Brain Behavior and Immunity Integrative最新文献

{"title":"Advances in non-pharmacological therapies for depressive disorders: A systematic review","authors":"Hong Liu,&nbsp;Jiazhen Cai,&nbsp;Lei Mao,&nbsp;Boyang Dai,&nbsp;Yansong Wang,&nbsp;Yue Gao,&nbsp;Qiuyu Gu,&nbsp;Yifei Liu,&nbsp;Ran Jing,&nbsp;Xin Zhou,&nbsp;Wei Wang","doi":"10.1016/j.bbii.2026.100177","DOIUrl":"10.1016/j.bbii.2026.100177","url":null,"abstract":"<div><div>Depression is a prevalent mood disorder characterized by persistent dysphoria, anhedonia, feelings of guilt, fatigue, and a spectrum of concomitant emotional and somatic symptoms. As a major public health burden, depression is responsive to both pharmacological and non-pharmacological interventions; however, the clinical utility of these therapeutic strategies is largely undermined by adverse effects and significant interindividual heterogeneity in treatment response. Furthermore, monotherapy with pharmacological agents fails to guarantee adequate clinical efficacy in all patients—a shortcoming that may erode the fragile sense of optimism and motivational drive inherent to this patient population, who are inherently prone to hopelessness due to the core pathophysiological features of depression. Non-pharmacological interventions for depression refer to a set of therapeutic approaches designed to ameliorate the disease, relieve symptoms, alleviate pain, improve function, prolong survival, and facilitate overall health recovery in affected individuals. These interventions, including psychological interventions, medicated food homology-based regimens, dietary therapy, music therapy, acupuncture, and traditional Chinese medicine (TCM) modalities, exert antidepressant effects through multiple mechanistic pathways, such as the attenuation of neuroinflammation, modulation of neurotransmitter release and metabolism, enhancement of neuronal plasticity, and regulation of the gut-brain axis. In light of the aforementioned challenges and potential of non-pharmacological interventions, this review systematically summarizes their clinical applications and mechanistic underpinnings to provide an objective evidence-based evaluation, and further explores the therapeutic efficacy of different non-pharmacological interventions in mitigating depressive symptomatology.</div></div>","PeriodicalId":100197,"journal":{"name":"Brain Behavior and Immunity Integrative","volume":"15 ","pages":"Article 100177"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148539425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The strain-dependent antidepressant-like activity of Yueju Pill: An electrophysiological, and behavioral pharmacological study","authors":"Wei Wang,&nbsp;Shan Xing,&nbsp;Tong Zhou,&nbsp;Changyu Wu,&nbsp;Yuhan Peng,&nbsp;Jiaming Zhu,&nbsp;Xin Zhou,&nbsp;Haoxin Wu,&nbsp;Qiuyu Gu,&nbsp;Yanbin Jia,&nbsp;Gang Chen","doi":"10.1016/j.bbii.2026.100178","DOIUrl":"10.1016/j.bbii.2026.100178","url":null,"abstract":"<div><div>The antidepressant efficacy exhibits significant individual variation influenced by genetic factors. Traditional Chinese Medicine (TCM) as a personalized medicine is intrinsically contributed by genetic variation, but experimental investigation remains scarce. This study investigated the genetic impacts of the antidepressant effects of Yueju Pill (YJ), a classic TCM formula, using Balb/c and C57BL/6 J mouse strains, and the underlying electrophysiological and molecular mechanisms. We found that the same dose of YJ induced immediate and sustained antidepressant-like effects exclusively in Balb/c mice, accompanied by a specific enhancement of long-term potentiation (LTP) in the hippocampus. These effects were absent in C57BL/6 J mice. Further pharmacological validation confirmed the key role of the PKA-CREB pathway: treatment with a PKA signaling inhibitor H-89, administered either before or after YJ, completely blocked its antidepressant effects, indicating that this pathway is essential for both the initiation and maintenance of its efficacy. Notably, a comparative analysis with ketamine revealed mechanistic differences between the two: PKA activation was not required for the initiation of ketamine's antidepressant effect, and PKA signaling was only responsible for the early but short maintenance stage of ketamine's antidepressant effects. Furthermore, in the LPS-induced inflammatory depression model using Balb/c mice, YJ demonstrated antidepressant effects 24 h after a single administration and western blot analysis of hippocampal tissue revealed that YJ treatment significantly down‑regulated the protein expression of phospho‑NF‑κB (p‑NF‑κB) and the microglial marker Iba1, indicating a suppression of neuroinflammatory activation. In summary, differences in genetic background influenced the behavioral and electrophysiological effects of YJ. The activation of PKA signaling is required for both the initiation and early maintenance of its antidepressant actions, and attenuation of neuroinflammation may also contribute to the maintainence of its antidepressant effects.