Brain Behavior and Immunity Integrative最新文献

{"title":"Effects of group trauma-sensitive yoga on inflammatory markers and psychological well-being in women veterans with PTSD: A randomized controlled trial","authors":"Belle Zaccari ,&nbsp;Ursula A. Kelly ,&nbsp;Travis I. Lovejoy ,&nbsp;Kimberly Hubbard ,&nbsp;Aurora Newman ,&nbsp;Jennifer M. Loftis","doi":"10.1016/j.bbii.2023.100031","DOIUrl":"https://doi.org/10.1016/j.bbii.2023.100031","url":null,"abstract":"<div><h3>Background</h3><p>Lifetime prevalence of post-traumatic stress disorder (PTSD) is double among veterans compared to civilians and women compared to men. Inflammatory factors are increasingly implicated in symptoms of PTSD. Yoga shows promise to reduce psychological symptoms of PTSD and positively impact inflammatory responses. The present study aimed to examine the effectiveness of yoga to reduce symptoms of PTSD and depression in addition to investigating the impact of treatment on inflammatory markers in women veterans with PTSD secondary to military sexual trauma.</p></div><div><h3>Methods</h3><p>We collected dried blood spot samples, self-report and clinician administered measures of PTSD, and self-reported depression symptoms at baseline, 2 weeks, and 3 months post-intervention from a subset of women veterans diagnosed with PTSD (N = 27) who were randomized to either Trauma Center Trauma-Sensitive Yoga (TCTSY; a movement therapy) or cognitive processing therapy (CPT; a talk therapy) as part of a larger multisite RCT. Concentrations of interleukin (IL)-6, IL-10, and C-reactive protein (CRP) were measured using multiplex bead-based immunoassay at baseline and post-intervention (2 weeks and 3 months). Generalized estimating equations examined changes in symptoms of PTSD, depression, and inflammatory markers over time. We hypothesized decreases in IL-6 and CRP and increases in IL-10 in TCTSY participants compared to CPT participants and that PTSD and depression symptoms would improve over time in both groups.</p></div><div><h3>Results</h3><p>From baseline to 3 months post-intervention, IL-6 (β = 0.10, <em>p</em> &lt; 0.05), IL-10 (β = 0.68, <em>p</em> &lt; 0.05), and CRP (β = 0.77, <em>p</em> &lt; 0.05) increased in TCTSY participants relative to those randomized to CPT<em>.</em> PTSD and depression symptoms reduced in both groups over time (CAPS-5 β = −3.96, PCL-5 β = −4.66, and BDI-II β = −2.70, all <em>p</em> &lt; 0.05); groups did not differ in magnitude of symptom reduction.</p></div><div><h3>Conclusions</h3><p>Findings indicate that TCTSY has the potential to improve symptoms of PTSD and depression and alter inflammatory markers. The findings are limited by our sample size and the immune factors we examined. Future directions for related research would benefit from measuring a wider array of stress response components.</p></div>","PeriodicalId":100197,"journal":{"name":"Brain Behavior and Immunity Integrative","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949834123000302/pdfft?md5=13a225deeed1de8e1c87f41187245582&pid=1-s2.0-S2949834123000302-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91992741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microglia in the pathogenesis of depression, insomnia and their comorbidity","authors":"Fanglin Liu ,&nbsp;Dan Guo ,&nbsp;Teng Gao ,&nbsp;Mengqi Diao ,&nbsp;Ying Han","doi":"10.1016/j.bbii.2023.100030","DOIUrl":"https://doi.org/10.1016/j.bbii.2023.100030","url":null,"abstract":"<div><p>Microglia have been shown to regulate sleep homeostasis and depressive behavior. However, the mechanism of how microglia are involved in the pathogenesis of depression and insomnia is not well understood. Given the complex and interdependent relationship between sleep and depression, it is important and worthy to clarify the role of microglia in this comorbidity. This review summarizes the current understandings of microglia in insomnia and depression, as well as suggesting their shared mechanisms in neuroinflammation, synaptic plasticity and purinergic signaling, which may promote the precise treatment of comorbid insomnia and depression and facilitate early intervention of insomnia to prevent the onset of depression.