Chinese Journal of Natural Medicines最新文献

{"title":"Design and synthesis of novel saponin-triazole derivatives in the regulation of adipogenesis","authors":"Yongsheng Fang ,&nbsp;Zhiyun Zhu ,&nbsp;Chun Xie,&nbsp;Dazhen Xia,&nbsp;Huimin Zhao,&nbsp;Zihui Wang,&nbsp;Qian Lu,&nbsp;Caimei Zhang,&nbsp;Wenyong Xiong,&nbsp;Xiaodong Yang","doi":"10.1016/S1875-5364(25)60830-2","DOIUrl":"10.1016/S1875-5364(25)60830-2","url":null,"abstract":"<div><div>Saponins associated with <em>Panax notoginseng</em> (<em>P. notoginseng</em>) demonstrate significant therapeutic efficacy across multiple diseases. However, certain high-yield saponins face limited clinical applications due to their reduced pharmacological efficacy. This study synthesized and evaluated 36 saponin-1,2,3-triazole derivatives of ginsenosides Rg1/Rb1 and notoginsenoside R1 for anti-adipogenesis activity <em>in vitro</em>. The research revealed that the ginsenosides Rg1-1,2,3-triazole derivative <strong>a17</strong> demonstrates superior adipogenesis inhibitory effects. Structure-activity relationships (SARs) analysis indicates that incorporating an amidyl-substituted 1,2,3-triazole into the saponin side chain <em>via</em> Click reaction enhances anti-adipogenesis activity. Additionally, several other derivatives exhibit general adipogenesis inhibition. Compound <strong>a17</strong> demonstrated enhanced potency compared to the parent ginsenoside Rg1. Mechanistic investigations revealed that <strong>a17</strong> exhibits dose-dependent inhibition of adipogenesis <em>in vitro</em>, accompanied by decreased expression of preadipocytes. Peroxisome proliferator-activated receptor γ (PPARγ), fatty acid synthase (FAS), and fatty acid binding protein 4 (FABP4) adipogenesis regulators. These findings establish the ginsenoside Rg1-1,2,3-triazole derivative <strong>a17</strong> as a promising adipocyte differentiation inhibitor and potential therapeutic agent for obesity and associated metabolic disorders. This research provides a foundation for developing effective therapeutic approaches for various metabolic syndromes.</div></div>","PeriodicalId":10002,"journal":{"name":"Chinese Journal of Natural Medicines","volume":"23 8","pages":"Pages 920-931"},"PeriodicalIF":4.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144749691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"(±)-Talapyrones A−F: six pairs of dimeric polyketide enantiomers with unusual 6/6/6 and 6/6/6/5 ring systems from Talaromycesadpressus","authors":"Meijia Zheng ,&nbsp;Xinyi Zhao ,&nbsp;Chenxi Zhou ,&nbsp;Hong Liao ,&nbsp;Qin Li ,&nbsp;Yuling Lu ,&nbsp;Bingbing Dai ,&nbsp;Weiguang Sun ,&nbsp;Ying Ye ,&nbsp;Chunmei Chen ,&nbsp;Yonghui Zhang ,&nbsp;Hucheng Zhu","doi":"10.1016/S1875-5364(25)60928-9","DOIUrl":"10.1016/S1875-5364(25)60928-9","url":null,"abstract":"<div><div>(±)-Talapyrones A−F (<strong>1</strong>−<strong>6</strong>), six pairs of dimeric polyketide enantiomers featuring unusual 6/6/6 and 6/6/6/5 ring systems, were isolated from the fungus <em>Talaromyces adpressus</em>. Their structures were determined by spectroscopic analysis and HR-ESI-MS data, and their absolute configurations were elucidated using a modified Mosher’s method and electronic circular dichroism (ECD) calculations. (±)-Talapyrones A−F (<strong>1</strong>−<strong>6</strong>) possess a 6/6/6 tricyclic skeleton, presumably formed through a Michael addition reaction between one molecule of <em>α</em>-pyrone derivative and one molecule of C₈ poly-<em>β</em>-keto chain. In addition, compounds <strong>2</strong>/<strong>3</strong> and <strong>4</strong>/<strong>5</strong> are two pairs of C-18 epimers, respectively. Putative biosynthetic pathways of <strong>1</strong>−<strong>6</strong> were discussed.