Chinese Journal of Natural Medicines最新文献

{"title":"Diketopiperazines with anti-skin inflammation from marine-derived endophytic fungus Aspergillus sp. and configurational reassignment of aspertryptanthrins","authors":"Jin Yang ,&nbsp;Xianmei Xiong ,&nbsp;Lizhi Gong ,&nbsp;Fengyu Gan ,&nbsp;Hanling Shi ,&nbsp;Bin Zhu ,&nbsp;Haizhen Wu ,&nbsp;Xiujuan Xin ,&nbsp;Lingyi Kong ,&nbsp;Faliang An","doi":"10.1016/S1875-5364(25)60933-2","DOIUrl":"10.1016/S1875-5364(25)60933-2","url":null,"abstract":"<div><div>Two novel diketopiperazines (<strong>1</strong> and <strong>5</strong>), along with ten known compounds (<strong>2</strong>−<strong>4</strong>, <strong>6</strong>−<strong>12</strong>) demonstrating significant skin inflammation inhibition, were isolated from a marine-derived fungus identified as <em>Aspergillus</em> sp. FAZW0001. The structural elucidation and configurational reassessments of compounds <strong>1</strong>−<strong>5</strong> were established through comprehensive spectral analyses, with their absolute configurations determined <em>via</em> single crystal X-ray diffraction using Cu K<em>α</em> radiation, Marfey’s method, and comparison between experimental and calculated electronic circular dichroism (ECD) spectra. Compounds <strong>1</strong>, <strong>2</strong>, and <strong>8</strong> exhibited significant anti-inflammatory activities in <em>Propionibacterium acnes</em> (<em>P. acnes</em>)-induced human monocyte cell lines. Compound <strong>8</strong> demonstrated the ability to down-regulate interleukin-1β (IL-1β) expression by inhibiting Toll-like receptor 2 (TLR2) expression and modulating the activation of myeloid differentiation factor 88 (MyD88), mitogen-activated protein kinase (MAPK), and nuclear factor <em>κ</em>B (NF-<em>κ</em>B) signaling pathways, thus reducing the cellular inflammatory response induced by <em>P. acnes</em>. Additionally, compound <strong>8</strong> showed the capacity to suppress mitochondrial reactive oxygen species (ROS) production and nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome activation, thereby reducing IL-1β maturation and secretion. A three-dimensional quantitative structure-activity relationships (3D-QSAR) model was applied to compounds <strong>5</strong>−<strong>12</strong> to analyze their anti-inflammatory structure-activity relationships.</div></div>","PeriodicalId":10002,"journal":{"name":"Chinese Journal of Natural Medicines","volume":"23 8","pages":"Pages 980-989"},"PeriodicalIF":4.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144749698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The transcriptomic-based disease network reveals synergistic therapeutic effect of total alkaloids from Coptis chinensis and total ginsenosides from Panax ginseng on type 2 diabetes mellitus","authors":"Qian Chen ,&nbsp;Shuying Zhang ,&nbsp;Xuanxi Jiang ,&nbsp;Jie Liao ,&nbsp;Xin Shao ,&nbsp;Xin Peng ,&nbsp;Zheng Wang ,&nbsp;Xiaoyan Lu ,&nbsp;Xiaohui Fan","doi":"10.1016/S1875-5364(25)60935-6","DOIUrl":"10.1016/S1875-5364(25)60935-6","url":null,"abstract":"<div><div><em>Coptis chinensis</em> Franch. and <em>Panax ginseng</em> C. A. Mey. are traditional herbal medicines with millennia of documented use and broad therapeutic applications, including anti-diabetic properties. However, the synergistic effect of total alkaloids from <em>Coptis chinensis</em> and total ginsenosides from <em>Panax ginseng</em> on type 2 diabetes mellitus (T2DM) and its underlying mechanism remain unclear. The research demonstrated that the optimal ratio of total alkaloids from <em>Coptis chinensis</em> and total ginsenosides from <em>Panax ginseng</em> was 4∶1, exhibiting maximal efficacy in improving insulin resistance and gluconeogenesis in primary mouse hepatocytes. This combination demonstrated significant synergistic effects in improving glucose tolerance, reducing fasting blood glucose (FBG), the weight ratio of epididymal white adipose tissue (eWAT), and the homeostasis model assessment of insulin resistance (HOMA-IR) in leptin receptor-deficient (db/db) mice. Subsequently, a T2DM liver-specific network was constructed based on RNA sequencing (RNA-seq) experiments and public databases by integrating transcriptional properties of disease-associated proteins and protein-protein