong Chen, Jun Zhu, Yang Chen, Xueyi Chen, Shahao Li, Mengze Lu, Yuhui Du, Panchao Yin, Tingjian Chen, Taolin Sun","doi":"10.1021/cbe.4c00190","DOIUrl":"10.1021/cbe.4c00190","url":null,"abstract":"Bio-based plastics offer the advantage of biodegradability over traditional petroleum-based plastics, enabling natural reintegration into the environment and positioning them as a more sustainable alternative. DNA, as a natural biopolymer, exhibits excellent biocompatibility and degradability. However, the mechanical strength of currently biomass DNA-based materials is inferior to that of other bio-based and petroleum-based plastics. In this work, DNA plastics with a ″brick-and-mortar\" structure were fabricated using DNA extracted from onions through bidirectional freezing, water vapor annealing, and compression densification. This biomimetic design significantly enhances the fracture toughness (∼1.5 MPa·m1/2) while possessing a high elastic modulus (∼560 MPa) of DNA plastic, making it superior or comparable to existing bio-based plastics and petroleum-based plastics, and thus positioning it as a potential structural material. Analysis of crack propagation behavior in DNA plastics reveals that their high toughness stems from a hierarchical ″brick-and-mortar″ structure operating across multiple length scales, facilitating a multiscale fracture process from macroscopic to molecular levels. Furthermore, these DNA plastics can be efficiently recycled in aqueous environments and fully biodegraded by enzymes, demonstrating strong environmental friendliness and significant potential for sustainable development.","PeriodicalId":100230,"journal":{"name":"Chem & Bio Engineering","volume":"2 5","pages":"303-311"},"PeriodicalIF":0.0,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12104841/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144164081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioinspired DNA Plastics with Brick-and-Mortar Structure: Enhanced Toughness, Recyclability, and Degradability 生物启发DNA塑料砖和砂浆结构：增强韧性，可回收性和可降解性

Chem & Bio Engineering Pub Date : 2025-03-14 DOI: 10.1021/cbe.4c0019010.1021/cbe.4c00190

Xiaofeng Li, Xi Shan, Jiadong Chen, Jun Zhu, Yang Chen, Xueyi Chen, Shahao Li, Mengze Lu, Yuhui Du, Panchao Yin, Tingjian Chen* and Taolin Sun*,

{"title":"Bioinspired DNA Plastics with Brick-and-Mortar Structure: Enhanced Toughness, Recyclability, and Degradability","authors":"Xiaofeng Li, Xi Shan, Jiadong Chen, Jun Zhu, Yang Chen, Xueyi Chen, Shahao Li, Mengze Lu, Yuhui Du, Panchao Yin, Tingjian Chen* and Taolin Sun*, ","doi":"10.1021/cbe.4c0019010.1021/cbe.4c00190","DOIUrl":"https://doi.org/10.1021/cbe.4c00190https://doi.org/10.1021/cbe.4c00190","url":null,"abstract":"Bio-based plastics offer the advantage of biodegradability over traditional petroleum-based plastics, enabling natural reintegration into the environment and positioning them as a more sustainable alternative. DNA, as a natural biopolymer, exhibits excellent biocompatibility and degradability. However, the mechanical strength of currently biomass DNA-based materials is inferior to that of other bio-based and petroleum-based plastics. In this work, DNA plastics with a ″brick-and-mortar” structure were fabricated using DNA extracted from onions through bidirectional freezing, water vapor annealing, and compression densification. This biomimetic design significantly enhances the fracture toughness (∼1.5 MPa·m1/2) while possessing a high elastic modulus (∼560 MPa) of DNA plastic, making it superior or comparable to existing bio-based plastics and petroleum-based plastics, and thus positioning it as a potential structural material. Analysis of crack propagation behavior in DNA plastics reveals that their high toughness stems from a hierarchical ″brick-and-mortar″ structure operating across multiple length scales, facilitating a multiscale fracture process from macroscopic to molecular levels. Furthermore, these DNA plastics can be efficiently recycled in aqueous environments and fully biodegraded by enzymes, demonstrating strong environmental friendliness and significant potential for sustainable development.","PeriodicalId":100230,"journal":{"name":"Chem & Bio Engineering","volume":"2 5","pages":"303–311 303–311"},"PeriodicalIF":0.0,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/cbe.4c00190","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144104874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Solvent Screening for Separation Processes Using Machine Learning and High-Throughput Technologies 利用机器学习和高通量技术筛选分离过程中的溶剂

