Brain Behavior and Immunity Integrative最新文献

{"title":"An insightful comparison of the current neuroimmune mechanism(s) with the thoughts of differential syndromes from traditional Chinese medicine for the treatment of MDD","authors":"Jiyi Xu ,&nbsp;Yi Zhang ,&nbsp;Lei Li ,&nbsp;Xiaodong Zhao ,&nbsp;Feilong Huang ,&nbsp;Jing Du","doi":"10.1016/j.bbii.2024.100100","DOIUrl":"10.1016/j.bbii.2024.100100","url":null,"abstract":"<div><div>Major depressive disorder (MDD) is a common disease affecting 300 million people worldwide. Current drugs are ineffective for at least 30 % of the patients. Novel and personalized medication is needed urgently. Cumulative studies suggest that the neuroinflammation of the glial cells, particularly NOD-like receptor thermal protein domain associated protein 3 (NLRP3) inflammasome activation and subsequent regulation of synaptic functions may be the key for the pathophysiology and treatment of MDD. In this review, we delve to compare the modern mechanism of MDD treatment with the theories of differential symptoms for personalized treatment of the ancient decoctions from traditional Chinese Medicine (TCM). Interestingly, the mechanisms of MDD treatment from Western and TCM theories overlap to a nexus on regulating neuro-immune signaling pathways, including NLRP 3 inflammasome, cytokine expressions and synaptic functions. In this review, we have summarized 8 differential syndromes and 10 decoctions for the TCM treatment of MDD in modulation of immune system and synaptic functions. The neuroimmune modulation of the 10 decoctions for the treatment MDD from TCM are amazingly similar towards the anti-inflammatory effects and enhancing synaptic functions. The comparison of theories and therapies from Western medicine and TCM may contribute to the development of more effective and safer medication for MDD.</div></div>","PeriodicalId":100197,"journal":{"name":"Brain Behavior and Immunity Integrative","volume":"9 ","pages":"Article 100100"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143097035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"School-based yoga intervention for internet resilience and holistic well-being of adolescents","authors":"Reshu ,&nbsp;Surendra Kumar ,&nbsp;Ashutosh Rathi","doi":"10.1016/j.bbii.2024.100102","DOIUrl":"10.1016/j.bbii.2024.100102","url":null,"abstract":"<div><h3>Background</h3><div>In today’s educational milieu, rising mental and physical health issues among adolescents pose an imperative concern for schools. While yoga has shown growing therapeutic benefits, research addressing emerging concerns—such as internet addiction, and associated cognitive and sleep disorders—remains underexplored, especially in the post-COVID-19 era and within school curricula.</div></div><div><h3>Objective</h3><div>This pilot, randomized-controlled trial with high school students aimed to validate a concise, 25-minute yogic intervention tailored for adolescent well-being in academic settings.</div></div><div><h3>Measures</h3><div>Quantitative assessment tools included the Academic Anxiety Scale for Children, Concentration Questionnaire, Internet Addiction Test, Insomnia Severity Index, and General Health Questionnaire.</div></div><div><h3>Results</h3><div>Over a three-month period, students who practiced yoga reported marked improvements in internet resilience, academic anxiety, concentration, and insomnia symptoms (all p &lt; 0.0001). Additionally, they showed significant reductions in general health complaints (e.g., headaches, stomach aches), with p-values ranging from p &lt; 0.05 to p &lt; 0.001. Conversely, the control group showed no significant changes, except for a worsening of internet addiction.</div></div><div><h3>Conclusion</h3><div>These findings suggest that even brief, consistent yoga practice can yield substantial benefits, advocating for its integration into school curricula to promote a healthier, more resilient generation of learners.