Advanced Sensor Research最新文献_第4页

On-Chip Multiplexed Voltammetry Using a Universal Antifouling Hydrogel and Porous Gold Foam Interface for Stress and Inflammation Monitoring 片上复用伏安法使用通用防污水凝胶和多孔金泡沫界面进行应力和炎症监测

IF 3.5

Advanced Sensor Research Pub Date : 2025-06-30 DOI: 10.1002/adsr.202400198

Vuslat B. Juska, Stacey Hendriks, Esmeralda Santillan-Urquiza, Nadia Moukri, Pedro Estrela, Graeme D. Maxwell, Bernadette O'Brien, Bernardo Patella, Rosalinda Inguanta, Alan O'Riordan

{"title":"On-Chip Multiplexed Voltammetry Using a Universal Antifouling Hydrogel and Porous Gold Foam Interface for Stress and Inflammation Monitoring","authors":"Vuslat B. Juska, Stacey Hendriks, Esmeralda Santillan-Urquiza, Nadia Moukri, Pedro Estrela, Graeme D. Maxwell, Bernadette O'Brien, Bernardo Patella, Rosalinda Inguanta, Alan O'Riordan","doi":"10.1002/adsr.202400198","DOIUrl":"10.1002/adsr.202400198","url":null,"abstract":"Affinity based electrochemical biosensing systems with integrated miniaturized interfaces has enabled key advancement toward rapid, sensitive, precise and deployable detection platforms. Translation of the biosensing tools for routine monitoring of dairy cows’ functional welfare through non-invasive methods may have implications for identifying welfare compromise and improving welfare on-farm. The goal is to develop an on-chip voltammetric device to evaluate measures of inflammation and stress in biofluids of dairy cows, that is, milk. The straightforward fabrication of highly reproducible silicon devices designed is demonstrated for an electrochemical interface, using an efficient scale-up process for batch manufacturing of sensitive multiplexed sensor arrays. Lift-off and passivation lithography are used subsequently to construct the electroactive arrays with excellent reproducibility allowing micro and nano-scale patterning. Then the non-specific binding challenge is addressed via a rapid formation of a biocompatible antibiofouling coating onto porous gold surfaces on a single chip – simultaneously – in approximately two minutes. The developed coating provides flexibility in the experimental design due to abundant functional groups (-COOH and –NH2). The coating is combined with glutaraldehyde cross-linked Protein A/G to achieve a universal matrix for Anti-Immunoglobulin G (IgG)-based biosensing and validate by the attainment of two sensors of cortisol and haptoglobin by using milk samples.","PeriodicalId":100037,"journal":{"name":"Advanced Sensor Research","volume":"4 9","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://advanced.onlinelibrary.wiley.com/doi/epdf/10.1002/adsr.202400198","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145051216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Wireless Soft Optical Blood Sensor for Colonoscopy 一种用于结肠镜检查的无线软光学血液传感器

IF 3.5

Advanced Sensor Research Pub Date : 2025-06-26 DOI: 10.1002/adsr.202500004

Kamin Palkawong-Na-Ayuddhaya, Arincheyan Gerald, Addison Chu, Johann Pang, Arnav Mankad, Hiroyuki Aihara, Sheila Russo

引用次数: 0

Advancements in Plant Diagnostic and Sensing Technologies 植物诊断与传感技术进展

IF 3.5

Advanced Sensor Research Pub Date : 2025-06-23 DOI: 10.1002/adsr.202500045

Shalini Krishnamoorthi, Sally Shuxian Koh, Mervin Chun-Yi Ang, Mark Ju Teng Teo, Randall Ang Jie, U. S. Dinish, Michael S. Strano, Daisuke Urano

{"title":"Advancements in Plant Diagnostic and Sensing Technologies","authors":"Shalini Krishnamoorthi, Sally Shuxian Koh, Mervin Chun-Yi Ang, Mark Ju Teng Teo, Randall Ang Jie, U. S. Dinish, Michael S. Strano, Daisuke Urano","doi":"10.1002/adsr.202500045","DOIUrl":"10.1002/adsr.202500045","url":null,"abstract":"Recent advancements in plant sensing technologies have significantly improved agricultural productivity while reducing resource inputs, resulting in higher yields by enabling early disease detection, precise diagnostics, and optimized fertilizer and pesticide applications. Each adopted technology offers unique advantages suitable for various farm operations, breeding programs, and laboratory research. This review article first summarizes key target traits, endogenous structures, and metabolites that serve as focal points for plant diagnostic and sensing technologies. Next, conventional plant sensing technologies based on light reflectance and fluorescence, which rely on foliar phytopigments and fluorophores such as chlorophylls are discussed. These methods, along with advanced analytical strategies incorporating machine learning, enable accurate stress detection and classification beyond general assessments of plant health and stress status. Advanced optical techniques such as Fourier transform infrared spectroscopy (FT-IR) and Raman spectroscopy, which allow specific measurements of various plant metabolites and structural components are then highlighted. Furthermore, the design and applications of nanotechnology chemical sensors capable of highly sensitive and selective detection of specific phytochemicals, including phytohormones and signaling second messengers, which regulate physiological and developmental processes at micro- to sub-micromolar concentrations are introduced. By selecting appropriate sensing methodologies, agricultural production, and relevant research activities can be significantly improved.","PeriodicalId":100037,"journal":{"name":"Advanced Sensor Research","volume":"4 8","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://advanced.onlinelibrary.wiley.com/doi/epdf/10.1002/adsr.202500045","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145135528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Digital Bioassays on the Slipchip Microfluidic Devices Slipchip微流控装置的数字生物分析