interactions (PPIs). The network recovery index (NRI) score of the combined treatment group with a 4∶1 ratio exceeded that of groups treated with individual components. The research identified that activated adenosine 5’-monophosphate-activated protein kinase (AMPK)/acetyl-CoA carboxylase (ACC) signaling in the liver played a crucial role in the synergistic treatment of T2DM, as verified by western blot experiment in db/db mice. These findings demonstrate that the 4∶1 combination of total alkaloids from <em>Coptis chinensis</em> and total ginsenosides from <em>Panax ginseng</em> significantly improves insulin resistance and glucose and lipid metabolism disorders in db/db mice, surpassing the efficacy of individual treatments. The synergistic mechanism correlates with enhanced AMPK/ACC signaling pathway activity.</div></div>","PeriodicalId":10002,"journal":{"name":"Chinese Journal of Natural Medicines","volume":"23 8","pages":"Pages 997-1008"},"PeriodicalIF":4.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144749837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in the study of pharmacotherapy for addiction to naturally-derived psychoactive substances","authors":"Kexin Xie ,&nbsp;Deli Xiao ,&nbsp;Peng Xu ,&nbsp;Haowei Shen ,&nbsp;Bin Di","doi":"10.1016/S1875-5364(25)60831-4","DOIUrl":"10.1016/S1875-5364(25)60831-4","url":null,"abstract":"<div><div>Drug addiction, a disorder characterized by chronic relapse and compulsive drug use, poses a significant threat to public safety and human health. Addictive substances can be categorized as natural, semi-synthetic, or synthetic based on their origin. Additionally, they can be classified into three groups according to their pharmacological targets: opioids, hallucinogens, and cannabinoids that act on G-protein-coupled receptors (GPCRs); alcohols, nicotine, ketamine, barbiturates, and benzodiazepines (BDZs) that affect ligand-gated ion channel-type receptors; and psychostimulants that interact with monoamine transporters. Current treatments for drug addiction primarily include substitution therapy and non-pharmacological approaches. However, these methods have limitations, particularly in addressing the underlying causes of relapse. Several drugs in clinical trials have demonstrated potential therapeutic effects for addiction to opioids, heroin, cocaine, and other substances. This review examines the origins and pharmacological mechanisms of addiction to naturally-derived psychoactive substances (NPS) and provides an overview of recent advancements in pharmacotherapy for drug addiction.</div></div>","PeriodicalId":10002,"journal":{"name":"Chinese Journal of Natural Medicines","volume":"23 8","pages":"Pages 897-908"},"PeriodicalIF":4.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144749688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New tetrahydroanthraquinones and γ-butenolides from the fungus Auxarthron umbrinum DSM3193","authors":"Ling Tian,&nbsp;Bingyu Liu,&nbsp;Qian Wei,&nbsp;Chen Zhang,&nbsp;Jiamin Shang,&nbsp;Xiaoxue Li,&nbsp;Xiuying Yang,&nbsp;Jinhua Wang,&nbsp;Youcai Hu","doi":"10.1016/S1875-5364(25)60930-7","DOIUrl":"10.1016/S1875-5364(25)60930-7","url":null,"abstract":"<div><div>Nine novel compounds, comprising seven tetrahydroanthraquinones (auxarthrolones A−G, <strong>1</strong>−<strong>7</strong>), a <em>γ</em>-butenolide glycoside (malfilamentoside E, <strong>26</strong>), and a <em>γ</em>-butenolide (auxarthrolide A, <strong>27</strong>), together with eighteen known compounds (<strong>8</strong>−<strong>25</strong>) were isolated from rice-based solid culture of <em>Auxarthron umbrinum</em> (<em>A. umbrinum</em>) DSM3193 using the one strain many compounds (OSMAC) approach. The structural elucidation of these compounds was accomplished through nuclear magnetic resonance (NMR), mass spectrometry (MS), and NMR calculation combined with DP4+ analysis or MAEΔΔ<em>δ</em> parameter, while the absolute configurations of new compounds were established through single-crystal X-ray diffraction, electronic circular dichroism (ECD) spectroscopic data analysis and/or chemical derivatization. Austrocortilutein (<strong>10</strong>) and auxarthrol H (<strong>14</strong>) demonstrated moderate cytotoxicity against U87 and U251 [half maximal inhibitory concentration (IC₅₀) 3.5−12.1 μmol·L⁻¹]. Additionally, auxarthrolone A (<strong>1</strong>), auxarthrol H (<strong>14</strong>), eupolyphagin B (<strong>15</strong>), and 7-hydroxy-2-(2-hydroxypropyl)-5-methylchromone (<strong>17</strong>) exhibited torsional effects on fibroblast proliferation challenges induced by oleic acid, thus demonstrating fibroblast proliferation-promoting activity.