Brain Behavior and Immunity Integrative最新文献

{"title":"A systemic and dialectical paradigm for Psychoneuroendocrineimmunology and integrated care science","authors":"Francesco Bottaccioli ,&nbsp;Anna Giulia Bottaccioli","doi":"10.1016/j.bbii.2025.100138","DOIUrl":"10.1016/j.bbii.2025.100138","url":null,"abstract":"<div><div>The integrated care needs of a philosophical paradigm. Psychoneuroendocrineimmunology can be it, provided that a consensus is created on its profound meaning. What is Psychoneuroendocrineimmunology (PNEI)? It is not Neuroendocrinoimmunology. PNEI (also called PNI, Psychoneuroimmunology) describes the relationships of mutual influence between the psyche and biological systems and between the whole organism and the physical and social environment, showing the scientific inconsistency of the reductionist dogma that makes the psyche a mere epiphenomenon of brain activity. We are in a phase of research that allows the definitive overcoming of the dualistic conception of the human being without falling into the trap of the mind-brain identity, in the reduction of the psychic dimension to the biological one, from which it undoubtedly originates but on which it influences. To this end, it is essential to critique the philosophical foundations of contemporary reductionism, while, at the same time, highlighting the theoretical-conceptual paradigm that underlies PNEI research and the practice of treatments that integrate medicine and psychology, which descend from this paradigm.</div></div>","PeriodicalId":100197,"journal":{"name":"Brain Behavior and Immunity Integrative","volume":"12 ","pages":"Article 100138"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144926626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New mechanisms of aging: From vascular to neurological system","authors":"Qingwen Hu ,&nbsp;Fuyuan Zhang ,&nbsp;Hanxuan Wang ,&nbsp;Ruixiang Wang ,&nbsp;Dan Zhang ,&nbsp;Rong Fu ,&nbsp;Menglin Zhu ,&nbsp;Hao Zhang ,&nbsp;Meng Gu ,&nbsp;Chunhong Shao ,&nbsp;Yi Zhun Zhu","doi":"10.1016/j.bbii.2025.100143","DOIUrl":"10.1016/j.bbii.2025.100143","url":null,"abstract":"<div><div>Aging is marked by progressive physiological decline, with vascular aging emerging as a pivotal contributor to chronic diseases, including cardiovascular disorders and neurological disorders. As emphasized by Thomas Sydenham’s axiom, “a man is as old as his arteries,” age-dependent arterial remodeling—characterized by endothelial dysfunction, oxidative stress, and arterial stiffening—compromises cerebral perfusion and blood-brain barrier integrity. These vascular alterations disrupt cerebral homeostasis, fostering hypoperfusion, microvascular damage, and neurotoxic inflammation, which synergize with amyloid-β and tau pathologies to accelerate cognitive decline. Understanding the processes of arterial aging is crucial, as numerous age-related cardiovascular and cerebrovascular diseases stem from alterations in arterial function or are exacerbated by functional and phenotypic changes in the arteries. Prioritizing vascular health in aging populations may thus offer a dual benefit: delaying arterial aging and preserving cognitive function, addressing one of the most urgent public health challenges of the 21st century. This review highlights the critical role of vascular aging in the pathophysiology of neurological disorders and discusses emerging therapeutic targets for their alleviation.</div></div>","PeriodicalId":100197,"journal":{"name":"Brain Behavior and Immunity Integrative","volume":"12 ","pages":"Article 100143"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145623334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Personalized homeopathic treatment for Major Depressive Disorder: Insights from an N-of-1 trial and translational analysis","authors":"Yuxuan Zhang ,&nbsp;Gang Chen","doi":"10.1016/j.bbii.2025.100136","DOIUrl":"10.1016/j.bbii.2025.100136","url":null,"abstract":"","PeriodicalId":100197,"journal":{"name":"Brain Behavior and Immunity Integrative","volume":"11 ","pages":"Article 100136"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144851930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Shenqi