Biomedicine & Preventive Nutrition最新文献_第9页

Anti-HSV-1 and antioxidant activities of dicaffeoyl and digalloyl esters of quinic acid 奎宁酸二咖啡酯和二烯丙酯抗hsv -1及抗氧化活性

Biomedicine & Preventive Nutrition Pub Date : 2014-01-01 DOI: 10.1016/j.bionut.2013.09.007

Celso O. Rezende Jr. , Caroline Rigotto , Wiliam Caneschi , Carlos A.M. Rezende , Mireille Le Hyaric , Mara R.C. Couri , Cláudia M.O. Simões , Mauro V. de Almeida

引用次数: 9

Marine derived natural products for osteoporosis 海洋衍生的骨质疏松症天然产品

Biomedicine & Preventive Nutrition Pub Date : 2014-01-01 DOI: 10.1016/j.bionut.2013.12.005

Kalimuthu Senthilkumar , Jayachandran Venkatesan , Se-Kwon Kim

引用次数: 15

Nutraceutical applications of gourd family vegetables: Benincasa hispida, Lagenaria siceraria and Momordica charantia 葫芦科蔬菜的营养保健应用:贝南卡菜、丝瓜Lagenaria siceraria和苦瓜

Biomedicine & Preventive Nutrition Pub Date : 2014-01-01 DOI: 10.1016/j.bionut.2013.03.004

S. Palamthodi, S.S. Lele

{"title":"Nutraceutical applications of gourd family vegetables: Benincasa hispida, Lagenaria siceraria and Momordica charantia","authors":"S. Palamthodi, S.S. Lele","doi":"10.1016/j.bionut.2013.03.004","DOIUrl":"10.1016/j.bionut.2013.03.004","url":null,"abstract":"<div>The use of food and food products as medicine has been in practice over centuries in many civilizations. The extracts from the family Cucurbitaceae have been used in the preparation of medicines for a variety of diseases in Ayurveda and ancient Chinese medicine. The article focuses on medicinal properties of extracts derived from different vegetative parts of three Cucurbitaceae species viz. ash gourd (Benincasa hispida), bottle gourd (Lagenaria siceraria) and bitter gourd (Momordica charantia). The competency of extracts derived from these plants using different extraction solutions and techniques were tested against various diseases. These plants were found to possess antioxidant activity, analgesic and anti-inflammatory activity, central nervous system activity, antihyperglycemic and antidiabetics, anti-hyperlipidemic activity, antimicrobial activity and anthelmintic activity, cytotoxic and anticancer activity, immunomodulatory effect, cardioprotective effects, hepatoprotective activity, bronchospasm protective activity, antidiarrheal activity, and diuretic activity.</div>","PeriodicalId":100182,"journal":{"name":"Biomedicine & Preventive Nutrition","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bionut.2013.03.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83654750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 41

Hibiscus sabdariffa: An ideal yet under-exploited candidate for nutraceutical applications 芙蓉:一个理想的但尚未开发的候选营养保健应用

Biomedicine & Preventive Nutrition Pub Date : 2014-01-01 DOI: 10.1016/j.bionut.2013.10.004

Seema Patel

引用次数: 88

Wortmannin and its effects on tumor progression and proliferation Wortmannin及其对肿瘤进展和增殖的影响

Biomedicine & Preventive Nutrition Pub Date : 2014-01-01 DOI: 10.1016/j.bionut.2013.06.004

Shailendra Kapoor

引用次数: 0

WITHDRAWN: Immunomodulatory effect of water-soluble polysaccharides isolated from Metroxylon sagu in rats 撤下:木杉水溶性多糖对大鼠的免疫调节作用

Biomedicine & Preventive Nutrition Pub Date : 2013-10-31 DOI: 10.1016/J.BIONUT.2013.06.008

P. Sireesha, S. Nagarjuna, S. Challa

引用次数: 0

Formulation and characterisation of self-microemulsifying drug delivery system of pioglitazone 吡格列酮自微乳化给药体系的研制与表征

Biomedicine & Preventive Nutrition Pub Date : 2013-10-01 DOI: 10.1016/j.bionut.2013.09.005

P. Hyma , K. Abbulu

{"title":"Formulation and characterisation of self-microemulsifying drug delivery system of pioglitazone","authors":"P. Hyma , K. Abbulu","doi":"10.1016/j.bionut.2013.09.005","DOIUrl":"10.1016/j.bionut.2013.09.005","url":null,"abstract":"<div>The aim of the study was to develop self-microemulsifying drug delivery system (SMEDDS) of a poorly water soluble drug, pioglitazone. Approximately 40% of new drug candidates have poor water solubility and the oral delivery of such drugs is frequently associated with implications of low bioavailability, high intra- and intersubject variability and lack of dose proportionality. Hydrophobic drugs can often be dissolved in microemulsion allowing them to be encapsulated in the form of fine globules, so that drug remains undissolved in the gut avoiding the dissolution step, which frequently limit the rate of absorption of hydrophobic drugs. Phase solubility studies were conducted for the maximum solubility of pioglitazone. Highest was found in Tween 80 (surfactant) polyethylene glycol 400 (cosurfactant) and cottonseed oil. Ternary phase diagrams were constructed to evaluate microemulsion regions. FTIR analysis was done for investigating the drug–excipient interactions. The mean globule size of SMEDDS was observed to be below 200 nm for the optimized formulations and the zeta potential was negative. The dissolution of emulsion formulations was compared with commercial tablets; the results indicated that the rate of dissolution of developed formulations containing pioglitazone was 2 to 3 folds increased compared with that of commercial tablets. SEM studies were done for the shape and morphology of the globules. Thus, SMEDDS can be regarded as novel and commercially feasible alternative to the current pioglitazone formulations.</div>","PeriodicalId":100182,"journal":{"name":"Biomedicine & Preventive Nutrition","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bionut.2013.09.005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83252039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