Chem & Bio Engineering Pub Date : 2025-03-05 DOI: 10.1021/cbe.4c0017010.1021/cbe.4c00170

Justin P. Edaugal, Difan Zhang*, Dupeng Liu*, Vassiliki-Alexandra Glezakou and Ning Sun*,

{"title":"Solvent Screening for Separation Processes Using Machine Learning and High-Throughput Technologies","authors":"Justin P. Edaugal, Difan Zhang*, Dupeng Liu*, Vassiliki-Alexandra Glezakou and Ning Sun*, ","doi":"10.1021/cbe.4c0017010.1021/cbe.4c00170","DOIUrl":"https://doi.org/10.1021/cbe.4c00170https://doi.org/10.1021/cbe.4c00170","url":null,"abstract":"As the chemical industry shifts toward sustainable practices, there is a growing initiative to replace conventional fossil-derived solvents with environmentally friendly alternatives such as ionic liquids (ILs) and deep eutectic solvents (DESs). Artificial intelligence (AI) plays a key role in the discovery and design of novel solvents and the development of green processes. This review explores the latest advancements in AI-assisted solvent screening with a specific focus on machine learning (ML) models for physicochemical property prediction and separation process design. Additionally, this paper highlights recent progress in the development of automated high-throughput (HT) platforms for solvent screening. Finally, this paper discusses the challenges and prospects of ML-driven HT strategies for green solvent design and optimization. To this end, this review provides key insights to advance solvent screening strategies for future chemical and separation processes.","PeriodicalId":100230,"journal":{"name":"Chem & Bio Engineering","volume":"2 4","pages":"210–228 210–228"},"PeriodicalIF":0.0,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/cbe.4c00170","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143863226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Solvent Screening for Separation Processes Using Machine Learning and High-Throughput Technologies. 利用机器学习和高通量技术筛选分离过程中的溶剂。

Chem & Bio Engineering Pub Date : 2025-03-05 eCollection Date: 2025-04-24 DOI: 10.1021/cbe.4c00170

Justin P Edaugal, Difan Zhang, Dupeng Liu, Vassiliki-Alexandra Glezakou, Ning Sun

引用次数: 0

Experimental Investigation into Dissociation Characteristics of Methane Hydrate in Sediments with Different Contents of Montmorillonite Clay 不同蒙脱土含量沉积物中甲烷水合物解离特性的实验研究

Chem & Bio Engineering Pub Date : 2025-03-03 DOI: 10.1021/cbe.4c0017410.1021/cbe.4c00174