</div></div>","PeriodicalId":10002,"journal":{"name":"Chinese Journal of Natural Medicines","volume":"23 8","pages":"Pages 951-960"},"PeriodicalIF":4.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144749693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dimeric sesquiterpenoids with anti-inflammatory activities from Inula britannica","authors":"Juan Zhang ,&nbsp;Jiankun Yan ,&nbsp;Hongjun Dong ,&nbsp;Rui Zhang ,&nbsp;Jing Chang ,&nbsp;Yanli Feng ,&nbsp;Xinrong Xu ,&nbsp;Wei Li ,&nbsp;Feng Qiu ,&nbsp;Chengpeng Sun","doi":"10.1016/S1875-5364(25)60931-9","DOIUrl":"10.1016/S1875-5364(25)60931-9","url":null,"abstract":"<div><div>In continuation of research aimed at identifying anti-inflammatory agents from natural sesquiterpenoids, an activity-guided fractionation approach utilizing lipopolysaccharide (LPS)-mediated RAW264.7 cells was employed to investigate chemical constituents from <em>Inula Britannica</em> (<em>I. britannica</em>). Seven novel sesquiterpenoid dimers inulabritanoids A−G (<strong>1</strong>−<strong>7</strong>) and two novel sesquiterpenoid monomers inulabritanoids H (<strong>8</strong>) and I (<strong>9</strong>) were isolated from <em>I. britannica</em> together with eighteen known compounds (<strong>10</strong>−<strong>27</strong>). The structural elucidation was accomplished through comprehensive analysis of 1D and 2D nuclear magnetic resonance (NMR), high-resolution mass spectrometry (HR-MS), and electronic circular dichroism (ECD) spectra, complemented by quantum chemical calculations. Compounds <strong>1</strong>, <strong>2</strong>, <strong>12</strong>, <strong>16</strong>, <strong>19</strong>, and <strong>26</strong> demonstrated inhibitory effects on NO production, with IC₅₀ values of 3.65, 5.48, 3.29, 6.91, 3.12, and 5.67 μmol·L⁻¹, respectively. Mechanistic studies revealed that compound <strong>1</strong> inhibited I<em>κ</em>B kinase β (IKKβ) phosphorylation, thereby blocking nuclear factor <em>κ</em>B (NF-<em>κ</em>B) nuclear translocation, and activated the kelch-like ECH-associated protein 1 (Keap1)/nuclear factor erythroid 2-related factor 2 (Nrf2) signal pathway, leading to decreased expression of NADPH oxidase 2 (NOX-2), inducible nitric oxide synthase (iNOS), tumor necrosis factor α (TNF-α), interleukin-6 (IL-6), monocyte chemotactic protein-1 (MCP-1), IL-1β, and IL-1α and increased expression of NAD(P)H: quinone oxidoreductase 1 (NQO-1) and heme oxygenase-1 (HO-1), thus exhibiting anti-inflammatory effects <em>in vitro</em>. These results indicate that dimeric sesquiterpenoids may serve as promising candidates for anti-inflammatory drug development.</div></div>","PeriodicalId":10002,"journal":{"name":"Chinese Journal of Natural Medicines","volume":"23 8","pages":"Pages 961-971"},"PeriodicalIF":4.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144749696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wenxia Changfu Formula inhibits NSCLC metastasis by halting TAMs-induced epithelial-mesenchymal transition via antagonisticallymodulating CCL18","authors":"Qianyu Bi ,&nbsp;Mengran Wang ,&nbsp;Li Luo ,&nbsp;Beiying Zhang ,&nbsp;Siyuan Lv ,&nbsp;Zengna Wang ,&nbsp;Xuming Ji","doi":"10.1016/S1875-5364(25)60912-5","DOIUrl":"10.1016/S1875-5364(25)60912-5","url":null,"abstract":"<div><div>Our previous research demonstrated that the Wenxia Changfu Formula (WCF), as a neoadjuvant therapy, inhibits M2 macrophage infiltration in the tumor microenvironment and prevents lung cancer metastasis. Given tumor-associated macrophages (TAMs) in epithelial-mesenchymal transition (EMT), this study investigated whether WCF impedes lung cancer metastasis by attenuating TAM-induced EMT in non-small cell lung cancer (NSCLC) cells. Utilizing a co-culture model treated with or without WCF, we observed that WCF downregulated cluster of differentiation 163 (CD163) expression in macrophages, reduced CCL18 levels in the conditioned medium, and inhibited the growth, invasion, and EMT of NSCLC cells induced by macrophage co-culture. Manipulation of CCL18 levels and Src overexpression in NSCLC cells revealed that WCF's effects are mediated through CCL18 and Src signaling. <em>In vivo</em>, WCF inhibited recombinant CCL18 (rCCL18)-induced tumor metastasis in nude mice by blocking Src signaling. These findings indicate that WCF inhibits NSCLC metastasis by impeding TAM-induced EMT <em>via</em> antagonistic modulation of CCL18, providing evidence for its potential development and clinical application in NSCLC patients.