Brain Behavior and Immunity Integrative最新文献

{"title":"Global traditional and Indigenous medicine in psychoneuroimmunology","authors":"Sarah J. Spencer","doi":"10.1016/j.bbii.2024.100054","DOIUrl":"https://doi.org/10.1016/j.bbii.2024.100054","url":null,"abstract":"<div><p>Humans have successfully used traditional botanicals as medicines for thousands of years. Many of these continue to be used today. Indeed, one of today’s most used medicinal drugs, salicylic acid (Aspirin), was in common use in ancient Egypt, more than 3000 years ago. Aspirin inhibits pro-inflammatory COX-1 and promotes the anti-inflammatory activity of COX-2 to reduce inflammation, a mechanism useful in curbing pain and reducing fever. Another example is artemisinin, a compound extracted from a Chinese medicinal herb known as artemisia, which has been widely used to treat against malaria. Across the world similar compounds are being used in traditional medicine with crucial relevance to modern psychoneuroimmunology. This Special Issue highlights outstanding mechanistic and reproducible research on traditional medicines that will inform modern psychoneuroimmunology and related study. This Special Issue showcases traditional medicines from across the globe, from the Himalayas to Africa and many places in between. The Special Issue describes important anti-inflammatory and anti-oxidant properties of a variety of botanicals with clinical and pre-clinical outcomes. It also describes some equally important “negative” data on some popular candidates including green tea and cannabis. Together these studies reveal candidate traditional medicines with real-world effects at least as good as current pharmaceuticals.</p></div>","PeriodicalId":100197,"journal":{"name":"Brain Behavior and Immunity Integrative","volume":"6 ","pages":"Article 100054"},"PeriodicalIF":0.0,"publicationDate":"2024-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949834124000102/pdfft?md5=654a9a7dc412ec517f8af99243dc0270&pid=1-s2.0-S2949834124000102-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140069555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dysfunction of olfactory structures: A conserved mechanism of neurodegeneration?","authors":"Adriana Jiménez ,&nbsp;Diana Organista-Juárez ,&nbsp;Luisa Rocha ,&nbsp;Enrique Estudillo ,&nbsp;Verónica Fernández-Sánchez ,&nbsp;Mónica Alethia Cureño-Díaz ,&nbsp;Mara A. Guzmán-Ruiz ,&nbsp;Rosalinda Guevara-Guzmán","doi":"10.1016/j.bbii.2024.100053","DOIUrl":"https://doi.org/10.1016/j.bbii.2024.100053","url":null,"abstract":"<div><p>The olfactory system participates in the reception, integration, and interpretation of olfactory signals. This chemical sense is essential for survival since it is involved in basic behaviors and physiological processes. Olfactory function decreases with age; however, olfactory impairments are also observed in several neurodegenerative and psychiatric pathologies. It is widely described that olfactory dysfunction is an early symptom in Parkinson (PD) and Alzheimer (AD) diseases, furthermore, olfactory brain areas are affected by the pathological hallmarks of these diseases before the brain areas involved in the motor and cognitive impairments, respectively. This information suggests a key role of olfactory system damage in the beginning of a neurodegenerative process. Not only does the early injury of the olfactory system occur in AD and PD, but also in other pathologies since increasing evidence indicate the presence of olfactory impairments in other neurogenerative and psychiatric diseases namely, depression, schizophrenia, and autism among others. In addition, people with systemic chronic diseases that promote central nervous system damage such as type 2 diabetes and obesity also show olfactory dysfunction, which also suggests that olfactory alterations in these individuals could be an early manifestation of a neurodegenerative process. Then, the aim of the manuscript is to describe the information which supports that olfactory system impairment is a prodromal factor for the development of several neurodegenerative and psychiatric disorders, to recognize it as a shared mechanism of degeneration among diverse neuropathologies, and discuss the relevance of the assessment of the olfactory function in the diagnosis and improvement of neurodegeneration.