Chang Chen, Yu Zhang, Xiaosen Li*, Yuru Chen and Du Wang,

{"title":"Experimental Investigation into Dissociation Characteristics of Methane Hydrate in Sediments with Different Contents of Montmorillonite Clay","authors":"Chang Chen, Yu Zhang, Xiaosen Li*, Yuru Chen and Du Wang, ","doi":"10.1021/cbe.4c0017410.1021/cbe.4c00174","DOIUrl":"https://doi.org/10.1021/cbe.4c00174https://doi.org/10.1021/cbe.4c00174","url":null,"abstract":"The characteristics of gas production in sediments are crucial to the safe and efficient exploitation of gas hydrate resources. However, research on methane hydrate dissociation in these sediments, particularly in silty-clayey sediments, which are commonly found in nature, remains limited and contains significant gaps. To address this, a series of depressurization experiments were conducted to investigate the dissociation behavior of methane hydrate in silty-clayey sediments with montmorillonite contents ranging from 0 to 20 wt %. The results indicate that montmorillonite significantly inhibits methane hydrate dissociation. When the montmorillonite content increases from 10 to 20 wt %, the average dissociation rate of methane hydrate decreases by approximately 47%–78% compared to sandy sediments. An excess temperature drop of around 0.13 to 0.40 K was observed in the depressurization process as the montmorillonite content increased from 10 to 20 wt %. Methane hydrate dissociates unevenly in montmorillonite clay-bearing sediments due to the nonuniform distribution of the methane hydrate, coupled with the low thermal conductivity and high-water absorption capacity of montmorillonite, which restrict the supply of extra heat. The electrical resistance changes further reveal that the increased bound water content in clayey sediments reduces the impact of water fluctuation on the resistivity changes. Consequently, the resistivity changes in sandy sediments are more pronounced compared to silty-clayey sediments. These findings provide valuable insights for optimizing methane hydrate production technology via depressurization.","PeriodicalId":100230,"journal":{"name":"Chem & Bio Engineering","volume":"2 4","pages":"260–271 260–271"},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/cbe.4c00174","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143863222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Experimental Investigation into Dissociation Characteristics of Methane Hydrate in Sediments with Different Contents of Montmorillonite Clay. 不同蒙脱土含量沉积物中甲烷水合物解离特性的实验研究。

Chem & Bio Engineering Pub Date : 2025-03-03 eCollection Date: 2025-04-24 DOI: 10.1021/cbe.4c00174

Chang Chen, Yu Zhang, Xiaosen Li, Yuru Chen, Du Wang

{"title":"Experimental Investigation into Dissociation Characteristics of Methane Hydrate in Sediments with Different Contents of Montmorillonite Clay.","authors":"Chang Chen, Yu Zhang, Xiaosen Li, Yuru Chen, Du Wang","doi":"10.1021/cbe.4c00174","DOIUrl":"https://doi.org/10.1021/cbe.4c00174","url":null,"abstract":"The characteristics of gas production in sediments are crucial to the safe and efficient exploitation of gas hydrate resources. However, research on methane hydrate dissociation in these sediments, particularly in silty-clayey sediments, which are commonly found in nature, remains limited and contains significant gaps. To address this, a series of depressurization experiments were conducted to investigate the dissociation behavior of methane hydrate in silty-clayey sediments with montmorillonite contents ranging from 0 to 20 wt %. The results indicate that montmorillonite significantly inhibits methane hydrate dissociation. When the montmorillonite content increases from 10 to 20 wt %, the average dissociation rate of methane hydrate decreases by approximately 47%-78% compared to sandy sediments. An excess temperature drop of around 0.13 to 0.40 K was observed in the depressurization process as the montmorillonite content increased from 10 to 20 wt %. Methane hydrate dissociates unevenly in montmorillonite clay-bearing sediments due to the nonuniform distribution of the methane hydrate, coupled with the low thermal conductivity and high-water absorption capacity of montmorillonite, which restrict the supply of extra heat. The electrical resistance changes further reveal that the increased bound water content in clayey sediments reduces the impact of water fluctuation on the resistivity changes. Consequently, the resistivity changes in sandy sediments are more pronounced compared to silty-clayey sediments. These findings provide valuable insights for optimizing methane hydrate production technology via depressurization.","PeriodicalId":100230,"journal":{"name":"Chem & Bio Engineering","volume":"2 4","pages":"260-271"},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12035566/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144060919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advanced Separation Materials and Processes 先进的分离材料和工艺

Chem & Bio Engineering Pub Date : 2025-02-27 DOI: 10.1021/cbe.5c0000910.1021/cbe.5c00009

Zongbi Bao*, and , Banglin Chen*,

引用次数: 0

Advanced Separation Materials and Processes. 先进的分离材料和工艺。

Chem & Bio Engineering Pub Date : 2025-02-27 DOI: 10.1021/cbe.5c00009

Zongbi Bao, Banglin Chen

引用次数: 0

Injectable Hydrogels Based on Hyperbranched Polymers for Biomedical Applications 基于超支化聚合物的可注射水凝胶在生物医学中的应用

Chem & Bio Engineering Pub Date : 2025-02-18 DOI: 10.1021/cbe.4c0017310.1021/cbe.4c00173