</div></div>","PeriodicalId":10002,"journal":{"name":"Chinese Journal of Natural Medicines","volume":"23 8","pages":"Pages 932-937"},"PeriodicalIF":4.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144749692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ten new lignans with anti-inflammatory activities from the leaves of Illicium dunnianum","authors":"Ting Li ,&nbsp;Xiaoqing He ,&nbsp;Dabo Pan ,&nbsp;Xiaochun Zeng ,&nbsp;Siying Zeng ,&nbsp;Zhenzhong Wang ,&nbsp;Xinsheng Yao ,&nbsp;Wei Xiao ,&nbsp;Haibo Li ,&nbsp;Yang Yu","doi":"10.1016/S1875-5364(25)60934-4","DOIUrl":"10.1016/S1875-5364(25)60934-4","url":null,"abstract":"<div><div>The anti-inflammatory phytochemical investigation of the leaves of <em>Illicium dunnianum</em> (<em>I. dunnianum</em>) resulted in the isolation of five pairs of new lignans (<strong>1</strong>–<strong>5</strong>), and 7 known analogs (<strong>6</strong>–<strong>12</strong>). The separation of enantiomer mixtures <strong>1</strong>–<strong>5</strong> to <strong>1a</strong>/<strong>1b</strong>–<strong>5a</strong>/<strong>5b</strong> was achieved using a chiral column with acetonitrile−water mixtures as eluents. The planar structures of <strong>1</strong>–<strong>2</strong> were previously undescribed, and the chiral separation and absolute configurations of <strong>3</strong>–<strong>5</strong> were reported for the first time. Their structures were determined through comprehensive spectroscopic data analysis [nuclear magnetic resonance (NMR), high-resolution electrospray ionization mass (HR-ESI-MS), infrared (IR), and ultraviolet (UV)] and quantum chemistry calculations (ECD). The new isolates were evaluated by measuring their inhibitory effect on NO in lipopolysaccharide (LPS)-stimulated BV-2 cells. Compounds <strong>1a</strong>, <strong>3a</strong>, <strong>3b</strong>, and <strong>5a</strong> demonstrated partial inhibition of NO production in a concentration-dependent manner. Western blot and real-time polymerase chain reaction (PCR) assays revealed that <strong>1a</strong> down-regulated the messenger ribonucleic acid (mRNA) levels of tumor necrosis factor α (<em>TNF-α</em>), interleukin-6 (<em>IL-6</em>), <em>COX-2</em>, and <em>iNOS</em> and the protein expressions of COX-2 and iNOS. This research provides guidance and evidence for the further development and utilization of <em>I. dunnianum</em>.</div></div>","PeriodicalId":10002,"journal":{"name":"Chinese Journal of Natural Medicines","volume":"23 8","pages":"Pages 990-996"},"PeriodicalIF":4.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144749836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combining label-free quantitative proteomics and 2D-DIGE to identify the potential targets of Sini Decoction acting on myocardial infarction","authors":"Fei Feng ,&nbsp;Weiyue Zhang ,&nbsp;Yan Cao ,&nbsp;Diya Lv ,&nbsp;Yifeng Chai ,&nbsp;Dandan Guo ,&nbsp;Xiaofei Chen","doi":"10.1016/S1875-5364(25)60937-X","DOIUrl":"10.1016/S1875-5364(25)60937-X","url":null,"abstract":"<div><div>Sini Decoction (SNT) is a traditional formula recognized for its efficacy in warming the spleen and stomach and dispersing cold. However, elucidating the mechanism of action of SNT remains challenging due to its complex multiple components. This study utilized a synergistic approach combining two-dimensional fluorescence difference in gel electrophoresis (2D-DIGE)-based drug affinity responsive target stability (DARTS) with label-free quantitative proteomics techniques to identify the direct and indirect protein targets of SNT in myocardial infarction. The analysis identified 590 proteins, with 30 proteins showing significant upregulation and 51 proteins showing downregulation when comparing the SNT group with the model group. Through the integration of 2D-DIGE DARTS with proteomics data and pharmacological assessments, the findings indicate that protein disulfide-isomerase A3 (PDIA3) may serve as a potential protein target through which SNT provides protective effects on myocardial cells during myocardial infarction.