Advanced Sensor Research最新文献_第5页

Empirical Modification of Force Fields for the Development of Peptide-Based Gas Sensors

Advanced Sensor Research Pub Date : 2024-11-29 DOI: 10.1002/adsr.202400122

Thuc Anh Ngo, Tanju Yildirim, Meng-Qun Feng, Kosuke Minami, Kota Shiba, Genki Yoshikawa

{"title":"Empirical Modification of Force Fields for the Development of Peptide-Based Gas Sensors","authors":"Thuc Anh Ngo, Tanju Yildirim, Meng-Qun Feng, Kosuke Minami, Kota Shiba, Genki Yoshikawa","doi":"10.1002/adsr.202400122","DOIUrl":"https://doi.org/10.1002/adsr.202400122","url":null,"abstract":"Molecular dynamics models combined with computational approaches can be used as advanced screening techniques for finding highly efficient material-molecule interactions based on binding affinity, including in the development of gas sensors. However, most models are originally designed for liquid phase interactions, which do not align with gas sensing conditions, resulting in lower-than-expected performance. This study introduces an empirical modification method to adjust peptide interaction models for a gas phase, aiming to better accommodate the interaction between pentapeptides and target gas molecules. By adapting the weights of terms in the Gibbs free energy equation given in an empirical force field model, we demonstrate a significant increase in the absolute value of coefficient of determination (R02) , from an average of 0.05 with conventional liquid phase models to 0.90 with proposed gas phase models. An empirical modification technique for gas phase interactions markedly enhances the prediction accuracy of models, facilitating the effective development of peptide-based gas sensors.","PeriodicalId":100037,"journal":{"name":"Advanced Sensor Research","volume":"4 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adsr.202400122","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143818792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Sensitive, Specific and Fast Electrochemical-based Nanobiosensor Diagnostic for Xanthomonas albilineans, the Cause of Sugarcane Leaf Scald Disease

Advanced Sensor Research Pub Date : 2024-11-29 DOI: 10.1002/adsr.202400103

Moutoshi Chakraborty, Shamsul Arafin Bhuiyan, Simon Strachan, Muhammad J.A. Shiddiky, Nam-Trung Nguyen, Narshone Soda, Rebecca Ford

{"title":"A Sensitive, Specific and Fast Electrochemical-based Nanobiosensor Diagnostic for Xanthomonas albilineans, the Cause of Sugarcane Leaf Scald Disease","authors":"Moutoshi Chakraborty, Shamsul Arafin Bhuiyan, Simon Strachan, Muhammad J.A. Shiddiky, Nam-Trung Nguyen, Narshone Soda, Rebecca Ford","doi":"10.1002/adsr.202400103","DOIUrl":"https://doi.org/10.1002/adsr.202400103","url":null,"abstract":"Leaf scald (LS) caused by Xanthomonas albilineans (Xalb), is a major bacterial disease of sugarcane. The unreliable symptom expressions make traditional visual detection challenging. The molecular methods of detection require expensive equipment, labor-intensive, and time-consuming. This study proposes a novel electrochemical (EC)-approach, that is relatively easy to use and less expensive to detect Xalb DNA in LS-infected sugarcane leaves, meristematic tissue, and xylem sap samples. This method involves three key steps: i) DNA isolation from sugarcane samples via boiling lysis; ii) magnetic purification of target sequences from the lysate using magnetic bead-bound capture probes; and iii) EC detection of the target DNA. The method shows excellent detection sensitivity (10 cells µL−1), reproducibility (Standard deviation, SD <5%, for n = 3), and a wide linear dynamic range (1 nM–1 fM or 106–10° copies µL−1, r = 0.99). The EC assay has a strong negative correlation with quantitative polymerase chain reaction (qPCR) results (r = −0.95–0.97, n = 24, p < 0.001), and weak or no correlation with the varietal resistance ratings. This EC-based assay can be a commercially viable alternative, providing a DNA isolation/purification-free solution, and can potentially be adapted into a handheld device for on-farm detection and quantification of the LS-causing pathogen.","PeriodicalId":100037,"journal":{"name":"Advanced Sensor Research","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adsr.202400103","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143120551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Micro/Nanofibers for Flexible, Stretchable, and Strain-Insensitive Wearable Electronics- A Review

