Chinese Journal of Natural Medicines最新文献

{"title":"Potential role of Natural Herbal Tea as a healthy beverage in reducing the risk of liver cancer and chronic liver disease mortality","authors":"HOU Xiaoying , LIU Yuchen , DU Hongzhi","doi":"10.1016/S1875-5364(23)60507-2","DOIUrl":"10.1016/S1875-5364(23)60507-2","url":null,"abstract":"","PeriodicalId":10002,"journal":{"name":"Chinese Journal of Natural Medicines","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139024526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abietane diterpenoids and iridoids from Caryopteris mongolica","authors":"ZHANG Shanshan ,&nbsp;MAO Xudong ,&nbsp;XU Hongtao ,&nbsp;WEI Xiaohui ,&nbsp;CHOU Guixin","doi":"10.1016/S1875-5364(23)60409-1","DOIUrl":"10.1016/S1875-5364(23)60409-1","url":null,"abstract":"<div><p>Six new abietane diterpenoids (<strong>1−6</strong>) and five undescribed iridoids (<strong>7−11</strong>) have been isolated from the aerial parts of <em>Caryopteris mongolica</em>. The intricate structural characterization of these compounds was meticulously undertaken using an array of advanced spectroscopic techniques. This process was further enhanced by the application of DP4+ probability analyses and electronic circular dichroism (ECD) calculations. Following isolation and structural elucidation, the cytotoxicity of these compounds was evaluated. Among them, compound <strong>3</strong> stood out, displaying significant cytotoxic activity against HeLa cells with an IC₅₀ value of 7.83 ± 1.28 μmol·L⁻¹. Additionally, compounds <strong>1, 2, 4, 9</strong>, and <strong>10</strong> manifested moderate cytotoxic effects on specific cell lines, with IC₅₀ values ranging from 11.7 to 20.9 μmol·L⁻¹.</p></div>","PeriodicalId":10002,"journal":{"name":"Chinese Journal of Natural Medicines","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139014208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discovery and bioassay of disubstituted β-elemene-NO donor conjugates: synergistic enhancement in the treatment of leukemia","authors":"ZHU Junlong ,&nbsp;JIANG Xiaoying ,&nbsp;LUO Xinyu ,&nbsp;GAO Yuan ,&nbsp;ZHAO Rui ,&nbsp;LI Junjie ,&nbsp;CAI Hong ,&nbsp;DANG Xiawen ,&nbsp;YE Xiangyang ,&nbsp;BAI Renren ,&nbsp;XIE Tian","doi":"10.1016/S1875-5364(23)60404-2","DOIUrl":"10.1016/S1875-5364(23)60404-2","url":null,"abstract":"<div><p>Natural products are essential sources of antitumor drugs. One such molecule, <em>β</em>-elemene, is a potent antitumor compound extracted from <em>Curcuma wenyujin</em>. In the present investigation, a series of novel 13,14-disubstituted nitric oxide (NO)-donor <em>β</em>-elemene derivatives were designed, with <em>β</em>-elemene as the foundational compound, and subsequently synthesized to evaluate their therapeutic potential against leukemia. Notably, the derivative labeled as compound <strong>13d</strong> demonstrated a potent anti-proliferative activity against the K562 cell line, with a high NO release. <em>In vivo</em> studies indicated that compound <strong>13d</strong> could effectively inhibit tumor growth, exhibiting no discernible toxic manifestations. Specifically, a significant tumor growth inhibition rate of 62.9% was observed in the K562 xenograft tumor mouse model. The accumulated data propound the potential therapeutic application of compound <strong>13d</strong> in the management of leukemia.</p></div>","PeriodicalId":10002,"journal":{"name":"Chinese Journal of Natural Medicines","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138988550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tu-Xian Decoction ameliorates diabetic cognitive impairment by inhibiting DAPK-1","authors":"WANG Danyang ,&nbsp;YAN Bin ,&nbsp;WANG An ,&nbsp;SUN Qing ,&nbsp;PANG Junyi ,&nbsp;CUI Yangming ,&nbsp;TIAN Guoqing","doi":"10.1016/S1875-5364(23)60428-5","DOIUrl":"10.1016/S1875-5364(23)60428-5","url":null,"abstract":"<div><p>Tu-Xian decoction (TXD), a traditional Chinese medicine (TCM) formula, has been frequently administered to manage diabetic cognitive impairment (DCI). Despite