Brain Behavior and Immunity Integrative最新文献

{"title":"The modulation of post-translational modification of proteins by physical exercise to improve brain functions via affecting metabolic homeostasis","authors":"Li Zhang","doi":"10.1016/j.bbii.2025.100120","DOIUrl":"10.1016/j.bbii.2025.100120","url":null,"abstract":"<div><div>Exercise training effectively prevents mental or cognitive deficits, as supported by both animal studies and clinical trials. Our group has been focused on the peripheral derived molecules under endurance exercise scheme and is investigating the possible function of these factors in modulating brain functions. In particular, our recent works have shown the involvement of specific exercise metabolites in reshaping the posttranslational modification of synaptic proteins, to enhance the neural networking for counteracting mental disorders. In this article, I will briefly elaborate the recent progress regarding the linkage among exercise training, circulating metabolites and synaptic functions, in order to provide some previously unrecognized pathways for the brain health effect of exercise. In addition, the possibly future directions of the study for exercise-mediated metabolic homeostasis and brain function will be discussed.</div></div>","PeriodicalId":100197,"journal":{"name":"Brain Behavior and Immunity Integrative","volume":"10 ","pages":"Article 100120"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143786283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Xathine unveiled: Bridging CD4+ T cell and stress-induced disorders through purine metabolism","authors":"Li Zhang ,&nbsp;Jia-xin Dong ,&nbsp;Yi-yuan Li ,&nbsp;Jin Jin","doi":"10.1016/j.bbii.2025.100113","DOIUrl":"10.1016/j.bbii.2025.100113","url":null,"abstract":"<div><div>Neuroimmunology, a field exploring the intricate interplay between the nervous and immune systems, has long focused on the regulatory effects of stress on immune function. Chronic stress activates the hypothalamic-pituitary-adrenal axis and the sympathetic-adrenal-medullary system, leading to glucocorticoid and catecholamine release, which modulate T cell activity. Clinical studies reveal that chronic stress dysregulates peripheral T cells, particularly reducing CD4⁺ T cell counts, which are implicated in anxiety and obsessive-compulsive disorders. The current research demonstrates that chronic stress depletes peripheral CD4⁺ T cells, and their depletion protects against stress-induced anxiety-like behaviors. Furthermore, adoptive transfer of CD4⁺ T cells from anxious mice induces anxiety in recipient mice, highlighting the pivotal role of these cells in stress-related disorders. This finding uncovers a novel mechanism where stress triggers purine metabolism dysregulation in CD4⁺ T cells, leading to elevated xanthine and adenine levels. Xanthine enhances amygdala neuronal activity, contributing to anxiety-like behaviors, while adenine suppresses it. Stress-induced leukotriene B4 promotes mitochondrial fission in CD4⁺ T cells, enhancing IRF1 nuclear accumulation and upregulating purine synthesis enzymes, resulting in xanthine overproduction. This metabolic shift links mitochondrial dysfunction to stress-induced anxiety. Purines exert their effects via adenosine receptors, with A1 in oligodendrocytes mediating xanthine-induced neuronal activation in the brain. In the gut, stress-induced xanthine elevation activates A2B receptors, driving exosome biogenesis and contributing to irritable bowel syndrome pathogenesis. These findings identify dysregulated purine metabolism in CD4⁺ T cells as a hallmark of stress-related disorders, offering novel therapeutic targets. Purine synthesis inhibitors and adenosine receptor antagonists show promise in alleviating anxiety and IBS symptoms, paving the way for innovative treatments for stress-induced diseases. This research bridges neuroimmunology and metabolism, providing a comprehensive understanding of stress-related disorders and their therapeutic potential.</div></div>","PeriodicalId":100197,"journal":{"name":"Brain Behavior and Immunity Integrative","volume":"10 ","pages":"Article 100113"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143643768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic inflammation linking atherosclerosis to cognitive impairment: Multi-target mechanisms and therapeutic advances in chinese herbal medicine","authors":"Rumin Huang ,&nbsp;Xiangrui Zhang ,&nbsp;Meiling Ni ,&nbsp;Xinyi Chen ,&nbsp;Yanqing Wang ,&nbsp;Wenwen Chang ,&nbsp;Yan Sun ,&nbsp;Haoxin Wu","doi":"10.1016/j.bbii.2025.100122","DOIUrl":"10.1016/j.bbii.2025.100122","url":null,"abstract":"<div><div>The chronic inflammatory state associated with vascular aging plays a critical role in the pathogenesis of age-related diseases, including occurrence and progression