</div></div>","PeriodicalId":100197,"journal":{"name":"Brain Behavior and Immunity Integrative","volume":"15 ","pages":"Article 100178"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148539426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of an international ceremonial ayahuasca retreat on the diversity and community composition of the human gut microbiome: A preliminary observational single-arm pre-post study","authors":"Lyanna R. Kessler,&nbsp;Lamya’a M. Dawud,&nbsp;John D. Sterrett,&nbsp;Nathan D. Andersen,&nbsp;Ahmed I. Elsayed,&nbsp;Jesse J. Gould,&nbsp;Kathryn M. Pate,&nbsp;W. Keith Campbell,&nbsp;Jim Grigsby,&nbsp;Brandon M. Weiss,&nbsp;Christopher A. Lowry","doi":"10.1016/j.bbii.2026.100182","DOIUrl":"10.1016/j.bbii.2026.100182","url":null,"abstract":"<div><div>Posttraumatic stress disorder (PTSD) is a mental health condition that can develop following exposure to a traumatic event, often with persistent anxiety and depressive symptoms. Recent research suggests the microbiome-gut-brain axis may play an important role in the etiology and pathophysiology of PTSD. At the same time, retreats incorporating psychedelic-assisted therapies have gained increasing attention as potential treatments for PTSD. However, little is known about how participation in these retreats may affect the gut microbiome. Therefore, we conducted a preliminary observational single-arm pre-post study investigating the diversity and community composition of the gut microbiome pre/post participation in a retreat involving ceremonial ayahuasca use, as well as associations between microbiome features, PTSD symptoms, and personality traits. Participants included U.S. Veterans and non-Veterans with varied PTSD symptoms (<em>N</em> = 22). The international retreat took place over one week and included three ayahuasca ceremonies. PTSD Checklist for the DSM-5 (PCL-5) scores, Five-Factor Model (FFM) personality measures, and fecal samples were collected from participants pre/post retreat. Fecal samples were analyzed using 16S rRNA gene amplicon sequencing to assess gut microbiome diversity and community composition. PCL-5 scores decreased following the retreat, relative to baseline. Openness, Conscientiousness, Extraversion, and Agreeableness increased, while Neuroticism decreased. Measures of gut microbiome alpha diversity did not change. However, beta diversity analyses revealed a within-subjects shift in microbial community composition at the end of the retreat relative to baseline. Post retreat there was an increase in the relative abundances of several short-chain fatty acid-producing bacteria associated with gut health, including <em>Lachnospiraceae UCG-004, Colidextribacter, Oscillospira,</em> and <em>Blautia.</em> Although the study design has limitations and does not establish causality, it highlights within-subjects effects of participation in an ayahuasca retreat on the gut microbiome, effects that should be evaluated further in future large randomized double-blind, placebo-controlled clinical trials.</div></div>","PeriodicalId":100197,"journal":{"name":"Brain Behavior and Immunity Integrative","volume":"15 ","pages":"Article 100182"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148737728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Traditional Chinese herbal medicine and compounds on cancer-related fatigue: The current understandings of the mechanisms","authors":"Changyu Wu,&nbsp;Akinori Nishi,&nbsp;Zhiting Sun,&nbsp;Jianfu Zhao,&nbsp;Gang Chen","doi":"10.1016/j.bbii.2026.100175","DOIUrl":"10.1016/j.bbii.2026.100175","url":null,"abstract":"<div><div>Cancer-related fatigue (CRF) is one of the most prevalent and debilitating symptoms experienced by cancer patients, significantly affecting treatment