丁香酸对实验性糖尿病大鼠碳水化合物代谢关键酶的降血糖作用

Subramani Srinivasan , Jayachandran Muthukumaran , Udaiyar Muruganathan , Rantham Subramaniyam Venkatesan , Abdulkadhar Mohamed Jalaludeen
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引用次数: 38

摘要

糖尿病是最常见的内分泌疾病之一,它与碳水化合物代谢缺陷并存。印度传统的医学体系为包括糖尿病在内的疾病开出了植物化学疗法。本研究旨在通过测定丁香酸(SA)对实验性糖尿病大鼠碳水化合物代谢关键酶的活性,评价其治疗潜力。采用四氧嘧啶(150 mg/kg)腹腔注射诱导雄性白化Wistar大鼠患上糖尿病。分别以25、50和100 mg/kg b.w灌胃SA,每日1次,连用30 d。评估血糖、胰岛素、血红蛋白(Hb)、糖化血红蛋白(HbA1c)和糖原水平、碳水化合物代谢酶水平、肝脏和肾脏标志物水平。口服SA (50 mg/kg) 30天,剂量依赖性地改善糖尿病大鼠的血糖状态。SA处理大鼠胰岛素、血红蛋白和糖原水平升高,葡萄糖和糖化血红蛋白水平显著降低。碳水化合物代谢酶活性、肝肾指标恢复到接近正常水平。胰腺组织病理学分析显示,SA可减轻糖尿病大鼠四氧嘧啶引起的胰腺损伤,刺激β细胞再生。本研究结果提示SA的降糖作用及其治疗糖尿病的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Antihyperglycemic effect of syringic acid on attenuating the key enzymes of carbohydrate metabolism in experimental diabetic rats

Diabetes mellitus is one of the most common endocrine entities, which coexist with defect in carbohydrate metabolism. The Indian traditional system of medicine prescribed plant phytochemical therapies for diseases including diabetes mellitus. The present study was aimed to evaluate the therapeutic potential of syringic acid (SA) by assaying the activities of key enzymes of carbohydrate metabolism in experimental diabetic rats. Diabetes was induced into male albino Wistar rats by intraperitoneal administration of alloxan (150 mg/kg). SA was administered to diabetic rats intragastrically at 25, 50 and 100 mg/kg b.w daily once for 30 days. The levels of plasma glucose, insulin, hemoglobin (Hb), glycated hemoglobin (HbA1c) and glycogen, levels of carbohydrate metabolic enzymes, liver and kidney markers were evaluated. Oral administration of SA (50 mg/kg) for 30 days, dose dependently improved the glycemic status in diabetic rats. The levels of insulin, Hb and glycogen increased with significant decrease in glucose and HbA1c levels in SA treated rats. The altered activities of carbohydrate metabolic enzymes, hepatic and renal marker were restored to near normal. Histopathological analysis of pancreas revealed that treatment with SA reduced the pancreatic damage induced by alloxan and stimulated β-cell regeneration in diabetic rats. The present findings suggest the antihyperglycemic effect of SA and its therapeutic potential for the management of diabetes.

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