Chinese Journal of Natural Medicines最新文献

Wenxia Changfu Formula inhibits NSCLC metastasis by halting TAMs-induced epithelial-mesenchymal transition via antagonisticallymodulating CCL18 文霞长补方通过拮抗调节CCL18抑制tam诱导的上皮-间质转化，从而抑制NSCLC转移

IF 4 2区医学

Chinese Journal of Natural Medicines Pub Date : 2025-07-01 DOI: 10.1016/S1875-5364(25)60912-5

Qianyu Bi , Mengran Wang , Li Luo , Beiying Zhang , Siyuan Lv , Zengna Wang , Xuming Ji

{"title":"Wenxia Changfu Formula inhibits NSCLC metastasis by halting TAMs-induced epithelial-mesenchymal transition via antagonisticallymodulating CCL18","authors":"Qianyu Bi , Mengran Wang , Li Luo , Beiying Zhang , Siyuan Lv , Zengna Wang , Xuming Ji","doi":"10.1016/S1875-5364(25)60912-5","DOIUrl":"10.1016/S1875-5364(25)60912-5","url":null,"abstract":"<div><div>Our previous research demonstrated that the Wenxia Changfu Formula (WCF), as a neoadjuvant therapy, inhibits M2 macrophage infiltration in the tumor microenvironment and prevents lung cancer metastasis. Given tumor-associated macrophages (TAMs) in epithelial-mesenchymal transition (EMT), this study investigated whether WCF impedes lung cancer metastasis by attenuating TAM-induced EMT in non-small cell lung cancer (NSCLC) cells. Utilizing a co-culture model treated with or without WCF, we observed that WCF downregulated cluster of differentiation 163 (CD163) expression in macrophages, reduced CCL18 levels in the conditioned medium, and inhibited the growth, invasion, and EMT of NSCLC cells induced by macrophage co-culture. Manipulation of CCL18 levels and Src overexpression in NSCLC cells revealed that WCF's effects are mediated through CCL18 and Src signaling. <em>In vivo</em>, WCF inhibited recombinant CCL18 (rCCL18)-induced tumor metastasis in nude mice by blocking Src signaling. These findings indicate that WCF inhibits NSCLC metastasis by impeding TAM-induced EMT <em>via</em> antagonistic modulation of CCL18, providing evidence for its potential development and clinical application in NSCLC patients.</div></div>","PeriodicalId":10002,"journal":{"name":"Chinese Journal of Natural Medicines","volume":"23 7","pages":"Pages 838-847"},"PeriodicalIF":4.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144604779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of 8-OxoG and its repair systems in liver diseases progression: responsible mechanisms and promising natural products 8-OxoG及其修复系统在肝脏疾病进展中的作用：负责任的机制和有前途的天然产物

IF 4 2区医学

Chinese Journal of Natural Medicines Pub Date : 2025-07-01 DOI: 10.1016/S1875-5364(25)60848-X

