长期服用阿斯巴甜(人工甜味剂)对Wistar白化大鼠焦虑、运动活动和情绪行为的影响

Iyaswamy Ashok, Rathinasamy Sheeladevi, Dapkupar Wankhar
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引用次数: 22

摘要

本研究旨在探讨长期(90天)口服阿斯巴糖(75 mg/kg)是否对Wistar系雄性白化大鼠的焦虑、运动活动和情绪行为产生影响。阿斯巴甜在代谢过程中释放甲醇作为其代谢产物之一。为了模拟人类的甲醇代谢,使用甲氨蝶呤(MTX)处理的叶酸缺乏大鼠。阿斯巴甜被口服给服用甲氨蝶呤的动物,并与对照组和服用甲氨蝶呤的对照组一起进行研究。服用甲氨蝶呤的动物的运动活动和情绪行为与对照组没有差异。然而,阿斯巴甜处理的MTX动物在固定、粪便丸剂方面表现出明显的增加,而在行走(外围广场和中心广场)、饲养、梳理方面则明显减少。接受甲氨蝶呤治疗的动物的焦虑状态行为与对照组没有差异。然而,阿斯巴甜治疗的MTX动物在张开手臂进入的次数、张开手臂进入的百分比、张开手臂的时间、张开手臂的时间百分比和头部下降的次数上都比对照组和服用MTX的动物明显减少。值得注意的是,阿斯巴甜释放的甲醇可能会对大脑产生影响,这可能是观察到的运动和焦虑水平变化的另一个因素。这项研究旨在证实长期食用阿斯巴甜可以改变行为。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effect of long-term aspartame (artificial sweetener) on anxiety, locomotor activity and emotionality behavior in Wistar Albino rats

The focus of the study is to investigate whether the long-term (90 days) oral administration of aspartame (75 mg/kg) has an effect in the anxiety, locomotor activity and emotionality behavior of Wistar strain male Albino rats. Aspartame releases methanol as one of its metabolites during metabolism. To mimic the human methanol metabolism, the methotrexate (MTX)-treated folate-deficient rats were used. Aspartame was administered orally to the MTX-treated animals and was studied along with controls and MTX-treated controls. The locomotor activity and emotionality behavior in the MTX-treated animals did not differ from the controls. However, the aspartame-treated MTX animals showed a marked increase in the immobilization, fecal bolus with a marked decrease in ambulation (peripheral square and central square), rearing, grooming from the control as well the MTX-treated animals. The anxiety state behavior in the MTX-treated animals did not differ from the controls. However, the aspartame-treated MTX animals showed a marked decrease in the number of open arm entry, percentage of open arm entry, time spent in open arm, percentage of time spent in open arm and number of head dips from the control as well the MTX-treated animals. It is relevant to point out that methanol released by aspartame may add an effect in the brain and that could be the additional contributing factor for the observed changes in the locomotor and their anxiety levels. This study intends to substantiate that long-term aspartame consumption can alter the behavior.

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