Lorena Di Zazzo, Ilaria di Filippo, Lorenzo Guido, Gabriele Magna, Larisa Lvova, Fabrizio Caroleo, Manuela Stefanelli, Leonardo Duranti, Sara Nardis, Corrado Di Natale, Roberto Paolesse
{"title":"Corrole Polymers as a Novel Materials for Room Temperature Resistive Gas Sensors","authors":"Lorena Di Zazzo, Ilaria di Filippo, Lorenzo Guido, Gabriele Magna, Larisa Lvova, Fabrizio Caroleo, Manuela Stefanelli, Leonardo Duranti, Sara Nardis, Corrado Di Natale, Roberto Paolesse","doi":"10.1002/adsr.202400005","DOIUrl":"https://doi.org/10.1002/adsr.202400005","url":null,"abstract":"<p>Corroles, a family of contracted porphyrinoids, exhibit broad chemical interactions, undergo straightforward synthetic preparation and functionalization, and enable versatile thin film deposition. These attributes render them promising candidates for use in chemical sensors. Nevertheless, the inherently limited conductivity of corrole solid films constrains their application in mass and optical sensors. Despite this impediment, there is a great interest in matching the sensitive properties of the corrole with the features of facile miniaturization and integration into low-cost electronic circuits. This work explores the possibility of directly and simply depositing conductometric polymeric films of [5,10,15-(4-aminophenyl)corrolato] copper onto interdigitated electrodes. Remarkably, the electropolymerization protocol allows the selection of the semiconductive nature (p- or n-type) of these films, yielding two distinct sensor types: the former exhibiting high sensitivity and selectivity toward nitrogen monoxide (NO) with a slight influence of relative humidity and the other manifesting a broad spectrum of sensitivities. This breakthrough lays the foundation for developing miniaturized conductometric gas detectors, nonlinear conductometric sensing elements, and electronic nose platforms based on polycorroles.</p>","PeriodicalId":100037,"journal":{"name":"Advanced Sensor Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adsr.202400005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142404857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Enrico Condemi, Joanna Kunikowski, Spyridon Schoinas, Philippe Passeraub
{"title":"Pad Printing of Carbon Electrodes with Argon Plasma Activation as a Simple and Low Temperature Manufacturing Process for Antibody-Type Biosensors","authors":"Enrico Condemi, Joanna Kunikowski, Spyridon Schoinas, Philippe Passeraub","doi":"10.1002/adsr.202400015","DOIUrl":"https://doi.org/10.1002/adsr.202400015","url":null,"abstract":"<p>In diagnostic tools, rapid in vitro tests such as COVID-19 antigen or pregnancy tests are gaining significance for identifying various pathologies or health conditions. This shift contributes to a change in the way diagnostic efforts are carried out, emphasizing decentralized approaches that offer valuable services within communities, yielding long-term advantages for the healthcare system. Considering the substantial quantity of these tests manufactured and used annually, a straightforward manufacturing process is proposed for highly sensitive carbon electrodes designed for antibody-type biomarker sensors. This process, utilizing pad printing – an additive, low-temperature, and cost-effective method, coupled with plasma activation – has proven the electrodes capability to measure interferon gamma protein, a tuberculosis biomarker. Using electrochemical impedance spectroscopy, the electrodes display high sensitivity and are capable of measuring concentrations from 10 to 1000 pg mL<sup>−1</sup> in undiluted serum within an hour. The sensor, utilizing solely a monolayer of antibodies, achieves a performance equivalent to that of a commercial standard sandwich ELISA tested in this study.</p>","PeriodicalId":100037,"journal":{"name":"Advanced Sensor Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adsr.202400015","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142170315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Svetlana Shachneva, Anna Lielpetere, Wolfgang Schuhmann
{"title":"Pencil-Lead-Based Quasi-Equilibrium Glucose Biosensors","authors":"Svetlana Shachneva, Anna Lielpetere, Wolfgang Schuhmann","doi":"10.1002/adsr.202400024","DOIUrl":"https://doi.org/10.1002/adsr.202400024","url":null,"abstract":"<p>Foreign body response is the main reason for the limited lifetime of implantable glucose biosensors. A new measurement strategy exerting minimal disturbance from the equilibrium glucose concentration in the sensor compartment has been proposed to mitigate its adverse effects on the sensor signal. Here, a new measurement strategy using automatically fabricated and robust pencil-lead-based glucose biosensors is implemented. The sensor response depends on critical parameters such as redox-polymer film thickness, film uniformity, rigidity, polymer composition, and the ratio between the enzyme and the polymer. These parameters are controlled by introducing a short-chain redox polymer, a low crosslinker amount, a short-chain electrografting agent and linker, pulse electrografting, and an automated fabrication procedure.</p>","PeriodicalId":100037,"journal":{"name":"Advanced Sensor Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adsr.202400024","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142170311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Viktor Vanoppen, Diethelm Johannsmann, Xu Hou, Jens Sjölund, Peter Broqvist, Erik J. Berg
