Biomedicine & Preventive Nutrition最新文献

Antidiabetic and antidyslipidemic nature of trigonelline, a major alkaloid of fenugreek seeds studied in high-fat-fed and low-dose streptozotocin-induced experimental diabetic rats 葫芦巴种子中的主要生物碱葫芦巴碱在高脂肪喂养和低剂量链脲佐菌素诱导的实验性糖尿病大鼠中抗糖尿病和降血脂的作用

Biomedicine & Preventive Nutrition Pub Date : 2014-10-01 DOI: 10.1016/j.bionut.2014.07.001

Sorimuthu Pillai Subramanian, Gopalan Sriram Prasath

{"title":"Antidiabetic and antidyslipidemic nature of trigonelline, a major alkaloid of fenugreek seeds studied in high-fat-fed and low-dose streptozotocin-induced experimental diabetic rats","authors":"Sorimuthu Pillai Subramanian, Gopalan Sriram Prasath","doi":"10.1016/j.bionut.2014.07.001","DOIUrl":"10.1016/j.bionut.2014.07.001","url":null,"abstract":"<div>Fenugreek (Trigonella foenum graecum) is one of the most widely used medicinal plants in folk medicine. It is known to have diuretic, cardio tonic, hypotensive, hypoglycemic and hypolipidemic effect. Trigonelline, a major alkaloid component of fenugreek, is reported to be responsible for most of its pharmacological activities. The present study was designed to investigate the effect of trigonelline on blood glucose, glycosylated hemoglobin and plasma insulin levels in high-fat-fed (HFD)/streptozotocin (STZ)-induced type 2 diabetic rats. Diabetes was induced by high-fat diet and low-dose STZ (35   days. The toxicological as well as biochemical parameters such as blood glucose, HbA1C, insulin, insulin resistance (HOMA-IR) and lipid profile were measured. The activities of serum AST, ALT and ALP were also assayed. Trigonelline supplementation attenuated the elevated levels of glucose, glycosylated hemoglobin, AST, ALT and ALP. The insulin level was improved with an improvement in hepatic and muscle glycogen content of insulin resistant diabetic rats. Trigonelline effectively normalized the status of lipid profile. These results showed that trigonelline have potential anti-hyperglycemic and antidyslipidemic effects in HFD/STZ-induced type 2 diabetic rats.</div>","PeriodicalId":100182,"journal":{"name":"Biomedicine & Preventive Nutrition","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bionut.2014.07.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79934388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 36

Antioxidative potential of chrysin, a flavone in streptozotocin–nicotinamide-induced diabetic rats 黄酮类化合物大黄素在链脲佐菌素-烟酰胺诱导的糖尿病大鼠中的抗氧化潜力

Biomedicine & Preventive Nutrition Pub Date : 2014-10-01 DOI: 10.1016/j.bionut.2014.08.008

T.A. Anitha , M. Rajadurai

{"title":"Antioxidative potential of chrysin, a flavone in streptozotocin–nicotinamide-induced diabetic rats","authors":"T.A. Anitha , M. Rajadurai","doi":"10.1016/j.bionut.2014.08.008","DOIUrl":"10.1016/j.bionut.2014.08.008","url":null,"abstract":"<div>Increasing evidence in both experimental and clinical studies suggests that oxidative stress has been suggested as a contributory factor in development and complications of both types of diabetes mellitus. The objective of the present study was to evaluate the protective effect of chrysin (5,7-dihydroxyflavone) against streptozotocin–nicotinamide (STZ–NA)-induced oxidative stress in male Wistar rats. Diabetes was induced by a single intraperitoneal (i.p.) injection of STZ (45      mg/kg b.w., respectively. The oxidative stress was measured by examining the enzymatic activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione-S-transferase (GST) and the non-enzymatic antioxidants, such as vitamin C, vitamin E and reduced glutathione (GSH) in liver and kidney. They were decreased while increasing the levels of LPO markers were observed in liver and kidney tissues of diabetic control rats as compared to normal control rats. Oral administration of chrysin (100  <!-->mg/kg b.w. can act as a potent antioxidant and anti-inflammatory agent in type II diabetic rats.</div>","PeriodicalId":100182,"journal":{"name":"Biomedicine & Preventive Nutrition","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bionut.2014.08.008","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72780169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 18