of atherosclerosis (AS) and cognitive impairment (CI). The detrimental impacts of inflammation are multifaceted. On the one hand, inflammation impairs the function of vascular endothelial cells (EC) and contributes to vascular remodeling. On the other hand, it triggers a cascade of events resulting in cerebral small vessel disease (CSVD), which disrupts the blood-brain barrier (BBB), induces neuroinflammation and ultimately impairs cognitive function. Consequently, these processes establish a strong pathological link between atherosclerosis (AS) and cognitive impairment (CI). Chinese Herbal Medicine(CHM) posits that AS and CI share common pathological factors and similar pathogeneses. According to CHM theory, the aging process is associated with a gradual deficiency of healthy qi, which subsequently results in spleen qi deficiency and impaired transportation functions. This dysfunction leads to the accumulation of water-dampness, which can further transform into pathogenic fire, thereby causing damage to the veins and channels. Clinically, such pathological changes may manifest as cardiac pain, dementia, and other symptoms. The treatment of AS in CHM follows principles such as clearing heat, removing toxins, as well as eliminating phlegm and resolving blood stasis. It is notable that numerous studies have demonstrated that Chinese herbs exhibit distinctive therapeutic potential in modulating the progression of CI associated with AS. These herbs have been observed to target multiple pathways intricately involved in AS-related inflammatory processes and cognitive impairment, offering a comprehensive therapeutic approach. In light of the above, this review aims to provide an overview of the evidence supporting the association between AS and CI. It will explore the pathological mechanisms and processes by which AS contributes to the development of CI, and summarize the mechanism of action of Chinese herbs in the treatment of AS-related CI. The findings aim to inform future therapeutic strategies for cognitive disorders and guide research directions in this field.</div></div>","PeriodicalId":100197,"journal":{"name":"Brain Behavior and Immunity Integrative","volume":"10 ","pages":"Article 100122"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143807016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bridging psychoneuroimmunology (PNI) and cancer: New insights and innovations from China","authors":"Min Yan,&nbsp;Keith W. Kelley,&nbsp;Quentin Liu","doi":"10.1016/j.bbii.2025.100125","DOIUrl":"10.1016/j.bbii.2025.100125","url":null,"abstract":"<div><div>Psychoneuroimmunology (PNI) is an emerging interdisciplinary field that explores interactions among the brain, nervous and systems and their collective influence on health and disease. In recent years, growing evidence has highlighted the relevance of PNI in oncology, offering new insights into how stress, neuroimmune signaling, and mental health affect cancer initiation, progression, and therapeutic outcomes. This special issue, “Showcasing PNI Cancer Discoveries in China,” features recent advances from Chinese researchers at the forefront of this field. The articles cover topics ranging from neural regulation of tumor progression and immune responses to the therapeutic potential of traditional Chinese medicine (TCM) and lifestyle interventions. Together, these contributions underscore the critical role of PNI in advancing cancer research and developing more holistic, personalized therapeutic strategies.</div></div>","PeriodicalId":100197,"journal":{"name":"Brain Behavior and Immunity Integrative","volume":"10 ","pages":"Article 100125"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143937664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of Jin's three-needle therapy for Tardive dyskinesia","authors":"Yaodong Xian ,&nbsp;Jinxiu Hu ,&nbsp;Xueying Yang ,&nbsp;Yan Ding ,&nbsp;Wei Li ,&nbsp;Lanying Liu","doi":"10.1016/j.bbii.2025.100118","DOIUrl":"10.1016/j.bbii.2025.100118","url":null,"abstract":"<div><div>The objective of this case study was to investigate the effectiveness of Jin’s three-needle therapy in treating tardive dyskinesia (TD). TD is a movement disorder resulting from long-term use of antipsychotics. It is characterized by uncontrollable, abnormal, and repetitive movements of the face, torso, and/or other body parts.The participant in this study was a 69-year-old male who had been diagnosed with schizophrenia at the age of 45 years and TD at the age of 64 years. His chief complaints included “mouth pumping,” sucking, and a rubbing motion of his fingers. After using Jin’s three-needle therapy five times a week for 20 treatments, the patient reported an 80 % reduction in all symptoms. The patient’s Abnormal Involuntary Movement Scale (AIMS) score decreased from 19 to 10, and the