Advanced Sensor Research Pub Date : 2024-11-29 DOI: 10.1002/adsr.202400133

Adeela Hanif, Dong Sung Kim

{"title":"Micro/Nanofibers for Flexible, Stretchable, and Strain-Insensitive Wearable Electronics- A Review","authors":"Adeela Hanif, Dong Sung Kim","doi":"10.1002/adsr.202400133","DOIUrl":"https://doi.org/10.1002/adsr.202400133","url":null,"abstract":"The development of flexible and stretchable wearable electronics has significantly advanced smart fabrics, biomedical devices, and healthcare technologies. However, these devices often face challenges from mechanical deformations that disrupt signals, emphasizing the need for strain-insensitive architectures to maintain functionality under varying strain conditions. Progress in this field relies on multifunctional, strain-insensitive microfibers and nanofibers (NFs) to ensure consistent performance while minimizing signal interference caused by mechanical stress. This review highlights the advantages of fibers for flexible, stretchable, and strain-insensitive wearable electronics, analyzing materials, fabrication methods, and design strategies that optimize strain insensitivity in single free-standing microfibers (SFMs) and NF-based devices. It emphasizes maintaining mechanical and electrical stability under large strains through strategic material selection, advanced fiber spinning techniques, and innovative structural designs. While emphasizing SFMs, this review also provides a concise exploration of the role of NFs within this context. The applications of SFMs in wearable electronics, particularly as conductors, sensors, and components in smart textiles, are discussed with an emphasis on strain insensitivity. The review concludes by addressing challenges in this evolving field of wearable electronics and outlining future research directions, offering insights to drive innovations in fiber-based wearable electronics for reliable, lightweight, breathable, user-friendly, and high-performance wearable devices.","PeriodicalId":100037,"journal":{"name":"Advanced Sensor Research","volume":"4 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adsr.202400133","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143380970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Real-Time Lactate Detection in A Dynamic Environment Using Micrsensing Needles

Advanced Sensor Research Pub Date : 2024-11-14 DOI: 10.1002/adsr.202400089

Yuan-Sin Tang, Ting-Wei Huang, Tung-Lin Yang, Huei-Ying Cheng, Yu-Ting Cheng, Hsiao-En Tsai, Yung-Chieh Lo, Y. S. Chen

{"title":"Real-Time Lactate Detection in A Dynamic Environment Using Micrsensing Needles","authors":"Yuan-Sin Tang, Ting-Wei Huang, Tung-Lin Yang, Huei-Ying Cheng, Yu-Ting Cheng, Hsiao-En Tsai, Yung-Chieh Lo, Y. S. Chen","doi":"10.1002/adsr.202400089","DOIUrl":"https://doi.org/10.1002/adsr.202400089","url":null,"abstract":"This study introduces a novel microneedle-based lactate sensor with SU-8 micropillar enhancement, designed for real-time monitoring in dynamic environments. Utilizing inkjet-printing technology, the sensor demonstrates enhanced sensitivity and a reduced limit of detection (LoD), addressing critical challenges in clinical applications like hemodialysis and patient monitoring in ICU. Design enhancements in the medical steel needle improve stress resistance during insertion, contributing to the sensor's reliability. The experimental findings demonstrate that the microneedle is capable of achieving a high level of linearity at 0.99, with a sensitivity of 3.38 µA mM−1/mm−2–0.5 µA mM−1/mm−2 observed within the range of 0.1–0.5 mM and 1–10 mM, respectively. Meanwhile, the microneedle exhibits a low limit of detection (LoD) of 0.01 mM when tested in phosphate-buffered saline (PBS) with varying lactate concentrations. Moreover, it demonstrates a linearity of 0.98, sensitivity of 1.13 µA mM−1 mm−2, and the same LoD of 0.01 mM in urine. The sensor maintains its performance at flow rates up to 500 mL min−1. Overall, this flexible and inkjet-printed lactate sensor represents a significant advancement in real-time clinical monitoring technology.","PeriodicalId":100037,"journal":{"name":"Advanced Sensor Research","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adsr.202400089","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143115050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

All Solid Photonic Crystal Fiber Enabled by 3D Printing Fiber Technology for Sensing of Multiple Parameters (Adv. Sensor Res. 11/2024) 利用三维打印光纤技术实现全固态光子晶体光纤，用于传感多种参数（传感器研究，2011/2024）

Advanced Sensor Research Pub Date : 2024-11-06 DOI: 10.1002/adsr.202470030

Yanhua Luo, Yushi Chu, Jiaying Wang, Xinghu Fu, John Canning, Yang Cao, Haoyu Pan, Yongxiang Zhang, Jianzhong Zhang, Binbin Yan, Jianxiang Wen, Tingyun Wang, Xiaohong Sun, Gang-Ding Peng

引用次数: 0

Transforming Renal Diagnosis: Graphene-Enhanced Lab-On-a-Chip for Multiplexed Kidney Biomarker Detection in Capillary Blood (Adv. Sensor Res. 11/2024) 改变肾脏诊断：用于毛细管血液中多重肾脏生物标记物检测的石墨烯增强型片上实验室（传感器研究进展 11/2024）

