Chem & Bio Engineering最新文献_第7页

Injectable Hydrogels Based on Hyperbranched Polymers for Biomedical Applications. 基于超支化聚合物的可注射水凝胶在生物医学中的应用。

Chem & Bio Engineering Pub Date : 2025-02-18 eCollection Date: 2025-05-22 DOI: 10.1021/cbe.4c00173

Gaolong Lin, Xiaolin Li, Grzegorz Nowaczyk, Wei Wang

{"title":"Injectable Hydrogels Based on Hyperbranched Polymers for Biomedical Applications.","authors":"Gaolong Lin, Xiaolin Li, Grzegorz Nowaczyk, Wei Wang","doi":"10.1021/cbe.4c00173","DOIUrl":"10.1021/cbe.4c00173","url":null,"abstract":"Injectable hydrogels (IHs) have garnered significant attention in biomedical applications due to their minimally invasive nature, adaptability, and high degree of customization. However, traditional design methods of IHs have limitations in addressing complex clinical needs, such as precise regulation of the gelation time and mechanical strength within a wide window. Hyperbranched polymers (HBPs), due to their unique highly branched structures and abundant functional sites, can be easily prepared and functionalized to enable decoupled modulation of mechanical properties of IHs and address the clinical challenges of IHs. Our research group developed a library of HBPs via a dynamically controllable polymerization method and built a series of adjustable, controllable, and responsive IHs based on the resulting HBPs. The prepared IHs fed by HBPs demonstrate an adjustable gelation process, a wide-range tuning of mechanical properties, and responsiveness on demand, which show the capabilities in the various biomedical applications. In this review, we summarize the role of HBPs in the gelation process, mechanical properties, self-healing ability, and responsiveness of IHs. However, achieving IHs through HBPs and extending them to a broad range of biomedical applications are still in its infancy. This review provides an overview of IHs fabricated by a variety of multifunctional HBPs, and their biomedical applications in diverse fields are also presented. Meanwhile, we point out the future development of IHs based on HBPs and their potential challenges.","PeriodicalId":100230,"journal":{"name":"Chem & Bio Engineering","volume":"2 5","pages":"283-302"},"PeriodicalIF":0.0,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12104845/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144164157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Robust Oxygen Evolution on Ni-Doped MoO₃: Overcoming Activity-Stability Trade-Off in Alkaline Water Splitting. ni掺杂MoO3的稳健析氧：克服碱性水裂解的活性-稳定性权衡。

Chem & Bio Engineering Pub Date : 2025-02-12 eCollection Date: 2025-04-24 DOI: 10.1021/cbe.4c00160

Ankit Kumar Verma, Shahan Atif, Abhisek Padhy, Tej S Choksi, Prabeer Barpanda, Ananth Govind Rajan

{"title":"Robust Oxygen Evolution on Ni-Doped MoO3: Overcoming Activity-Stability Trade-Off in Alkaline Water Splitting.","authors":"Ankit Kumar Verma, Shahan Atif, Abhisek Padhy, Tej S Choksi, Prabeer Barpanda, Ananth Govind Rajan","doi":"10.1021/cbe.4c00160","DOIUrl":"https://doi.org/10.1021/cbe.4c00160","url":null,"abstract":"Electrochemical water splitting using earth-abundant materials is crucial for enabling green hydrogen production and energy storage. In recent years, molybdenum trioxide (MoO3), a semiconducting material, has been proposed as a candidate catalyst for the oxygen evolution reaction (OER). Here, we advance nickel (Ni) doping of MoO3 as a strategy to increase the activity and stability of the material during alkaline electrochemical water splitting, thereby overcoming the typical activity-stability trade-off encountered with OER catalysts. The instability of MoO3 in alkaline media can be mitigated by doping with Ni, whose oxide is stable under such conditions. Using density functional theory (DFT) with Hubbard corrections, we show that Ni doping reduces the thermodynamic OER overpotential on the MoO3 basal plane to 0.64 V. Experiments demonstrate that Ni-doped MoO3 requires an overpotential of 0.34 V for an OER current density of 10 mA/cm2 (and 0.56 V at 100 mA/cm2), as opposed to a value of 0.40 V for pure MoO3. Further, Ni-doped MoO3 exhibits a lower Tafel slope of 74.8 mV/dec, compared to 98.3 mV/dec for the pristine material under alkaline conditions. While Mo leaches in alkaline conditions, X-ray photoelectron spectroscopy reveals enhanced stability with Ni doping. Overall, our work advances Ni-doped MoO3 as a promising water-splitting electrocatalyst and provides new insights into its OER mechanism and stability in alkaline media. More generally, the work sheds light on choosing a dopant to increase a material's activity and stability, which will also find applications in other catalytic materials.","PeriodicalId":100230,"journal":{"name":"Chem & Bio Engineering","volume":"2 4","pages":"241-252"},"PeriodicalIF":0.0,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12035564/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144061299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Robust Oxygen Evolution on Ni-Doped MoO3: Overcoming Activity–Stability Trade-Off in Alkaline Water Splitting ni掺杂MoO3的稳健析氧：克服碱性水裂解的活性-稳定性权衡