</p></div>","PeriodicalId":100197,"journal":{"name":"Brain Behavior and Immunity Integrative","volume":"6 ","pages":"Article 100053"},"PeriodicalIF":0.0,"publicationDate":"2024-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949834124000096/pdfft?md5=1e843d403963c67320ab2b818dea1b96&pid=1-s2.0-S2949834124000096-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139985949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Yoga and Naturopathy intervention on psychological comorbidities and autonomic function for irritable bowel syndrome patient: A case study","authors":"Premalatha Palanimurugan ,&nbsp;Velan Arumugam ,&nbsp;Arthi Balakrishnan ,&nbsp;Gayathri Annamalai ,&nbsp;Maheshkumar Kuppusamy ,&nbsp;S.T. Venkateswaran ,&nbsp;Jenita Princy ,&nbsp;Preethi Chandrasekaran","doi":"10.1016/j.bbii.2023.100042","DOIUrl":"10.1016/j.bbii.2023.100042","url":null,"abstract":"<div><p>Irritable bowel syndrome (IBS) is a common functional disorder of the gut-brain axis, characterized by abdominal pain and altered bowel habits. A 38-year-old male patient with a sedentary lifestyle, diagnosed with IBS based on Rome IV criteria, was underwent Yoga and Naturopathy interventions for one month in our outpatient department. The result showed a reduced Irritable Bowel Syndrome Severity Score (IBS-SSS) (315 to 109) and perceived stress (PSS) score (29 to 12) level. Heart rate variability (HRV) analysis showed increased SDNN (35.4 to 48.3 ms) and RMSSD (41.3 to 58.3 ms) values, indicative of improved HRV. Notably, parasympathetic dominance was observed, evidenced by increased pNN50% (14.56 to 18.41) and H.F (41.92 to 59.63 n.u) values, while the LF/HF ratio (1.381 to 0.675) decreased. This case report suggests that lifestyle change through Yoga and Naturopathic intervention is useful in the management of IBS with psychological co-morbidities .</p></div>","PeriodicalId":100197,"journal":{"name":"Brain Behavior and Immunity Integrative","volume":"5 ","pages":"Article 100042"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949834123000417/pdfft?md5=79ea8350c4f5b5b3d93a65bcc2b7f2c9&pid=1-s2.0-S2949834123000417-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139395677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The suggestions of ancient Chinese philosophy and medicine for contemporary scientific research, and integrative care.","authors":"Francesco Bottaccioli ,&nbsp;Anna Giulia Bottaccioli","doi":"10.1016/j.bbii.2023.100024","DOIUrl":"10.1016/j.bbii.2023.100024","url":null,"abstract":"<div><p>According to Kelley et al. (2023), BBI Integrative ‘recognises the historical importance of Eastern health practices in the entire field of PNI’ (psychoneuroimmunology). We applaud this editorial innovation and believe that it is an important step in advancing the ability to provide healing to human beings.This article aims to illustrate suggestions for scientific research and integrative care derived from studying the ancient Chinese medicine and philosophy using pathophysiological and clinical examples. It shows how some fundamental categories of ancient Chinese philosophies, such as the yin–yang theory, and healing models, such as yang sheng (nurturing life), can help us understand how the immune system works and where the foundations of health are rooted. It also examines some examples of the yin–yang dialectic in immunology, such as T helper 1 (Th1) circuit control by the same cells that initially produce cytokines (IL-12 and IFN-γ) to activate this circuit and then produce Th2 circuit cytokines (IL-4) to moderate it. In addition, the transformation of regulatory T-cells into inflammatory T-cells (Th17) and the IL-6 dual pro- or anti-inflammatory face, depends on the context. In the first example, yin is present in yang. In the second, the yang is in the yin. Finally, we present an example of the cytokine yin–yang. This article also shows the surprising concordances of ancient Chinese chronobiology with the modern science of circadian rhythms and the unknown connections between organs, such as between the lungs and gut, which has drawn the attention of modern scientific research only recently. Finally, this article highlights the peculiar approach of ancient Chinese medicine to prevention and treatment, called yang sheng, which shows strong concordance with the model proposed by Psychoneuroendocrineimmunology.