Chem & Bio Engineering最新文献_第6页

Hydrostable Fluorinated Metal–Organic Frameworks for CO2 Capture from a Wet Flue Gas: Multiscale Computational Screening 用于从湿烟气中捕获CO2的水稳定氟化金属-有机框架：多尺度计算筛选

Chem & Bio Engineering Pub Date : 2024-10-29 DOI: 10.1021/cbe.4c0011110.1021/cbe.4c00111

Athulya S. Palakkal, Saad Aldin Mohamed and Jianwen Jiang*,

{"title":"Hydrostable Fluorinated Metal–Organic Frameworks for CO2 Capture from a Wet Flue Gas: Multiscale Computational Screening","authors":"Athulya S. Palakkal, Saad Aldin Mohamed and Jianwen Jiang*, ","doi":"10.1021/cbe.4c0011110.1021/cbe.4c00111","DOIUrl":"https://doi.org/10.1021/cbe.4c00111https://doi.org/10.1021/cbe.4c00111","url":null,"abstract":"Metal–organic frameworks (MOFs) are promising adsorbents for CO2 capture due to readily tunable porosity and diverse functionality; however, their performance is deteriorated by the presence of H2O in a flue gas. Fluorinated MOFs (FMOFs) may impede H2O interaction with frameworks and enhance CO2 adsorption under humid conditions. In this study, a multiscale computational screening study is reported to identify the top FMOFs for CO2 capture from a wet flue gas. Initially, geometric properties as well as heats of H2O adsorption are used to shortlist FMOFs with a suitable pore size and weak H2O affinity. Then, grand-canonical Monte Carlo simulations are conducted for adsorption of a CO2/N2/H2O mixture with 60% relative humidity in 5061 FMOFs. Based on the adsorption performance, 19 FMOFs are identified as top candidates. It is revealed that the position of F atom, rather than the amount, affects CO2 adsorption; moreover, N-decorated FMOFs are preferential for selective CO2 adsorption. Finally, the hydrostability of the top FMOFs is confirmed by first-principles molecular dynamics simulations. From a microscopic level, this study provides quantitative structure–performance relationships, discovers hydrostable FMOFs with high CO2 capture performance from a wet flue gas, and would facilitate the development of new MOFs toward efficient CO2 capture under humid conditions.","PeriodicalId":100230,"journal":{"name":"Chem & Bio Engineering","volume":"1 11","pages":"970–978 970–978"},"PeriodicalIF":0.0,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/cbe.4c00111","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143127704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hydrostable Fluorinated Metal-Organic Frameworks for CO₂ Capture from a Wet Flue Gas: Multiscale Computational Screening. 用于从湿烟气中捕获CO2的水稳定氟化金属-有机框架：多尺度计算筛选。

Chem & Bio Engineering Pub Date : 2024-10-29 eCollection Date: 2024-12-26 DOI: 10.1021/cbe.4c00111

Athulya S Palakkal, Saad Aldin Mohamed, Jianwen Jiang

{"title":"Hydrostable Fluorinated Metal-Organic Frameworks for CO2 Capture from a Wet Flue Gas: Multiscale Computational Screening.","authors":"Athulya S Palakkal, Saad Aldin Mohamed, Jianwen Jiang","doi":"10.1021/cbe.4c00111","DOIUrl":"10.1021/cbe.4c00111","url":null,"abstract":"Metal-organic frameworks (MOFs) are promising adsorbents for CO2 capture due to readily tunable porosity and diverse functionality; however, their performance is deteriorated by the presence of H2O in a flue gas. Fluorinated MOFs (FMOFs) may impede H2O interaction with frameworks and enhance CO2 adsorption under humid conditions. In this study, a multiscale computational screening study is reported to identify the top FMOFs for CO2 capture from a wet flue gas. Initially, geometric properties as well as heats of H2O adsorption are used to shortlist FMOFs with a suitable pore size and weak H2O affinity. Then, grand-canonical Monte Carlo simulations are conducted for adsorption of a CO2/N2/H2O mixture with 60% relative humidity in 5061 FMOFs. Based on the adsorption performance, 19 FMOFs are identified as top candidates. It is revealed that the position of F atom, rather than the amount, affects CO2 adsorption; moreover, N-decorated FMOFs are preferential for selective CO2 adsorption. Finally, the hydrostability of the top FMOFs is confirmed by first-principles molecular dynamics simulations. From a microscopic level, this study provides quantitative structure-performance relationships, discovers hydrostable FMOFs with high CO2 capture performance from a wet flue gas, and would facilitate the development of new MOFs toward efficient CO2 capture under humid conditions.","PeriodicalId":100230,"journal":{"name":"Chem & Bio Engineering","volume":"1 11","pages":"970-978"},"PeriodicalIF":0.0,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11835262/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143461560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Engineered Extracellular Vesicles as a New Class of Nanomedicine. 工程细胞外囊泡作为一类新的纳米药物。