</div></div>","PeriodicalId":10002,"journal":{"name":"Chinese Journal of Natural Medicines","volume":"23 8","pages":"Pages 1016-1024"},"PeriodicalIF":4.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144749839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structurally novel tryptamine-derived alkaloids from the seeds of Peganum harmala and their antiviral activities against respiratory syncytial virus","authors":"Zhongnan Wu ,&nbsp;Yubo Zhang ,&nbsp;Guocai Wang ,&nbsp;Qing Tang ,&nbsp;Yaolan Li ,&nbsp;Xiaoqing Xie ,&nbsp;Yushen Liang ,&nbsp;Wen Cheng","doi":"10.1016/S1875-5364(25)60932-0","DOIUrl":"10.1016/S1875-5364(25)60932-0","url":null,"abstract":"<div><div><em>Peganum harmala</em> L. (<em>P. harmala</em>) is a significant economic and medicinal plant. The seeds of <em>P. harmala</em> have been extensively utilized in traditional Chinese medicine, Uighur medicine, and Mongolian medicine, as documented in the <em>Drug Standard of the Ministry of Health of China</em>. Twelve novel tryptamine-derived alkaloids (<strong>1</strong>−<strong>12</strong>) and eight known compounds (<strong>13</strong>−<strong>20</strong>) were isolated from <em>P. harmala</em> seeds. Compounds <strong>1</strong> and <strong>2</strong> represent the first reported instances of tryptamine-derived heteromers, comprising tryptamine and aniline fragments with previously undocumented C-3−N-1′ linkage and C-3−C-4′ connection, respectively. Compounds <strong>3</strong>−<strong>5</strong> were identified as indole-quinazoline heteromers, exhibiting a novel C-3 and NH-1′ linkage between indole and quinazoline-derived fragments. Compound <strong>6</strong> demonstrates the dimerization pattern of C-C linked tryptamine-quinazoline dimer. Compound <strong>8</strong> represents a tryptamine-derived heterodimer with a distinctive carbon skeleton, featuring an unusual spiro-tricyclic ring (<strong>7</strong>) and conventional bicyclic tryptamine. Compounds <strong>9</strong>−<strong>11</strong> constitute novel 6/5/5/5 spiro-tetracyclic tryptamine-derived alkaloids presenting a unique ring system of tryptamine-spiro-pyrrolizine. Compounds <strong>1</strong>−<strong>3</strong> and <strong>6</strong>−<strong>11</strong> were identified as racemates. Compounds <strong>2</strong>, <strong>7</strong>, <strong>9</strong>, <strong>10</strong>, and <strong>12</strong> were confirmed <em>via</em> X-ray crystallographic analysis. All isolated compounds (<strong>1</strong>−<strong>20</strong>) exhibited varying degrees of antiviral efficacy against respiratory syncytial virus (RSV). Notably, the anti-RSV activity of compound <strong>12</strong> (IC₅₀ 5.01 ± 0.14 μmol·L⁻¹) surpassed that of the positive control (ribavirin, IC₅₀ 6.23 ± 0.95 μmol·L⁻¹), as validated through plaque reduction and immunofluorescence assays. The identification of anti-RSV compounds from <em>P. harmala</em> seeds may enhance the development and application of this plant in antiviral therapeutic products.</div></div>","PeriodicalId":10002,"journal":{"name":"Chinese Journal of Natural Medicines","volume":"23 8","pages":"Pages 972-979"},"PeriodicalIF":4.