Ying Zheng, Junxin Chen, Ze Liu, Kaibo Wang, Hao Zhang

{"title":"The role of 8-OxoG and its repair systems in liver diseases progression: responsible mechanisms and promising natural products","authors":"Ying Zheng, Junxin Chen, Ze Liu, Kaibo Wang, Hao Zhang","doi":"10.1016/S1875-5364(25)60848-X","DOIUrl":"10.1016/S1875-5364(25)60848-X","url":null,"abstract":"<div><div>The accumulation of deoxyribonucleic acid (DNA) oxidative damage mediated by reactive oxygen species (ROS) is closely associated with liver diseases. 8-Oxoguanine (8-OxoG), a prevalent DNA oxidation product, plays a significant role in liver disease progression. The base excision repair (BER) pathway, comprising over 30 proteins including 8-OxoG DNA glycosylase1 (OGG1), MutY homolog (MUTYH), and MutT homolog protein 1 (MTH1), is responsible for the clearance and mismatch repair of 8-OxoG. Abnormally high levels of 8-OxoG and dysregulated expression and function of 8-OxoG repair enzymes contribute to the onset and development of liver diseases. Consequently, targeting the 8-OxoG production and repair system with agonists or inhibitors may offer a promising approach to liver disease treatment. This review summarizes the impact of 8-OxoG accumulation and dysregulated repair enzymes on various liver diseases, including viral liver disease, alcoholic liver disease (ALD), metabolic dysfunction-associated steatotic liver disease (MASLD), cholestatic liver disease (CLD), liver fibrosis, cirrhosis, and liver cancer. Additionally, we review natural constituents as potential therapeutic agents that regulate 8-OxoG production, repair enzymes, and repair system-related signal pathways in oxidative damage-induced liver diseases.</div></div>","PeriodicalId":10002,"journal":{"name":"Chinese Journal of Natural Medicines","volume":"23 7","pages":"Pages 815-823"},"PeriodicalIF":4.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144604183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification and biomimetic synthesis of iphionanes and cyperanes from Artemisia hedinii and their anti-hepatic fibrosis activity 青蒿中伊菲酮类和环己烷类的鉴定、仿生合成及其抗肝纤维化活性

IF 4 2区医学

Chinese Journal of Natural Medicines Pub Date : 2025-07-01 DOI: 10.1016/S1875-5364(25)60915-0

Xiaofei Liu , Xing Wang , Chunping Tang , Changqiang Ke , Bintao Hu , Sheng Yao , Yang Ye

{"title":"Identification and biomimetic synthesis of iphionanes and cyperanes from Artemisia hedinii and their anti-hepatic fibrosis activity","authors":"Xiaofei Liu , Xing Wang , Chunping Tang , Changqiang Ke , Bintao Hu , Sheng Yao , Yang Ye","doi":"10.1016/S1875-5364(25)60915-0","DOIUrl":"10.1016/S1875-5364(25)60915-0","url":null,"abstract":"<div><div>Two novel skeleton sesquiterpenoids (<strong>1</strong> and <strong>6</strong>), along with four new iphionane-type sesquiterpenes (<strong>2</strong>−<strong>5</strong>) and six new cyperane-type sesquiterpenes (<strong>7</strong>−<strong>11</strong>), were isolated from the whole plant of <em>Artemisia hedinii</em> (<em>A. hedinii</em>). The two novel skeleton compounds (<strong>1</strong> and <strong>6</strong>) were derived from the decarbonization of iphionane and cyperane-type sesquiterpenes, respectively. Their structures were elucidated through a comprehensive analysis of spectroscopic data, including high-resolution electrospray ionization mass spectrometry (HR-ESI-MS) and 1D and 2D nuclear magnetic resonance (NMR) spectra. The absolute configurations were determined using electronic circular dichroism (ECD) spectra, single-crystal X-ray crystallographic analyses, time-dependent density functional theory (TDDFT) ECD calculation, density functional theory (DFT) NMR calculations, and biomimetic syntheses. The biomimetic syntheses of the two novel skeletons (<strong>1</strong> and <strong>6</strong>) were inspired by potential biogenetic pathways, utilizing a predominant eudesmane-type sesquiterpene (<strong>A</strong>) in <em>A. hedinii</em> as the substrate. All compounds were evaluated in LX-2 cells for their anti-hepatic fibrosis activity. Compounds <strong>2</strong>, <strong>8</strong>, and <strong>10</strong> exhibited significant activity in downregulating the expression of <em>α</em>-smooth muscle actin (<em>α</em>-SMA), a protein involved in hepatic fibrosis.</div></div>","PeriodicalId":10002,"journal":{"name":"Chinese Journal of Natural Medicines","volume":"23 7","pages":"Pages 871-880"},"PeriodicalIF":4.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144604780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diterpenoids and lignans from fossil Chinese medicinal succinum and their activity against renal fibrosis 中药古琥珀二萜类、木脂素及其抗肾纤维化活性研究

