Antidiabetic therapeutics from natural source: A systematic review

Palanisamy Arulselvan , Hasfar Amynurliyana Abdul Ghofar , Govindarajan Karthivashan , Mohd Firdaus Abdul Halim , Muhammad Syafiq Abdul Ghafar , Sharida Fakurazi
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引用次数: 70

Abstract

Diabetes mellitus (DM) is a common metabolic/endocrine disorder throughout the world and cause serious medical problems to human health. Recent drastic changes over human dietary habits and contemporary lifestyle lead to various chronic disorders/diseases particularly metabolic diseases including obesity. Traditional medicinal plants and their active phyto-constituents have been used throughout the world for the therapy of diabetes and associated secondary complications. Among many medications and other alternative medicines, numerous herbs have been well-known to cure and prevent diabetes. Several traditionally important medicinal plants have been investigated for their beneficial use in different types of diabetes and its complications. The effects of these plants may delay the development of diabetic complications and alter the metabolic abnormalities using a variety of cellular and molecular mechanisms. A considerable number of active medicinal plants and their bioactive compounds were subjected to clinical trials and were found effective. Moreover, during the past few years many phyto-constituents responsible for antidiabetic effects have been isolated from plants showed higher potential than synthetic drugs. As a result, recently, considerable scientific attention has been directed towards classification/identification of traditional medicinal plants with antihyperglycemic ability that may be used for daily consumption along with the food. This review paper mainly focuses on natural phytoextracts with their pharmacological mechanism of action and their preclinical experimental model, which attracts the attention of pharmacologist, phytochemist and pharmocognosist for further scientific research towards endocrine metabolic disorder.

天然来源的抗糖尿病药物:系统综述
糖尿病(DM)是世界范围内常见的代谢/内分泌疾病,对人类健康造成严重的医学问题。最近人类饮食习惯和现代生活方式的剧烈变化导致各种慢性疾病/疾病,特别是代谢疾病,包括肥胖。传统药用植物及其活性植物成分已在世界各地用于治疗糖尿病和相关的继发性并发症。在许多药物和其他替代药物中,许多草药已经被认为可以治疗和预防糖尿病。几种传统上重要的药用植物已被研究用于治疗不同类型的糖尿病及其并发症。这些植物的作用可能通过多种细胞和分子机制延缓糖尿病并发症的发展和改变代谢异常。相当多的活性药用植物及其生物活性化合物进行了临床试验,并发现有效。此外,在过去的几年中,从植物中分离出的许多具有抗糖尿病作用的植物成分显示出比合成药物更高的潜力。因此,近年来,具有抗高血糖能力的传统药用植物的分类/鉴定已成为科学界关注的焦点,这些植物可与食品一起日常食用。本文主要对天然植物提取物的药理作用机制及其临床前实验模型进行综述,以期引起药理学家、植物化学家和药理学家对内分泌代谢紊乱的进一步科学研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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