Chem & Bio Engineering Pub Date : 2025-02-11 DOI: 10.1021/cbe.4c0016010.1021/cbe.4c00160

Ankit Kumar Verma, Shahan Atif, Abhisek Padhy, Tej S. Choksi, Prabeer Barpanda and Ananth Govind Rajan*,

{"title":"Robust Oxygen Evolution on Ni-Doped MoO3: Overcoming Activity–Stability Trade-Off in Alkaline Water Splitting","authors":"Ankit Kumar Verma, Shahan Atif, Abhisek Padhy, Tej S. Choksi, Prabeer Barpanda and Ananth Govind Rajan*, ","doi":"10.1021/cbe.4c0016010.1021/cbe.4c00160","DOIUrl":"https://doi.org/10.1021/cbe.4c00160https://doi.org/10.1021/cbe.4c00160","url":null,"abstract":"Electrochemical water splitting using earth-abundant materials is crucial for enabling green hydrogen production and energy storage. In recent years, molybdenum trioxide (MoO3), a semiconducting material, has been proposed as a candidate catalyst for the oxygen evolution reaction (OER). Here, we advance nickel (Ni) doping of MoO3 as a strategy to increase the activity and stability of the material during alkaline electrochemical water splitting, thereby overcoming the typical activity-stability trade-off encountered with OER catalysts. The instability of MoO3 in alkaline media can be mitigated by doping with Ni, whose oxide is stable under such conditions. Using density functional theory (DFT) with Hubbard corrections, we show that Ni doping reduces the thermodynamic OER overpotential on the MoO3 basal plane to 0.64 V. Experiments demonstrate that Ni-doped MoO3 requires an overpotential of 0.34 V for an OER current density of 10 mA/cm2 (and 0.56 V at 100 mA/cm2), as opposed to a value of 0.40 V for pure MoO3. Further, Ni-doped MoO3 exhibits a lower Tafel slope of 74.8 mV/dec, compared to 98.3 mV/dec for the pristine material under alkaline conditions. While Mo leaches in alkaline conditions, X-ray photoelectron spectroscopy reveals enhanced stability with Ni doping. Overall, our work advances Ni-doped MoO3 as a promising water-splitting electrocatalyst and provides new insights into its OER mechanism and stability in alkaline media. More generally, the work sheds light on choosing a dopant to increase a material’s activity and stability, which will also find applications in other catalytic materials.","PeriodicalId":100230,"journal":{"name":"Chem & Bio Engineering","volume":"2 4","pages":"241–252 241–252"},"PeriodicalIF":0.0,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/cbe.4c00160","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143863159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in Cell Separation: Harnessing DNA Nanomaterials for High-Specificity Recognition and Isolation. 细胞分离的进展：利用DNA纳米材料进行高特异性识别和分离。

Chem & Bio Engineering Pub Date : 2025-01-31 eCollection Date: 2025-03-27 DOI: 10.1021/cbe.4c00185