IF 4 2区医学

Chinese Journal of Natural Medicines Pub Date : 2025-07-01 DOI: 10.1016/S1875-5364(25)60916-2

Yefei Chen , Yunfei Wang , Yunyun Liu , Yongming Yan , Yongxian Cheng

{"title":"Diterpenoids and lignans from fossil Chinese medicinal succinum and their activity against renal fibrosis","authors":"Yefei Chen , Yunfei Wang , Yunyun Liu , Yongming Yan , Yongxian Cheng","doi":"10.1016/S1875-5364(25)60916-2","DOIUrl":"10.1016/S1875-5364(25)60916-2","url":null,"abstract":"<div><div>Five previously undescribed diterpenoids, named succipenoids D‒H (<strong>1</strong>‒<strong>5</strong>), along with four undescribed lignans, named succignans A‒D (<strong>6</strong>‒<strong>9</strong>), were isolated from the dichloromethane extract of Chinese medicinal succinum. Compounds <strong>1</strong>‒<strong>5</strong> were characterized as nor-abietane diterpenoids, while compounds <strong>6</strong>‒<strong>9</strong> were identified as lignans polymerized from two groups of phenylpropanoid units. The structures of these novel compounds, including their absolute configurations, were determined through spectroscopic and computational methods. Biological assessments of renal fibrosis demonstrated that compounds <strong>6</strong> and <strong>7</strong> effectively reduce the expression of proteins associated with renal fibrosis, including <em>α</em>-smooth muscle actin (<em>α</em>-SMA), collagen I, and fibronectin in transforming growth factor-β1 (TGF-β1) induced normal rat kidney proximal tubular epithelial cells (NRK-52e).</div></div>","PeriodicalId":10002,"journal":{"name":"Chinese Journal of Natural Medicines","volume":"23 7","pages":"Pages 888-896"},"PeriodicalIF":4.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144604784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Naturally occurring seco- and nor-polycyclic polyprenylated acylphloroglucinols: distribution, structural diversity, andbiological activity 天然存在的二环和非多环聚戊烯基酰基间苯三酚：分布、结构多样性和生物活性

IF 4 2区医学

Chinese Journal of Natural Medicines Pub Date : 2025-07-01 DOI: 10.1016/S1875-5364(25)60911-3

Yulin Duan , Ying Tang , Changxing Qi , Yonghui Zhang

{"title":"Naturally occurring seco- and nor-polycyclic polyprenylated acylphloroglucinols: distribution, structural diversity, andbiological activity","authors":"Yulin Duan , Ying Tang , Changxing Qi , Yonghui Zhang","doi":"10.1016/S1875-5364(25)60911-3","DOIUrl":"10.1016/S1875-5364(25)60911-3","url":null,"abstract":"<div><div>Polycyclic polyprenylated acylphloroglucinols (PPAPs) represent a distinct subclass of specialized metabolites predominantly found in the plant kingdom, particularly within the Guttiferae (Clusiaceae) family. These compounds exhibit remarkable structural diversity and a wide range of biological activities. <em>Seco</em>- and <em>nor</em>-PPAPs, two unique variants of PPAPs with diverse skeletal structures, have been extensively investigated. As of June 2023, 200 compounds have been isolated from four genera, with <em>Hypericum</em> being the primary source. Notably, 115 of these compounds were identified in the past four years, indicating a significant increase in research activity. <em>Seco</em>- and <em>nor</em>-PPAPs can be categorized into six main subgroups based on the original PPAP scaffolds. Biological studies have revealed their potential in various therapeutic applications, including anti-cancer, anti-inflammatory, hepatoprotective, anti-Alzheimer's disease (anti-AD), multidrug resistance (MDR) reversal, anti-depressant, neuroprotective, and immunosuppressive effects. This review provides a comprehensive overview of the occurrence, structures, and bioactivities of natural <em>seco</em>- and <em>nor</em>-PPAPs, offering valuable insights for the further development of PPAPs.</div></div>","PeriodicalId":10002,"journal":{"name":"Chinese Journal of Natural Medicines","volume":"23 7","pages":"Pages 824-837"},"PeriodicalIF":4.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144604181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