Chem & Bio Engineering Pub Date : 2024-10-28 eCollection Date: 2025-01-23 DOI: 10.1021/cbe.4c00122

Xiaowei Wen, Zerun Hao, Haofan Yin, Jie Min, Xueying Wang, Sihan Sun, Gang Ruan

{"title":"Engineered Extracellular Vesicles as a New Class of Nanomedicine.","authors":"Xiaowei Wen, Zerun Hao, Haofan Yin, Jie Min, Xueying Wang, Sihan Sun, Gang Ruan","doi":"10.1021/cbe.4c00122","DOIUrl":"10.1021/cbe.4c00122","url":null,"abstract":"Extracellular vesicles (EVs) are secreted from biological cells and contain many molecules with diagnostic values or therapeutic functions. There has been great interest in academic and industrial communities to utilize EVs as tools for diagnosis or therapeutics. In addition, EVs can also serve as delivery vehicles for therapeutic molecules. An indicator of the enormous interest in EVs is the large number of review articles published on EVs, with the focus ranging from their biology to their applications. An emerging trend in EV research is to produce and utilize \"engineered EVs\", which are essentially the enhanced version of EVs. EV engineering can be conducted by cell culture condition control, genetic engineering, or chemical engineering. Given their nanometer-scale sizes and therapeutic potentials, engineered EVs are an emerging class of nanomedicines. So far, an overwhelming majority of the research on engineered EVs is preclinical studies; there are only a very small number of reported clinical trials. This Review focuses on engineered EVs, with a more specific focus being their applications in therapeutics. The various approaches to producing engineered EVs and their applications in various diseases are reviewed. Furthermore, in vivo imaging of EVs, the mechanistic understandings, and the clinical translation aspects are discussed. The discussion is primarily on preclinical studies while briefly mentioning the clinical trials. With continued interdisciplinary research efforts from biologists, pharmacists, physicians, bioengineers, and chemical engineers, engineered EVs could become a powerful solution for many major diseases such as neurological, immunological, and cardiovascular diseases.","PeriodicalId":100230,"journal":{"name":"Chem & Bio Engineering","volume":"2 1","pages":"3-22"},"PeriodicalIF":0.0,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11835263/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143461471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Engineered Extracellular Vesicles as a New Class of Nanomedicine 工程细胞外囊泡作为一类新的纳米药物

Chem & Bio Engineering Pub Date : 2024-10-28 DOI: 10.1021/cbe.4c0012210.1021/cbe.4c00122

Xiaowei Wen*, Zerun Hao, Haofan Yin, Jie Min, Xueying Wang, Sihan Sun and Gang Ruan*,

