Brain Behavior and Immunity Integrative最新文献

{"title":"Targeting mental health: A scoping review of acupoints selection in acupressure for depression, anxiety, and stress","authors":"Yu Liu,&nbsp;Daniel H. Lee,&nbsp;Ella Kosowicz,&nbsp;Justin Lin,&nbsp;Linting Ma,&nbsp;Sean Yao,&nbsp;Kyra Bi,&nbsp;Jennifer Huang,&nbsp;Julia Chang,&nbsp;Yuanyuan Li ,&nbsp;Keming Yan ,&nbsp;Albert S. Yeung,&nbsp;Jian Kong","doi":"10.1016/j.bbii.2025.100111","DOIUrl":"10.1016/j.bbii.2025.100111","url":null,"abstract":"<div><h3>Background</h3><div>Depression, anxiety, and stress are prevalent mental health conditions that significantly affect global well-being. Conventional treatments, including pharmacological and psychotherapeutic approaches, often have limitations. Acupressure, a Traditional Chinese Medicine (TCM) technique, has gained attention as a complementary, non-invasive therapy. Acupressure stimulates specific acupoints to balance the body’s energy (<em>Qi</em>) and promote relaxation. This scoping review explores the effectiveness of acupressure for managing depression, anxiety, and stress by analyzing the frequency and selection of key acupoints in randomized controlled trials.</div></div><div><h3>Methods</h3><div>A comprehensive search was conducted in the PubMed database, focusing on RCTs that evaluated acupressure's effects on depression, anxiety, and stress. Studies were screened based on predefined inclusion criteria, including formal diagnoses, well-documented acupressure points, and standardized outcome measures. Data on acupoint usage, meridian applications, and treatment outcomes were also extracted and analyzed.</div></div><div><h3>Results</h3><div>Nineteen studies met the inclusion criteria, with a median sample size of 58 participants. The analysis highlighted the frequent use of auricular Shenmen (TF4) in treating depression, stress, and combined conditions, while Yintang (EX-HN3) and body acupoint Shenmen (HT7) were prominent for managing anxiety. Auricular points played a central role in stress management, comprising 62.50 % of applications, while body acupoints like Taichong (LV3) and Zusanli (ST36) supported overall emotional balance and physical well-being. Although no significant adverse events were reported, studies often lacked standardized safety reporting and follow-up data.</div></div><div><h3>Conclusion</h3><div>This review highlights the frequent use of acupoints such as the auricular Shenmen (TF4), as well as body acupoints Yintang (EX-HN3)and Shenmen (HT7) in promoting emotional regulation and stress relief. The integration of auricular and body acupoints, combined with targeted meridians, provides a foundational framework for utilizing acupressure as a complementary therapy for depression, anxiety, and stress.</div></div>","PeriodicalId":100197,"journal":{"name":"Brain Behavior and Immunity Integrative","volume":"10 ","pages":"Article 100111"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143509939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential benefits of kefir and its compounds on Alzheimer's disease: A systematic review","authors":"Yuri Castelo Branco Tanure ,&nbsp;Ana Clara Morais Mafra ,&nbsp;Bruna Luiza Motta Guimarães ,&nbsp;Rafael Coelho Magalhães ,&nbsp;Catherine Fagundez ,&nbsp;Israel Júnior Borges do Nascimento ,&nbsp;Julio Cesar Moreira Brito","doi":"10.1016/j.bbii.2025.100115","DOIUrl":"10.1016/j.bbii.2025.100115","url":null,"abstract":"<div><div>Alzheimer's disease, characterized by the progressive loss of cognitive functions of the brain, is still an incurable pathology. Current treatments primarily aim to alleviate symptoms, acting mainly on behavioral changes, having a modest impact in the disease course. Recently, potential role of probiotics in managing Alzheimer's has been explored. Kefir, a fermented food teeming with live microorganisms, is thought to influence the gut microbiota, potentially reducing inflammation and the accumulation of toxic proteins in the brain. Additionally, kefir contains bioactive compounds, such as B vitamins, choline, and folic acid, which are essential for neuronal health and cognitive function. Thus, kefir