</p></div>","PeriodicalId":100197,"journal":{"name":"Brain Behavior and Immunity Integrative","volume":"5 ","pages":"Article 100024"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949834123000235/pdfft?md5=0f05184945cf95ec6042afcdb700a55d&pid=1-s2.0-S2949834123000235-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135346667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advances on the role of pro-inflammatory cytokine interleukin-18 in post-stroke depression","authors":"Yutong Zhang ,&nbsp;Hao Li ,&nbsp;Zeheng Li ,&nbsp;Shuming Yang ,&nbsp;Dan Niu ,&nbsp;Yi Yang ,&nbsp;Xingshun Xu","doi":"10.1016/j.bbii.2023.100037","DOIUrl":"10.1016/j.bbii.2023.100037","url":null,"abstract":"<div><p>Post-stroke depression (PSD) is a prevalent neuropsychiatric condition that affects approximately one-third of stroke survivors, leading to impaired rehabilitation and reduced quality of life. Despite its significant impact, the precise mechanisms underlying PSD remain incompletely understood. Emerging evidence suggests that inflammation may play a pivotal role in its pathogenesis. Notably, recent studies have highlighted the involvement of the pro-inflammatory cytokine interleukin-18 (IL-18) in PSD. Elevated levels of IL-18 following stroke have been observed, indicating its potential contribution to the propagation of inflammation, disruption of neurotransmitter balance, and neuronal damage. IL-18 may also serve as a valuable biomarker for predicting the risk of PSD. Moreover, dysregulation of IL-18 signaling has emerged as a critical factor in the development of PSD. Therefore, modulating IL-18 expression holds promise as a strategy to prevent the progression of PSD. This review provided a comprehensive summary of the current evidence elucidating the diverse immunological and pathological mechanisms of IL-18 in PSD. We also assessed therapeutic strategies that target IL-18 signaling for the management and treatment of PSD. By elucidating the multifaceted role of IL-18 in PSD, this review provides insights into potential therapeutic avenues for improving the outcomes and well-being of individuals affected by PSD.</p></div>","PeriodicalId":100197,"journal":{"name":"Brain Behavior and Immunity Integrative","volume":"5 ","pages":"Article 100037"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949834123000363/pdfft?md5=cd417bcaa57379f504bbc2a07eab48cb&pid=1-s2.0-S2949834123000363-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139023712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integration of genomics database and bioinformatics to identify genome-wide variants for myasthenia gravis across multiple continents","authors":"Dwiki Fitri ,&nbsp;Lalu Muhammad Irham ,&nbsp;Nanik Sulistyani ,&nbsp;Muhammad Ma’ruf ,&nbsp;Anisa Nova Puspitaningrum ,&nbsp;Wirawan Adikusuma ,&nbsp;Maulida Mazaya ,&nbsp;Rockie Chong","doi":"10.1016/j.bbii.2023.100041","DOIUrl":"https://doi.org/10.1016/j.bbii.2023.100041","url":null,"abstract":"<div><p>Autoimmune disease is an immune response that damages the body’s tissues, thereby disrupting the body’s physiological functions. Myasthenia gravis represents one such condition characterized by muscle weakness due to impaired neuromuscular transmission. While it can affect anyone, it tends to be more prevalent among women aged 20–30 and men over 50. This disease, deemed a genetic disorder, typically emerges in old age when antibodies target receptors in the muscles. In this study, we sought to identify the genes that can affect myasthenia gravis by leveraging several databases, including the GWAS Catalog, HaploReg, GTEx portal, and Ensembl. Specifically, our focus was on exploring genomic variants and the expression of the <em>LTA</em> and <em>CTLA4</em> genes. Our findings reveal that two variants (rs2071591 and rs231770) impact <em>LTA</em> expression in both muscle and brain tissue, while affecting <em>CTLA4</em> expression in testicular cell tissue. Subsequently, we assessed the allele frequency of these variants across regional populations, namely African, American, East Asian, European, and Southeast Asian. This study demonstrates that the <em>LTA</em> and <em>CTLA4</em> genes have a higher frequency in African, East Asian, and European populations compared to American and Southeast Asian populations. Consequently, our finding suggests that the latter two populations might have relatively higher susceptibility to the autoimmune disease myasthenia gravis. Therefore, variations in these genes not only offer insights into disease susceptibility, diagnostic or prognostic biomarkers, but also open up avenues for identifying candidate drug targets through genomic-driven drug repurposing.