Biomedicine & Preventive Nutrition最新文献_第8页

WITHDRAWN: A review on pharmacological use of recombinant human erythropoietin in renal and non-renal anemia and other potential applications in clinical practice 综述了重组人促红细胞生成素在肾性和非肾性贫血中的药理应用及其在临床实践中的潜在应用

Biomedicine & Preventive Nutrition Pub Date : 2014-01-15 DOI: 10.1016/J.BIONUT.2013.09.004

G. K. Thilaka, S. V. Kumar

引用次数: 0

Free-radical-scavenging activity and antioxidant effect of ascophyllan from marine brown algae Padina tetrastromatica 海洋褐藻叶青素的自由基清除活性及抗氧化作用

Biomedicine & Preventive Nutrition Pub Date : 2014-01-01 DOI: 10.1016/j.bionut.2013.08.006

S. Mohsin, R. Mahadevan, G. Muraleedhara Kurup

{"title":"Free-radical-scavenging activity and antioxidant effect of ascophyllan from marine brown algae Padina tetrastromatica","authors":"S. Mohsin, R. Mahadevan, G. Muraleedhara Kurup","doi":"10.1016/j.bionut.2013.08.006","DOIUrl":"10.1016/j.bionut.2013.08.006","url":null,"abstract":"<div>Brown seaweeds are rich in sulfated polysaccharides that could potentially be exploited as functional ingredients for human health. Over the years, sulfated polysaccharides with potential pharmacological, nutraceutical and functional food properties have been isolated from brown seaweeds. This study was designed to characterise and evaluate the antioxidant activity of a sulfated polysaccharide ascophyllan isolated from marine brown algae Padina tetrastromatica. Four polysaccharide fractions were purified from crude ascophyllan. Antioxidant activities of the polysaccharide fractions were evaluated by various in vitro assay systems, including 2,2-diphenyl-1-picrylhydrazyl (DPPH), superoxide anion, hydroxyl radical-scavenging activity, lipid peroxidation and reducing power assay. The results showed that the ascophyllan fraction AF3 showed stronger free-radical-scavenging abilities and had good antioxidant effect. Available data obtained by in vitro models suggest that there is a correlation between the sulfate content and antioxidant activity.</div>","PeriodicalId":100182,"journal":{"name":"Biomedicine & Preventive Nutrition","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bionut.2013.08.006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78606830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 18

Effect of long-term aspartame (artificial sweetener) on anxiety, locomotor activity and emotionality behavior in Wistar Albino rats 长期服用阿斯巴甜(人工甜味剂)对Wistar白化大鼠焦虑、运动活动和情绪行为的影响

Biomedicine & Preventive Nutrition Pub Date : 2014-01-01 DOI: 10.1016/j.bionut.2013.04.002

Iyaswamy Ashok, Rathinasamy Sheeladevi, Dapkupar Wankhar

{"title":"Effect of long-term aspartame (artificial sweetener) on anxiety, locomotor activity and emotionality behavior in Wistar Albino rats","authors":"Iyaswamy Ashok, Rathinasamy Sheeladevi, Dapkupar Wankhar","doi":"10.1016/j.bionut.2013.04.002","DOIUrl":"10.1016/j.bionut.2013.04.002","url":null,"abstract":"<div>The focus of the study is to investigate whether the long-term (90<!--> days) oral administration of aspartame (75 mg/kg) has an effect in the anxiety, locomotor activity and emotionality behavior of Wistar strain male Albino rats. Aspartame releases methanol as one of its metabolites during metabolism. To mimic the human methanol metabolism, the methotrexate (MTX)-treated folate-deficient rats were used. Aspartame was administered orally to the MTX-treated animals and was studied along with controls and MTX-treated controls. The locomotor activity and emotionality behavior in the MTX-treated animals did not differ from the controls. However, the aspartame-treated MTX animals showed a marked increase in the immobilization, fecal bolus with a marked decrease in ambulation (peripheral square and central square), rearing, grooming from the control as well the MTX-treated animals. The anxiety state behavior in the MTX-treated animals did not differ from the controls. However, the aspartame-treated MTX animals showed a marked decrease in the number of open arm entry, percentage of open arm entry, time spent in open arm, percentage of time spent in open arm and number of head dips from the control as well the MTX-treated animals. It is relevant to point out that methanol released by aspartame may add an effect in the brain and that could be the additional contributing factor for the observed changes in the locomotor and their anxiety levels. This study intends to substantiate that long-term aspartame consumption can alter the behavior.</div>","PeriodicalId":100182,"journal":{"name":"Biomedicine & Preventive Nutrition","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bionut.2013.04.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90995138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 22