Tardive Dyskinesia Rating Scale (TDRS) score decreased from 67 to 55. In this case, the results indicated that Jin’s three-needle therapy was able to decrease the symptoms of TD. Further investigation is needed to support this argument. The treatment for TD is mainly based on western medicine. However, currently Western medicine cannot completely control symptoms, and there is a high possibility of drug side effects. It was challenging to find literature on acupuncture for treating TD, particularly in English. Jin’s three-needle therapy, a characteristic acupuncture therapy in China, is widely used in clinical practice.This article analyzes the treatment process of a case of treating TD with “Jin’s three-needle therapy.” It is hoped that it can provide reference for the treatment of such diseases and feasibility for the next large-scale related research.</div></div>","PeriodicalId":100197,"journal":{"name":"Brain Behavior and Immunity Integrative","volume":"10 ","pages":"Article 100118"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143724375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The crosstalk between glioma and nervous system","authors":"Changjin Xing ,&nbsp;Anhao Tian ,&nbsp;Chong Liu","doi":"10.1016/j.bbii.2025.100123","DOIUrl":"10.1016/j.bbii.2025.100123","url":null,"abstract":"<div><div>As a primary brain tumor, glioma is distinct by the abundance of nervous system components within its microenvironment. Recent researches reveal highly intricate interactions between glioma and the nervous system. The nervous system influences the occurrence and progression of glioma, while glioma, in turn, affects neuronal activity. Neurons and nerve fibers modulate glioma cells via various neurotransmitters and trophic factors. In certain instances, neurons can establish direct synaptic connections with glioma cells, mechanisms that can impact tumor cell proliferation and metastasis. And on the other hand, glioma can enhance neuronal excitability, potentially triggering epilepsy. Additionally, glioma-derived synaptogenic factors also facilitate the functional reshaping of neural circuits. Hence, gaining a comprehensive understanding of the interactions between the glioma and nervous system, and developing targeted therapies focused on the neural components within the tumor microenvironment, will enhance the treatment outcomes for this challenging tumor.</div></div>","PeriodicalId":100197,"journal":{"name":"Brain Behavior and Immunity Integrative","volume":"10 ","pages":"Article 100123"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143844091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Personalized exercise prescriptions: Advancing precision health through interdisciplinary research","authors":"Yu-Bu Wang,&nbsp;Zhihao Zhang,&nbsp;Yanxia Chen,&nbsp;Zijun Liu,&nbsp;Kaiqi Guan,&nbsp;Meijun Hou,&nbsp;Yanping Gao,&nbsp;Jinming Li,&nbsp;Qian Yu,&nbsp;Keith W. Kelley,&nbsp;Liye Zou","doi":"10.1016/j.bbii.2024.100099","DOIUrl":"10.1016/j.bbii.2024.100099","url":null,"abstract":"","PeriodicalId":100197,"journal":{"name":"Brain Behavior and Immunity Integrative","volume":"9 ","pages":"Article 100099"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143488849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of chronic diseases on cognitive impairment in rural population of India: A focus on diabetes, hypertension, cardiovascular disease, and stroke","authors":"Jeevitha Gowda R ,&nbsp;Anish Mehta ,&nbsp;Krishnamurthy Jayanna","doi":"10.1016/j.bbii.2025.100107","DOIUrl":"10.1016/j.bbii.2025.100107","url":null,"abstract":"<div><h3>Background</h3><div>Chronic diseases such as diabetes, hypertension, cardiovascular disease, and stroke have long been associated with a range of metabolic and cardiovascular complications. Increasing evidence also suggests that these conditions contribute significantly to cognitive impairment, including dementia. This is particularly concerning for rural populations, where access to healthcare is limited, and the prevalence of chronic diseases is high. This review explores the relationship between multiple chronic diseases and cognitive decline, highlighting the mechanisms involved, the specific challenges rural populations face, and potential strategies to mitigate the effects of chronic diseases on brain health.</div></div><div><h3>Methods</h3><div>A rapid evidence-based review was conducted, focusing on existing literature about the impact of chronic diseases on cognitive health, particularly in rural settings. The studies gathered were assessed to understand how these chronic diseases contribute to cognitive impairment, the socio-economic factors influencing rural healthcare, and strategies for improving management and prevention in these communities.