IF 3.5

Advanced Sensor Research Pub Date : 2025-06-23 DOI: 10.1002/adsr.202500030

Qingqing Luo, Ziqing Yu, Weiyuan Lyu, Yang Luo, Lei Xu, Feng Shen

{"title":"Digital Bioassays on the Slipchip Microfluidic Devices","authors":"Qingqing Luo, Ziqing Yu, Weiyuan Lyu, Yang Luo, Lei Xu, Feng Shen","doi":"10.1002/adsr.202500030","DOIUrl":"10.1002/adsr.202500030","url":null,"abstract":"The SlipChip, designed to achieve “simple, low-cost, instrument-free, and precise” biomarker analysis, has demonstrated significant potential in both biological research and clinical diagnostics. The technology utilizes the relative movement of two microfluidic plates with microstructures to manipulate fluids. This review focuses specifically on digital bioassays performed on SlipChip microfluidic platforms, which eliminate the need for sophisticated fluidic systems by generating partitions through simple “load and slip” operations. For digital nucleic acid analysis including digital PCR, digital LAMP, and digital RPA the SlipChip can extend the dynamic range of analysis through multivolume, serial dilution, and digital-analog strategies. It also enables real-time digital PCR, digital melt curve analysis, and digital CRISPR-based and Argonaute-based analysis with parallel droplet manipulation. Additionally, the SlipChip method can be integrated with functionalized microbeads for digital protein analysis. Furthermore, the SlipChip has been applied in single-bacterium separation and cultivation, active bacteriophage quantification, and single-cell analysis. These developments will pave the way for broader applications in precision medicine, infectious disease detection, and personalized healthcare.","PeriodicalId":100037,"journal":{"name":"Advanced Sensor Research","volume":"4 9","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://advanced.onlinelibrary.wiley.com/doi/epdf/10.1002/adsr.202500030","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145051263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Silk-Fibroin as Biocompatible and Bioresorbable Enzyme Immobilization Matrix for Screen-Printed Amperometric Glucose Biosensors 丝素蛋白作为生物相容性和生物可吸收的酶固定基质用于丝网印刷安培葡萄糖生物传感器

IF 3.5

Advanced Sensor Research Pub Date : 2025-06-18 DOI: 10.1002/adsr.202500048

Kevin A. Janus, Stefan Achtsnicht, Benedetta Isella, Alexander Kopp, Koichiro Miyamoto, Tatsuo Yoshinobu, Michael Keusgen, Michael J. Schöning

{"title":"Silk-Fibroin as Biocompatible and Bioresorbable Enzyme Immobilization Matrix for Screen-Printed Amperometric Glucose Biosensors","authors":"Kevin A. Janus, Stefan Achtsnicht, Benedetta Isella, Alexander Kopp, Koichiro Miyamoto, Tatsuo Yoshinobu, Michael Keusgen, Michael J. Schöning","doi":"10.1002/adsr.202500048","DOIUrl":"10.1002/adsr.202500048","url":null,"abstract":"Silk-fibroin is utilized as a biocompatible and bioresorbable enzyme immobilization matrix and exemplarily demonstrated for a screen-printed amperometric glucose biosensor. The silk-fibroin is derived from the silkworm Bombyx mori. The enzyme immobilization matrix consisting of silk-fibroin, together with glucose oxidase from Aspergillus niger, is applied to a screen-printed carbon-based, biocompatible, and biodegradable working electrode on a flexible silk-fibroin substrate. The biosensor is characterized electrochemically at physiological glucose concentrations in the range from 0.5 to 10 mm. The results are compared to a “conventional” glucose biosensor, also fabricated on a flexible silk-fibroin substrate, however utilizing a laboratory standard enzyme immobilization matrix based on bovine serum albumin and glutaraldehyde. Furthermore, the influence of pH (pH 5.5 to pH 8.0) and temperature variations (21 to 70 °C) on these two different immobilization matrices are studied.","PeriodicalId":100037,"journal":{"name":"Advanced Sensor Research","volume":"4 8","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://advanced.onlinelibrary.wiley.com/doi/epdf/10.1002/adsr.202500048","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145135458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Zero-Power, Optical Toxic Gas and Vapor Sensors Utilizing Printed Nematic Liquid Crystal Patterns on Selectively Reactive Substrates (Adv. Sensor Res. 6/2025) 零功率，光学有毒气体和蒸汽传感器，利用印刷向列液晶图案在选择性反应基板上（ad . Sensor Res. 6/2025）