Insilico prediction of anticancer cyanobacterial drug from Nostoc 来自Nostoc的抗癌蓝藻药物的计算机预测

Biomedicine & Preventive Nutrition Pub Date : 2014-01-01 DOI: 10.1016/j.bionut.2013.08.008

M. Sangeetha, M. Menakha, S. Vijayakumar

引用次数: 2

Iridoid glucoside attenuates hyperglycemia-mediated oxidative stress and thyroid hormone function in streptozotocin–induced diabetic rats 环烯醚萜苷减轻链脲佐菌素诱导的糖尿病大鼠高血糖介导的氧化应激和甲状腺激素功能

Biomedicine & Preventive Nutrition Pub Date : 2014-01-01 DOI: 10.1016/j.bionut.2013.06.002

Ramalingam Sundaram , Palanivelu Shanthi , Panchanatham Sachdanandam

{"title":"Iridoid glucoside attenuates hyperglycemia-mediated oxidative stress and thyroid hormone function in streptozotocin–induced diabetic rats","authors":"Ramalingam Sundaram , Palanivelu Shanthi , Panchanatham Sachdanandam","doi":"10.1016/j.bionut.2013.06.002","DOIUrl":"10.1016/j.bionut.2013.06.002","url":null,"abstract":"<div>The present study was to evaluate the effect of iridoid glucoside on the levels of blood glucose, plasma insulin, serum total protein, albumin, thyroid hormone (T3, T4), TSH, LPO and activities of both enzymic and non-enzymic antioxidants in streptozocin-induced diabetic rats. The levels of blood glucose, TBARS and hydroperoxide were significantly increased whereas the levels of plasma insulin and activities of enzymic antioxidants (SOD, CAT, GPx and GST) and the levels of non-enzymic antioxidants (vitamin C, vitamin E) and reduced glutathione were decreased in the liver and kidney tissues of diabetic rats. In addition, serum levels of total protein, albumin, T3, T4 and TSH were also decreased in diabetic rats when compared to control rats. Oral administration of iridoid glucoside to diabetic rats showed significant ameliorative effects on all the biochemical parameters studied. Moreover, the iridoid glucoside showed free radical scavenging activity assessed by the 2,2-diphenyl-1-picrylhydrazyl (DPPH) in vitro which may have responsible for these hypoglycemic and improved antioxidant statuses in vivo. The effect produced by iridoid glucoside on various parameters was comparable to that of glibenclamide. These results indicated that iridoid glucoside possesses antidiabetic and antioxidant potential in addition to synthesis and/or secretion of circulating thyroid hormone.</div>","PeriodicalId":100182,"journal":{"name":"Biomedicine & Preventive Nutrition","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bionut.2013.06.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80652190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Protective role of earthworm powder (Eudrilus eugenaie) on antioxidant status and DNA fragmentation on isoproterenol-induced myocardial infarcted rats 蚯蚓粉对异丙肾上腺素致心肌梗死大鼠抗氧化及DNA断裂的保护作用

Biomedicine & Preventive Nutrition Pub Date : 2014-01-01 DOI: 10.1016/j.bionut.2013.08.010