</div></div>","PeriodicalId":10002,"journal":{"name":"Chinese Journal of Natural Medicines","volume":"23 7","pages":"Pages 838-847"},"PeriodicalIF":4.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144604779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of 8-OxoG and its repair systems in liver diseases progression: responsible mechanisms and promising natural products","authors":"Ying Zheng,&nbsp;Junxin Chen,&nbsp;Ze Liu,&nbsp;Kaibo Wang,&nbsp;Hao Zhang","doi":"10.1016/S1875-5364(25)60848-X","DOIUrl":"10.1016/S1875-5364(25)60848-X","url":null,"abstract":"<div><div>The accumulation of deoxyribonucleic acid (DNA) oxidative damage mediated by reactive oxygen species (ROS) is closely associated with liver diseases. 8-Oxoguanine (8-OxoG), a prevalent DNA oxidation product, plays a significant role in liver disease progression. The base excision repair (BER) pathway, comprising over 30 proteins including 8-OxoG DNA glycosylase1 (OGG1), MutY homolog (MUTYH), and MutT homolog protein 1 (MTH1), is responsible for the clearance and mismatch repair of 8-OxoG. Abnormally high levels of 8-OxoG and dysregulated expression and function of 8-OxoG repair enzymes contribute to the onset and development of liver diseases. Consequently, targeting the 8-OxoG production and repair system with agonists or inhibitors may offer a promising approach to liver disease treatment. This review summarizes the impact of 8-OxoG accumulation and dysregulated repair enzymes on various liver diseases, including viral liver disease, alcoholic liver disease (ALD), metabolic dysfunction-associated steatotic liver disease (MASLD), cholestatic liver disease (CLD), liver fibrosis, cirrhosis, and liver cancer. Additionally, we review natural constituents as potential therapeutic agents that regulate 8-OxoG production, repair enzymes, and repair system-related signal pathways in oxidative damage-induced liver diseases.</div></div>","PeriodicalId":10002,"journal":{"name":"Chinese Journal of Natural Medicines","volume":"23 7","pages":"Pages 815-823"},"PeriodicalIF":4.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144604183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification and biomimetic synthesis of iphionanes and cyperanes from Artemisia hedinii and their anti-hepatic fibrosis activity","authors":"Xiaofei Liu ,&nbsp;Xing Wang ,&nbsp;Chunping Tang ,&nbsp;Changqiang Ke ,&nbsp;Bintao Hu ,&nbsp;Sheng Yao ,&nbsp;Yang Ye","doi":"10.1016/S1875-5364(25)60915-0","DOIUrl":"10.1016/S1875-5364(25)60915-0","url":null,"abstract":"<div><div>Two novel skeleton sesquiterpenoids (<strong>1</strong> and <strong>6</strong>), along with four new iphionane-type sesquiterpenes (<strong>2</strong>−<strong>5</strong>) and six new cyperane-type sesquiterpenes (<strong>7</strong>−<strong>11</strong>), were isolated from the whole plant of <em>Artemisia hedinii</em> (<em>A. hedinii</em>). The two novel skeleton compounds (<strong>1</strong> and <strong>6</strong>) were derived from the decarbonization of iphionane and cyperane-type sesquiterpenes, respectively. Their structures were elucidated through a comprehensive analysis of spectroscopic data, including high-resolution electrospray ionization mass spectrometry (HR-ESI-MS) and 1D and 2D nuclear magnetic resonance (NMR) spectra. The absolute configurations were determined using electronic circular dichroism (ECD) spectra, single-crystal X-ray crystallographic analyses, time-dependent density functional theory (TDDFT) ECD calculation, density functional theory (DFT) NMR calculations, and biomimetic syntheses. The biomimetic syntheses of the two novel skeletons (<strong>1</strong> and <strong>6</strong>) were inspired by potential biogenetic pathways, utilizing a predominant eudesmane-type sesquiterpene (<strong>A</strong>) in <em>A. hedinii</em> as the substrate. All compounds were evaluated in LX-2 cells for their anti-hepatic fibrosis activity. Compounds <strong>2</strong>, <strong>8</strong>, and <strong>10</strong> exhibited significant activity in downregulating the expression of <em>α</em>-smooth muscle actin (<em>α</em>-SMA), a protein involved in hepatic fibrosis.