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144749697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diketopiperazines with anti-skin inflammation from marine-derived endophytic fungus Aspergillus sp. and configurational reassignment of aspertryptanthrins","authors":"Jin Yang ,&nbsp;Xianmei Xiong ,&nbsp;Lizhi Gong ,&nbsp;Fengyu Gan ,&nbsp;Hanling Shi ,&nbsp;Bin Zhu ,&nbsp;Haizhen Wu ,&nbsp;Xiujuan Xin ,&nbsp;Lingyi Kong ,&nbsp;Faliang An","doi":"10.1016/S1875-5364(25)60933-2","DOIUrl":"10.1016/S1875-5364(25)60933-2","url":null,"abstract":"<div><div>Two novel diketopiperazines (<strong>1</strong> and <strong>5</strong>), along with ten known compounds (<strong>2</strong>−<strong>4</strong>, <strong>6</strong>−<strong>12</strong>) demonstrating significant skin inflammation inhibition, were isolated from a marine-derived fungus identified as <em>Aspergillus</em> sp. FAZW0001. The structural elucidation and configurational reassessments of compounds <strong>1</strong>−<strong>5</strong> were established through comprehensive spectral analyses, with their absolute configurations determined <em>via</em> single crystal X-ray diffraction using Cu K<em>α</em> radiation, Marfey’s method, and comparison between experimental and calculated electronic circular dichroism (ECD) spectra. Compounds <strong>1</strong>, <strong>2</strong>, and <strong>8</strong> exhibited significant anti-inflammatory activities in <em>Propionibacterium acnes</em> (<em>P. acnes</em>)-induced human monocyte cell lines. Compound <strong>8</strong> demonstrated the ability to down-regulate interleukin-1β (IL-1β) expression by inhibiting Toll-like receptor 2 (TLR2) expression and modulating the activation of myeloid differentiation factor 88 (MyD88), mitogen-activated protein kinase (MAPK), and nuclear factor <em>κ</em>B (NF-<em>κ</em>B) signaling pathways, thus reducing the cellular inflammatory response induced by <em>P. acnes</em>. Additionally, compound <strong>8</strong> showed the capacity to suppress mitochondrial reactive oxygen species (ROS) production and nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome activation, thereby reducing IL-1β maturation and secretion. A three-dimensional quantitative structure-activity relationships (3D-QSAR) model was applied to compounds <strong>5</strong>−<strong>12</strong> to analyze their anti-inflammatory structure-activity relationships.</div></div>","PeriodicalId":10002,"journal":{"name":"Chinese Journal of Natural Medicines","volume":"23 8","pages":"Pages 980-989"},"PeriodicalIF":4.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144749698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The transcriptomic-based disease network reveals synergistic therapeutic effect of total alkaloids from Coptis chinensis and total ginsenosides from Panax ginseng on type 2 diabetes mellitus","authors":"Qian Chen ,&nbsp;Shuying Zhang ,&nbsp;Xuanxi Jiang ,&nbsp;Jie Liao ,&nbsp;Xin Shao ,&nbsp;Xin Peng ,&nbsp;Zheng Wang ,&nbsp;Xiaoyan Lu ,&nbsp;Xiaohui Fan","doi":"10.1016/S1875-5364(25)60935-6","DOIUrl":"10.1016/S1875-5364(25)60935-6","url":null,"abstract":"<div><div><em>Coptis chinensis</em> Franch. and <em>Panax ginseng</em> C. A. Mey. are traditional herbal medicines with millennia of documented use and broad therapeutic applications, including anti-diabetic properties. However, the synergistic effect of total alkaloids from <em>Coptis chinensis</em> and total ginsenosides from <em>Panax ginseng</em> on type 2 diabetes mellitus (T2DM) and its underlying mechanism remain unclear. The research demonstrated that the optimal ratio of total alkaloids from <em>Coptis chinensis</em> and total ginsenosides from <em>Panax ginseng</em> was 4∶1, exhibiting maximal efficacy in improving insulin resistance and gluconeogenesis in primary mouse hepatocytes. This combination demonstrated significant synergistic effects in improving glucose tolerance, reducing fasting blood glucose (FBG), the weight ratio of epididymal white adipose tissue (eWAT), and the homeostasis model assessment of insulin resistance (HOMA-IR) in leptin receptor-deficient (db/db) mice. Subsequently, a T2DM liver-specific network was constructed based on RNA sequencing (RNA-seq) experiments and public databases by integrating transcriptional properties of