could emerge as a promising complementary treatment for Alzheimer's disease. This systematic review, conducted in January 2024, examined the effects of kefir in both in vivo animal models and human patients with neurodegenerative conditions. The review was based on studies retrieved from BVS, Embase, PubMed/MEDLINE, Scopus, and Web of Science databases. Seven studies were included, involving invertebrates, murine models, and human participants. In animal models, the primary outcomes were antioxidant effects, reduced beta-amyloid deposition, and attenuation of vascular damage and neurodegeneration. In human studies, kefir supplementation resulted in decreased levels of inflammatory cytokines, reactive oxygen species (ROS), and oxidative proteins, and was associated with improvements in memory. Given its potential benefits, kefir could serve as a valuable adjunct to conventional treatments for Alzheimer's disease, warranting further investigation in clinical settings.</div></div>","PeriodicalId":100197,"journal":{"name":"Brain Behavior and Immunity Integrative","volume":"10 ","pages":"Article 100115"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143681558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combining network pharmacology and bioinformatics approaches to explore the molecular mechanism of Erdong Nourishing Heart oral solution in the treatment of anxiety disorders","authors":"Yihan Guo ,&nbsp;Dongdong Shi ,&nbsp;Qing Zhao ,&nbsp;Weidi Wang ,&nbsp;Lanying Liu ,&nbsp;Zhen Wang","doi":"10.1016/j.bbii.2025.100117","DOIUrl":"10.1016/j.bbii.2025.100117","url":null,"abstract":"<div><h3>Background</h3><div>Erdong Nourishing Heart oral solution (EDYX) is a traditional in-hospital formula used for the clinical treatment of anxiety disorders at the Shanghai Mental Health Center; however, its active medicinal components and mechanisms of action remain unexplored.</div></div><div><h3>Methods</h3><div>Active compounds of EDYX and their corresponding targets were identified using the TCMSP, Symmap, and Herb databases. Data intersecting the targets of EDYX and anxiety disorders were obtained from the GeneCards, OMIM, and CTD databases.We take the intersecting targets of EDYX and anxiety disorders to construct a PPI network and a ingredient-disease-target network.Network parameters were analyzed systematically using Cytoscape software, deriving the core targets and key components of EDYX's mechanism.Molecular docking methods assessed and verified interactions between core targets and key components, while the reliability of drug targets was confirmed using the GEO dataset.</div></div><div><h3>Findings</h3><div>A total of 59 active compounds and 3574 corresponding pharmacotherapeutic targets were identified for EDYX, while 6894 targets relevant to anxiety disorders were also screened. Systematic analysis of 1587 potential common targets between EDYX and anxiety disorders revealed core components of EDYX, including polyphenolic compounds such as quercetin, stigmasterol, and γ-sitosterol, and core targets such as TP53,SRC,AKT1,CXCL8 and CXCR4. Pathway enrichment analysis suggested that EDYX potentially inhibits neuroinflammation, enhances cell proliferation and metabolism, and alleviates anxiety by modulating signaling pathways including JUN-STAT, MAPK-NK-κB, PI3K-AKT-mTOR, and neuroactive ligand-receptor interactions.The results of molecular docking showed that the docking scores of JUN and EP300 target proteins with the key compounds were significantly lower than the other proteins, which may be the potential binding targets of EDYX for the treatment of Anxiety. The results of GEO database validation indicated that MMP8 and FOSB may be potential impact genes for EDYX treatment of Anxiety.</div></div><div><h3>Conclusions</h3><div>EDYX is a Chinese medicine compound preparation with multi-component, multi-target, and multi-pathway antidepressant efficacy, which is expected to be a powerful choice for the future adjuvant treatment of Anxiety.Further molecular experiments are required to verify the molecular mechanism of EDYX and its active ingredients, providing a theoretical basis for clinical application.