Antihyperglycemic effect of syringic acid on attenuating the key enzymes of carbohydrate metabolism in experimental diabetic rats 丁香酸对实验性糖尿病大鼠碳水化合物代谢关键酶的降血糖作用

Biomedicine & Preventive Nutrition Pub Date : 2014-10-01 DOI: 10.1016/j.bionut.2014.07.010

Subramani Srinivasan , Jayachandran Muthukumaran , Udaiyar Muruganathan , Rantham Subramaniyam Venkatesan , Abdulkadhar Mohamed Jalaludeen

{"title":"Antihyperglycemic effect of syringic acid on attenuating the key enzymes of carbohydrate metabolism in experimental diabetic rats","authors":"Subramani Srinivasan , Jayachandran Muthukumaran , Udaiyar Muruganathan , Rantham Subramaniyam Venkatesan , Abdulkadhar Mohamed Jalaludeen","doi":"10.1016/j.bionut.2014.07.010","DOIUrl":"10.1016/j.bionut.2014.07.010","url":null,"abstract":"<div>Diabetes mellitus is one of the most common endocrine entities, which coexist with defect in carbohydrate metabolism. The Indian traditional system of medicine prescribed plant phytochemical therapies for diseases including diabetes mellitus. The present study was aimed to evaluate the therapeutic potential of syringic acid (SA) by assaying the activities of key enzymes of carbohydrate metabolism in experimental diabetic rats. Diabetes was induced into male albino Wistar rats by intraperitoneal administration of alloxan (150   days. The levels of plasma glucose, insulin, hemoglobin (Hb), glycated hemoglobin (HbA1c) and glycogen, levels of carbohydrate metabolic enzymes, liver and kidney markers were evaluated. Oral administration of SA (50  days, dose dependently improved the glycemic status in diabetic rats. The levels of insulin, Hb and glycogen increased with significant decrease in glucose and HbA1c levels in SA treated rats. The altered activities of carbohydrate metabolic enzymes, hepatic and renal marker were restored to near normal. Histopathological analysis of pancreas revealed that treatment with SA reduced the pancreatic damage induced by alloxan and stimulated β-cell regeneration in diabetic rats. The present findings suggest the antihyperglycemic effect of SA and its therapeutic potential for the management of diabetes.</div>","PeriodicalId":100182,"journal":{"name":"Biomedicine & Preventive Nutrition","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bionut.2014.07.010","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80346655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 38

Plant flavone apigenin protects against cyclosporine-induced histological and biochemical changes in the kidney in rats 植物黄酮类芹菜素对环孢素诱导的大鼠肾脏组织和生化变化具有保护作用

Biomedicine & Preventive Nutrition Pub Date : 2014-10-01 DOI: 10.1016/j.bionut.2014.07.006

Nagaraja Haleagrahara , Srikumar Chakravarthi , Anupama Bangra Kulur , Tan Mun Yee