adherence and quality of life. Its pathogenesis is multifaceted, involving inflammatory responses, hypothalamic-pituitary-adrenal (HPA) axis dysfunction, and mitochondrial energy metabolism disorders. To date, the therapeutic outcomes of CRF have not met clinical needs, and no pharmacological or non-pharmacological approach has been specifically approved for CRF. This review examines the current understanding of CRF mechanisms, discusses the limitations of current therapeutic modalities, and highlights the unique potential advantages of traditional Chinese medicine (TCM) interventions for CRF. Existing evidence indicates that TCM, with its advantages of holistic regulation and multi-targeted intervention, may have clinical value in alleviating symptoms, improving quality of life, and mitigating adverse reactions associated with Western medical treatments in patients with CRF. These beneficial effects may be closely associated with anti-inflammatory activity, restoration of HPA axis homeostasis, and improvement of mitochondrial energy metabolism. In this review, classic Chinese herbal formulas used for CRF management are briefly summarized. As increasing studies have investigated active components from individual herbs, particularly those with both medicinal and food properties, recent progress regarding these active components, including oil compounds, flavonoids, polysaccharides, and saponins, is reviewed in greater detail. Future studies focusing on therapeutic efficacy, novel and specific mechanisms, and interactions among active compounds in TCM treatment of CRF may help establish more effective and safer therapeutic strategies.</div></div>","PeriodicalId":100197,"journal":{"name":"Brain Behavior and Immunity Integrative","volume":"15 ","pages":"Article 100175"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148539427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating traditional ayurvedic medicine into modern HIV/AIDS management: A randomized controlled clinical trial","authors":"Shivani Karnwal,&nbsp;Rudra B. Bhandari,&nbsp;C.B. Dhanraj,&nbsp;N. Sujatha,&nbsp;Mukesh C. Bairwa,&nbsp;Meenakshi Khapre","doi":"10.1016/j.bbii.2026.100183","DOIUrl":"10.1016/j.bbii.2026.100183","url":null,"abstract":"<div><div>HIV infection remains a major global health challenge. Although antiretroviral therapy (ART) effectively suppresses viral replication, HIV remains incurable because latent, replication-competent proviruses persist in diverse cellular and tissue reservoirs. This study investigated the effect of <em>Yogaraj Rasāyana</em> (YR), a classical Ayurvedic formulation, in augmenting CD4 + T lymphocyte counts in ART-treated HIV-positive individuals. In a randomized controlled trial (RCT), 52 HIV-positive participants (males/females/transgender: 29/20/3) with respective age (mean ± SD: 30.6 ± 7.9, 34.2 ± 10.3 and 32.0 ± 11.1 years), receiving standard ART, were recruited from Patanjali Ayurved Hospital Haridwar, and All India Institute of Medical Sciences Rishikesh, India. Participants were randomized into an Interventional Group (IG; <em>n</em> = 26) receiving YR (2 g/day orally) and ART, and a Conventional Group (CG; <em>n</em> = 26) receiving ART alone for 90 days. Clinical endpoints included CD4+ T cell counts and hematological/biochemical indices (Hemoglobin: Hb, Erythrocyte Sedimentation Rate: ESR, Random Blood Sugar: RBS, Serum Glutamic Oxaloacetic Transaminase: SGOT, Serum Glutamate Pyruvate Transaminase: SGPT, Blood Urea, Serum Creatinine), assessed at baseline and post-intervention. IG demonstrated a statistically significant increase in CD4 + counts and Hb levels (<em>p</em> &lt; 0.05), with no hepatotoxic or nephrotoxic effects. The observed improvements suggest possible immunomodulatory actions of YR, potentially involving enhanced Regulatory T cell (Treg) activity, cytokine balance, and modulation of transcriptional regulators. YR exhibited potential as a safe, affordable adjunct to ART in HIV management. Future studies employing immunophenotyping, cytokine assays, and epigenetic analyses are recommended to elucidate its mechanistic pathways.