</p></div>","PeriodicalId":100197,"journal":{"name":"Brain Behavior and Immunity Integrative","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49709741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psycho-biological effects with practicing Mano Shakti Yoga to stressed college students: A randomized controlled trial","authors":"Rishi Pal ,&nbsp;Kexin Gao ,&nbsp;Xinyu Li ,&nbsp;Bishal Guragai ,&nbsp;Tianhuan Li ,&nbsp;Qiushui Xie ,&nbsp;Gujing Li","doi":"10.1016/j.bbii.2023.100029","DOIUrl":"https://doi.org/10.1016/j.bbii.2023.100029","url":null,"abstract":"<div><h3>Objective</h3><p>There is no existing yoga that is designed specifically according to the traits of college-stressed students. So a novel Mano Shakti Yoga (MSY) was designed to alleviate stress-induced anxiety and depression in college students, which was assessed by physical and psychological measurements.</p></div><div><h3>Methods</h3><p>A total number of 73 students with stress were recruited and were then randomly allocated into two groups: a) the yoga group received MSY intervention for 12 sessions, and b) the control group received no yogic intervention. And Zung’s self-rating anxiety scale (SAS), Zung’s self-rating depression scale (SDS), and cortisol saliva (CS) were assessed pre- and post- yoga intervention in both groups.</p></div><div><h3>Results</h3><p>The post-yoga measurement, including SAS, SDS, and CS levels, were significantly decreased compared with the pre-yoga in the yoga group. However, there was no significant difference in the control group.</p></div><div><h3>Conclusion</h3><p>MSY, which focuses on body-mind interaction and integration, can effectively improve the psychological and physical state of high-stressed college students.</p></div>","PeriodicalId":100197,"journal":{"name":"Brain Behavior and Immunity Integrative","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49709761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conditioned pain modulation and analgesia of local acupuncture for chronic musculoskeletal pain: An exploratory study","authors":"Dawn Wong Lit Wan ,&nbsp;Yanyi Wang ,&nbsp;Lester Jones ,&nbsp;Zhen Zheng","doi":"10.1016/j.bbii.2023.100028","DOIUrl":"https://doi.org/10.1016/j.bbii.2023.100028","url":null,"abstract":"<div><h3>Objective</h3><p>Conditioned pain modulation (CPM) has been found to be inefficient in patients with chronic pain. Animal and human studies showed that CPM is involved in acupuncture analgesia. This study explored the relationship between the potency of CPM and the extent of acupuncture analgesia.</p></div><div><h3>Materials and methods</h3><p>Thirty-five (35) participants with chronic non-specific low back pain or knee osteoarthritis were given sessions of acupuncture treatment at the pain sites twice per week for four weeks. Participants were asked to complete a diary, before and after the treatment, to monitor changes in clinical pain intensity, daily pain duration and analgesic intake. The potency of CPM was assessed before and after the treatment course. Correlation between potency of CPM and extent of acupuncture analgesia was analysed.</p></div><div><h3>Results</h3><p>Clinical average pain intensity (0.79 ± 1.09, p &lt; 0.01), daily pain duration (1.45 ± 3.77 hr, p = 0.03) and analgesic intake (1.41 ± 3.96, p = 0.04) decreased significantly after treatment, while potency of CPM increased significantly (18.21 ± 49.94%, p = 0.04). Pearson correlations showed those with less efficient baseline CPM presented with better pain reduction after treatment. Those with less efficient baseline CPM were associated with greater improvement in potency of CPM after treatment (r = 0.60, p &lt; 0.01). There was no association between the change in potency of CPM and the change in clinical pain intensity.</p></div><div><h3>Conclusions</h3><p>Individuals have varied acupuncture analgesia. People with less efficient baseline CPM would likely benefit from local acupuncture with greater pain relief and improved potency of CPM. Larger studies with a control arm are needed to confirm these results.</p></div>","PeriodicalId":100197,"journal":{"name":"Brain Behavior and Immunity Integrative","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49709718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of raw onion juice therapy in improving sleep, quality of life and alleviating fatigue among older adults: A triple blinded randomized placebo controlled trial","authors":"Gulab Rai Tewani ,&nbsp;Karishma Silwal ,&nbsp;Sucheta Kriplani ,&nbsp;Prakash Babu Kodali ,&nbsp;Hemanshu Sharma ,&nbsp;Pradeep M.K. Nair","doi":"10.1016/j.bbii.2023.100026","DOIUrl":"https://doi.org/10.1016/j.bbii.2023.100026","url":null,"abstract":"<div><h3>Background</h3><p>Insomnia is associated with long-term morbidity for the patient’s health and well-being. This study was intended to determine if raw onion juice therapy, an anecdotal home-remedy, is effective in improving sleep, reducing fatigue, and improving quality of life (QoL) when used along with yoga and naturopathy-based lifestyle interventions (YNBL).