</div></div>","PeriodicalId":100197,"journal":{"name":"Brain Behavior and Immunity Integrative","volume":"9 ","pages":"Article 100102"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143097043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fu-Fang-Li-Shao Pill alleviates neuroinflammation through blocking TLR4/MyD88/MAPKs pathway in chronic migraine rats","authors":"Jianmei Yang ,&nbsp;Yining Gu ,&nbsp;Guang Yang ,&nbsp;Waimao Gao ,&nbsp;Lei Chen ,&nbsp;Yiyun Bao ,&nbsp;Kai Meng ,&nbsp;Lingyan Zhu ,&nbsp;Tengteng Zhou ,&nbsp;Xingyu Wang ,&nbsp;Ying Xu","doi":"10.1016/j.bbii.2025.100105","DOIUrl":"10.1016/j.bbii.2025.100105","url":null,"abstract":"<div><div>Neuroinflammation is supposed to be a crucial factor in the pathophysiology of migraine, which is caused by intracranial vasodilation and the release of vasoactive peptides. Fu-Fang-Li-Shao Pill (FFLSP), a prescription composed of Tribulus terrestris, Radix Paeoniae Alba, Radix Puerariae, Radix Salviae Miltiorrhizae, White Chrysanthemum, Uncariae Ramulus Cum Uncis, Concha Margaritifera, Fructus Viticis, Angelica Dahurica and Mentha Haplocalyx Briq, is an effective proved recipe for migraine patients which is developed by Shanghai Xuhui District Central Hospital. However, the pharmacological mechanisms of FFLSP in relieving migraine are not well understood. This study aims to assess the therapeutic effect of FFLSP on chronic migraine and to elucidate the underlying mechanisms. In our study, through the repeated subcutaneous injection of nitroglycerin (NTG), an animal model of chronic migraine was established which showed migraine-like symptoms such as head pain, ear redness and irritability. Here, NTG-induced chronic migraine rats were used to evaluate the inhibitory effect of FFLSP on neuroinflammation by conducting behavioral tests and molecular biology analyses. We observed that FFLSP possesses an excellent ability to relieve chronic migraine. FFLSP treatment was able to inhibit vasodilation by decreasing c-Fos and CGRP expressions in dura mater and trigeminal ganglion. Moreover, headache alleviation of NTG-induced migraine rats was decided by the inhibition of neuroinflammatory responses through FFLSP’s interruptive effect on the TLR4/MyD88/MAPKs pathway. FFLSP should be attentively considered as a potential therapeutic agent for chronic migraine by blocking inflammatory signal pathway in dura mater and trigeminal ganglion.</div></div>","PeriodicalId":100197,"journal":{"name":"Brain Behavior and Immunity Integrative","volume":"9 ","pages":"Article 100105"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143097037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of a residential yoga and naturopathy intervention on blood glucose and diabetes related risk factors in patients with type 2 diabetes mellitus: A retrospective study","authors":"A. Mooventhan ,&nbsp;L. Nivethitha ,&nbsp;K. Kahlil Subramanian ,&nbsp;A. Vijay ,&nbsp;N. Manavalan","doi":"10.1016/j.bbii.2024.100101","DOIUrl":"10.1016/j.bbii.2024.100101","url":null,"abstract":"<div><h3>Background</h3><div>Diabetes mellitus is a group of metabolic illnesses characterised by elevated blood sugar levels brought on by abnormalities in insulin action, production, or both. Previous studies indicate that integrated yoga and naturopathy (IYN) intervention may be useful in the prevention of type-2 diabetes mellitus (T2DM). But there is no known retrospective study with a larger sample size has examined the impact of IYN on blood glucose in T2DM. Thus, the aim of this study was to find the impact of a residential IYN on blood glucose level and other diabetes-related risk factors in patients with T2DM.</div></div><div><h3>Materials and methods</h3><div>A retrospective study design was adopted in which data between August 2019 and October 2022 were screened from hospital inpatient record. A total of 407 eligible patients’ data were included. Subject received IYN. Their baseline and post assessment parameter were extracted from medical record and data were analyzed using SPSS, Version-16.</div></div><div><h3>Results</h3><div>There was a significant reduction in fasting blood glucose, post-prandial blood glucose, weight, body mass index, hip circumference, waist circumference, waist-hip ratio, mid-arm circumference, mid-thigh circumference, perceived stress scale score, blood pressure, pulse rate, mean arterial pressure, rate pressure product and double pressure product in the post-test compared to its’ respective pre-test assessments following yoga and naturopathy intervention.</div></div><div><h3>Conclusion</h3><div>Residential yoga and naturopathy intervention have potential therapeutic impact in reducing blood glucose and its diabetes related risk factors in patients with T2DM. However, prospective randomized controlled trials are recommended to warrant the results of the study.