{"title":"Engineered Extracellular Vesicles as a New Class of Nanomedicine","authors":"Xiaowei Wen*, Zerun Hao, Haofan Yin, Jie Min, Xueying Wang, Sihan Sun and Gang Ruan*, ","doi":"10.1021/cbe.4c0012210.1021/cbe.4c00122","DOIUrl":"https://doi.org/10.1021/cbe.4c00122https://doi.org/10.1021/cbe.4c00122","url":null,"abstract":"Extracellular vesicles (EVs) are secreted from biological cells and contain many molecules with diagnostic values or therapeutic functions. There has been great interest in academic and industrial communities to utilize EVs as tools for diagnosis or therapeutics. In addition, EVs can also serve as delivery vehicles for therapeutic molecules. An indicator of the enormous interest in EVs is the large number of review articles published on EVs, with the focus ranging from their biology to their applications. An emerging trend in EV research is to produce and utilize “engineered EVs”, which are essentially the enhanced version of EVs. EV engineering can be conducted by cell culture condition control, genetic engineering, or chemical engineering. Given their nanometer-scale sizes and therapeutic potentials, engineered EVs are an emerging class of nanomedicines. So far, an overwhelming majority of the research on engineered EVs is preclinical studies; there are only a very small number of reported clinical trials. This Review focuses on engineered EVs, with a more specific focus being their applications in therapeutics. The various approaches to producing engineered EVs and their applications in various diseases are reviewed. Furthermore, in vivo imaging of EVs, the mechanistic understandings, and the clinical translation aspects are discussed. The discussion is primarily on preclinical studies while briefly mentioning the clinical trials. With continued interdisciplinary research efforts from biologists, pharmacists, physicians, bioengineers, and chemical engineers, engineered EVs could become a powerful solution for many major diseases such as neurological, immunological, and cardiovascular diseases.","PeriodicalId":100230,"journal":{"name":"Chem & Bio Engineering","volume":"2 1","pages":"3–22 3–22"},"PeriodicalIF":0.0,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/cbe.4c00122","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143091668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Carbazole-Bearing Conjugated Microporous Polymer Electrodes for Uranium Extraction from Seawater with Good Anti-biofouling Feature. 用于从海水中提取铀的咔唑共轭微孔聚合物电极，具有良好的防生物污损特性。

Chem & Bio Engineering Pub Date : 2024-10-19 eCollection Date: 2025-01-23 DOI: 10.1021/cbe.4c00141

Xinyue Zhang, Xinying Lei, Hongfei Sun, Hanming Ke, Jingxuan Xu, Yuhao Yang, Sai Zhang, Tao Wen, Zhuoyu Ji, Xiangke Wang

{"title":"Carbazole-Bearing Conjugated Microporous Polymer Electrodes for Uranium Extraction from Seawater with Good Anti-biofouling Feature.","authors":"Xinyue Zhang, Xinying Lei, Hongfei Sun, Hanming Ke, Jingxuan Xu, Yuhao Yang, Sai Zhang, Tao Wen, Zhuoyu Ji, Xiangke Wang","doi":"10.1021/cbe.4c00141","DOIUrl":"10.1021/cbe.4c00141","url":null,"abstract":"Emerging electrochemical uranium extraction from seawater offers a promising route for a sustainable fuel supply for nuclear reactor operation. In this work, we intentionally synthesized a conjugated microporous polymer (CMP) with π-conjugated skeletons and permanent porosity, which was induced by in situ electropolymerization on flexible carbon cloths, followed by postdecorating amidoxime groups to create functional materials (CMP-AO). Driven by an extra asymmetrical alternating current electrochemical extraction, the self-supporting and binder-free electrode is exceptionally capable of selectively and rapidly capturing U(VI) from simulated solution, affording an extraction capacity of ∼1806.4 mg/g without saturation. Experimental observation in combination with ex/in situ spectroscopy revealed that CMP-AO enabled surface selective binding sites (amidoxime groups) to U(VI), followed by electrocatalytic reduction (carbazole groups) to yield yellow precipitates (Na2O(UO3·H2O) x ) via reversible electron transfer in the presence of sodium electrolyte. Furthermore, the integrating adsorption-electrocatalysis system achieved an extraction capacity of 18.8 mg/g in real seawater for 21 days and good antibiofouling abilities, validating its feasibility for practical application.","PeriodicalId":100230,"journal":{"name":"Chem & Bio Engineering","volume":"2 1","pages":"53-63"},"PeriodicalIF":0.0,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11835288/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143461461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Carbazole-Bearing Conjugated Microporous Polymer Electrodes for Uranium Extraction from Seawater with Good Anti-biofouling Feature 含咔唑共轭微孔聚合物海水提铀电极具有良好的抗生物污染性能