disease-associated proteins and protein-protein interactions (PPIs). The network recovery index (NRI) score of the combined treatment group with a 4∶1 ratio exceeded that of groups treated with individual components. The research identified that activated adenosine 5’-monophosphate-activated protein kinase (AMPK)/acetyl-CoA carboxylase (ACC) signaling in the liver played a crucial role in the synergistic treatment of T2DM, as verified by western blot experiment in db/db mice. These findings demonstrate that the 4∶1 combination of total alkaloids from <em>Coptis chinensis</em> and total ginsenosides from <em>Panax ginseng</em> significantly improves insulin resistance and glucose and lipid metabolism disorders in db/db mice, surpassing the efficacy of individual treatments. The synergistic mechanism correlates with enhanced AMPK/ACC signaling pathway activity.</div></div>","PeriodicalId":10002,"journal":{"name":"Chinese Journal of Natural Medicines","volume":"23 8","pages":"Pages 997-1008"},"PeriodicalIF":4.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144749837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dimeric sesquiterpenoids with anti-inflammatory activities from Inula britannica","authors":"Juan Zhang ,&nbsp;Jiankun Yan ,&nbsp;Hongjun Dong ,&nbsp;Rui Zhang ,&nbsp;Jing Chang ,&nbsp;Yanli Feng ,&nbsp;Xinrong Xu ,&nbsp;Wei Li ,&nbsp;Feng Qiu ,&nbsp;Chengpeng Sun","doi":"10.1016/S1875-5364(25)60931-9","DOIUrl":"10.1016/S1875-5364(25)60931-9","url":null,"abstract":"<div><div>In continuation of research aimed at identifying anti-inflammatory agents from natural sesquiterpenoids, an activity-guided fractionation approach utilizing lipopolysaccharide (LPS)-mediated RAW264.7 cells was employed to investigate chemical constituents from <em>Inula Britannica</em> (<em>I. britannica</em>). Seven novel sesquiterpenoid dimers inulabritanoids A−G (<strong>1</strong>−<strong>7</strong>) and two novel sesquiterpenoid monomers inulabritanoids H (<strong>8</strong>) and I (<strong>9</strong>) were isolated from <em>I. britannica</em> together with eighteen known compounds (<strong>10</strong>−<strong>27</strong>). The structural elucidation was accomplished through comprehensive analysis of 1D and 2D nuclear magnetic resonance (NMR), high-resolution mass spectrometry (HR-MS), and electronic circular dichroism (ECD) spectra, complemented by quantum chemical calculations. Compounds <strong>1</strong>, <strong>2</strong>, <strong>12</strong>, <strong>16</strong>, <strong>19</strong>, and <strong>26</strong> demonstrated inhibitory effects on NO production, with IC₅₀ values of 3.65, 5.48, 3.29, 6.91, 3.12, and 5.67 μmol·L⁻¹, respectively. Mechanistic studies revealed that compound <strong>1</strong> inhibited I<em>κ</em>B kinase β (IKKβ) phosphorylation, thereby blocking nuclear factor <em>κ</em>B (NF-<em>κ</em>B) nuclear translocation, and activated the kelch-like ECH-associated protein 1 (Keap1)/nuclear factor erythroid 2-related factor 2 (Nrf2) signal pathway, leading to decreased expression of NADPH oxidase 2 (NOX-2), inducible nitric oxide synthase (iNOS), tumor necrosis factor α (TNF-α), interleukin-6 (IL-6), monocyte chemotactic protein-1 (MCP-1), IL-1β, and IL-1α and increased expression of NAD(P)H: quinone oxidoreductase 1 (NQO-1) and heme oxygenase-1 (HO-1), thus exhibiting anti-inflammatory effects <em>in vitro</em>. These results indicate that dimeric sesquiterpenoids may serve as promising candidates for anti-inflammatory drug development.</div></div>","PeriodicalId":10002,"journal":{"name":"Chinese Journal of Natural Medicines","volume":"23 8","pages":"Pages 961-971"},"PeriodicalIF":4.