The crosstalk between glioma and nervous system

Abstract

As a primary brain tumor, glioma is distinct by the abundance of nervous system components within its microenvironment. Recent researches reveal highly intricate interactions between glioma and the nervous system. The nervous system influences the occurrence and progression of glioma, while glioma, in turn, affects neuronal activity. Neurons and nerve fibers modulate glioma cells via various neurotransmitters and trophic factors. In certain instances, neurons can establish direct synaptic connections with glioma cells, mechanisms that can impact tumor cell proliferation and metastasis. And on the other hand, glioma can enhance neuronal excitability, potentially triggering epilepsy. Additionally, glioma-derived synaptogenic factors also facilitate the functional reshaping of neural circuits. Hence, gaining a comprehensive understanding of the interactions between the glioma and nervous system, and developing targeted therapies focused on the neural components within the tumor microenvironment, will enhance the treatment outcomes for this challenging tumor.