{"title":"Plant flavone apigenin protects against cyclosporine-induced histological and biochemical changes in the kidney in rats","authors":"Nagaraja Haleagrahara , Srikumar Chakravarthi , Anupama Bangra Kulur , Tan Mun Yee","doi":"10.1016/j.bionut.2014.07.006","DOIUrl":"10.1016/j.bionut.2014.07.006","url":null,"abstract":"<div>Cyclosporine (CsA) is an immunosuppressant drug universally used for the prevention of transplant rejection and also for the treatment of autoimmune diseases. Use of cyclosporine has been limited by its side effects such as hypertension and renal damage. Antioxidants are known to protect free radical induced damage of tissues during drug toxicity. The aim of this study was to test the role of plant flavone apigenin against cyclosporine-induced nephrotoxicity. Adult male Sprague Dawley rats were randomly divided into control, cyclosporine alone, and cyclosporine with apigenin (10, 15 and 20  days to induce nephrotoxicity. From the blood samples, urea, uric acid, total antioxidants and lipid hydroperoxide assays were done. There was a significant renal damage with cyclosporine alone treatment. Blood urea nitrogen, urea, uric acid and lipid hydroperoxides were significantly elevated whereas there was a significant decrease in the total antioxidant levels. Treatment with apigenin significantly reduced the lipid hydroperoxides and increased the total antioxidant levels. Concurrent apigenin treatment significantly reduced the histopathological changes in the CsA treated groups. In conclusion, the study confirmed the role of oxidative stress in the pathogenesis of cyclosporine-induced nephrotoxicity and protective effects of flavone apigenin against free radical-induced renal damage.</div>","PeriodicalId":100182,"journal":{"name":"Biomedicine & Preventive Nutrition","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bionut.2014.07.006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"95866197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Neuroprotective effect of Prunus avium on streptozotocin induced neurotoxicity in mice 鸟李对链脲佐菌素所致小鼠神经毒性的保护作用

Biomedicine & Preventive Nutrition Pub Date : 2014-10-01 DOI: 10.1016/j.bionut.2014.08.004

Edula Vinitha, Hanish J.C. Singh, Rahul Motiram Kakalij, Rahul Padmakar Kshirsagar, Boyina Hemanth Kumar, Prakash V. Diwan

{"title":"Neuroprotective effect of Prunus avium on streptozotocin induced neurotoxicity in mice","authors":"Edula Vinitha, Hanish J.C. Singh, Rahul Motiram Kakalij, Rahul Padmakar Kshirsagar, Boyina Hemanth Kumar, Prakash V. Diwan","doi":"10.1016/j.bionut.2014.08.004","DOIUrl":"10.1016/j.bionut.2014.08.004","url":null,"abstract":"<div><h3>Objective</h3>To evaluate the anti-amnesic and neuroprotective activity of ethanolic extract of Prunus avium (EEPA) on streptozotocin (STZ) induced neurotoxicity in mice.</div><div><h3>Methods</h3>The mice were pre-treated with EEPA at selective doses (200, 400mg/kg, p.o.) for a period of 3 days of treatment with EEPA was effective in averting neurotoxicity. EEPA supplementation significantly reduced AChE, corticosterone, TBARS, tissue nitrite levels and ameliorated the deficits in learning and memory impairment with increased levels of antioxidants.</div><div><h3>Conclusions</h3>These results envisage that ethanolic extract of Prunus avium exhibit cognitive improvement which is most likely related, at least in part, to its antioxidant and neuroprotective activity. Further studies are suggested to evaluate the isolated bioactive Prunus avium fruits to identify the molecular mechanism involved in modulation of cholinergic transmission.</div>","PeriodicalId":100182,"journal":{"name":"Biomedicine & Preventive Nutrition","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bionut.2014.08.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"95682180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Efficiency of lycopene against reproductive and developmental toxicity of Bisphenol A in male Sprague Dawley rats 番茄红素对雄性大鼠双酚A生殖和发育毒性的影响

Biomedicine & Preventive Nutrition Pub Date : 2014-10-01 DOI: 10.1016/j.bionut.2014.07.008

Peranandam Tamilselvan , Kulanthaivel Langeswaran , Shanmugam Vijayaprakash , Subbaraj Gowtham kumar , Rajendran Revathy , Maruthaiveeran Periyaswamy Balasubramanian