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144749696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in the study of pharmacotherapy for addiction to naturally-derived psychoactive substances","authors":"Kexin Xie ,&nbsp;Deli Xiao ,&nbsp;Peng Xu ,&nbsp;Haowei Shen ,&nbsp;Bin Di","doi":"10.1016/S1875-5364(25)60831-4","DOIUrl":"10.1016/S1875-5364(25)60831-4","url":null,"abstract":"<div><div>Drug addiction, a disorder characterized by chronic relapse and compulsive drug use, poses a significant threat to public safety and human health. Addictive substances can be categorized as natural, semi-synthetic, or synthetic based on their origin. Additionally, they can be classified into three groups according to their pharmacological targets: opioids, hallucinogens, and cannabinoids that act on G-protein-coupled receptors (GPCRs); alcohols, nicotine, ketamine, barbiturates, and benzodiazepines (BDZs) that affect ligand-gated ion channel-type receptors; and psychostimulants that interact with monoamine transporters. Current treatments for drug addiction primarily include substitution therapy and non-pharmacological approaches. However, these methods have limitations, particularly in addressing the underlying causes of relapse. Several drugs in clinical trials have demonstrated potential therapeutic effects for addiction to opioids, heroin, cocaine, and other substances. This review examines the origins and pharmacological mechanisms of addiction to naturally-derived psychoactive substances (NPS) and provides an overview of recent advancements in pharmacotherapy for drug addiction.</div></div>","PeriodicalId":10002,"journal":{"name":"Chinese Journal of Natural Medicines","volume":"23 8","pages":"Pages 897-908"},"PeriodicalIF":4.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144749688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New tetrahydroanthraquinones and γ-butenolides from the fungus Auxarthron umbrinum DSM3193","authors":"Ling Tian,&nbsp;Bingyu Liu,&nbsp;Qian Wei,&nbsp;Chen Zhang,&nbsp;Jiamin Shang,&nbsp;Xiaoxue Li,&nbsp;Xiuying Yang,&nbsp;Jinhua Wang,&nbsp;Youcai Hu","doi":"10.1016/S1875-5364(25)60930-7","DOIUrl":"10.1016/S1875-5364(25)60930-7","url":null,"abstract":"<div><div>Nine novel compounds, comprising seven tetrahydroanthraquinones (auxarthrolones A−G, <strong>1</strong>−<strong>7</strong>), a <em>γ</em>-butenolide glycoside (malfilamentoside E, <strong>26</strong>), and a <em>γ</em>-butenolide (auxarthrolide A, <strong>27</strong>), together with eighteen known compounds (<strong>8</strong>−<strong>25</strong>) were isolated from rice-based solid culture of <em>Auxarthron umbrinum</em> (<em>A. umbrinum</em>) DSM3193 using the one strain many compounds (OSMAC) approach. The structural elucidation of these compounds was accomplished through nuclear magnetic resonance (NMR), mass spectrometry (MS), and NMR calculation combined with DP4+ analysis or MAEΔΔ<em>δ</em> parameter, while the absolute configurations of new compounds were established through single-crystal X-ray diffraction, electronic circular dichroism (ECD) spectroscopic data analysis and/or chemical derivatization. Austrocortilutein (<strong>10</strong>) and auxarthrol H (<strong>14</strong>) demonstrated moderate cytotoxicity against U87 and U251 [half maximal inhibitory concentration (IC₅₀) 3.5−12.1 μmol·L⁻¹]. Additionally, auxarthrolone A (<strong>1</strong>), auxarthrol H (<strong>14</strong>), eupolyphagin B (<strong>15</strong>), and 7-hydroxy-2-(2-hydroxypropyl)-5-methylchromone (<strong>17</strong>) exhibited torsional effects on fibroblast proliferation challenges induced by oleic acid, thus demonstrating fibroblast proliferation-promoting activity.</div></div>","PeriodicalId":10002,"journal":{"name":"Chinese Journal of Natural Medicines","volume":"23 8","pages":"Pages 951-960"},"PeriodicalIF":4.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144749693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}