Chem & Bio Engineering Pub Date : 2024-10-19 DOI: 10.1021/cbe.4c0014110.1021/cbe.4c00141

Xinyue Zhang, Xinying Lei, Hongfei Sun, Hanming Ke, Jingxuan Xu, Yuhao Yang, Sai Zhang, Tao Wen*, Zhuoyu Ji and Xiangke Wang*,

{"title":"Carbazole-Bearing Conjugated Microporous Polymer Electrodes for Uranium Extraction from Seawater with Good Anti-biofouling Feature","authors":"Xinyue Zhang, Xinying Lei, Hongfei Sun, Hanming Ke, Jingxuan Xu, Yuhao Yang, Sai Zhang, Tao Wen*, Zhuoyu Ji and Xiangke Wang*, ","doi":"10.1021/cbe.4c0014110.1021/cbe.4c00141","DOIUrl":"https://doi.org/10.1021/cbe.4c00141https://doi.org/10.1021/cbe.4c00141","url":null,"abstract":"Emerging electrochemical uranium extraction from seawater offers a promising route for a sustainable fuel supply for nuclear reactor operation. In this work, we intentionally synthesized a conjugated microporous polymer (CMP) with π-conjugated skeletons and permanent porosity, which was induced by in situ electropolymerization on flexible carbon cloths, followed by postdecorating amidoxime groups to create functional materials (CMP-AO). Driven by an extra asymmetrical alternating current electrochemical extraction, the self-supporting and binder-free electrode is exceptionally capable of selectively and rapidly capturing U(VI) from simulated solution, affording an extraction capacity of ∼1806.4 mg/g without saturation. Experimental observation in combination with ex/in situ spectroscopy revealed that CMP-AO enabled surface selective binding sites (amidoxime groups) to U(VI), followed by electrocatalytic reduction (carbazole groups) to yield yellow precipitates (Na2O(UO3·H2O)x) via reversible electron transfer in the presence of sodium electrolyte. Furthermore, the integrating adsorption-electrocatalysis system achieved an extraction capacity of 18.8 mg/g in real seawater for 21 days and good antibiofouling abilities, validating its feasibility for practical application.","PeriodicalId":100230,"journal":{"name":"Chem & Bio Engineering","volume":"2 1","pages":"53–63 53–63"},"PeriodicalIF":0.0,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/cbe.4c00141","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143091722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design and Fabrication of Viscoelastic Hydrogels as Extracellular Matrix Mimicry for Cell Engineering 用于细胞工程的细胞外基质模拟物粘弹性水凝胶的设计与制备

Chem & Bio Engineering Pub Date : 2024-10-08 DOI: 10.1021/cbe.4c0012910.1021/cbe.4c00129

Zi-Yuan Li, Tian-Yue Li, Hao-Chen Yang, Mu-Hua Ding, Lin-Jie Chen, Shi-Yun Yu, Xiang-Sen Meng, Jia-Jun Jin, Shi-Zhe Sun, Junji Zhang* and He Tian,