{"title":"Efficiency of lycopene against reproductive and developmental toxicity of Bisphenol A in male Sprague Dawley rats","authors":"Peranandam Tamilselvan , Kulanthaivel Langeswaran , Shanmugam Vijayaprakash , Subbaraj Gowtham kumar , Rajendran Revathy , Maruthaiveeran Periyaswamy Balasubramanian","doi":"10.1016/j.bionut.2014.07.008","DOIUrl":"10.1016/j.bionut.2014.07.008","url":null,"abstract":"<div>Bisphenol A (BPA) is an estrogenic environmental toxicant and it is a globally used endocrine disruptor that is incorporated in many plastic industries. The revelation BPA has been implicated to have perilous consequences on reproductive healthiness in human and experimental animals. Present examination endeavor to appraise a powerful antioxidant lycopene against an estrogenic compound BPA. Healthy adult male Sprague Dawley rats were subjected to Bisphenol A (200 mg/kg body weight) dissolved in corn oil (1 mL) administered orally for 30 days. The pathological alterations due to BPA encouraged oxidative stress were evaluated in testis and epidydimis tissues. Simultaneously, adjustments in testicular hormones, sperm characteristic, biological enzymes like antioxidant enzymes, elevated peroxide reactions and enhanced ROS formations were measured in reproductive toxicity rats. Captivatingly, oral administration of lycopene (10 <!-->mg/kg body weight) with BPA intoxicated rats reduced the testicular toxic condition, biochemical and morphological changes were brought back to normal. In termination, antioxidant potential of lycopene, ameliorates the changes that are induced by BPA.</div>","PeriodicalId":100182,"journal":{"name":"Biomedicine & Preventive Nutrition","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bionut.2014.07.008","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89119703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

RETRACTED: In vitro cytotoxic and apoptotic effect of Mimusops elengi Linn. methanolic bark extract 撤下:水仙草体外细胞毒及细胞凋亡作用。甲醇树皮提取物

Biomedicine & Preventive Nutrition Pub Date : 2014-10-01 DOI: 10.1016/j.bionut.2014.07.004

Harish Kumar , K. Sreedhara Ranganath Pai , Naseer Maliyakkal , Savaliya Mihir , Charanjeet Singh

引用次数: 0

Insignificant viability of the granules of probiotic and prebiotic with skimmed milk powder 益生菌颗粒和益生元与脱脂奶粉的活力不显著

Biomedicine & Preventive Nutrition Pub Date : 2014-10-01 DOI: 10.1016/j.bionut.2014.08.005

Chayanika Sahni , Rajinder K. Gupta , Pratibha Nand

{"title":"Insignificant viability of the granules of probiotic and prebiotic with skimmed milk powder","authors":"Chayanika Sahni , Rajinder K. Gupta , Pratibha Nand","doi":"10.1016/j.bionut.2014.08.005","DOIUrl":"10.1016/j.bionut.2014.08.005","url":null,"abstract":"<div>Currently, there is an escalating demand of people for probiotic health-based products. Further, the survival of these bacteria in the human gastrointestinal system is questionable. Viability of probiotic in food and food products is a challenge for the food processing industry. Providing probiotic living cells with a physical barrier against adverse environmental conditions is therefore an approach currently receiving considerable interest to achieve longer shelf-life of the product. In the present study, skimmed milk powder along with probiotic (Lactobacillus acidophilus) and prebiotic (Fructooligosaccharide) were used to make granules by wet granulation method and the viability of the granulated probiotic organism was investigated. Results indicated poor survival of the L. acidophilus after granulation. Physico-chemical characteristics of two optimised F1 and F2 formulations were assessed for pH, water holding capacity and moisture content determination. Major future challenges are also spotlighted.</div>","PeriodicalId":100182,"journal":{"name":"Biomedicine & Preventive Nutrition","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bionut.2014.08.005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74561783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Antidiabetic therapeutics from natural source: A systematic review 天然来源的抗糖尿病药物:系统综述

Biomedicine & Preventive Nutrition Pub Date : 2014-10-01 DOI: 10.1016/j.bionut.2014.07.009