</p></div><div><h3>Materials and methods</h3><p>Fifty-eight patients were randomized into two groups: the onion juice group (10 ml onion juice) or the placebo group (10 ml rice water) for 10 days along with the YNBL intervention. The Epworth sleepiness scale, insomnia severity index, total sleep time, sleep latency onset, fatigue severity scale, and SF-12 QoL were assessed at baseline and at the end of the 10th day. All the participants, investigators, and statisticians were blinded to the participants’ group assignments.</p></div><div><h3>Results</h3><p>The raw onion juice group reported a significant reduction in daytime sleepiness (z = −2.839, p = 0.005), insomnia severity (z = −2.493, p = 0.013) and a significant improvement in total sleep time (z = −3.388, p = 0.001), when compared to the placebo group receiving rice water. Similarly, we observed a significant improvement in the quality of life domains (i) physical component summary (PCS) t(54) = 5.345, p = 0.000, and (ii) mental component summary (MCS) t(54) = 3.579, p = 0.001 in the experimental group compared to placebo.</p></div><div><h3>Conclusion</h3><p>Raw onion juice therapy is safe and effective in the management of insomnia as it improves sleep-related parameters, reduces fatigue, and enhances QoL. Future studies with longer follow-up periods and a larger sample size are warranted to substantiate the present findings.</p></div>","PeriodicalId":100197,"journal":{"name":"Brain Behavior and Immunity Integrative","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49709791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in the study of the role of chemokines in drug addiction and the potential effects of traditional Chinese medicines","authors":"Zhuo-Xiu Liu ,&nbsp;Xiao-Qian Wang ,&nbsp;Abbas Haghparast ,&nbsp;Wen-Bin He ,&nbsp;Jian-Jun Zhang","doi":"10.1016/j.bbii.2023.100025","DOIUrl":"https://doi.org/10.1016/j.bbii.2023.100025","url":null,"abstract":"<div><p>Drug abuse significantly affects the neuroimmune system, which in turn contributes to the development of addiction. Chemokines, the critical components of neuroimmune factors, mediate many brain functions, including neuroinflammation, neuronal activity, and endocrine function. Extensive abnormalities in chemokines have been found in models of drug addiction; however, the underlying mechanisms and treatment efficacy remain unclear. Traditional Chinese medicines (TCMs) are increasingly recognized and applied in immune regulation and drug addiction. This review highlights the recent advances in our understanding of chemokine changes associated with exposure to drugs of abuse, including cocaine, opiates, and methamphetamine. We provide a brief overview of what is known about the role of chemokines in brain function and addiction and the TCMs that could be applied in chemokine regulation.</p></div>","PeriodicalId":100197,"journal":{"name":"Brain Behavior and Immunity Integrative","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49709894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum BDNF predicts increases in telomere length during a month-long residential meditation retreat","authors":"Quinn A. Conklin ,&nbsp;Cavan E. Patterson ,&nbsp;Brandon G. King ,&nbsp;Anthony P. Zanesco ,&nbsp;Jennifer J. Pokorny ,&nbsp;María Jesús Álvarez-López ,&nbsp;Marta Cosín-Tomás ,&nbsp;Perla Kaliman ,&nbsp;Clifford D. Saron","doi":"10.1016/j.bbii.2023.100023","DOIUrl":"https://doi.org/10.1016/j.bbii.2023.100023","url":null,"abstract":"<div><h3>Background</h3><p>Brain-derived neurotrophic factor (BDNF) is a modulatory neuroprotein implicated in learning, memory, and neuroplasticity. Studies have found increased peripheral BDNF in participants of meditation interventions, indicating that BDNF may play a role in the learning and habit formation that occurs with meditation training. In this study, we assessed changes in peripheral BDNF protein and gene expression across a month-long insight meditation retreat. We also explored relationships between BDNF and previously reported measures of telomerase activity and telomere length—biomarkers implicated in cell aging and longevity.