{"title":"Design and Fabrication of Viscoelastic Hydrogels as Extracellular Matrix Mimicry for Cell Engineering","authors":"Zi-Yuan Li, Tian-Yue Li, Hao-Chen Yang, Mu-Hua Ding, Lin-Jie Chen, Shi-Yun Yu, Xiang-Sen Meng, Jia-Jun Jin, Shi-Zhe Sun, Junji Zhang* and He Tian, ","doi":"10.1021/cbe.4c0012910.1021/cbe.4c00129","DOIUrl":"https://doi.org/10.1021/cbe.4c00129https://doi.org/10.1021/cbe.4c00129","url":null,"abstract":"The extracellular matrix (ECM) performs both as a static scaffold and as a dynamic, viscoelastic milieu that actively participates in cell signaling and mechanical feedback loops. Recently, biomaterials with tunable viscoelastic properties have been utilized to mimic the native ECM in the fields of tissue engineering and regenerative medicines. These materials can be designed to support cell attachment, proliferation, and differentiation, facilitating the repair or replacement of damaged tissues. Moreover, viscoelasticity modulation of ECM mimicry helps to develop therapeutic strategies for diseases involving altered mechanical properties of tissues such as fibrosis or cancer. The study of biomaterial viscoelasticity thus intersects with a broad spectrum of biological and medical disciplines, offering insights into fundamental cell biology and practical solutions for improving human health. This review delves into the design and fabrication strategies of viscoelastic hydrogels, focusing particularly on two major viscoelastic parameters, mechanical strength and stress relaxation, and how the hydrogel mechanics influence the interactions between living cells and surrounding microenvironments. Meanwhile, this review discusses current bottlenecks in hydrogel-cell mechanics studies, highlighting the challenges in viscoelastic parameter decoupling, long-term stable maintenance of viscoelastic microenvironment, and the general applicability of testing standards and conversion protocols.","PeriodicalId":100230,"journal":{"name":"Chem & Bio Engineering","volume":"1 11","pages":"916–933 916–933"},"PeriodicalIF":0.0,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/cbe.4c00129","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143127569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design and Fabrication of Viscoelastic Hydrogels as Extracellular Matrix Mimicry for Cell Engineering. 设计和制造粘弹性水凝胶作为细胞工程的细胞外基质模拟物。

Chem & Bio Engineering Pub Date : 2024-10-08 eCollection Date: 2024-12-26 DOI: 10.1021/cbe.4c00129

Zi-Yuan Li, Tian-Yue Li, Hao-Chen Yang, Mu-Hua Ding, Lin-Jie Chen, Shi-Yun Yu, Xiang-Sen Meng, Jia-Jun Jin, Shi-Zhe Sun, Junji Zhang, He Tian

{"title":"Design and Fabrication of Viscoelastic Hydrogels as Extracellular Matrix Mimicry for Cell Engineering.","authors":"Zi-Yuan Li, Tian-Yue Li, Hao-Chen Yang, Mu-Hua Ding, Lin-Jie Chen, Shi-Yun Yu, Xiang-Sen Meng, Jia-Jun Jin, Shi-Zhe Sun, Junji Zhang, He Tian","doi":"10.1021/cbe.4c00129","DOIUrl":"10.1021/cbe.4c00129","url":null,"abstract":"The extracellular matrix (ECM) performs both as a static scaffold and as a dynamic, viscoelastic milieu that actively participates in cell signaling and mechanical feedback loops. Recently, biomaterials with tunable viscoelastic properties have been utilized to mimic the native ECM in the fields of tissue engineering and regenerative medicines. These materials can be designed to support cell attachment, proliferation, and differentiation, facilitating the repair or replacement of damaged tissues. Moreover, viscoelasticity modulation of ECM mimicry helps to develop therapeutic strategies for diseases involving altered mechanical properties of tissues such as fibrosis or cancer. The study of biomaterial viscoelasticity thus intersects with a broad spectrum of biological and medical disciplines, offering insights into fundamental cell biology and practical solutions for improving human health. This review delves into the design and fabrication strategies of viscoelastic hydrogels, focusing particularly on two major viscoelastic parameters, mechanical strength and stress relaxation, and how the hydrogel mechanics influence the interactions between living cells and surrounding microenvironments. Meanwhile, this review discusses current bottlenecks in hydrogel-cell mechanics studies, highlighting the challenges in viscoelastic parameter decoupling, long-term stable maintenance of viscoelastic microenvironment, and the general applicability of testing standards and conversion protocols.","PeriodicalId":100230,"journal":{"name":"Chem & Bio Engineering","volume":"1 11","pages":"916-933"},"PeriodicalIF":0.0,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11835267/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143461493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Type III Collagen Promotes Pseudopodium-Driven Cell Migration. III型胶原促进假足驱动的细胞迁移。

Chem & Bio Engineering Pub Date : 2024-10-07 eCollection Date: 2025-02-27 DOI: 10.1021/cbe.4c00133