J. Anitha, Indira A. Jayraaj

{"title":"Protective role of earthworm powder (Eudrilus eugenaie) on antioxidant status and DNA fragmentation on isoproterenol-induced myocardial infarcted rats","authors":"J. Anitha, Indira A. Jayraaj","doi":"10.1016/j.bionut.2013.08.010","DOIUrl":"10.1016/j.bionut.2013.08.010","url":null,"abstract":"<div>Earthworm powder (EWP), a natural boon for medicine, has showed a wide variety of biological activities, which make it a good candidate for the treatment of many oxidative stress-mediated diseases. The present study is aimed to evaluate its therapeutic potential by estimating the levels of lipid peroxidation and assaying activities for various antioxidants in ISO-induced myocardial infarction bearing rats. Subcutaneous injection of ISO (85 mg/kg body weight administered subcutaneously) to Wistar male rats for 2 consecutive days caused myocardial damage in rat heart, which was determined by the increased activity of lipid peroxidation (LPO). The heart tissue antioxidant enzymes, such as glucose-6-phosphate dehydrogenase (G6PD), glutathione reductase (GR), glutathione peroxidase (GPx), superoxide dismutase (SOD) and catalase (CAT) and the non-enzymatic antioxidant, like reduced glutathione (GSH), vitamin C and vitamin E levels were altered in MI rats. Further, EWP (200 mg/kg body weight suspended in saline) administration attenuated the antioxidant mechanism from lipid peroxidation. Thus, the modulatory effects of EWP on attenuating the lipid peroxidation, upregulation of both enzymic and non-enzymic antioxidants, and DNA fragmentation afford an assurance for the treatment of myocardial infarction in the future.</div>","PeriodicalId":100182,"journal":{"name":"Biomedicine & Preventive Nutrition","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bionut.2013.08.010","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80780924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Anti-tumor effect of paeonol via regulating NF-κB, AKT and MAPKs activation: A quick review 丹皮酚通过调控NF-κB、AKT和MAPKs活化的抗肿瘤作用

Biomedicine & Preventive Nutrition Pub Date : 2014-01-01 DOI: 10.1016/j.bionut.2013.08.002

Jing Wu , Xia Xue , Zhen Wu , Heng-Li Zhao , Hong-Mei Cao , De-Qing Sun , Rong-Mei Wang , Jing Sun , Ying Liu , Rui-Chen Guo

引用次数: 10

Immunomodulatory effects of probiotics in the treatment of human immunodeficiency virus (HIV) infection 益生菌治疗人类免疫缺陷病毒(HIV)感染的免疫调节作用

Biomedicine & Preventive Nutrition Pub Date : 2014-01-01 DOI: 10.1016/j.bionut.2013.04.003

A.R. Patel , N.P. Shah , J.B. Prajapati

{"title":"Immunomodulatory effects of probiotics in the treatment of human immunodeficiency virus (HIV) infection","authors":"A.R. Patel , N.P. Shah , J.B. Prajapati","doi":"10.1016/j.bionut.2013.04.003","DOIUrl":"10.1016/j.bionut.2013.04.003","url":null,"abstract":"<div>Recent scientific investigation has supported the important role of probiotics as a part of healthy diet for human as well as animals and may be an avenue to provide a safe, cost effective, and natural approach that adds a barrier against microbial infection. The immunomodulatory property of probiotics is the main base of designing clinical studies in various diseased conditions. Diarrhea is one of the most common symptoms in patients with HIV infection and the risk of diarrhea is increased with advanced immunodeficiency and in patients taking antiretroviral therapy. Probiotic supplements proved to be effective in shortening the duration of diarrhea and to enhance humoral responses in children and adults too. Furthermore, it is suggested that genetically bioengineered lactobacilli can significantly decrease the infectivity of HIV. Current clinical studies suggest that expanding the use of probiotics in immunocompromised patients appears promising; however, it is difficult to extrapolate results from these studies to the expected effects on human health due to very limited testing on immune function effects in humans.</div>","PeriodicalId":100182,"journal":{"name":"Biomedicine & Preventive Nutrition","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bionut.2013.04.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87780688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Protective effects of deferiprone and desferrioxamine in brain tissue of aluminum intoxicated mice: An FTIR study 去铁胺和去铁胺对铝中毒小鼠脑组织的保护作用:FTIR研究