{"title":"Exploring Metal Electroplating for Energy Storage by Quartz Crystal Microbalance: A Review","authors":"Viktor Vanoppen, Diethelm Johannsmann, Xu Hou, Jens Sjölund, Peter Broqvist, Erik J. Berg","doi":"10.1002/adsr.202400025","DOIUrl":"10.1002/adsr.202400025","url":null,"abstract":"<p>The development and application of Electrochemical Quartz Crystal Microbalance (EQCM) sensing to study metal electroplating, especially for energy storage purposes, are reviewed. The roles of EQCM in describing electrode/electrolyte interface dynamics, such as the electric double-layer build-up, ionic/molecular adsorption, metal nucleation, and growth, are addressed. Modeling of the QCM sensor is introduced and its importance is emphasized. Challenges of metal electrode use, including side reactions and dendrite formation, along with their mitigation strategies are reviewed. Numerous factors affecting the electroplating processes, such as electrolyte composition, additives, temperature, and current density, and their influence on the electroplated metals’ mass, structural, and mechanical characteristics are discussed. Looking forward, the need for deeper fundamental understanding and advancing simulations of the QCM signal response as a result of electroplating metal nanostructures is stressed. Further development and integration of innovative EQCM-strategies will provide unique future means to fundamentally understand and optimize metal electroplating for energy storage and application alike.</p>","PeriodicalId":100037,"journal":{"name":"Advanced Sensor Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adsr.202400025","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141120819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kang Wang, Junhui Zhang, Heng Li, Jingzhi Wu, Qiwu Wan, Taiju Chen, Wenjing Liu, Hai Peng, Hong Zhang, Yang Luo
{"title":"Smart Hydrogel Sensors for Health Monitoring and Early Warning","authors":"Kang Wang, Junhui Zhang, Heng Li, Jingzhi Wu, Qiwu Wan, Taiju Chen, Wenjing Liu, Hai Peng, Hong Zhang, Yang Luo","doi":"10.1002/adsr.202400003","DOIUrl":"10.1002/adsr.202400003","url":null,"abstract":"<p>Smart hydrogel sensors, functioning as implantable devices, play a vital role in health monitoring and early warning, overcoming the limitations of conventional clinical methods to achieve direct, continuous, and precise monitoring. Widely employed across various biomedical fields, these sensors offer unique advantages for early health monitoring, ensuring direct, continuous, and highly accurate monitoring. In addition to detecting biomolecules, smart hydrogel sensors, with their flexibility and biocompatibility, monitor disease-specific markers, offer insights into disease progression, and contribute to the early identification of diseases. This article provides a comprehensive review of the types of hydrogel sensors employed in human health monitoring. The study discusses recent advancements in smart hydrogel sensor research, aiming to offer promising methods for human health monitoring. Finally, the paper outlines prospective research directions for hydrogel sensors in the field of human health monitoring. While further research and clinical validation are essential, hydrogel sensors are poised to play a pivotal role in clinical applications, furnishing people with accurate and continuous health monitoring.</p>","PeriodicalId":100037,"journal":{"name":"Advanced Sensor Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adsr.202400003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140979367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Diagnosis of Serous Effusion with Intelligent Imaging Flow Cytometry","authors":"Mengping Long, Yueyun Weng, Liye Mei, Dingchao Yang, Shubin Wei, Guanxiong Meng, Wanyue Zhao, Sheng Liu, Du Wang, Yiqiang Liu, Hui Shen, Jianxuan Hou, Yu Xu, Liang Tao, Fuling Zhou, Hongwei Chen, Taobo Hu, Cheng Lei","doi":"10.1002/adsr.202300183","DOIUrl":"10.1002/adsr.202300183","url":null,"abstract":"<p>A serous effusion is a buildup of extra fluid in the serous cavities including pleural, peritoneal, and pericardial cavities. It is important to distinguish benign reactive effusions from effusions caused by malignant proliferation in cytopathology since different diagnoses can lead to completely different disease staging and therapeutic choices. The conventional cytopathology procedure has the disadvantages of low throughput and low objectivity. To enhance the efficiency and accuracy of malignant serous effusion diagnosis, in this paper, an imaging flow cytometry, called optofluidic time-stretch microscopy is first employed, to image the cells in the serous effusion at an event rate of 100 000 events per second and with a spatial resolution better than 1 µm. The acquired cellular images are then analyzed using a convolutional neural network, by which the malignant cells are accurately detected. The performance of the method is validated with 18 clinical samples, including 14 malignant and 4 benign ones. The results show that the method can detect malignant cells at an accuracy of 90.53%. The high throughput, high accuracy, and high convenience of the method make it a potential solution for malignant serous effusion diagnosis in various scenarios.