</div></div>","PeriodicalId":100197,"journal":{"name":"Brain Behavior and Immunity Integrative","volume":"9 ","pages":"Article 100101"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143097036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does lateral habenula mediate effects of gestational stress on rat maternal behavior?","authors":"Bo Wang ,&nbsp;Ming Li","doi":"10.1016/j.bbii.2024.100098","DOIUrl":"10.1016/j.bbii.2024.100098","url":null,"abstract":"<div><div>This exploratory study investigated the neural substrate underlying the effect of gestational stress on rat maternal behavior. We tested the hypothesis that the lateral habenula (LHb)-centered neural circuitry (e.g., raphe, ventral tegmental area, nucleus accumbens, etc.) mediates the maternal disruptive effect of gestational stress. Pregnant Sprague-Dawley rats were subjected to daily 30-min restraining stress from approximately gestation day (GD) 5 to 21, white noise from GD 5 to 12 and mild foot shock from GD 13 to 21. Maternal behavior in the home cage and pup retrieval on an elevated plus maze (EPM) were observed during the first postpartum week. The gestational stress reduced body weight gain of stressed females, and reduced time that they spent outside of the nest, a sign of increased maternal anxiety and hypervigilant parenting style. On the open arms of EPM, the stressed dams showed higher frequently sniffing pups than non-stressed ones. Testing with pups (pup exposure) on the EPM decreased c-Fos expression in the LHb in the non-stressed control dams, but it increased c-Fos expression in the dorsal and medial raphe regions of the control dams. Gestational stress reduced this pup effect in all three regions, implying that gestational stress attenuated the ability of pup exposure to activate the maternally relevant brain regions. Our findings indicate that gestational stress may act upon the LHb (as a putative center that mediates negative emotion) and its downstream projection sites (i.e., dorsal and median raphe) to compromise the quality of maternal care.</div></div>","PeriodicalId":100197,"journal":{"name":"Brain Behavior and Immunity Integrative","volume":"9 ","pages":"Article 100098"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143097034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal social isolation during pre-conception and pregnancy programs inflammatory markers and biobehavioural aging trajectories in distant F4 offspring","authors":"Mirela Ambeskovic ,&nbsp;Sorina Truica ,&nbsp;J. Keiko McCreary ,&nbsp;Jamshid Faraji ,&nbsp;Xin Fang ,&nbsp;David M. Olson ,&nbsp;Gerlinde A.S. Metz","doi":"10.1016/j.bbii.2025.100104","DOIUrl":"10.1016/j.bbii.2025.100104","url":null,"abstract":"<div><div>Social isolation and loneliness during pre-conception and pregnancy can negatively impact maternal and offspring health. Here we report that maternal social isolation prior to and during pregnancy generates a distinct physiological and behavioural phenotype in 4th generation great-great-grandoffspring. Male and female F4 offspring born to lineages of transgenerational prenatal stress (TPS, where the F0 mother was socially isolated before and during pregnancy), multigenerational prenatal stress (MPS, where gestational isolation occurred in four consecutive generations), and group-housed controls were tested at 6, 12 and 18 months of age. Assessments included endocrine (corticosterone) and immune markers (IL-18, MCP-1 and M-CSF), motor and cognitive function, and brain morphology via <em>in vivo</em> magnetic resonance imaging (MRI) across the lifespan. Ancestral social isolation in F4 generation rats exacerbated aging-associated stress responses and elevated the production of proinflammatory cytokines and chemokines across all groups. Exploratory behaviours, skilled reaching, skilled walking, spatial learning and memory revealed a stress-sensitive phenotype in TPS males and females along with greater hippocampal and prefrontal cortex atrophy. Thus, maternal social isolation mainly represents a stressful challenge with lifelong consequences for future generations. By contrast, MPS females revealed superior reaching skills that indicate behavioural flexibility with adaptive benefits. The MPS model therefore allows interpretations about the origins of resilience in the face of ongoing stress. Both TPS and MPS shifted cognitive strategies indicative of accelerated aging. Thus, social isolation potentially has adverse long-term consequences for future generations. These findings provide a conceptual framework for better risk prediction and prevention of developmental disabilities and aging-related disorders.