Jieyu Formula on perfusion and brain structure in the hippocampus and prefrontal cortex of postpartum depressed rats: A functional magnetic resonance imaging study","authors":"Qisheng Tang ,&nbsp;Boliang Li ,&nbsp;Wenjun Sun ,&nbsp;Shengnan Jiang ,&nbsp;Yingnan Liu ,&nbsp;Xiuxuan Xu ,&nbsp;Di Sun ,&nbsp;Miao Qu","doi":"10.1016/j.bbii.2025.100129","DOIUrl":"10.1016/j.bbii.2025.100129","url":null,"abstract":"<div><div>Postpartum depression (PPD) is a prevalent mental disorder affecting approximately 20 % of mothers, with profound implications for maternal and infant health. Current pharmacotherapies pose risks during lactation, highlighting the urgent need for safer alternatives. Shenqi Jieyu Formula (SQJYF) is a traditional Chinese medicine herbal preparation that has demonstrated clinical efficacy in alleviating PPD symptoms, yet its neurobiological mechanisms remain unclear. This study nvestigated the effects of SQJYF on cerebral blood flow and microstructure in the hippocampus (HP) and prefrontal cortex (PFC) using a maternal separation-induced PPD rat model. We established a maternal separation model of PPD. 24 SD rats were randomized into normal group, PPD group, SQJYF-treated group and fluoxetine-treated group. Maternal separation was performed from the first day to the 21st day, 4 hours a day, controls remained undisturbed. Pharmacological intervention was applied from postnatal day 15, SQJYF (1.25 g/100 g/d) or Fluoxetine Hydrochloride Capsules or saline was administered by gavage for 1 week. Forced swim test, sucrose preference test and open field test were conducted post-intervention. Rats were scanned with functional magnetic resonance imaging, arterial spin labeling (ASL) measured cerebral blood flow, and diffusion tensor imaging (DTI) assessed fractional anisotropy (FA) and apparent diffusion coefficient (ADC) in HP and PFC. Results demonstrated that maternal separation induced depressive-like behaviors and also caused hypoperfusion and impaired tissue integrity in the HP and PFC. SQJYF could alleviate depressive-like behavior in PPD rats, also restore cerebral perfusion levels and improve tissue integrity damage. Compared with the PPD group, the horizontal and vertical scores were significantly increased (P &lt; 0.01), sucrose consumption was significantly increased (P &lt; 0.01), and immobility time was significantly reduced (P &lt; 0.01). the perfusion level of bilateral HP and PFC were significantly increased (P &lt; 0.01, P &lt; 0.05), ADC values of bilateral HP and PFC were significantly reduced (P &lt; 0.01, P &lt; 0.05), FA values of bilateral PFC and left HP were significantly increased (P &lt; 0.01). These findings highlight SQJYF;s dual neurorestorative role in ameliorating PPD through enhanced cerebral perfusion and microstructural repair. This study provides the multimodal neuroimaging evidence supporting SQJYF’s efficacy, bridging traditional medicine with modern neurobiological insights to address a critical gap in PPD therapeutics.</div></div>","PeriodicalId":100197,"journal":{"name":"Brain Behavior and Immunity Integrative","volume":"11 ","pages":"Article 100129"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144205428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progesterone restores blood-brain barrier and memory after chronic cerebral hypoperfusion in male rats","authors":"Maydelín Espadín ,&nbsp;Miguel Cervantes ,&nbsp;Angélica Coyoy-Salgado ,&nbsp;Claudia Espinosa-Garcia ,&nbsp;Beatriz Gómez-González ,&nbsp;Gabriela Moralí","doi":"10.1016/j.bbii.2025.100132","DOIUrl":"10.1016/j.bbii.2025.100132","url":null,"abstract":"<div><h3>Introduction</h3><div>Aging is associated with chronic cerebral hypoperfusion (CCH). These blood flow age-related alterations might be attenuated by progesterone (P4), a neurosteroid which has been proven to exert pleiotropic neuroprotective effects in brain injury models. The aim of this study was to evaluate the effects of P4 on the blood-brain barrier (BBB) and on spatial learning and memory in rats subjected to CCH.