去铁胺和去铁胺对铝中毒小鼠脑组织的保护作用:FTIR研究

Sivaprakasam Sivakumar , Chandra Prasad Khatiwada , Jeganathan Sivasubramanian , Boobalan Raja
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引用次数: 8

摘要

本研究旨在研究氯化铝对小鼠脑组织中谷胱甘肽过氧化物酶、过氧化氢酶、超氧化物歧化酶、TBARS等生化指标的显著影响。傅里叶变换红外光谱反映了ROS过量产生对小鼠脑组织中主要生化成分如蛋白质、脂质和核酸的改变。此外,给药去铁素和去铁胺可显著提高蛋白质水平,并将酰胺I和酰胺II的峰值位置移回接近控制值,表明tau蛋白、β-淀粉样蛋白、淀粉样斑块和神经原纤维缠结减少,从而防止阿尔茨海默病和脑组织中许多神经元功能障碍的其他主要危险因素。因此,铝毒性对包括动植物在内的所有生物都是一种广泛的危机。此外,它还造成环境和健康的广泛退化。因此,本研究表明,DFO和DFP是有效的铝中毒螯合剂,可以降低铝的浓度。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Protective effects of deferiprone and desferrioxamine in brain tissue of aluminum intoxicated mice: An FTIR study

The present study was designed to study aluminum chloride which caused marked alterations in biochemical parameters such as glutathione peroxidase, catalase, superoxide dismutase, and TBARS in brain tissues of mice. Fourier transform infrared spectroscopy spectra reflect the alterations on major biochemical constituents in brain tissues of mice such as proteins, lipids and nucleic acids due to the overproduction of ROS. Furthermore, administration of deferiprone and deferoxamine significantly improved the level of protein and shifted back the peak positions of amide I and II to near control values indicating tau protein, β-amyloid, amyloid plaques and neurofibrillary tangles decreased, consequently protected from Alzheimer's disease and other major risk factor of many neuronal dysfunctions in brain tissues. Therefore, aluminum toxicity is a widespread crisis to all living organisms, including both flora and fauna. Furthermore, it causes widespread degradation of the environment and health. Therefore, the present investigation suggested that DFO and DFP are efficient chelators for aluminum poisoning and they reduced the aluminum concentration.

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