</div></div>","PeriodicalId":100197,"journal":{"name":"Brain Behavior and Immunity Integrative","volume":"10 ","pages":"Article 100117"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143681559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case report of chronic abdominal pain caused by non digestive or psychological disorders","authors":"Jianchang Wei,&nbsp;Yonglong Bao,&nbsp;Ping Yang,&nbsp;Shanqi Zeng,&nbsp;Jie Cao,&nbsp;Tong Zhang","doi":"10.1016/j.bbii.2025.100114","DOIUrl":"10.1016/j.bbii.2025.100114","url":null,"abstract":"<div><h3>Background</h3><div>Chronic abdominal pain (CAP) is defined as ongoing or recurring abdominal pain that lasts for three months or longer, presenting a complex medical challenge due to its wide range of possible causes. Here, we report a case of CAP caused by a non-digestive and non-psychological disorder.</div></div><div><h3>Case presentation</h3><div>A 49-year-old man began experiencing intermittent upper abdominal pain three months ago. Gastroenteroscopy revealed chronic non-atrophic gastritis with erosion and multiple colon polyps. He received treatment including proton pump inhibitors (PPIs), Chinese medicine, painkillers, and psychological therapy, but his symptoms did not improve. One day ago, his abdominal pain worsened along with fever of 38.5 °C. Computed tomography (CT) scan showed a foreign body (FB) and pneumoperitoneum. Urgent laparoscopic exploration was performed, revealing a 3.5 cm fishbone penetrating the left lobe of the liver. The fishbone was successfully removed, and his abdominal pain finally disappeared.</div></div><div><h3>Conclusion</h3><div>CAP is a complex condition with significant diagnostic challenges. Hepatic foreign bodies are very rare and are frequently overlooked in gastroenteroscopic evaluations, which can lead to delayed diagnoses. CT scanning is a crucial diagnostic tool for identifying FBs. Laparoscopic minimally invasive extraction is a viable option for FB removal when indicated. This case underscores the necessity of addressing both physical and psychological factors when managing CAP.</div></div>","PeriodicalId":100197,"journal":{"name":"Brain Behavior and Immunity Integrative","volume":"10 ","pages":"Article 100114"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143619705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcriptome profiling after Sudarshan Kriya Yoga and its practice – A pilot study","authors":"Vinod Mony,&nbsp;Saumya Subramanian,&nbsp;Divya Kanchibhotla","doi":"10.1016/j.bbii.2025.100109","DOIUrl":"10.1016/j.bbii.2025.100109","url":null,"abstract":"<div><h3>Background and objectives</h3><div>Mind body interventions (MBIs) originated in ancient India like yoga, pranayama and meditation have been found to provide positive health benefits. How these interventions bring about changes affecting improved holistic health at the molecular level is still being investigated. Earlier indications are that the mind body interventions reprogram the body towards improved immunity and reduced inflammation that contrasts with the transcriptome response to chronic stress. Beyond this, if there are other gene expression signatures that are common to MBIs, or any other functions affected are yet to be looked into.</div></div><div><h3>Methods</h3><div>Sudarshan Kriya Yoga (SKY) is an integrated yoga-pranayama-meditation technique that has shown to provide multiple health benefits including better immunity and stress reduction. Previous work looking at the transcriptome changes after SKY has found that the genes involved in immune functions are upregulated. Nevertheless, how novices respond to SKY at the level of their gene expression is still largely unknown. In this study, we looked at the global transcriptome after SKY program as well as its practice in novices in a longitudinal study.</div></div><div><h3>Results</h3><div>Immediately after the SKY program, we found 175 genes changed in expression that mainly relates to functions such as neuronal regeneration, resisting cancer progression and lowering inflammation. Interestingly, after 30 days of SKY practice a separate set of 44 genes are differentially expressed, cytoskeletal reorganization being one of the major functions.