</div></div>","PeriodicalId":100197,"journal":{"name":"Brain Behavior and Immunity Integrative","volume":"9 ","pages":"Article 100104"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143140661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevention and early intervention strategies for perinatal mental health disorders mediated by neuroimmune modulation and anti-inflammatory mechanisms through non-invasive transcranial magnetic stimulation: A narrative review","authors":"Yoshihiro Noda ,&nbsp;Shinichiro Nakajima","doi":"10.1016/j.bbii.2025.100103","DOIUrl":"10.1016/j.bbii.2025.100103","url":null,"abstract":"<div><div>Perinatal mental health disorders, including postpartum depression (PPD), affect approximately 20 % of females during pregnancy and the postpartum period; however, are often undiagnosed and untreated. Traditional treatments, such as antidepressants, have limitations, particularly in terms of safety and efficacy during pregnancy. Recent advancements in brain stimulation therapies, such as repetitive transcranial magnetic stimulation (rTMS), offer promising non-invasive alternatives that may be safer and more effective in treating PPD. rTMS therapy uses magnetic pulses to stimulate the brain areas associated with psychiatric disorders without systemic side effects or the need for anesthesia, making it safe for pregnant patients. This review aims to provide a narrative overview of the potential of rTMS neuromodulation from a neuroimmune–neuroendocrine–neuroinflammatory perspective with a focus on perinatal depression. rTMS exerts its antidepressant effects by indirectly modulating neuroimmune and anti-inflammatory processes, with few maternal side effects and no fetal risks, as is common with pharmacotherapy. Perinatal mental health disorders may arise from abnormalities in the inflammatory and immune system homeostasis, which are influenced by hormonal changes during the perinatal period. Neuroinflammation, driven by cytokines and immune cells crossing the blood–brain barrier, plays a significant role. The interaction between the central and peripheral nervous systems is crucial for neuroinflammation and immune responses. The neurotransmitters produced by neurons and immune cells regulate the immune responses and inflammation, emphasizing the importance of neuroendocrine–immune system interactions. Immune-mediated inflammatory diseases cause chronic inflammation due to the dysregulation of the immune response, affecting the central nervous system in conditions such as perinatal depression or long COVID (post-COVID-19 syndrome). rTMS therapy can potentially reduce or ameliorate the pathophysiology of neurological and neuropsychiatric disorders by modulating the neuroimmune interactions, reducing inflammation, and promoting neuronal protection and repair, thereby highlighting its potential for managing neuroinflammation and related symptoms.</div></div>","PeriodicalId":100197,"journal":{"name":"Brain Behavior and Immunity Integrative","volume":"9 ","pages":"Article 100103"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143097521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The interaction of second trimester prenatal maternal inflammation and psychosocial stress on offspring depressive symptoms in adolescence","authors":"Rachel H. Furlan ,&nbsp;Madeline R. Pike ,&nbsp;Emily Lipner ,&nbsp;Elizabeth C. Breen ,&nbsp;Barbara A. Cohn ,&nbsp;Piera M. Cirillo ,&nbsp;Nickilou Y. Krigbaum ,&nbsp;Ann M. Kring ,&nbsp;Thomas M. Olino ,&nbsp;Lauren B. Alloy ,&nbsp;Lauren M. Ellman","doi":"10.1016/j.bbii.2024.100096","DOIUrl":"10.1016/j.bbii.2024.100096","url":null,"abstract":"<div><h3>Background</h3><div>Higher second trimester (T2) prenatal maternal inflammation (PNMI) and prenatal maternal psychosocial stress have been shown to independently contribute to offspring depression risk. Similarly, interactions between sources of inflammation and maternal daily life stress in T2, previously have been associated with increased offspring adolescent depressive symptoms. We aimed to extend previous findings by examining the potential interaction between exposure to higher T2 PNMI and maternal daily life stress on offspring depressive symptoms in adolescence.</div></div><div><h3>Methods</h3><div>614 mother-offspring dyads from the Child Health and Development Studies (CHDS) had data available for T2 maternal serum interleukin (IL)-6, IL-8, IL-1 receptor antagonist (IL-1ra), and soluble TNF receptor-II (sTNF-RII), presence/absence of maternal reported daily life stress coded from interviews primarily conducted in T2, and adolescent offspring (ages 15–18 years) depressive symptoms assessed via self-report. Interactions were evaluated using hierarchical multiple regressions, controlling for maternal education.