Celso O. Rezende Jr. , Caroline Rigotto , Wiliam Caneschi , Carlos A.M. Rezende , Mireille Le Hyaric , Mara R.C. Couri , Cláudia M.O. Simões , Mauro V. de Almeida
{"title":"Anti-HSV-1 and antioxidant activities of dicaffeoyl and digalloyl esters of quinic acid","authors":"Celso O. Rezende Jr. , Caroline Rigotto , Wiliam Caneschi , Carlos A.M. Rezende , Mireille Le Hyaric , Mara R.C. Couri , Cláudia M.O. Simões , Mauro V. de Almeida","doi":"10.1016/j.bionut.2013.09.007","DOIUrl":null,"url":null,"abstract":"<div><p><span><span>Nine caffeic and gallic acids derivatives were synthesized and evaluated for their antioxidant activity using the </span>DPPH radical scavenging activity assay and for their antiherpes activity against HSV-1. All compounds displayed higher antioxidant activities than α-tocopherol. The most active antioxidant was compound </span><strong>8</strong> (IC<sub>50</sub> <!-->=<!--> <!-->177<!--> <!-->μM). Five compounds (<strong>7, 10, 11, 12</strong> and <strong>14</strong><span>) were found to possess anti-HSV-1 activity with selectivity indices values ranging from 7.0 to 27.1. The most active was compound </span><strong>10</strong> (IC<sub>50</sub> <!-->=<!--> <!-->15.2<!--> <!-->μM; SI<!--> <!-->=<!--> <!-->27.1).</p></div>","PeriodicalId":100182,"journal":{"name":"Biomedicine & Preventive Nutrition","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bionut.2013.09.007","citationCount":"9","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomedicine & Preventive Nutrition","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2210523913000639","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 9
Abstract
Nine caffeic and gallic acids derivatives were synthesized and evaluated for their antioxidant activity using the DPPH radical scavenging activity assay and for their antiherpes activity against HSV-1. All compounds displayed higher antioxidant activities than α-tocopherol. The most active antioxidant was compound 8 (IC50 = 177 μM). Five compounds (7, 10, 11, 12 and 14) were found to possess anti-HSV-1 activity with selectivity indices values ranging from 7.0 to 27.1. The most active was compound 10 (IC50 = 15.2 μM; SI = 27.1).
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