</div></div><div><h3>Conclusions</h3><div>Contrary to the transcriptional responses to chronic stress, molecular reprogramming after MBIs such as SKY reduced inflammatory responses along with improved regenerative functions.</div></div>","PeriodicalId":100197,"journal":{"name":"Brain Behavior and Immunity Integrative","volume":"10 ","pages":"Article 100109"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143452794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuro-immune-cancer interactions: Mechanisms and therapeutic implications for tumor modulation","authors":"Jianzhuang Wu,&nbsp;Xinyi Lu,&nbsp;Chao Yan","doi":"10.1016/j.bbii.2025.100119","DOIUrl":"10.1016/j.bbii.2025.100119","url":null,"abstract":"<div><div>The interplay between neurons, the immune system, and cancer is a critical area of research with significant therapeutic potential. Neurons regulate immune responses and directly influence tumor progression through neurotransmitters, neurotrophic factors, and synaptic interactions with tumor cells. The peripheral nervous system modulates immune cell activity and inflammation, while the central nervous system coordinates systemic immune responses, influencing tumor growth and metastasis. This neuro-immune-tumor crosstalk is particularly important in peripheral tumors, where local neuroimmune regulation plays a pivotal role. Emerging neuromodulatory therapies, such as Vagus Nerve Stimulation (VNS), offer promising strategies to modulate these interactions. Despite these advances, challenges remain in optimizing neuromodulation and understanding the molecular mechanisms underlying these complex interactions. This perspective highlights the potential for targeting neuro-immune-cancer pathways, with a focus on personalized and precise therapies to address tumor heterogeneity and improve treatment outcomes.</div></div>","PeriodicalId":100197,"journal":{"name":"Brain Behavior and Immunity Integrative","volume":"10 ","pages":"Article 100119"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143799291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The rapid onset of response to depression treatment by Yueju pill: From discovery of a novel treatment target to clinical perspective","authors":"Ruiyi Liu ,&nbsp;Zhangjie Wu ,&nbsp;Ying Yin ,&nbsp;Shan Xing ,&nbsp;Changyu Wu ,&nbsp;Yan Sun ,&nbsp;Hailou Zhang ,&nbsp;Gang Chen","doi":"10.1016/j.bbii.2025.100121","DOIUrl":"10.1016/j.bbii.2025.100121","url":null,"abstract":"<div><div>Depression, marked by persistent low mood and anhedonia, poses significant global health challenges, whereas mainstream antidepressants like SSRIs often have delayed onset and limited efficacy. Yueju Pill, a traditional Chinese herbal medicine formulated 800 years ago to treat “stagnation syndrome”, which overlaps with depression. Yueju pill has been shown to have the rapid onset and sustained antidepressant potential since 2013. It has been revealed to have similarities to the prototype rapid antidepressant ketamine in neuroplasticity mechanisms, including instant stimulation of protein synthesis signaling in the hippocampus and prefrontal cortex, subsequently enhancing expressions of BDNF and synaptic proteins. More recently, some targets and compound substrates that were not known before have been revealed from Yueju pill, and some clinical evidence has been provided. This review will focus on the advances in the discovery of a novel target, the neuropeptide PACAP in the hippocampus for the onset of depression treatment, the study paradigm employed to identify the synergism of the composing compounds in Yueju pill targeting PACAP, the mechanisms of neuroinflammation and gut-brain axis, and clinical trials showing fast alleviation of depression symptoms by adjunct or monotherapy with Yueju pill, in relationship to the improvement in serum BDNF levels. The perspective for a broader use of Yueju pill as a therapeutic avenue for depression and further mechanistic and clinical research directions is also provided.