First-in-class drug oroxylin A tablets for treating hepatic and gastrointestinal disorders: from preclinical development to clinical research 治疗肝脏和胃肠道疾病的一流药物奥罗霉素A片：从临床前开发到临床研究

IF 4 2区医学

Chinese Journal of Natural Medicines Pub Date : 2025-07-01 DOI: 10.1016/S1875-5364(25)60910-1

Chengju Luo , Xuhong Li , Yuan Gao , Junyi Yang , Weiming Fang , Libin Wei

{"title":"First-in-class drug oroxylin A tablets for treating hepatic and gastrointestinal disorders: from preclinical development to clinical research","authors":"Chengju Luo , Xuhong Li , Yuan Gao , Junyi Yang , Weiming Fang , Libin Wei","doi":"10.1016/S1875-5364(25)60910-1","DOIUrl":"10.1016/S1875-5364(25)60910-1","url":null,"abstract":"<div><div>Oroxylin A (OA) is a natural flavonoid primarily derived from the plants <em>Oroxylum indicum</em> and <em>Scutellaria baicalensis</em>. Currently, OA is obtainable through chemical synthesis and exhibits polypharmacological properties, including anti-cancer, anti-inflammatory, anti-microbial, and multi-organ protective effects. The first-in-class drug OA tablets are presently undergoing phase Ib/IIa clinical trials for hepatocellular carcinoma (HCC) treatment. Substantial evidence suggests that OA demonstrates therapeutic potential against various hepatic and gastrointestinal (GI) disorders, including HCC, hepatic fibrosis, fatty liver disease, hepatitis, liver injury, colitis, and colorectal cancer (CRC). OA exerts its therapeutic effects primarily by modulating several crucial signaling pathways, including those associated with apoptosis, oxidative stress, inflammation, glucolipid metabolism, and fibrosis activation. The oral pharmacokinetics of OA is characterized by phase II metabolism, hydrolysis, and enterohepatic recycling. This review provides a comprehensive overview of the critical stages involved in the development of OA tablets, presenting a holistic perspective on the progression of this first-in-class drug from preclinical to clinical phases. It encompasses the synthesis of active pharmaceutical ingredients, pharmacokinetics, pharmacological efficacy, toxicology, drug delivery, and recent advancements in clinical trials. Importantly, this review examines the potential mechanisms by which OA may influence the gut-liver axis, hypothesizing that these interactions may confer health benefits associated with OA that transcend the limitations posed by its poor bioavailability.</div></div>","PeriodicalId":10002,"journal":{"name":"Chinese Journal of Natural Medicines","volume":"23 7","pages":"Pages 801-814"},"PeriodicalIF":4.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144604182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Natural diosmin alleviating obesity and nonalcoholic fatty liver disease by regulating the activating the AMP-activated protein kinase (AMPK) pathway 天然薯蓣皂苷通过调节活化amp活化蛋白激酶（AMPK）途径减轻肥胖和非酒精性脂肪肝疾病

IF 4 2区医学

Chinese Journal of Natural Medicines Pub Date : 2025-07-01 DOI: 10.1016/S1875-5364(25)60914-9

Can Liu , Siyu Hao , Mengdi Zhang , Xueyu Wang , Baiwang Chu , Tingjie Wen , Ruoyu Dang , Hua Sun