</div></div>","PeriodicalId":10002,"journal":{"name":"Chinese Journal of Natural Medicines","volume":"23 7","pages":"Pages 871-880"},"PeriodicalIF":4.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144604780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diterpenoids and lignans from fossil Chinese medicinal succinum and their activity against renal fibrosis","authors":"Yefei Chen ,&nbsp;Yunfei Wang ,&nbsp;Yunyun Liu ,&nbsp;Yongming Yan ,&nbsp;Yongxian Cheng","doi":"10.1016/S1875-5364(25)60916-2","DOIUrl":"10.1016/S1875-5364(25)60916-2","url":null,"abstract":"<div><div>Five previously undescribed diterpenoids, named succipenoids D‒H (<strong>1</strong>‒<strong>5</strong>), along with four undescribed lignans, named succignans A‒D (<strong>6</strong>‒<strong>9</strong>), were isolated from the dichloromethane extract of Chinese medicinal succinum. Compounds <strong>1</strong>‒<strong>5</strong> were characterized as nor-abietane diterpenoids, while compounds <strong>6</strong>‒<strong>9</strong> were identified as lignans polymerized from two groups of phenylpropanoid units. The structures of these novel compounds, including their absolute configurations, were determined through spectroscopic and computational methods. Biological assessments of renal fibrosis demonstrated that compounds <strong>6</strong> and <strong>7</strong> effectively reduce the expression of proteins associated with renal fibrosis, including <em>α</em>-smooth muscle actin (<em>α</em>-SMA), collagen I, and fibronectin in transforming growth factor-β1 (TGF-β1) induced normal rat kidney proximal tubular epithelial cells (NRK-52e).</div></div>","PeriodicalId":10002,"journal":{"name":"Chinese Journal of Natural Medicines","volume":"23 7","pages":"Pages 888-896"},"PeriodicalIF":4.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144604784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Naturally occurring seco- and nor-polycyclic polyprenylated acylphloroglucinols: distribution, structural diversity, andbiological activity","authors":"Yulin Duan ,&nbsp;Ying Tang ,&nbsp;Changxing Qi ,&nbsp;Yonghui Zhang","doi":"10.1016/S1875-5364(25)60911-3","DOIUrl":"10.1016/S1875-5364(25)60911-3","url":null,"abstract":"<div><div>Polycyclic polyprenylated acylphloroglucinols (PPAPs) represent a distinct subclass of specialized metabolites predominantly found in the plant kingdom, particularly within the Guttiferae (Clusiaceae) family. These compounds exhibit remarkable structural diversity and a wide range of biological activities. <em>Seco</em>- and <em>nor</em>-PPAPs, two unique variants of PPAPs with diverse skeletal structures, have been extensively investigated. As of June 2023, 200 compounds have been isolated from four genera, with <em>Hypericum</em> being the primary source. Notably, 115 of these compounds were identified in the past four years, indicating a significant increase in research activity. <em>Seco</em>- and <em>nor</em>-PPAPs can be categorized into six main subgroups based on the original PPAP scaffolds. Biological studies have revealed their potential in various therapeutic applications, including anti-cancer, anti-inflammatory, hepatoprotective, anti-Alzheimer's disease (anti-AD), multidrug resistance (MDR) reversal, anti-depressant, neuroprotective, and immunosuppressive effects. This review provides a comprehensive overview of the occurrence, structures, and bioactivities of natural <em>seco</em>- and <em>nor</em>-PPAPs, offering valuable insights for the further development of PPAPs.</div></div>","PeriodicalId":10002,"journal":{"name":"Chinese Journal of Natural Medicines","volume":"23 7","pages":"Pages 824-837"},"PeriodicalIF":4.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144604181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}