Anti-HSV-1 and antioxidant activities of dicaffeoyl and digalloyl esters of quinic acid

Celso O. Rezende Jr. , Caroline Rigotto , Wiliam Caneschi , Carlos A.M. Rezende , Mireille Le Hyaric , Mara R.C. Couri , Cláudia M.O. Simões , Mauro V. de Almeida
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引用次数: 9

Abstract

Nine caffeic and gallic acids derivatives were synthesized and evaluated for their antioxidant activity using the DPPH radical scavenging activity assay and for their antiherpes activity against HSV-1. All compounds displayed higher antioxidant activities than α-tocopherol. The most active antioxidant was compound 8 (IC50 = 177 μM). Five compounds (7, 10, 11, 12 and 14) were found to possess anti-HSV-1 activity with selectivity indices values ranging from 7.0 to 27.1. The most active was compound 10 (IC50 = 15.2 μM; SI = 27.1).

奎宁酸二咖啡酯和二烯丙酯抗hsv -1及抗氧化活性
合成了9种咖啡酸和没食子酸衍生物,并利用DPPH自由基清除活性测定法评估了它们的抗氧化活性和对HSV-1的抗疱疹活性。所有化合物的抗氧化活性均高于α-生育酚。化合物8的抗氧化活性最高(IC50 = 177 μM)。5个化合物(7、10、11、12和14)具有抗hsv -1活性,选择性指数在7.0 ~ 27.1之间。活性最高的是化合物10 (IC50 = 15.2 μM;si = 27.1)。
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