IF 3.5

Advanced Sensor Research Pub Date : 2025-06-12 DOI: 10.1002/adsr.70023

Ryan A. Williams, Grace A. R. Rohaley, Ashwathanarayana Gowda, Gisele Pegorin, Andrea Oprandi, Denis Motovilov, Anthony Schneider, Elda Hegmann, Marianne E. Prévôt, Torsten Hegmann

引用次数: 0

Microwave Monitoring by Compact Carbon Nanotube Photo-Thermoelectric Sensors Beyond the Diffraction Limit Toward Ultrabroadband Non-Destructive Inspections (Adv. Sensor Res. 6/2025) 超绕线型碳纳米管光热电传感器在超宽带无损检测中的微波监测（ad . Sensor Res. 6/2025）

IF 3.5

Advanced Sensor Research Pub Date : 2025-06-12 DOI: 10.1002/adsr.70021

Qi Zhang, Honghao Li, Ryo Koshimizu, Norika Takahashi, Yuya Kinoshita, Asumi Sano, Junyu Jin, Hiroki Okawa, Yuto Matsuzaki, Daiki Shikichi, Yukio Kawano, Kou Li

引用次数: 0

Issue Information (Adv. Sensor Res. 6/2025) 发布信息（Adv. Sensor Res. 6/2025）

IF 3.5

Advanced Sensor Research Pub Date : 2025-06-12 DOI: 10.1002/adsr.70022

引用次数: 0

A SERS-Based Antibody-Aptamer Sandwich Assay for Extracellular Vesicle-Associated Tau Detection Using Gold Nanoparticles 基于sers的抗体-适体夹心法检测细胞外囊泡相关Tau蛋白

IF 3.5

Advanced Sensor Research Pub Date : 2025-06-12 DOI: 10.1002/adsr.202500034

Saqer Al Abdullah, Samaneh Ghadami, Md. Arifur Rahman Khan, Farbod Ebrahimi, Kyle Nowlin, Tetyana Ignatova, Kristen Dellinger

{"title":"A SERS-Based Antibody-Aptamer Sandwich Assay for Extracellular Vesicle-Associated Tau Detection Using Gold Nanoparticles","authors":"Saqer Al Abdullah, Samaneh Ghadami, Md. Arifur Rahman Khan, Farbod Ebrahimi, Kyle Nowlin, Tetyana Ignatova, Kristen Dellinger","doi":"10.1002/adsr.202500034","DOIUrl":"10.1002/adsr.202500034","url":null,"abstract":"Extracellular vesicles (EVs) have emerged as sources of promising, minimally invasive biomarkers for diagnosing and monitoring diseases like Alzheimer's. Using EVs as a source of biomarkers for neurological diseases is highly relevant because they can carry pathogenic proteins, such as tau and amyloid-β, across the blood-brain barrier and can be easily accessed and collected since they are available in almost all biofluids, including blood, urine, and saliva. Here, a bioanalytical antibody-aptamer sandwich assay detection using surface-enhanced Raman spectroscopy (SERS) is developed to quantify the expression of EV-associated tau. Specifically, a gold surface conjugated with antibodies was developed to capture tau protein derived from EVs. Subsequently, adding gold nanoparticles functionalized with SERS probes and aptamers enabled the detection of tau in EVs using SERS. The sensing platform exhibited excellent reproducibility, selectivity, and sensitivity for tau in a broad range of 30 pm–10 nm with a calculated detection limit of 13 pm. Detecting molecular targets within and on the surface of EVs can enable the design of multiplex biosensors for the early diagnosis of multifactorial diseases by simultaneously detecting and quantifying pathogenic proteins, such as amyloid-β and tau in Alzheimer's disease.","PeriodicalId":100037,"journal":{"name":"Advanced Sensor Research","volume":"4 8","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12380370/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144985154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microneedles for Continuous, Minimally Invasive Monitoring: A Technology Overview 用于连续、微创监测的微针：技术综述

IF 3.5

Advanced Sensor Research Pub Date : 2025-06-09 DOI: 10.1002/adsr.202500057

Guillermo Conejo-Cuevas, Miguel Aller Pellitero, Leire Ruiz-Rubio, Francisco Javier del Campo

引用次数: 0