</div></div><div><h3>Methods</h3><div>Male Sprague-Dawley rats (12–14 month-old) were distributed in groups: CCH+vehicle; CCH+P4 and SHAM. At 7 and 14 days, the function of the BBB, the tight junction proteins and inflammatory factor levels were evaluated. At 180 days spatial learning and memory were evaluated.</div></div><div><h3>Results</h3><div>CCH induced BBB dysfunction, alters tight junction protein, inflammation factors and spatial learning and memory. Treatment with P4 ameliorated these alterations.</div></div><div><h3>Discussion</h3><div>Our results suggest that P4 plays an important role in protecting the brain from hypoperfusion in old male rats.</div></div>","PeriodicalId":100197,"journal":{"name":"Brain Behavior and Immunity Integrative","volume":"11 ","pages":"Article 100132"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144595516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancement of hearing capability among children with congenital sensorineural hearing impairment following the Prajñā Yoga: An Indian knowledge system based intervention","authors":"Jagrati Sharma ,&nbsp;Saumya Subramanian ,&nbsp;Puja Mali ,&nbsp;Dipika Das Mahapatra ,&nbsp;Divya Kanchibhotla","doi":"10.1016/j.bbii.2025.100131","DOIUrl":"10.1016/j.bbii.2025.100131","url":null,"abstract":"<div><h3>Background and purpose</h3><div>Congenital hearing impairment possesses a significant challenge to children's quality of life (QoL). This quasi-experimental study investigates the potential benefits of a two-day yogic practice, Prajñā Yoga in enhancing the auditory skills and improving QoL among hearing impaired children.</div></div><div><h3>Methods</h3><div>The total sample size is 304 with 178 children in the intervention arm who received the daily yogic practice and 126 children in the waitlist control arm. Audiological assessments were done by Pure Tone Audiometry, Immittance Audiometry and reflexometry. To capture any hearing enhancement, QoL and behavioral improvement various psychometric scales were used. The assessments were done at Day 0, 3, 15 and 30 days of practice. Quantitative data were presented using Mean (SD) while the categorical values were done in the form of numbers and percentages. Paired t test was used to compare the data across different time points.</div></div><div><h3>Results</h3><div>The results revealed a significant improvement in hearing ability among the intervention group practitioners evidenced by a 10–15 dB decrease in hearing thresholds compared to the control group (p value &lt;0.001). 91.5 % and 55 % of the participants in the intervention arm demonstrated an improvement in at least one ear and have turned responsive from non-responsive respectively. Additionally, the intervention group also demonstrated significant improvement in QoL, compared to the control group (p value &lt;0.001).</div></div><div><h3>Conclusion</h3><div>With the growing rate of hearing impairment among children, the present study underscores the importance of Prajñā Yoga as a non-pharmacological solution to improve the QoL and enhance auditory abilities.</div></div>","PeriodicalId":100197,"journal":{"name":"Brain Behavior and Immunity Integrative","volume":"11 ","pages":"Article 100131"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144879894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A personalized, integrative approach in treating major depressive disorder: N-of-1 study with plasma proteome and physicochemical analysis of homeopathic preparations","authors":"Ubiratan Cardinalli Adler ,&nbsp;Maristela Schiabel Adler ,&nbsp;Renan dos Santos Nogueira ,&nbsp;Márcio Normando Borges Coelho Filho ,&nbsp;Eugênio de Moura Campos ,&nbsp;Patrícia Andréa da Fonseca Magalhães ,&nbsp;Antonio Brazil Viana Júnior ,&nbsp;Suellen Monike do Vale Sabino ,&nbsp;Annyta Fernandes Frota ,&nbsp;Michelle Verde Ramo Soares ,&nbsp;Anderson Carneiro Costa ,&nbsp;Raelle Ferreira Gomes ,&nbsp;Regina Celia Monteiro de Paula ,&nbsp;Rosemayre Souza Freire ,&nbsp;Eduardo Mello Barroso Filho ,&nbsp;Carla Soraya Costa Maia ,&nbsp;Felipe Domingos de Sousa ,&nbsp;Allysson Allan de Farias ,&nbsp;Francisco