Palanisamy Arulselvan , Hasfar Amynurliyana Abdul Ghofar , Govindarajan Karthivashan , Mohd Firdaus Abdul Halim , Muhammad Syafiq Abdul Ghafar , Sharida Fakurazi

{"title":"Antidiabetic therapeutics from natural source: A systematic review","authors":"Palanisamy Arulselvan , Hasfar Amynurliyana Abdul Ghofar , Govindarajan Karthivashan , Mohd Firdaus Abdul Halim , Muhammad Syafiq Abdul Ghafar , Sharida Fakurazi","doi":"10.1016/j.bionut.2014.07.009","DOIUrl":"10.1016/j.bionut.2014.07.009","url":null,"abstract":"<div>Diabetes mellitus (DM) is a common metabolic/endocrine disorder throughout the world and cause serious medical problems to human health. Recent drastic changes over human dietary habits and contemporary lifestyle lead to various chronic disorders/diseases particularly metabolic diseases including obesity. Traditional medicinal plants and their active phyto-constituents have been used throughout the world for the therapy of diabetes and associated secondary complications. Among many medications and other alternative medicines, numerous herbs have been well-known to cure and prevent diabetes. Several traditionally important medicinal plants have been investigated for their beneficial use in different types of diabetes and its complications. The effects of these plants may delay the development of diabetic complications and alter the metabolic abnormalities using a variety of cellular and molecular mechanisms. A considerable number of active medicinal plants and their bioactive compounds were subjected to clinical trials and were found effective. Moreover, during the past few years many phyto-constituents responsible for antidiabetic effects have been isolated from plants showed higher potential than synthetic drugs. As a result, recently, considerable scientific attention has been directed towards classification/identification of traditional medicinal plants with antihyperglycemic ability that may be used for daily consumption along with the food. This review paper mainly focuses on natural phytoextracts with their pharmacological mechanism of action and their preclinical experimental model, which attracts the attention of pharmacologist, phytochemist and pharmocognosist for further scientific research towards endocrine metabolic disorder.</div>","PeriodicalId":100182,"journal":{"name":"Biomedicine & Preventive Nutrition","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bionut.2014.07.009","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73562450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 70

Combined action of Silymarin and Celecoxib in modulating inflammatory mediators in osteoarthritis 水飞蓟素和塞来昔布在骨关节炎炎症介质调节中的联合作用

Biomedicine & Preventive Nutrition Pub Date : 2014-10-01 DOI: 10.1016/j.bionut.2014.07.007

Z. Ashkavand , H. Malekinejad , B.S. Vishwanath

{"title":"Combined action of Silymarin and Celecoxib in modulating inflammatory mediators in osteoarthritis","authors":"Z. Ashkavand , H. Malekinejad , B.S. Vishwanath","doi":"10.1016/j.bionut.2014.07.007","DOIUrl":"10.1016/j.bionut.2014.07.007","url":null,"abstract":"<div>Inflammation is the hallmark of osteoarthritis (OA) leading to pain and disability. Objective of this investigation was to evaluate the effect of Silymarin (SMN, an antioxidant), Celecoxib (CLX, a selective COX inhibitor) and their combination on chemically induced arthritis in rats. The biochemical parameters and radiology impact of the treatment was also determined. Wistar male rats were assigned into five groups including control, OA+, OA+ CLX (100mg/kg), OA+ SMN (50mg/kg) and OA+ CLX+SMN (25days. In the SMN+CLX treated animals significant reduction in KL grade and normal joint space narrowing was observed. X-ray radiological studies supported the biochemical findings. These findings suggest that co-administration of SMN with CLX could be an effective antiarthritic treatment which can equally abolish the arthritis associated secondary complication.</div>","PeriodicalId":100182,"journal":{"name":"Biomedicine & Preventive Nutrition","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bionut.2014.07.007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82310101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4