Ruiwen Fu, Kuangzheng Zhu, Zhouyang Li, Liqun Lei, Ming Li, Xuye Lang, Yuan Yao

{"title":"Type III Collagen Promotes Pseudopodium-Driven Cell Migration.","authors":"Ruiwen Fu, Kuangzheng Zhu, Zhouyang Li, Liqun Lei, Ming Li, Xuye Lang, Yuan Yao","doi":"10.1021/cbe.4c00133","DOIUrl":"10.1021/cbe.4c00133","url":null,"abstract":"The extracellular matrix (ECM), particularly collagen, is acknowledged for its significant impact on cell migration. However, the detailed mechanisms through which it influences pseudopodium formation and cell motility are not yet fully understood. This study delves into the impact of recombinant human type III collagen (hCOL3) on cell migration, specifically focusing on the dynamics of pseudopodia and their contribution to cell motility. The research evaluates the impact of a fragmented form of hCOL3, engineered for the study, on cell motility and pseudopodium behavior using both single-cell and collective-cell migration assays. The results demonstrate that hCOL3 promotes cell migration velocity, augments the effective diffusion coefficient, and enhances directionality in both single-cell and collective migration contexts. Observations from scanning electron microscopy reveal that treatment with hCOL3 increases both the number and length of filopodia, which are crucial for cell migration and interaction with the ECM. The study suggests that hCOL3 facilitates a more targeted and rapid migration. The presence of an increased number of filopodia on surfaces treated with hCOL3 enhances the cell's ability to detect environmental cues and extent, thereby augmenting its migratory capacity. This discovery could potentially lead to greater efficiency in wound healing processes.","PeriodicalId":100230,"journal":{"name":"Chem & Bio Engineering","volume":"2 2","pages":"97-109"},"PeriodicalIF":0.0,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11873850/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143560542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Type III Collagen Promotes Pseudopodium-Driven Cell Migration III型胶原促进假足驱动的细胞迁移

Chem & Bio Engineering Pub Date : 2024-10-07 DOI: 10.1021/cbe.4c0013310.1021/cbe.4c00133

Ruiwen Fu, Kuangzheng Zhu, Zhouyang Li, Liqun Lei, Ming Li*, Xuye Lang* and Yuan Yao*,

{"title":"Type III Collagen Promotes Pseudopodium-Driven Cell Migration","authors":"Ruiwen Fu, Kuangzheng Zhu, Zhouyang Li, Liqun Lei, Ming Li*, Xuye Lang* and Yuan Yao*, ","doi":"10.1021/cbe.4c0013310.1021/cbe.4c00133","DOIUrl":"https://doi.org/10.1021/cbe.4c00133https://doi.org/10.1021/cbe.4c00133","url":null,"abstract":"The extracellular matrix (ECM), particularly collagen, is acknowledged for its significant impact on cell migration. However, the detailed mechanisms through which it influences pseudopodium formation and cell motility are not yet fully understood. This study delves into the impact of recombinant human type III collagen (hCOL3) on cell migration, specifically focusing on the dynamics of pseudopodia and their contribution to cell motility. The research evaluates the impact of a fragmented form of hCOL3, engineered for the study, on cell motility and pseudopodium behavior using both single-cell and collective-cell migration assays. The results demonstrate that hCOL3 promotes cell migration velocity, augments the effective diffusion coefficient, and enhances directionality in both single-cell and collective migration contexts. Observations from scanning electron microscopy reveal that treatment with hCOL3 increases both the number and length of filopodia, which are crucial for cell migration and interaction with the ECM. The study suggests that hCOL3 facilitates a more targeted and rapid migration. The presence of an increased number of filopodia on surfaces treated with hCOL3 enhances the cell’s ability to detect environmental cues and extent, thereby augmenting its migratory capacity. This discovery could potentially lead to greater efficiency in wound healing processes.","PeriodicalId":100230,"journal":{"name":"Chem & Bio Engineering","volume":"2 2","pages":"97–109 97–109"},"PeriodicalIF":0.0,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/cbe.4c00133","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143496247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0