Antioxidant properties of Lactuca sativa leaf extract involved in the protection of biomolecules 芥蓝叶提取物抗氧化性能涉及的生物分子保护

Biomedicine & Preventive Nutrition Pub Date : 2013-10-01 DOI: 10.1016/j.bionut.2013.06.003

S.N. Harsha , K.R. Anilakumar , M.V. Mithila

引用次数: 23

Diosgenin exhibits beneficial efficiency on human mammary carcinoma cell line MCF-7 and against N-nitroso-N-methylurea (NMU) induced experimental mammary carcinoma 薯蓣皂苷元对人乳腺癌细胞株MCF-7和n -亚硝基-n -甲基脲(NMU)诱导的实验性乳腺癌具有良好的抑制作用

Biomedicine & Preventive Nutrition Pub Date : 2013-10-01 DOI: 10.1016/j.bionut.2013.06.009

Jayaraman Jagadeesan , Kulanthaivel Langeswaran , Subbaraj Gowthamkumar , Maruthaiveeran Periyaswamy Balasubramanian

{"title":"Diosgenin exhibits beneficial efficiency on human mammary carcinoma cell line MCF-7 and against N-nitroso-N-methylurea (NMU) induced experimental mammary carcinoma","authors":"Jayaraman Jagadeesan , Kulanthaivel Langeswaran , Subbaraj Gowthamkumar , Maruthaiveeran Periyaswamy Balasubramanian","doi":"10.1016/j.bionut.2013.06.009","DOIUrl":"10.1016/j.bionut.2013.06.009","url":null,"abstract":"<div>The purpose of the present study was to investigate the impact of diosgenin on the human mammary carcinoma cell line (MCF-7) and to investigate its therapeutic potential against NMU-induced experimental breast cancer. Mammary carcinoma cells were treated with different concentrations of diosgenin and its cytotoxicity effect was measured by MTT method, lactate dehydrogenase leakage and by estimating GSH assays. N-nitroso-N-methylurea (NMU) is a highly reliable carcinogen, mutagen and teratogen used in the present study to promote breast carcinogenesis in experimental rats. In in vitro studies, diosgenin significantly inhibited the proliferation of MCF-7 cells in a dose-dependent manner and the depletion of GSH and an increase of LDH activity were observed in MCF-7 cells due to cytotoxic nature of the drug. Elevated lipid peroxidation in NMU-induced breast cancer-bearing animals were drim down (P  0.05) due to management with steroidal diosgenin. The altered lysosomal enzymes were neutralised by diosgenin and also, it protects macromolecular damage from oxidative stress and free fadicals production due to its antioxidant activity. From the results of our present analysis, it gives an idea about that diosgenin may be used as a chemoprotective agent against human mammary carcinoma.</div>","PeriodicalId":100182,"journal":{"name":"Biomedicine & Preventive Nutrition","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bionut.2013.06.009","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90690917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Design, synthesis and biological evaluation of some isatin-linked chalcones as novel anti-breast cancer agents: A molecular hybridization approach 一些isatin-linked chalcones作为新型抗乳腺癌药物的设计、合成和生物学评价:分子杂交方法

Biomedicine & Preventive Nutrition Pub Date : 2013-10-01 DOI: 10.1016/j.bionut.2013.04.001

Chandrabose Karthikeyan , Viswas Raja Solomon , Hoyun Lee , Piyush Trivedi

{"title":"Design, synthesis and biological evaluation of some isatin-linked chalcones as novel anti-breast cancer agents: A molecular hybridization approach","authors":"Chandrabose Karthikeyan , Viswas Raja Solomon , Hoyun Lee , Piyush Trivedi","doi":"10.1016/j.bionut.2013.04.001","DOIUrl":"10.1016/j.bionut.2013.04.001","url":null,"abstract":"<div>Isatins are endogenous molecules present in human and mammals which exhibits diverse pharmacological profiles including anticancer activity. Similarly, chalcones, which are common substructures in numerous natural products belonging to the flavonoid family, show potent anticancer properties. A novel series of 3-(2-oxo-2-phenylethylidene)indolin-2-ones incorporating pharmacophoric elements of isatins and chalcones were designed and synthesized. The compounds were evaluated for anticancer activity against three breast cancer cell lines. Most of the compounds showed promising anticancer activity (<  <!-->μM) against the studied cell lines. Compound 2c, bearing a 5-chloro substituent in the benzo ring of the isatin moiety and 3,4-dimethoxy substitutions in the phenyl ring, was found to be the most active in the series with GI50 values of 8.54, 4.76 and 3.59 against MDA-MB231, MDA-MB468 and MCF7 cells, respectively. Overall, the findings of the study highlight 3-(2-oxo-2-phenylethylidene)indolin-2-one as a potential new lead in the search of drugs for the treatment of breast cancer.</div>","PeriodicalId":100182,"journal":{"name":"Biomedicine & Preventive Nutrition","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bionut.2013.04.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91549606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 47