</p></div>","PeriodicalId":100197,"journal":{"name":"Brain Behavior and Immunity Integrative","volume":"5 ","pages":"Article 100041"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949834123000405/pdfft?md5=c52fc63177e914bca4da43eb8c630ef2&pid=1-s2.0-S2949834123000405-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139101003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential of asiaticoside encapsulated alginate chitosan nanoparticles in the management of antiproliferative activity in C6 glioma cells","authors":"Renju Kunjumon ,&nbsp;Gayathri Viswanathan ,&nbsp;Sabulal Baby","doi":"10.1016/j.bbii.2023.100043","DOIUrl":"10.1016/j.bbii.2023.100043","url":null,"abstract":"<div><h3>Background</h3><p>Asiaticoside is a pentacyclic triterpenoid saponin constituent of the medicinal herb <em>Centella asiatica</em>, known for its neuroprotective, anticancer and other biological effects. The present study aims to develop and characterise asiaticoside encapsulated alginate chitosan nanoparticles (ACNPs) and evaluate their antiproliferative potential on C6 glioma cells.</p></div><div><h3>Methods</h3><p>ACNPs were prepared by the ionic gelation polyelectrolyte complexation technique and characterised by dynamic light scattering, scanning electron microscopy and transmission electron microscopy. Cytotoxicity and antiproliferative effect of ACNPs were studied on C6 glioma cells using MTT and EdU-assays. Apoptosis/necrosis in C6 glioma cells was determined by annexin V and acridine orange/ethidium bromide (AO/EtBr) assays. Intracellular ROS generation in C6 glioma cells exposed with ACNP was determined by DCFDA assay using flow cytometry. Cell cycle analysis in C6 glioma cells treated with ACNP was performed by flow cytometry.</p></div><div><h3>Results</h3><p>Synthesised ACNPs showed spherical shape with 200 nm particle size, good thermal stability, and an acceptable polydispersity index. ASI from synthesized ACNPs demonstrated 90% encapsulation efficiency (EE) and 10% drug release within 24 h. Upon ACNP treatment mBA cells exhibited good cell viability and intact cell morphology. However, C6 cells displayed dose-dependent cytotoxicity when treated with ACNP. Annexin V and acridine orange/ethidium bromide (AO/EtBr) assays revealed late apoptosis and necrosis (p &lt; 0.05) in C6 glioma cells treated with ACNP. Likewise, ACNPs significantly augmented reactive oxygen species generation (p &lt; 0.05) in C6 glioma cells. ACNP treatment also resulted in cell cycle arrest at the G1 phase with chromatin condensation in C6 glioma cells.</p></div><div><h3>Conclusions</h3><p>These findings suggest that ACNPs act as an antiproliferative agent against C6 glioma cells <em>via</em> an increased intracellular ROS pathway that promotes apoptosis/necrosis. This study throws light on more in-depth mechanistic aspects of managing brain disorders using <em>C. asiatica</em> and its phytoconstituents.</p></div>","PeriodicalId":100197,"journal":{"name":"Brain Behavior and Immunity Integrative","volume":"5 ","pages":"Article 100043"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949834123000429/pdfft?md5=d0eb7edf1dc5fd30ac5adc2a65ecf567&pid=1-s2.0-S2949834123000429-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139393624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to Editor: Validated yoga protocol for college student mental health","authors":"Velan Arumugam ,&nbsp;Maheshkumar Kuppusamy ,&nbsp;G. Tarakeshwari ,&nbsp;Gayathri Annamalai ,&nbsp;B. Arthi","doi":"10.1016/j.bbii.2023.100039","DOIUrl":"10.1016/j.bbii.2023.100039","url":null,"abstract":"","PeriodicalId":100197,"journal":{"name":"Brain Behavior and Immunity Integrative","volume":"5 ","pages":"Article 100039"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949834123000387/pdfft?md5=5feaffcc5d8c755e3414db65d7ab2d21&pid=1-s2.0-S2949834123000387-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139394078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Daily cannabidiol and L-theanine beverage consumption does not alter anxiety, fatigue, cognitive function, or natural killer cell function: A randomized, controlled trial in healthy, young adults","authors":"Arjun Ramani ,&nbsp;Ryland Townsend ,&nbsp;Edwin Rodriguez ,&nbsp;James M. Haughian ,&nbsp;Laura K. Stewart","doi":"10.1016/j.bbii.2024.100045","DOIUrl":"https://doi.org/10.1016/j.bbii.2024.100045","url":null,"abstract":"<div><p>Cannabidiol (CBD), a non-psychotropic <em>Cannabis sativa</em> derivative, and L-theanine, a green tea derivative, are gaining attention as potential promotors of psychological and cognitive health. The purpose of this double-blind, randomized, placebo-controlled study was to determine whether eight-week, daily consumption of beverages containing CBD, along with L-theanine, would improve psychological health, cognitive function, serum