</div></div><div><h3>Results</h3><div>Chronic diseases such as diabetes, hypertension, cardiovascular disease, and stroke affect the brain through various mechanisms including insulin resistance, vascular damage, neuroinflammation, and cerebrovascular events. For rural populations, limited access to healthcare, lack of awareness, and insufficient infrastructure further exacerbate the risk of cognitive impairment. Inadequate healthcare resources in rural areas hinder effective management of these chronic conditions, thereby increasing the risk of cognitive decline.</div></div><div><h3>Conclusion</h3><div>The rising prevalence of chronic diseases globally and their association with cognitive impairment is a major concern, particularly for underserved rural populations. Addressing this issue requires integrated healthcare approaches, public health education, and significant improvements in rural healthcare infrastructure.</div></div>","PeriodicalId":100197,"journal":{"name":"Brain Behavior and Immunity Integrative","volume":"9 ","pages":"Article 100107"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143422485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advance in the mechanisms underlying prenatal stress-induced depressive-like behavior in offspring","authors":"Kaixuan Xu ,&nbsp;Dongli Song ,&nbsp;Hui Li ,&nbsp;Yushan Lu ,&nbsp;Zhongliang Zhu","doi":"10.1016/j.bbii.2025.100108","DOIUrl":"10.1016/j.bbii.2025.100108","url":null,"abstract":"<div><div>Prenatal stress (PS) represents a critical environmental factor that causes developmental disruptions in offspring, characterized by multisystemic vulnerabilities across neuropsychiatric, cardiovascular, metabolic, and immunological domains. Through intricate embryonic reprogramming mechanisms, PS alters brain developmental trajectories and physiological regulatory networks, resulting in increased long-term risks for neurodevelopmental disorders, particularly depressive-like behavior. PS causes dysregulation in multiple physiological processes, including hypothalamic-pituitary-adrenal (HPA) axis activation, epigenetic modifications, neurotransmitter systems, brain-derived neurotrophic factor (BDNF), gut microbiota, and neuroimmune responses. Additionally, genetic factors, sex specificity, and critical developmental windows further complicate the PS-mediated onset of depressive-like behavior. Here, we review clinical and animal studies and analyze how the multiple mechanisms form complex regulatory networks during intrauterine development, leading to long-lasting psychopathological effects in offspring.</div></div>","PeriodicalId":100197,"journal":{"name":"Brain Behavior and Immunity Integrative","volume":"9 ","pages":"Article 100108"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143379028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An insightful comparison of the current neuroimmune mechanism(s) with the thoughts of differential syndromes from traditional Chinese medicine for the treatment of MDD","authors":"Jiyi Xu ,&nbsp;Yi Zhang ,&nbsp;Lei Li ,&nbsp;Xiaodong Zhao ,&nbsp;Feilong Huang ,&nbsp;Jing Du","doi":"10.1016/j.bbii.2024.100100","DOIUrl":"10.1016/j.bbii.2024.100100","url":null,"abstract":"<div><div>Major depressive disorder (MDD) is a common disease affecting 300 million people worldwide. Current drugs are ineffective for at least 30 % of the patients. Novel and personalized medication is needed urgently. Cumulative studies suggest that the neuroinflammation of the glial cells, particularly NOD-like receptor thermal protein domain associated protein 3 (NLRP3) inflammasome activation and subsequent regulation of synaptic functions may be the key for the pathophysiology and treatment of MDD. In this review, we delve to compare the modern mechanism of MDD treatment with the theories of differential symptoms for personalized treatment of the ancient decoctions from traditional Chinese Medicine (TCM). Interestingly, the mechanisms of MDD treatment from Western and TCM theories overlap to a nexus on regulating neuro-immune signaling pathways, including NLRP 3 inflammasome, cytokine expressions and synaptic functions. In this review, we have summarized 8 differential syndromes and 10 decoctions for the TCM treatment of MDD in modulation of immune system and synaptic functions. The neuroimmune modulation of the 10 decoctions for the treatment MDD from TCM are amazingly similar towards the anti-inflammatory effects and enhancing synaptic functions. The comparison of theories and therapies from Western medicine and TCM may contribute to the development of more effective and safer medication for MDD.</div></div>","PeriodicalId":100197,"journal":{"name":"Brain Behavior and Immunity Integrative","volume":"9 ","pages":"Article 100100"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143097035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}