Huimin Bao, Yao Yao, Wenqi Tang, Dayong Yang

{"title":"Advances in Cell Separation: Harnessing DNA Nanomaterials for High-Specificity Recognition and Isolation.","authors":"Huimin Bao, Yao Yao, Wenqi Tang, Dayong Yang","doi":"10.1021/cbe.4c00185","DOIUrl":"10.1021/cbe.4c00185","url":null,"abstract":"Advancements in cell separation are essential for understanding cellular phenotypes and functions, with implications for both research and therapeutic applications. This review examines the evolution of cell separation techniques, categorizing them into physical and affinity-based methods, with a primary focus on the latter due to its high specificity. Among affinity techniques, DNA nanomaterials have emerged as powerful tools for biomolecular recognition owing to their unique properties and diverse range of nanostructures. We discuss various DNA nanomaterials, including linear aptamers, multivalent DNA constructs, DNA origami, and DNA hydrogels and their roles in cell recognition and separation. Each section highlights the distinctive characteristics of these DNA nanostructures, providing examples from recent studies that demonstrate their applications in cell isolation and release. We also compare the four DNA nanomaterials, outlining their individual contributions and identifying the remaining challenges and opportunities for further development. We conclude that DNA nanotechnology holds great promise as a transformative solution for cell separation, particularly in the context of personalized therapeutics.","PeriodicalId":100230,"journal":{"name":"Chem & Bio Engineering","volume":"2 3","pages":"171-181"},"PeriodicalIF":0.0,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11955853/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143766262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in Cell Separation: Harnessing DNA Nanomaterials for High-Specificity Recognition and Isolation 细胞分离的进展：利用DNA纳米材料进行高特异性识别和分离

Chem & Bio Engineering Pub Date : 2025-01-31 DOI: 10.1021/cbe.4c0018510.1021/cbe.4c00185

Huimin Bao, Yao Yao, Wenqi Tang and Dayong Yang*,

{"title":"Advances in Cell Separation: Harnessing DNA Nanomaterials for High-Specificity Recognition and Isolation","authors":"Huimin Bao, Yao Yao, Wenqi Tang and Dayong Yang*, ","doi":"10.1021/cbe.4c0018510.1021/cbe.4c00185","DOIUrl":"https://doi.org/10.1021/cbe.4c00185https://doi.org/10.1021/cbe.4c00185","url":null,"abstract":"Advancements in cell separation are essential for understanding cellular phenotypes and functions, with implications for both research and therapeutic applications. This review examines the evolution of cell separation techniques, categorizing them into physical and affinity-based methods, with a primary focus on the latter due to its high specificity. Among affinity techniques, DNA nanomaterials have emerged as powerful tools for biomolecular recognition owing to their unique properties and diverse range of nanostructures. We discuss various DNA nanomaterials, including linear aptamers, multivalent DNA constructs, DNA origami, and DNA hydrogels and their roles in cell recognition and separation. Each section highlights the distinctive characteristics of these DNA nanostructures, providing examples from recent studies that demonstrate their applications in cell isolation and release. We also compare the four DNA nanomaterials, outlining their individual contributions and identifying the remaining challenges and opportunities for further development. We conclude that DNA nanotechnology holds great promise as a transformative solution for cell separation, particularly in the context of personalized therapeutics.","PeriodicalId":100230,"journal":{"name":"Chem & Bio Engineering","volume":"2 3","pages":"171–181 171–181"},"PeriodicalIF":0.0,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/cbe.4c00185","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143703768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chem & Bio Engineering Pub Date : 2025-01-23

Mayank Vashishtha, Srinivas Gadipelli and K Vasanth Kumar*,

引用次数: 0

Chem & Bio Engineering Pub Date : 2025-01-23

Xiaowei Wen*, Zerun Hao, Haofan Yin, Jie Min, Xueying Wang, Sihan Sun and Gang Ruan*,

引用次数: 0

Chem & Bio Engineering Pub Date : 2025-01-23

引用次数: 0

Chem & Bio Engineering Pub Date : 2025-01-23

Pengcheng Li, Tianyu Ma, Youyang Wu, Jianping Wu, Haoran Yu, Lirong Yang and Gang Xu*,

引用次数: 0