Jing Wu , Xia Xue , Zhen Wu , Heng-Li Zhao , Hong-Mei Cao , De-Qing Sun , Rong-Mei Wang , Jing Sun , Ying Liu , Rui-Chen Guo
{"title":"Anti-tumor effect of paeonol via regulating NF-κB, AKT and MAPKs activation: A quick review","authors":"Jing Wu , Xia Xue , Zhen Wu , Heng-Li Zhao , Hong-Mei Cao , De-Qing Sun , Rong-Mei Wang , Jing Sun , Ying Liu , Rui-Chen Guo","doi":"10.1016/j.bionut.2013.08.002","DOIUrl":null,"url":null,"abstract":"<div><p><span>Paeonol<span>, an active component extracted from Chinese herbs, </span></span><span><em>Moutan cortex</em></span> and <em>Cynanchum paniculatum</em><span><span><span>, has been characterized for its various biological activities, including sedation, hypnosis, anti-inflammatory, anti-allergic, and immunoregulation. Recently, paeonol was investigated to regulate the </span>signalling pathways, including NF-κB, PI3K/PTEN/AKT and ERK/JNK/P38/MAPKs activations, which have been proposed to inhibit </span>apoptosis and induce proliferation in human cancer. In this review, we summarized the literature documenting the involvement of the relationship between anti-tumor effect of paeonol and those signalling pathways.</span></p></div>","PeriodicalId":100182,"journal":{"name":"Biomedicine & Preventive Nutrition","volume":"4 1","pages":"Pages 9-14"},"PeriodicalIF":0.0000,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.bionut.2013.08.002","citationCount":"10","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomedicine & Preventive Nutrition","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2210523913000482","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 10
Abstract
Paeonol, an active component extracted from Chinese herbs, Moutan cortex and Cynanchum paniculatum, has been characterized for its various biological activities, including sedation, hypnosis, anti-inflammatory, anti-allergic, and immunoregulation. Recently, paeonol was investigated to regulate the signalling pathways, including NF-κB, PI3K/PTEN/AKT and ERK/JNK/P38/MAPKs activations, which have been proposed to inhibit apoptosis and induce proliferation in human cancer. In this review, we summarized the literature documenting the involvement of the relationship between anti-tumor effect of paeonol and those signalling pathways.
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