</p></div><div><h3>Method</h3><p>All participants were experienced meditators. Retreat group participants (<em>n</em> = 28) were assessed at the beginning of, and 3 weeks into, a silent residential retreat. Control group participants (<em>n</em> = 34), who were similar in age, gender, and meditation experience, were also assessed across a 3-week interval. BDNF was measured in serum. BDNF transcripts, telomere length, and telomerase activity were measured in PBMCs.</p></div><div><h3>Results</h3><p>In retreat participants, higher levels of serum BDNF at the beginning of retreat predicted increases in telomere length during retreat. We also found negative correlations between serum BDNF and telomerase activity. Contrary to our prediction, we observed no mean-level change in serum BDNF or BDNF transcripts as a function of retreat.</p></div><div><h3>Conclusion</h3><p>Our results suggest that basal BDNF levels may play a role in retreat-related improvements observed in telomere biology.</p></div>","PeriodicalId":100197,"journal":{"name":"Brain Behavior and Immunity Integrative","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49709795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What Long COVID investigators can learn from four decades of ME/CFS research","authors":"Leonard A. Jason ,&nbsp;Benjamin H. Natelson ,&nbsp;Hector Bonilla ,&nbsp;Zaki A. Sherif ,&nbsp;Suzanne D. Vernon ,&nbsp;Monica Verduzco Gutierrez ,&nbsp;Lisa O’Brien ,&nbsp;Emily Taylor ,&nbsp;On behalf of the RECOVER consortium, by members of the Diagnostic Testing and Test Algorithms Subcommittee of the Commonalities with Other Post Viral Syndromes Task Force. We appreciate the edits and suggestions from Ben Z. Katz.","doi":"10.1016/j.bbii.2023.100022","DOIUrl":"https://doi.org/10.1016/j.bbii.2023.100022","url":null,"abstract":"<div><p>Four decades of research in the field of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) have yielded lessons that may be instructive for those devising criteria to better comprehend Post-Acute Sequelae of SARS CoV-2 Infection (PASC) and Long COVID. For instance, substantial effort has been devoted to defining classification systems, operationalizing methods, and developing instruments with adequate reliability and validity in the ME/CFS field. The current article provides guidelines for developing a case definition for Long COVID and discusses the significance of psychometric issues and criterion variance, including how to specify symptoms, and develop thresholds, subtypes, and exclusionary conditions. ME/CFS research could enhance our knowledge of Long COVID pathophysiology, early diagnosis, prognosis, and the identification of effective treatments.</p></div>","PeriodicalId":100197,"journal":{"name":"Brain Behavior and Immunity Integrative","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49709627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Critical review and mechanistic insights into the health-protective and Immunomodulatory activity of Tiryāq (Theriac) from the purview of Unani medicine","authors":"Sadia Nikhat ,&nbsp;Mohammad Fazil","doi":"10.1016/j.bbii.2023.100021","DOIUrl":"https://doi.org/10.1016/j.bbii.2023.100021","url":null,"abstract":"<div><h3>Background</h3><p>The theriac, known in Arabic as <em>tiryāq</em>, is a medicinal panacea and an alexipharmic which was conceptualized during the 2nd century BC. During medieval ages, the Unani physicians employed various theriac formulations as an antidote, health-protective, and therapeutic in various disorders. In general, the theriac formulations contained many drugs having heath-protective, preventive, and restorative effects. Since the advent of COVID-19 pandemic, there has been a renewed interest in theriac formulations, and researches are underway to elaborate the scientific basis of their action mechanism. This article is an attempt to provide a comprehensive overview of theriac in Unani literature, as well as to elaborate on the potential mode of actions.</p></div><div><h3>Methods</h3><p>Selected authoritative and comprehensive textbooks of Unani medicine and leading scientific websites (MEDLINE, PubMed, ScienceDirect, Springer, and PubMed Central) were explored for information regarding the theriac in Unani classical literature, and its potential usefulness in the present era. No time duration was specified for the search as certain drugs are now relatively obsolete. The keywords used for the search were ‘theriac’, ‘health’, ‘bioactive constituents’, ‘infection’, and ‘antidote’, etc., accompanied by names of drugs.