</div></div>","PeriodicalId":100197,"journal":{"name":"Brain Behavior and Immunity Integrative","volume":"10 ","pages":"Article 100121"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143783088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of neuroticism on immune fitness and susceptibility to developing immune-related complaints","authors":"Emina Išerić ,&nbsp;Guusje A. Ulijn ,&nbsp;Stephanie M.P. Oskam ,&nbsp;Gillian Bruce ,&nbsp;Johan Garssen ,&nbsp;Joris C. Verster","doi":"10.1016/j.bbii.2025.100126","DOIUrl":"10.1016/j.bbii.2025.100126","url":null,"abstract":"<div><h3>Aim</h3><div>Neuroticism, i.e. the tendency to experience negative affects such as stress, depression, and anxiety, can have a significant impact on daily life. The aim of the current study was to investigate to what extent neuroticism impacts the susceptibility to experiencing immune-related diseases.</div></div><div><h3>Methods</h3><div>Dutch university students were invited to complete an online survey. Neuroticism, immune fitness, and past year’s frequency of experiencing immune-related complaints were assessed. Correlational analyses determined the associations between neuroticism and immune outcomes, and possible sex differences were evaluated.</div></div><div><h3>Results</h3><div>Data from N = 1790 participants were included. Their mean (SD) age was 21.31 (2.1) years old and 82.2 % of the sample were females. Overall, higher levels of neuroticism were associated with significantly poorer immune fitness (r = -0.227, p &lt; 0.001). Significant correlations were found between neuroticism and sore throat, headache, flu, runny nose, coughing, mild fever, sudden high fever, sinusitis, diarrhea, eye infection, wound infection, and slow healing wounds. However, albeit statistically significant, the magnitude of these correlations was only modest (r &lt; 0.3). Females scored significantly higher on neuroticism (p &lt; 0.001) and reported significantly poorer immune fitness than males (p &lt; 0.001). Females experienced sore throat (p &lt; 0.001), headache (p &lt; 0.001), and eye infection (p = 0.002) significantly more often than males. No sex differences were observed in the magnitude of the correlations, except for the flu, which had a stronger correlation in females than males.</div></div><div><h3>Conclusions</h3><div>Significant associations were found between neuroticism, immune fitness, and the frequency of experiencing immune-related complaints.</div></div>","PeriodicalId":100197,"journal":{"name":"Brain Behavior and Immunity Integrative","volume":"10 ","pages":"Article 100126"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143905888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anxiolytic efficacy of Sphaeranthus indicus Linn Ghana Vati in Generalized Anxiety Disorder: A randomized, placebo-controlled trial","authors":"Sumedh Joshi ,&nbsp;Bhargav Vijay Bhide ,&nbsp;Shivani Ghildiyal ,&nbsp;Tanuja Manoj Nesari","doi":"10.1016/j.bbii.2025.100110","DOIUrl":"10.1016/j.bbii.2025.100110","url":null,"abstract":"<div><div>Generalized Anxiety Disorder (GAD) is a prevalent psychiatric condition marked by persistent worry that disrupts daily life. Conventional treatments, such as SSRIs and benzodiazepines, are often limited by side effects, including sedation and dependence. Sphaeranthus indicus Linn., a well-known Ayurvedic herb, has shown promising anxiolytic potential. This randomized, single-blind, placebo-controlled trial evaluated the efficacy and safety of Sphaeranthus indicus Ghana Vati (SIGV) in patients with GAD. Fifty patients diagnosed according to DSM-IV criteria were randomly assigned to receive either SIGV (500 mg, twice daily) or placebo for eight weeks. Anxiety reduction, the primary outcome, was measured using the Hamilton Anxiety Rating Scale (HAM-A), while secondary outcomes included psychological assessments with the NIMHANS Screening Tool and Manas Bhava Parikshana. The SIGV group exhibited significantly greater improvement in anxiety symptoms than the placebo group. Reductions in anxious mood (63.2 % vs. 41.7 %, p &lt; 0.05), tension (64.0 % vs. 40.4 %, p &lt; 0.01), and insomnia (72.9 % vs. 43.9 %, p &lt; 0.001) were notable. The most