Luan Fonsêca da Silva ,&nbsp;Caren Nádia Soares de Sousa ,&nbsp;Lia Lira Olivier Sanders","doi":"10.1016/j.bbii.2025.100133","DOIUrl":"10.1016/j.bbii.2025.100133","url":null,"abstract":"<div><h3>Background</h3><div>Major Depressive Disorder (MDD) treatment remains challenging. This N-of-1 study evaluated a personalized integrative homeopathic protocol for MDD. Methods: A 28-week, double-blind, randomized, placebo-controlled crossover trial assessed <em>Sulphur</em> fifty-millesimal potencies (LM4–7) effectiveness and safety in a 45-year-old female with MDD. The primary outcomes were Beck Depression Inventory-II (BDI-II) scores, and secondary outcomes included SF-12 and Clinical Global Impression Scale scores. We conducted Plasma proteomics and physicochemical analyses (SEM, DLS, ICP-MS) of <em>Sulphur</em> LM2–7.</div></div><div><h3>Results</h3><div>BDI-II scores increased significantly in the placebo group (P = 0.017), whereas no significant change was observed in the <em>Sulphur</em>-treated group (P = 0.243). Overall symptom improvement with homeopathy compared to placebo, controlling for baseline, was 78 % (p &lt; 0.05). MCS-12 significantly decreased during placebo (P = 0.008) but remained stable during homeopathic treatment (P = 0.542). No significant PCS-12 changes were observed (P &gt; 0.2). CGI-I scores improved during the run-in treatment but showed no further change during the N-of-1 trial. Sulfur-loaded LM formulations presented nanoparticles, as confirmed by SEM analysis, demonstrated distinct particle size characteristics via DLS, and exhibited quantifiable sulfur concentrations detected through ICP-MS. Proteomic analysis suggested that <em>Sulphur</em> treatment modulates immune response pathways, highlighting a potential mechanism underlying its antidepressant-like effects.</div></div><div><h3>Conclusions</h3><div>This personalized integrative homeopathic protocol demonstrated superior effectiveness to placebo in the studied individual. The physicochemical characteristics and proteomic findings indicate potential immunomodulatory effects mediated by nanomedicine mechanisms. However, further research involving larger cohorts is warranted to confirm these preliminary observations.</div></div>","PeriodicalId":100197,"journal":{"name":"Brain Behavior and Immunity Integrative","volume":"11 ","pages":"Article 100133"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144767095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing iron deficiency anemia outcomes: Integrating psychological relaxation with ayurvedic treatment","authors":"Nalini Saini,&nbsp;Shalini Rai,&nbsp;Rupashri Nath,&nbsp;Anand More","doi":"10.1016/j.bbii.2025.100135","DOIUrl":"10.1016/j.bbii.2025.100135","url":null,"abstract":"<div><h3>Introduction</h3><div>Iron deficiency anemia (IDA) affects nearly a quarter of the global population, disproportionately burdening women and children in resource-scarce settings like India, which reports the highest global incidence. Driven by inadequate iron intake, increased demand, poor absorption, or chronic blood loss, IDA impairs oxygen transport, physical capacity, cognition, and quality of life, delaying individual and societal progress. While global strategies like iron supplementation have curbed its prevalence, India lags behind. This study explored Ayurveda’s holistic framework, focusing on <em>Pandu Roga</em>, a condition mirroring IDA, and its unique emphasis on psychological triggers of excessive desire, anger, stress, fear, or sorrow as a contributing factor to this complex disorder. We investigated whether combining relaxation techniques (<em>Pranayama</em> and meditation) to mitigate the effects of the above mentioned psychological triggers, along with standard Ayurvedic treatments [<em>Punarnavadi Mandoor</em> (PM) and <em>Dadimadi Ghrita</em> (DG)], outperforms standalone therapy in managing IDA’s subjective and objective markers as a proof-of-concept study.