</div></div><div><h3>Results</h3><div>Maternal daily life stress interacted with higher serum levels of maternal T2 IL-6 and T2 IL-8 to predict adolescent offspring depressive symptoms. Higher IL-6 and higher IL-8 were <em>only</em> associated with offspring depression in the presence of daily life stress. Maternal T2 IL-1ra and sTNF-RII were not associated with offspring adolescent depressive symptoms.</div></div><div><h3>Conclusion</h3><div>The interaction of the adverse impacts of maternal daily life stress and higher maternal IL-6 and/or IL-8 levels during the second trimester may contribute significantly to exacerbate depression risk in adolescent offspring. These results have potential implications for multiple targets of future early intervention and prevention research.</div></div>","PeriodicalId":100197,"journal":{"name":"Brain Behavior and Immunity Integrative","volume":"8 ","pages":"Article 100096"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142744103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the links between pro-inflammatory diets, gut dysbiosis, serotonin, and their implications for psychiatric and neurodegenerative disorders","authors":"Juliana Marino Maia ,&nbsp;Isabelly G. Solon ,&nbsp;Renato Nery Soriano ,&nbsp;Luiz G.S. Branco","doi":"10.1016/j.bbii.2024.100097","DOIUrl":"10.1016/j.bbii.2024.100097","url":null,"abstract":"<div><div>Mounting evidence highlights the intricate relationships involving pro-inflammatory diets, gut dysbiosis, serotonin, and the landscape of psychiatric and neurodegenerative disorders. Pro-inflammatory diets have garnered attention due to their association with chronic systemic inflammation, which is implicated in the genesis and progression of diverse mental health conditions, ranging from anxiety and depression to complex neurodegenerative diseases like Alzheimer's and Parkinson's. In this scenario, the gut-brain axis plays a fundamental role, since alterations in gut microbiota impact the production of neurotransmitters, particularly serotonin – a central regulator of mood and emotion, thereby contributing to mood disorders and cognitive perturbations. The implications of these multifaceted interactions are profound, and the identification of these complex associations has catalyzed innovative therapeutic explorations. Within this article, we comprehensively review the nexus between pro-inflammatory diets, gut dysbiosis, serotonin dynamics, and their profound repercussions on psychiatric and neurodegenerative disorders. This exposition sheds light on a captivating realm of scientific inquiry, poised to unravel the mechanisms underpinning these connections. As these intricate pathways are elucidated, novel strategies for the prevention, management, and potential treatment of these debilitating conditions come into focus.</div></div>","PeriodicalId":100197,"journal":{"name":"Brain Behavior and Immunity Integrative","volume":"8 ","pages":"Article 100097"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143163201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-inflammatory effects of quercetin in lipopolysaccharide-activated cortical astrocytes","authors":"Arpita R. Dave ,&nbsp;Prakash P. Pillai","doi":"10.1016/j.bbii.2024.100095","DOIUrl":"10.1016/j.bbii.2024.100095","url":null,"abstract":"<div><div>Dysregulated neuroinflammation is a hallmark of multiple neurodegenerative diseases, characterized by increased pro-inflammatory cytokines, and reduced anti-inflammatory cytokines, and is mediated by resident astrocytes. Previous studies have demonstrated the neuroprotective effects of quercetin hydrate, a plant flavonoid, however, limited studies exist showing the targets of quercetin in astrocytes. Here, we demonstrate the anti-inflammatory effects of quercetin hydrate at the gene expression level and the involvement of signalling pathway molecules. The rat primary cortical astrocytes were preincubated with different concentrations of quercetin (25–200 μM) followed by lipopolysaccharide (LPS) stimulation. Semi-quantitative PCR analysis showed the therapeutic potential of quercetin by decreasing the gene expression of pro-inflammatory cytokines (IL-1β, IL-6), and Cyclooxygenase-2, and increasing Hemeoxygenase-1 in LPS-stimulated astrocytes. By Immunoblotting analysis, we document the modulatory effects of quercetin on phospho p38 and phospho ERK1/2 in LPS-stimulated astrocytes. The study indicates the anti-inflammatory effects of quercetin against inflammatory responses in astrocytes.</div></div>","PeriodicalId":100197,"journal":{"name":"Brain Behavior and Immunity Integrative","volume":"8 ","pages":"Article 100095"},"PeriodicalIF":0.0,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142720252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}