Diterpenoids and lignans from fossil Chinese medicinal succinum and their activity against renal fibrosis

IF 4 2区医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE

Chinese Journal of Natural Medicines Pub Date : 2025-07-01 DOI:10.1016/S1875-5364(25)60916-2

Yefei Chen , Yunfei Wang , Yunyun Liu , Yongming Yan , Yongxian Cheng

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Abstract

Five previously undescribed diterpenoids, named succipenoids D‒H (1‒5), along with four undescribed lignans, named succignans A‒D (6‒9), were isolated from the dichloromethane extract of Chinese medicinal succinum. Compounds 1‒5 were characterized as nor-abietane diterpenoids, while compounds 6‒9 were identified as lignans polymerized from two groups of phenylpropanoid units. The structures of these novel compounds, including their absolute configurations, were determined through spectroscopic and computational methods. Biological assessments of renal fibrosis demonstrated that compounds 6 and 7 effectively reduce the expression of proteins associated with renal fibrosis, including α-smooth muscle actin (α-SMA), collagen I, and fibronectin in transforming growth factor-β1 (TGF-β1) induced normal rat kidney proximal tubular epithelial cells (NRK-52e).

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中药古琥珀二萜类、木脂素及其抗肾纤维化活性研究

从中药琥珀的二氯甲烷提取物中分离得到5个未被描述的二萜类化合物，分别命名为succipenoids D-H（1-5）和4个未被描述的木脂素，分别命名为succipenoids A-D（6-9）。化合物1 ~ 5被鉴定为非枞烷二萜，而化合物6 ~ 9被鉴定为由两个苯基丙烷单元聚合而成的木脂素。这些新化合物的结构，包括它们的绝对构型，通过光谱和计算方法确定。肾纤维化生物学评估表明，化合物6和7可有效降低转化生长因子-β1 （TGF-β1）诱导的正常大鼠肾近端小管上皮细胞（NRK-52e）中α-平滑肌肌动蛋白（α-SMA）、I型胶原和纤维连接蛋白等肾纤维化相关蛋白的表达。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chinese Journal of Natural Medicines INTEGRATIVE & COMPLEMENTARY MEDICINE-PHARMACOLOGY & PHARMACY

CiteScore

7.50

自引率

4.30%

发文量

2235

期刊介绍： The Chinese Journal of Natural Medicines (CJNM), founded and sponsored in May 2003 by China Pharmaceutical University and the Chinese Pharmaceutical Association, is devoted to communication among pharmaceutical and medical scientists interested in the advancement of Traditional Chinese Medicines (TCM). CJNM publishes articles relating to a broad spectrum of bioactive natural products, leading compounds and medicines derived from Traditional Chinese Medicines (TCM). Topics covered by the journal are: Resources of Traditional Chinese Medicines; Interaction and complexity of prescription; Natural Products Chemistry (including structure modification, semi-and total synthesis, bio-transformation); Pharmacology of natural products and prescription (including pharmacokinetics and toxicology); Pharmaceutics and Analytical Methods of natural products.