Biomedicine & Preventive Nutrition Pub Date : 2014-01-01 DOI: 10.1016/j.bionut.2013.06.001

Sivaprakasam Sivakumar , Chandra Prasad Khatiwada , Jeganathan Sivasubramanian , Boobalan Raja

{"title":"Protective effects of deferiprone and desferrioxamine in brain tissue of aluminum intoxicated mice: An FTIR study","authors":"Sivaprakasam Sivakumar , Chandra Prasad Khatiwada , Jeganathan Sivasubramanian , Boobalan Raja","doi":"10.1016/j.bionut.2013.06.001","DOIUrl":"10.1016/j.bionut.2013.06.001","url":null,"abstract":"<div>The present study was designed to study aluminum chloride which caused marked alterations in biochemical parameters such as glutathione peroxidase, catalase, superoxide dismutase, and TBARS in brain tissues of mice. Fourier transform infrared spectroscopy spectra reflect the alterations on major biochemical constituents in brain tissues of mice such as proteins, lipids and nucleic acids due to the overproduction of ROS. Furthermore, administration of deferiprone and deferoxamine significantly improved the level of protein and shifted back the peak positions of amide I and II to near control values indicating tau protein, β-amyloid, amyloid plaques and neurofibrillary tangles decreased, consequently protected from Alzheimer's disease and other major risk factor of many neuronal dysfunctions in brain tissues. Therefore, aluminum toxicity is a widespread crisis to all living organisms, including both flora and fauna. Furthermore, it causes widespread degradation of the environment and health. Therefore, the present investigation suggested that DFO and DFP are efficient chelators for aluminum poisoning and they reduced the aluminum concentration.</div>","PeriodicalId":100182,"journal":{"name":"Biomedicine & Preventive Nutrition","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bionut.2013.06.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78660963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Phytopharmacological review on flowers: Source of inspiration for drug discovery 花卉植物药理学综述:药物发现的灵感来源

Biomedicine & Preventive Nutrition Pub Date : 2014-01-01 DOI: 10.1016/j.bionut.2013.08.009

Vikrant Arya , Dinesh Kumar , Manisha Gautam

{"title":"Phytopharmacological review on flowers: Source of inspiration for drug discovery","authors":"Vikrant Arya , Dinesh Kumar , Manisha Gautam","doi":"10.1016/j.bionut.2013.08.009","DOIUrl":"10.1016/j.bionut.2013.08.009","url":null,"abstract":"<div>The utility of natural products with therapeutic properties is as ancient as human civilization. For a prolonged time, the plant, animal and mineral products were the major sources of drugs. Plant source is the primeval source of drugs as most of the medicines (http://howmed.net/pharmacology/drug/<svg><path></path></svg>) in earliest times were discovered from plants. Almost all parts of the plants are used i.e. flowers, leaves, stem, bark, fruits and roots, rhizomes, blubs etc. in drug discovery. Flowers are the gift of nature and God kingdom to beautify the atmosphere around the globe throughout all the times. They proliferate fragrance all around along with wind and also have medicinal values. In this review, an attempt has been done to emphasize the phytopharmacological status of several medicinally important flowers such as pharmacological profile like anti-anxiety, anticancer, anti-diabetic, anti-inflammatory, anti-oxidant, aphrodisiac, anti-arthritic, diuretic, anthelmintic, immunomodulatory, anti-microbial along with its effective dosage. We have also summarized the presence chemical constituents and extracts, which were used for the pharmacological evaluations. Flowers are beautiful creature of spiritual power and phytopharmacological review pave a way of inspiration for drug discovery from their lap of flora.</div>","PeriodicalId":100182,"journal":{"name":"Biomedicine & Preventive Nutrition","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bionut.2013.08.009","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"105544475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 19