</div></div>","PeriodicalId":100197,"journal":{"name":"Brain Behavior and Immunity Integrative","volume":"15 ","pages":"Article 100183"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148737727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuro-endocrine-immune network mechanisms of non-pharmacological interventions for postoperative depression in breast cancer","authors":"Dai Boyang,&nbsp;Cai Jiazhen,&nbsp;Liu Yifei,&nbsp;Chen Xuelian,&nbsp;Nueryan Mahemuti,&nbsp;Wang Wei,&nbsp;Meng Yumei","doi":"10.1016/j.bbii.2026.100181","DOIUrl":"10.1016/j.bbii.2026.100181","url":null,"abstract":"<div><div>Postoperative depression in breast cancer (PDC) is a clinically consequential condition that can adversely affect treatment adherence, functional recovery, symptom burden, and overall quality of life. Emerging evidence indicates that the development and persistence of PDC are driven by dynamic interactions among psychological stress, endocrine dysregulation, autonomic imbalance, and immune-inflammatory activation. Within this context, the neuro-endocrine-immune (NEI) network offers a biologically and clinically informative framework for elucidating both the pathophysiological basis of PDC and the mechanistic underpinnings of non-pharmacological interventions (NPIs).</div><div>In this mechanism-oriented integrative review, the pathogenesis of PDC is synthesized across three interconnected NEI domains: neural dysregulation, endocrine disturbance, and immune-inflammatory activation. In parallel, the review critically evaluates current evidence for major NPIs, including cognitive behavioral therapy, mindfulness- and acceptance-based approaches, relaxation training, physical exercise, traditional mind–body practices, music- and art-based interventions, acupuncture, and dietary strategies.</div><div>Available evidence suggests that NPIs may ameliorate depressive symptoms and associated psychological distress through partially convergent mechanisms involving stress appraisal, emotional regulation, sleep and fatigue modulation, hypothalamic–pituitary–adrenal (HPA) axis functioning, autonomic nervous system balance, inflammatory signaling, oxidative stress, and immunometabolic regulation. Nevertheless, the robustness and mechanistic specificity of existing evidence vary considerably across intervention modalities. In general, evidence supporting clinical efficacy exceeds that for direct biological mechanisms, and many hypothesized NEI pathways remain insufficiently validated in populations specifically affected by PDC.</div><div>Future research should prioritize the integration of clinical outcomes with NEI-related biomarkers and advance symptom- and mechanism-informed intervention models to facilitate more precise and individualized supportive care in breast cancer rehabilitation.</div></div>","PeriodicalId":100197,"journal":{"name":"Brain Behavior and Immunity Integrative","volume":"15 ","pages":"Article 100181"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148634148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mind - body interaction system: An unforeseen perspective of holistic health","authors":"A. Srivastava,&nbsp;R. Verma","doi":"10.1016/j.bbii.2026.100180","DOIUrl":"10.1016/j.bbii.2026.100180","url":null,"abstract":"<div><div>Psychoneuroimmunology (PNI) offers a cohesive model explaining the interrelationships among psychological phenomena and the nervous, endocrine, and immune systems. While the fundamental principles of PNI are well documented, translating these multidimensional interactions into actionable experimental frameworks remains a challenge. This paper advances the current PNI literature by proposing a refined bio-psycho-social framework rooted in systems biology. By structurally mapping physiological mechanisms, from molecular cytokines to systemic neuroendocrine responses to environmental and psychological factors, this perspective bridges theoretical PNI and personalized healthcare routine. This review article contributes towards providing better understanding of these bidirectional pathways which clarifies the necessity for a multi-targeted, individualized healthcare system that integrates pharmacological interventions, evidence-based lifestyle changes, and mind-body therapies, ultimately improving experimental efficacy and holistic health outcomes.