Gaolong Lin, Xiaolin Li, Grzegorz Nowaczyk and Wei Wang*,

{"title":"Injectable Hydrogels Based on Hyperbranched Polymers for Biomedical Applications","authors":"Gaolong Lin, Xiaolin Li, Grzegorz Nowaczyk and Wei Wang*, ","doi":"10.1021/cbe.4c0017310.1021/cbe.4c00173","DOIUrl":"https://doi.org/10.1021/cbe.4c00173https://doi.org/10.1021/cbe.4c00173","url":null,"abstract":"Injectable hydrogels (IHs) have garnered significant attention in biomedical applications due to their minimally invasive nature, adaptability, and high degree of customization. However, traditional design methods of IHs have limitations in addressing complex clinical needs, such as precise regulation of the gelation time and mechanical strength within a wide window. Hyperbranched polymers (HBPs), due to their unique highly branched structures and abundant functional sites, can be easily prepared and functionalized to enable decoupled modulation of mechanical properties of IHs and address the clinical challenges of IHs. Our research group developed a library of HBPs via a dynamically controllable polymerization method and built a series of adjustable, controllable, and responsive IHs based on the resulting HBPs. The prepared IHs fed by HBPs demonstrate an adjustable gelation process, a wide-range tuning of mechanical properties, and responsiveness on demand, which show the capabilities in the various biomedical applications. In this review, we summarize the role of HBPs in the gelation process, mechanical properties, self-healing ability, and responsiveness of IHs. However, achieving IHs through HBPs and extending them to a broad range of biomedical applications are still in its infancy. This review provides an overview of IHs fabricated by a variety of multifunctional HBPs, and their biomedical applications in diverse fields are also presented. Meanwhile, we point out the future development of IHs based on HBPs and their potential challenges.","PeriodicalId":100230,"journal":{"name":"Chem & Bio Engineering","volume":"2 5","pages":"283–302 283–302"},"PeriodicalIF":0.0,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/cbe.4c00173","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144104872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Injectable Hydrogels Based on Hyperbranched Polymers for Biomedical Applications. 基于超支化聚合物的可注射水凝胶在生物医学中的应用。

Chem & Bio Engineering Pub Date : 2025-02-18 eCollection Date: 2025-05-22 DOI: 10.1021/cbe.4c00173

Gaolong Lin, Xiaolin Li, Grzegorz Nowaczyk, Wei Wang

{"title":"Injectable Hydrogels Based on Hyperbranched Polymers for Biomedical Applications.","authors":"Gaolong Lin, Xiaolin Li, Grzegorz Nowaczyk, Wei Wang","doi":"10.1021/cbe.4c00173","DOIUrl":"10.1021/cbe.4c00173","url":null,"abstract":"Injectable hydrogels (IHs) have garnered significant attention in biomedical applications due to their minimally invasive nature, adaptability, and high degree of customization. However, traditional design methods of IHs have limitations in addressing complex clinical needs, such as precise regulation of the gelation time and mechanical strength within a wide window. Hyperbranched polymers (HBPs), due to their unique highly branched structures and abundant functional sites, can be easily prepared and functionalized to enable decoupled modulation of mechanical properties of IHs and address the clinical challenges of IHs. Our research group developed a library of HBPs via a dynamically controllable polymerization method and built a series of adjustable, controllable, and responsive IHs based on the resulting HBPs. The prepared IHs fed by HBPs demonstrate an adjustable gelation process, a wide-range tuning of mechanical properties, and responsiveness on demand, which show the capabilities in the various biomedical applications. In this review, we summarize the role of HBPs in the gelation process, mechanical properties, self-healing ability, and responsiveness of IHs. However, achieving IHs through HBPs and extending them to a broad range of biomedical applications are still in its infancy. This review provides an overview of IHs fabricated by a variety of multifunctional HBPs, and their biomedical applications in diverse fields are also presented. Meanwhile, we point out the future development of IHs based on HBPs and their potential challenges.","PeriodicalId":100230,"journal":{"name":"Chem & Bio Engineering","volume":"2 5","pages":"283-302"},"PeriodicalIF":0.0,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12104845/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144164157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0