Advanced Sensor Research Pub Date : 2024-11-06 DOI: 10.1002/adsr.202470032

Joaquin F. Diforti, Thomas Cunningham, Zaira Zegalo, Esteban Piccinini, Waldemar A. Marmisollé, Jose M. Piccinini, Omar Azzaroni

引用次数: 0

Masthead (Adv. Sensor Res. 11/2024) 桅杆头（第 11/2024 号传感器预案）

Advanced Sensor Research Pub Date : 2024-11-06 DOI: 10.1002/adsr.202470031

引用次数: 0

A Step Toward ESIPT-Based Mitochondrial Probe That Responds to ATP Level

Advanced Sensor Research Pub Date : 2024-11-01 DOI: 10.1002/adsr.202400117

Yonghao Li, Dipendra Dahal, Yi Pang

引用次数: 0

Enhanced High-Performance β-Ray Detectors Based on GaN Multi-Quantum Well Structures

Advanced Sensor Research Pub Date : 2024-10-23 DOI: 10.1002/adsr.202400129

Yong Shi, Zhengxin Gao, Zhiyong Deng, Li Liu, Lu Zhang, Peixian Li, Weiwei Wu

{"title":"Enhanced High-Performance β-Ray Detectors Based on GaN Multi-Quantum Well Structures","authors":"Yong Shi, Zhengxin Gao, Zhiyong Deng, Li Liu, Lu Zhang, Peixian Li, Weiwei Wu","doi":"10.1002/adsr.202400129","DOIUrl":"https://doi.org/10.1002/adsr.202400129","url":null,"abstract":"β-ray detectors are crucial to ensure personnel safety, maintain the reliability of equipment and materials, and support scientific research and medical applications, current devices face challenges in sensitivity and stability. This study addresses these issues by demonstrating a β-ray detector based on GaN multi-quantum well (MQW) structures, which are expected to offer improved performance over existing technologies. Using a custom-developed electron irradiation source, the performance of the β-ray detector is systematically evaluated across a range of electron energies (5–50 keV) and irradiation intensities (0–50 mCi cm−2). At an acceleration voltage of 20 kV, the detectors demonstrate a high sensitivity of 2.68 ± 0.08 nA mCi−1 and exhibit a current variation of 126.4 nA under 50 mCi irradiation. Notably, the detectors maintain excellent detection performance with optimal response observed at 20 keV even in an unbiased state. These results underscore the capability of detectors to effectively convert irradiation energy into electrical signals, addressing the limitations of current β-ray detectors and demonstrating their potential for advanced radiation detection applications. The insights gained from this study are pivotal for optimizing GaN MQW-based β-ray detectors and advancing their use in high-performance radiation monitoring technologies.","PeriodicalId":100037,"journal":{"name":"Advanced Sensor Research","volume":"4 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adsr.202400129","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143571201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Percutaneous Wearable Biosensors: A Brief History and Systems Perspective 经皮可穿戴生物传感器：简史和系统的观点

Advanced Sensor Research Pub Date : 2024-10-20 DOI: 10.1002/adsr.202400068

Kaila L. Peterson, Rajendra P. Shukla, Michael A. Daniele

{"title":"Percutaneous Wearable Biosensors: A Brief History and Systems Perspective","authors":"Kaila L. Peterson, Rajendra P. Shukla, Michael A. Daniele","doi":"10.1002/adsr.202400068","DOIUrl":"https://doi.org/10.1002/adsr.202400068","url":null,"abstract":"Wearable biosensors are envisioned to disrupt both delivery and accessibility of healthcare by providing real-time, continuous monitoring of informative and predictive physiological markers in convenient, user-friendly, and portable designs. In recent years, there has been myriad demonstrations of biosensor-integrated clothing and skin-borne biosensor patches, enabled by device miniaturization, reduced power consumption, and new biosensing chemistries. Despite these impressive demonstrations, most consumer-grade wearables have been limited to biophotonic and biopotential sensing methods to extrapolate information such as pulse, blood oxygenation, and electrocardiograms. The only commercial example of wearable electrochemical sensing methods is for glucose monitoring. However, there is a growing interest in developing percutaneous biosensors for monitoring in interstitial fluid (ISF), which offers direct access to popular analytes such as glucose, lactate, and urea, as well as new targets like hormones, antibodies, and even medications. Herein, a brief context for the current status of wearable biosensors is provided and assess the major engineering successes and pitfalls of percutaneous biosensors over the past five years, with a view to identifying areas for further developments that will enable deployable, clinical- or consumer-grade systems.","PeriodicalId":100037,"journal":{"name":"Advanced Sensor Research","volume":"3 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adsr.202400068","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142868742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0