</div></div><div><h3>Materials and methods</h3><div>In a parallel-arm clinical trial, 76 IDA patients were randomized into two groups of 38 each, following informed consent and strict eligibility criteria. Conducted from October 2023 to May 2024, the 30-day intervention assigned the experimental group PM and DG plus daily guided relaxation (via online/offline sessions), while the control group received only PM and DG. Efficacy was assessed through symptomatic and laboratory outcomes.</div></div><div><h3>Observations and result</h3><div>Both groups showed significant improvements in anemia symptoms, Pandu Roga features, hemoglobin, complete blood count (CBC), and serum ferritin. However, the relaxation-augmented group demonstrated greater gains in hemoglobin, CBC parameters, and ferritin, and superior reductions in psychological distress (Manasa Bhava) with statistically significant differences.</div></div><div><h3>Conclusion</h3><div>This study highlights the value of integrating psychological care with Ayurvedic treatment for IDA. Patients receiving relaxation alongside PM and DG exhibited enhanced symptom relief and biomarker improvements, suggesting a synergistic effect. Larger, longer-term multicentric trials are needed to confirm these findings.</div></div>","PeriodicalId":100197,"journal":{"name":"Brain Behavior and Immunity Integrative","volume":"11 ","pages":"Article 100135"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144886092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep, gut microbiota, and mind-body medicine","authors":"Monalisa Das ,&nbsp;G. Muralitharan ,&nbsp;Sarashti Saini ,&nbsp;Sanjib Patra","doi":"10.1016/j.bbii.2025.100128","DOIUrl":"10.1016/j.bbii.2025.100128","url":null,"abstract":"<div><div>Sleep is an intricate physiological process that is essential to both mental and physical well-being. The microbiota-gut-brain axis may be a key factor in the etiology and pathophysiology of sleep disorders, according to mounting evidence that it, directly and indirectly, influences sleep behavior. Sleep problems are linked to altered gut microbial composition, and sleep deprivation causes malfunction of the gut microbiota. Because the gut microbiota produces many of the neurotransmitters involved in sleep, altered microbial diversity is also linked to disrupted sleep. By inhibiting the HPA axis, mindbody therapies such as yoga, tai chi, mindfulness-based cognitive therapy (MBCT), and mindful meditation primarily enhance sleep quality. The microbial community is also greatly impacted by mind-body treatment. Our hypothesis in this study is that mind-body medicine enhances the microbial population, which in turn improves the quality of sleep.</div></div>","PeriodicalId":100197,"journal":{"name":"Brain Behavior and Immunity Integrative","volume":"11 ","pages":"Article 100128"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144231337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Astrocytes: A potential avenue for depression and cancer","authors":"Cheng-Lin Lu ,&nbsp;Xiong Cao","doi":"10.1016/j.bbii.2025.100124","DOIUrl":"10.1016/j.bbii.2025.100124","url":null,"abstract":"<div><div>Recent findings have revealed the potential of neuroscience-based targets to develop novel therapeutic interventions for cancer. Depression has long been hypothesized to increase the risk of cancer, a condition that is significantly more prevalent among cancer patients. Astrocytes have a complex role in depression at the molecular, cellular, and network levels. The targeting of astrocytes has emerged as a promising therapeutic strategy for the treatment of depression. Additionally, astrocytes have also been implicated in cancer brain metastases and directly affect cancer progression. However, further research is necessary to elucidate the causal relationship and mechanisms by which astrocytes contribute to depression and cancer neuroscience. This interface between neurobiology and cancer biology may provide novel insights into the neuroscience-based targets for cancer therapy.</div></div>","PeriodicalId":100197,"journal":{"name":"Brain Behavior and Immunity Integrative","volume":"10 ","pages":"Article 100124"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143874439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}