significant difference was observed in fear reduction (80.0 % vs. 44.7 %, p &lt; 0.001). Additionally, improvements in depressed mood (62.2 % vs. 41.5 %, p &lt; 0.05) and somatic complaints were significant. However, autonomic symptom improvement (17.8 % vs. 38.1 %) did not reach statistical significance (p = 0.08). These findings suggest that SIGV is a safe and effective intervention for GAD, producing substantial improvements in core anxiety symptoms and emotional well-being compared to placebo. The results highlight SIGV’s potential as a natural and well-tolerated treatment option. Further research is warranted to assess its long-term efficacy and explore its integration into standard psychiatric care.</div></div>","PeriodicalId":100197,"journal":{"name":"Brain Behavior and Immunity Integrative","volume":"10 ","pages":"Article 100110"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143479925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of Chinese patent medicine Wuling capsule combined with antidepressant drugs in the treatment of major depressive disorder: A systematic review with meta-analysis","authors":"Wangtao Li ,&nbsp;Yang Shao ,&nbsp;Mengjuan Xing ,&nbsp;Qiong Xiang ,&nbsp;Liyuan Guo ,&nbsp;Yiying Hu ,&nbsp;Wei Li ,&nbsp;Lanying Liu","doi":"10.1016/j.bbii.2025.100116","DOIUrl":"10.1016/j.bbii.2025.100116","url":null,"abstract":"<div><h3>Background</h3><div>Major depressive disorder is a public health problem covering the world. Medical therapy is one of the main treatment for Major depressive disorder. However, antidepressants often have delayed efficacy and many side effects, which seriously affect the quality of life of patients. To systematically evaluate the efficacy and safety of Chinese patent medicine Wuling capsule combined with antidepressant drug in the treatment of patients with Major depressive disorder. Wuling capsule is a traditional Chinese medicine in China consisting of Wuling mycelia of Xylaria nigripes Sacc (a rare type of fungus).</div></div><div><h3>Methods</h3><div>Relevant documents published before December 1st, 2023 were retrieved from China national knowledge infrastructure, WANFANG DATA, SinoMed, Vip Journal Integration Platform, Chinese Bio Medical Literature Database, Web of Science, Pubmed, Embase, PsycINFO, International Clinical Trials Registry Platform, Scopus, CINAHL, ProQuest, Wiley Online Library and Clinicaltrials.gov. Randomized controlled trials that meet the inclusion criteria were selected. Their qualities were evaluated and classified. The meta-analysis was performed using RevMan 5.4, and heterogeneity test and publication bias evaluation were performed.</div></div><div><h3>Results</h3><div>This review includes 2148 patients from 24 studies. In this study, the intervention group chose Wuling capsule combined with Antidepressant, and the control group used antidepressants alone. The results show that compared with using antidepressant drug alone, using Wuling capsule combined with antidepressant drug displays statistical significance in reduction of patients’ Hamilton Depression Scale score [mean difference= -3.08, 95 %CI (-3.58,-2.57), P &lt; 0.001], Treatment Emergent Symptom Scale score [mean difference= -3.00, 95 %CI (-4.24, −1.75), P &lt; 0.001], and the effective rate [risk ratio= 1.18, 95 %CI (1.13, 1.23), P &lt; 0.001].</div></div><div><h3>Conclusions</h3><div>Compared with antidepressants alone, the Wuling capsule has an advantage in improving the Hamilton Depression score of patients with major depressive disorder. Through this study, we believe that the Wuling capsule can be used as a safe and effective adjunctive drug for the treatment of Chinese patients with major depressive disorder. However, the quality of the evidence still needs to be further improved, and more high-quality clinical trials from different regions are needed to enhance the credibility of the evidence.</div></div>","PeriodicalId":100197,"journal":{"name":"Brain Behavior and Immunity Integrative","volume":"10 ","pages":"Article 100116"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143724377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}