</div></div>","PeriodicalId":100197,"journal":{"name":"Brain Behavior and Immunity Integrative","volume":"15 ","pages":"Article 100180"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148634149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of traditional Chinese medicine on microglia immunometabolism: A new frontier in the treatment of neurodegenerative diseases","authors":"Qianqian Li,&nbsp;Manrui Ding,&nbsp;Renke He,&nbsp;Jinbo Cheng,&nbsp;Zengqiang Yuan","doi":"10.1016/j.bbii.2026.100179","DOIUrl":"10.1016/j.bbii.2026.100179","url":null,"abstract":"<div><div>The pathological progression of neurodegenerative diseases is tightly linked to microglia-mediated immune dysregulation. Immunometabolism reprogramming in microglia exerts a pivotal influence on their polarization toward pro-inflammatory or anti-inflammatory phenotypes, wherein imbalanced metabolic remodeling and immunometabolism disorders perpetuate a vicious cycle that perturbs immune homeostasis and exacerbates neuropathology. Dysregulated microglial immunometabolism is increasingly recognized as a central driver of neurodegenerative diseases, rendering microglia a prime therapeutic target. Recent advances have demonstrated that traditional Chinese medicine (TCM), with its inherent merits of multi-component and multi-target actions, confers substantial efficacy in mitigating neurological disorders by targeting microglial metabolic pathways. Notably, TCM exhibits unique potential in orchestrating the crosstalk between microglial metabolism and immunity; however, a systematic synthesis of these findings is still lacking. This review compiles TCM-based immunomodulators, including monomers, single herbs, and compound formulations, which alleviate metabolism-associated neuroinflammation by targeting key microglial metabolic cascades, such as aberrant glycolytic hyperactivation, impaired mitochondrial oxidative phosphorylation, and dysregulated glutamine and lipid metabolism. We aim to delineate the metabolic regulation of immunity, dissect microglial metabolic perturbations in neurodegenerative diseases, and summarize the salutary effects of TCM on microglial immunometabolism, thereby providing novel insights into the prevention and therapeutic intervention of neurodegenerative diseases.</div></div>","PeriodicalId":100197,"journal":{"name":"Brain Behavior and Immunity Integrative","volume":"15 ","pages":"Article 100179"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148539424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic stress, sensory neurons, and chronic pain: Integrating brain, periphery, and immune mechanisms","authors":"Geovana Agostinho de Amorim,&nbsp;Nathalia S. Carvalho,&nbsp;Marco Pagliusi Jr","doi":"10.1016/j.bbii.2026.100176","DOIUrl":"10.1016/j.bbii.2026.100176","url":null,"abstract":"<div><div>Chronic stress is a major risk factor for the development and persistence of chronic pain and is frequently associated with psychiatric comorbidities such as depression and post-traumatic stress disorder. However, the mechanisms linking stress exposure to pain chronification remain poorly integrated across peripheral and central levels. In this review, we examine chronic pain as a consequence of stress-driven brain–periphery–immune interactions, with a specific focus on primary sensory neurons as key integrators of immune, neuroendocrine, and neural signals. We discuss evidence showing that chronic stress reshapes immune function and promotes a pro-inflammatory milieu that directly targets nociceptors, increasing their excitability and susceptibility to peripheral sensitization. We then address how sustained nociceptive signaling and stress-related neuroimmune activation facilitate central sensitization within the spinal cord and limbic circuits, contributing to widespread pain and psychiatric vulnerability. By integrating findings from clinical and preclinical studies, this review highlights sensory neurons as a critical interface linking stress, immune dysregulation, and maladaptive pain processing across peripheral and central nervous system levels.</div></div>","PeriodicalId":100197,"journal":{"name":"Brain Behavior and Immunity Integrative","volume":"15 ","pages":"Article 100176"},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148539428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum regarding missing Data Statements in the previously published articles","authors":"","doi":"10.1016/j.bbii.2026.100162","DOIUrl":"10.1016/j.bbii.2026.100162","url":null,"abstract":"","PeriodicalId":100197,"journal":{"name":"Brain Behavior and Immunity Integrative","volume":"14 ","pages":"Article 100162"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147950967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}