</p></div><div><h3>Results</h3><p>Pharmacological researches on theriac ingredients have revealed the presence of several bioactive compounds, having anti-inflammatory, antioxidant, antipyretic, antivenin, neuroprotective, hepatoprotective, cytotoxic, etc. activities.‎ An interesting step in theriac preparation is the process of maturation. It is scientifically proven that during maturation, the drugs undergo biotransformation through fermentation. Besides, certain drugs like Saffron, Celery, and Fennel, etc. increase bioavailability of other drugs. Overall, the Theriac formulations are a complex mixture of health-preservative, protective, therapeutic and restorative drugs.</p></div><div><h3>Conclusions</h3><p>The theriac formulations contain a thoughtful mixture of ingredients, which have health-protective as well as restorative effects. It is known that most toxins as well as biological disease-causing agents damage the vital organs and processes which lead to complications and death. Hence, the theriac formulations can provide the much-needed protection to these organs, and also maintain the physiological processes, and gives the body the necessary time and strength to recover from these adverse effects.</p></div>","PeriodicalId":100197,"journal":{"name":"Brain Behavior and Immunity Integrative","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49709803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of naturopathy and yoga based intervention on atherosclerotic cardiovascular disease risk among metabolic syndrome individuals – A prospective single arm study","authors":"Shashikiran HC ,&nbsp;Sreegovind R ,&nbsp;Krithika A Ramaswamy ,&nbsp;Shivaprasad Shetty ,&nbsp;Prashanth Shetty","doi":"10.1016/j.bbii.2023.100020","DOIUrl":"https://doi.org/10.1016/j.bbii.2023.100020","url":null,"abstract":"<div><h3>Background</h3><p>Cardiovascular diseases are the leading cause of death in most developed and developing countries, thus representing one of the most significant health problems across the globe. The association between metabolic syndrome and increased risk of cardiovascular diseases has been proven by large multicentric studies. Calculating atherosclerotic cardiovascular diseases risk has been advocated as a preventive strategy. A little is known about its utility and applicability of atherosclerotic cardiovascular diseases risk calculation in individuals predisposed to cardiovascular diseases such as individuals with metabolic syndrome. Practice of a multifaceted naturopathy and yoga-based lifestyle is likely to improve cardiovascular health outcomes and may reduce healthcare costs in high-risk populations. Hence the present study aimed to evaluate the impact of naturopathy and yoga-based lifestyle intervention on the calculated atherosclerotic cardiovascular diseases risk among metabolic syndrome individuals.</p></div><div><h3>Methods</h3><p>This prospective single arm study recruited 70 individuals of both genders, with metabolic syndrome based on eligibility criteria. They underwent 10 days of supervised intensive naturopathy and yoga-based lifestyle intervention in a residential center. Blood pressure, Anthropometric measures and metabolic risk factors were assessed before and after the intervention.</p></div><div><h3>Results</h3><p>There was also a substantial decrease in both systolic blood pressure (p &lt; 0.001) and diastolic blood pressure (p &lt; 0.001) compared to baseline. There was a noteworthy decrease in weight (p &lt; 0.001), Body mass index (p &lt; 0.001), Waist circumference (p &lt; 0.001), Hip circumference (p &lt; 0.001) and Waist Hip Ratio (p = 0.005). The metabolic risk factors Fasting blood glucose (p &lt; 0.001), Total cholesterol (p &lt; 0.001), Triglycerides (p &lt; 0.001), High-density lipoprotein (p &lt; 0.01), Low-density lipoprotein (p &lt; 0.01), Very low-density lipoprotein (p &lt; 0.001), TC/HDL (p &lt; 0.001) and non-HDL (p &lt; 0.001) also showed a significant reduction. The 10-year (p &lt; 0.001) and lifetime risk of atherosclerotic cardiovascular diseases risk was assessed and found to be significantly reduced after the intervention.</p></div><div><h3>Conclusion</h3><p>A multidimensional intensive naturopathy and yoga-based lifestyle could be explored as a non-invasive and cost-effective measure in the mitigation of atherosclerotic cardiovascular diseases risk in predisposed individuals.</p></div>","PeriodicalId":100197,"journal":{"name":"Brain Behavior and Immunity Integrative","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49709796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}