{"title":"Natural diosmin alleviating obesity and nonalcoholic fatty liver disease by regulating the activating the AMP-activated protein kinase (AMPK) pathway","authors":"Can Liu , Siyu Hao , Mengdi Zhang , Xueyu Wang , Baiwang Chu , Tingjie Wen , Ruoyu Dang , Hua Sun","doi":"10.1016/S1875-5364(25)60914-9","DOIUrl":"10.1016/S1875-5364(25)60914-9","url":null,"abstract":"<div><div>Obesity and metabolic dysfunction-associated steatotic liver disease (MASLD) are linked to numerous chronic conditions, including cardiovascular disease, atherosclerosis, chronic kidney disease, and type II diabetes. Previous research identified the natural flavonoid diosmin, derived from <em>Chrysanthemum morifolium</em>, as a regulator of glucose metabolism. However, its effects on lipid metabolism and underlying mechanisms remained unexplored. The AMP-activated protein kinase (AMPK) pathway serves a critical function in glucose and lipid metabolism. The relationship between diosmin and the AMPK pathway has not been previously documented. This investigation examined diosmin's capacity to reduce lipid content through AMPK pathway activation in hepatoblastoma cell line G2 (HepG2) and 3T3-L1 cells. The study revealed that diosmin inhibits lipogenesis, indicating its potential as an anti-obesity agent in obese mice. Moreover, diosmin demonstrated effective MASLD alleviation <em>in vivo</em>. These findings suggest that diosmin may represent a promising therapeutic candidate for treating obesity and MASLD.</div></div>","PeriodicalId":10002,"journal":{"name":"Chinese Journal of Natural Medicines","volume":"23 7","pages":"Pages 863-870"},"PeriodicalIF":4.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144604782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Five new meroterpenoids from Rhododendron anthopogonoides and their anti-inflammatory activity 五种杜鹃花新萜类化合物及其抗炎活性

IF 4 2区医学

Chinese Journal of Natural Medicines Pub Date : 2025-07-01 DOI: 10.1016/S1875-5364(25)60850-8

Mengtian Li , Norbu Kelsang , Yongqin Zhao , Wensen Li , Feng Zhou , Pema , Lu Cui , Xianjie Bao , Qian Wang , Xin Feng , Minghua Yang

{"title":"Five new meroterpenoids from Rhododendron anthopogonoides and their anti-inflammatory activity","authors":"Mengtian Li , Norbu Kelsang , Yongqin Zhao , Wensen Li , Feng Zhou , Pema , Lu Cui , Xianjie Bao , Qian Wang , Xin Feng , Minghua Yang","doi":"10.1016/S1875-5364(25)60850-8","DOIUrl":"10.1016/S1875-5364(25)60850-8","url":null,"abstract":"<div><div>Five meroterpenoids, rhodonoids K–M (<strong>1</strong>–<strong>2</strong>), daurichromene E (<strong>3</strong>), and grifolins A–B (<strong>4</strong>–<strong>5</strong>), together with seven known compounds (<strong>6</strong>–<strong>12</strong>), were isolated from <em>Rhododendron anthopogonoides</em>. The chemical structures of these compounds were elucidated through comprehensive analysis of high-resolution electrospray ionization mass spectrometry (HR-ESI-MS), ultraviolet (UV), infrared spectroscopy (IR), and nuclear magnetic resonance (NMR) data. Their absolute configurations were determined by comparing experimental electronic circular dichroism (ECD) spectra with computed values. Notably, compounds <strong>1</strong> and <strong>3</strong> demonstrated significant inhibitory effects on lipopolysaccharide (LPS)-induced inflammation in RAW264.7 cells. These compounds markedly suppressed the mRNA expressions of inflammatory factors, including interleukin (IL)-1β, IL-6, and tumor necrosis factor-α (TNF-α) while also down-regulating the protein expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2).</div></div>","PeriodicalId":10002,"journal":{"name":"Chinese Journal of Natural Medicines","volume":"23 7","pages":"Pages 881-887"},"PeriodicalIF":4.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144604783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Host-microbe co-metabolism system as potential targets: the promising way for natural medicine to treat atherosclerosis 宿主-微生物共代谢系统作为潜在靶点：天然药物治疗动脉粥样硬化的有前景的途径