</p>","PeriodicalId":100037,"journal":{"name":"Advanced Sensor Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adsr.202300183","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140984621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Microfluidics Evolution and Surface Functionalization: A Pathway to Enhanced Heavy Metal Ion Detection","authors":"Zhejun Xu, Arun Jaiswal, Xiaochen Liu, Zhenxu Yang, Qiankun Yin, Kien Voon Kong, Ken-Tye Yong","doi":"10.1002/adsr.202400008","DOIUrl":"10.1002/adsr.202400008","url":null,"abstract":"<p>This review delves into the significant advancements in microfluidic technology since 2017, highlighting its critical role in shrinking device sizes and integrating advanced surface functionalization techniques. It showcases how microfluidics, an interdisciplinary field, has revolutionized fluid manipulation on a microscale, enabling the creation of cost-effective, portable devices for on-the-spot analyses, like heavy metal ion detection. From its early days rooted in ancient observations to cutting-edge uses of materials like silicon, glass, polydimethylsiloxane (PDMS), and paper, this review charts microfluidics’ dynamic evolution. It emphasizes the transformative impact of surface functionalization methods, including silanization and plasma treatments, in enhancing device materials' performance. Moreover, this review anticipates the exciting convergence of microfluidics with emerging technologies like droplet microfluidics and three-dimensional (3D) printing, alongside nanotechnology, forecasting a future of sophisticated analytical tools, point-of-care diagnostics, and improved detection systems. It acknowledges the hurdles in scaling production and achieving universal reliability and standardization. This review highlights the transformative impact of microfluidic technology on diagnostics and environmental surveillance, emphasizing its utility in deploying compact sensors for comprehensive and concurrent evaluations of water quality.</p>","PeriodicalId":100037,"journal":{"name":"Advanced Sensor Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adsr.202400008","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140997954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Highly Sensitive and Linear Vibration-Based Flexible Modulus Sensing System for Human Modulus Monitoring and Disease Prevention (Adv. Sensor Res. 5/2024)","authors":"Zewei Luo, Junhao Shen, Xu Ran, Zepeng Huang, Zaofeng Huang, Chaolun Wang, Chunhua Cai, Liangjian Lyv, Xin Lin, Litao Sun, Junhao Chu, Hengchang Bi, Xing Wu","doi":"10.1002/adsr.202470016","DOIUrl":"https://doi.org/10.1002/adsr.202470016","url":null,"abstract":"<p><b>Flexible Modulus Sensor</b></p><p>In article 2300148, Hengchang Bi, Xing Wu, and co-workers report a modulus sensing system with a characteristic of high linearity detection, which consists of a pressure sensor and a vibrator. It is able to quickly identify the physiological state of human body based on the modulus change of the detected tissues, exhibiting great potential in the health monitoring, such as the concept eye mask for migraine monitoring.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":100037,"journal":{"name":"Advanced Sensor Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adsr.202470016","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140895206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nikta Amiri, Aastha Shah, Amit Kumar Bhayadia, Chia-Chen Yu, M. Amin Karami, Canan Dagdeviren
{"title":"Design Approaches and Electromechanical Modeling of Conformable Piezoelectric-Based Ultrasound Systems","authors":"Nikta Amiri, Aastha Shah, Amit Kumar Bhayadia, Chia-Chen Yu, M. Amin Karami, Canan Dagdeviren","doi":"10.1002/adsr.202300175","DOIUrl":"10.1002/adsr.202300175","url":null,"abstract":"<p>Painless, needleless delivery of drugs through the skin can be realized through aphenomenon called sonophoresis by applying an ultrasound field to the biological tissue. Development of wearable embodiments of such systems demands comprehensive characterization of both the physical mechanism of sonophoresisas well as wearability parameters. Here, we present a framework for analyzing disk-type piezoelectric transducers in a polymeric substrate to create acoustic cavitation in a fluid coupling medium for sonophoresis applications. The device design and operating parameters such as the working frequency, applied voltage range, acoustic pressure distribution, and transducer spacing were determine dusing a finite element methods (FEM),and verified with experimental measurements. The influence of the surrounding water and tank reflections on the acoustic pressure field, and the interaction between the elements in the array structure were also studied.Finally, the impact of skin and the substrate geometry on the acoustic pressure fields was characterized to simulate the invivo use-case of the system. These analytical models can be used to guide critical parameters for device design such as the separation distance of the piezoelectric transducer from the skin boundary. We envision that this tool boxwill support rapid design iteration for realization of wearable ultrasound systems.</p>","PeriodicalId":100037,"journal":{"name":"Advanced Sensor Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adsr.202300175","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141001931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}