brain-derived neurotrophic factor (BDNF) as well as innate immune cell quantity and function in young, healthy adults. A total of 102 healthy participants were randomly assigned to, and successfully completed, 8 weeks of one of four treatment arms: 1) 60 mg CBD plus L-theanine (CB60; n = 25); 2) 30 mg CBD plus L-theanine (CB30; n = 28); 3) vehicle containing only L-theanine (LTV; n = 24); and 4) a calorie-matched placebo (PLAC; n = 25). After 8 weeks, plasma cannabinoid metabolite concentrations were significantly increased (p &lt; 0.001) in CB60 and CB30 groups. There were no significant changes in anxiety, fatigue, and cognition, or serum BDNF concentrations as a result of the intervention and no treatment-related changes in natural killer (NK) and NKT cell populations or function. ClinicalTrials.gov (NCT05189275).</p></div>","PeriodicalId":100197,"journal":{"name":"Brain Behavior and Immunity Integrative","volume":"5 ","pages":"Article 100045"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949834124000011/pdfft?md5=b4d3b8ed823a77e6ff4bc691035801ae&pid=1-s2.0-S2949834124000011-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139436620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Tibetan herbal formulas on symptom duration among ambulatory patients with native SARS-CoV-2 infection: A retrospective cohort study","authors":"Tawni L. Tidwell ,&nbsp;Tenzin Namdul ,&nbsp;Kristine E. Lee ,&nbsp;Kevin M. Riordan ,&nbsp;Natalie Skopicki ,&nbsp;Tenzin Palkyi ,&nbsp;Jetsun Jungney ,&nbsp;Kristin Blake ,&nbsp;Jetsun Cheme ,&nbsp;Nyima Youdon Namseling ,&nbsp;Dickyi Yangzom ,&nbsp;Tsering Tsomo ,&nbsp;Dawa Ridak ,&nbsp;Yangbum Gyal ,&nbsp;Tenzing Dakpa ,&nbsp;Tsundu S. Nyinda ,&nbsp;Nashalla G. Nyinda ,&nbsp;Tsering Youdon ,&nbsp;Anasuya Weil ,&nbsp;Yangdron Kalzang ,&nbsp;Melissa Rosenkranz","doi":"10.1016/j.bbii.2024.100051","DOIUrl":"https://doi.org/10.1016/j.bbii.2024.100051","url":null,"abstract":"<div><h3>Background</h3><p>Despite abundant data regarding factors that influence COVID-19 symptom severity and need for hospitalization, few studies examine time to resolution of symptoms and potential complementary and alternative therapies that may expedite outpatient recovery. Uncertainty in expected symptom duration and potential missed opportunities to decrease this time persist. Likewise, studies tracking outpatient COVID-19 experiences among marginalized communities are lacking.</p></div><div><h3>Objective</h3><p>To describe the impact of complex Tibetan herbal formula regimens on symptom duration among ambulatory patients with native SARS-CoV-2 infection.</p></div><div><h3>Methods</h3><p>This multi-center, cohort study assessed deidentified data from patients with laboratory-confirmed SARS-CoV-2 infection. The study assessed cases from March 12, 2020 to May 5, 2021 for which vaccinations were not available, and thus reflect native infections.</p></div><div><h3>Intervention</h3><p>Diagnoses were made via telemedicine by a traditional Tibetan medical physician, and herbal formulas were prescribed based on specific symptom presentation of COVID-19 using the personalized medicine approach integral to traditional Tibetan medicine.</p></div><div><h3>Results</h3><p>Of 145 patient cases assessed for eligibility, 86 (59.3%) met inclusion criteria, and 67 (46.2%) had documented symptom resolution. Resolution of symptoms occurred within a median [interquartile range (IQR)] of 11.7 (10.1–13.5) days. The most common symptoms reported were cough and fever. Time to recovery did not significantly differ based on symptom presentation at baseline, except for a couple symptom groupings such as headache and joint pain where recovery time was shorter when those symptoms were present.</p></div><div><h3>Conclusions and relevance</h3><p>Ambulatory patients diagnosed with SARS-CoV-2 infection receiving Tibetan herbal formulas had recovery from symptoms at a median of 11.7 days, fewer than other published reports in patients following standard of care. The Tibetan approach of targeting treatment based on symptom groups, especially those within classical Tibetan medical nosology, appears to result in quick symptom resolution.</p></div>","PeriodicalId":100197,"journal":{"name":"Brain Behavior and Immunity Integrative","volume":"5 ","pages":"Article 100051"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949834124000072/pdfft?md5=8e8726428dba56841522c11023441465&pid=1-s2.0-S2949834124000072-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139935389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}