IF 4 2区医学

Chinese Journal of Natural Medicines Pub Date : 2025-07-01 DOI: 10.1016/S1875-5364(25)60909-5

Yun Wang , Ziwei Zhou , Haiping Hao , Lijuan Cao

{"title":"Host-microbe co-metabolism system as potential targets: the promising way for natural medicine to treat atherosclerosis","authors":"Yun Wang , Ziwei Zhou , Haiping Hao , Lijuan Cao","doi":"10.1016/S1875-5364(25)60909-5","DOIUrl":"10.1016/S1875-5364(25)60909-5","url":null,"abstract":"<div><div>The host-microbe co-metabolism system, generating diverse exogenous and endogenous bioactive molecules that influence the host's immune and metabolic functions, plays a crucial role in the pathogenesis of atherosclerosis. Recent studies have elucidated the interaction between natural medicines and this co-metabolism system. Upon oral administration, natural medicine ingredients can undergo transformation by gut microbiota, potentially enhancing their bioavailability or anti-atherogenic efficacy. Furthermore, natural medicines can exert anti-atherogenic effects <em>via</em> modulation of endogenous host-microbe co-metabolism. This review presents an updated understanding of the dual association between natural medicines and host-microbe co-metabolites. It explores the critical function of microbial exogenous metabolites derived from natural medicines and uncovers the mechanisms underlying natural medicines’ intervention on key nodes of endogenous host-microbe co-metabolism. These insights may offer new perspectives for cardiovascular disease (CVD) treatment and guide future drug discovery efforts.</div></div>","PeriodicalId":10002,"journal":{"name":"Chinese Journal of Natural Medicines","volume":"23 7","pages":"Pages 790-800"},"PeriodicalIF":4.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144604778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Paclitaxel anti-cancer therapeutics: from discovery to clinical use 紫杉醇抗癌药物：从发现到临床应用

IF 4 2区医学

Chinese Journal of Natural Medicines Pub Date : 2025-07-01 DOI: 10.1016/S1875-5364(25)60833-8

Haizheng Yu , Fen Lan , Yuan Zhuang , Qizhang Li , Lianqing Zhang , Hongchang Tian , Xiao Bu , Ruibing Chen , Yingying Gao , Zhuo Wang , Lei Zhang

{"title":"Paclitaxel anti-cancer therapeutics: from discovery to clinical use","authors":"Haizheng Yu , Fen Lan , Yuan Zhuang , Qizhang Li , Lianqing Zhang , Hongchang Tian , Xiao Bu , Ruibing Chen , Yingying Gao , Zhuo Wang , Lei Zhang","doi":"10.1016/S1875-5364(25)60833-8","DOIUrl":"10.1016/S1875-5364(25)60833-8","url":null,"abstract":"<div><div>Paclitaxel (PTX), a valuable natural product derived from <em>Taxus</em> species, exhibits remarkable anti-cancer properties. It penetrates nanopores in microtubule walls, interacting with tubulin on the lumen surface and disrupting microtubule dynamics, thereby inducing cytotoxic effects in cancer cells. PTX and its derivatives have gained approval for treating various diseases due to their low toxicity, high efficiency, and broad-spectrum application. The widespread success and expanding applications of PTX have led to increased demand, raising concerns about accessibility. Consequently, researchers globally have focused on developing alternative production methods and applying nanocarriers in PTX delivery systems to enhance bioavailability. This review examines the challenges and advancements in PTX sourcing, production, physicochemical properties, anti-cancer mechanisms, clinical applications, trials, and chemo-immunotherapy. It aims to provide a comprehensive reference for the rational development and effective utilization of PTX.</div></div>","PeriodicalId":10002,"journal":{"name":"Chinese Journal of Natural Medicines","volume":"23 7","pages":"Pages 769-789"},"PeriodicalIF":4.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144604777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0