its widespread use, the mechanisms underlying TXD’s protective effects on DCI have yet to be fully elucidated. As a significant regulator in neurodegenerative conditions, death-associated protein kinase-1 (DAPK-1) serves as a focus for understanding the action of TXD. This study was designed to whether TXD mediates its beneficial outcomes by inhibiting DAPK-1. To this end, a diabetic model was established using Sprague-Dawley (SD) rats through a high-fat, high-sugar (HFHS) diet regimen, followed by streptozotocin (STZ) injection. The experimental cohort was stratified into six groups: Control, Diabetic, TC-DAPK6, high-dose TXD, medium-dose TXD, and low-dose TXD groups. Following a 12-week treatment period, various assessments—including blood glucose levels, body weight measurements, Morris water maze (MWM) testing for cognitive function, brain magnetic resonance imaging (MRI), and histological analyses using hematoxylin-eosin (H&amp;E), and Nissl staining—were conducted. Protein expression in the hippocampus was quantified through Western blotting analysis. The results revealed that TXD significantly improved spatial learning and memory abilities, and preserved hippocampal structure in diabetic rats. Importantly, TXD administration led to a down-regulation of proteins indicative of neurological damage and suppressed DAPK-1 activity within the hippocampal region. These results underscore TXD's potential in mitigating DCI<em>via</em> DAPK-1 inhibition, positioning it as a viable therapeutic candidate for addressing this condition. Further investigation into TXD's molecular mechanisms may elucidate new pathways for the treatment of DCI.</p></div>","PeriodicalId":10002,"journal":{"name":"Chinese Journal of Natural Medicines","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139014270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional characterization of CYP81C16 involved in the tanshinone biosynthetic pathway in Salvia miltiorrhiza","authors":"REN Li ,&nbsp;LUO Linglong ,&nbsp;HU Zhimin ,&nbsp;MA Ying ,&nbsp;WANG Jian ,&nbsp;CHENG Yatian ,&nbsp;JIN Baolong ,&nbsp;CHEN Tong ,&nbsp;TANG Jinfu ,&nbsp;CUI Guanghong ,&nbsp;GUO Juan ,&nbsp;HUANG Luqi","doi":"10.1016/S1875-5364(23)60484-4","DOIUrl":"10.1016/S1875-5364(23)60484-4","url":null,"abstract":"<div><p>Danshen, the dried roots and rhizomes of <em>Salvia miltiorrhiza</em> Bunge (<em>S. miltiorrhiza</em>), is widely used in the treatment of cardiovascular and cerebrovascular diseases. Tanshinones, the bioactive compounds from Danshen, exhibit a wide spectrum of pharmacological properties, suggesting their potential for future therapeutic applications. Tanshinone biosynthesis is a complex process involving at least six P450 enzymes that have been identified and characterized, most of which belong to the CYP76 and CYP71 families. In this study, CYP81C16, a member of the CYP71 clan, was identified in <em>S. miltiorrhiza</em>. An <em>in vitro</em> assay revealed that it could catalyze the hydroxylation of four <em>para</em>-quinone-type tanshinones, namely neocryptotanshinone, deoxyneocryptotanshinone, and danshenxinkuns A and B. SmCYP81C16 emerged as a potential broad-spectrum oxidase targeting the C-18 position of <em>para</em>-quinone-type tanshinones with an impressive relative conversion rate exceeding 90%. Kinetic evaluations and<em>in vivo</em> assays underscored its highest affinity towards neocryptotanshinone among the tested substrates. The overexpression of SmCYP81C16 promoted the accumulation of (iso)tanshinone in hairy root lines. The characterization of SmCYP81C16 in this study accentuates its potential as a pivotal tool in the biotechnological production of tanshinones, either through microbial or plant metabolic engineering.</p></div>","PeriodicalId":10002,"journal":{"name":"Chinese Journal of Natural Medicines","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139014304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-hepatitis B virus activities of natural products and their antiviral mechanisms","authors":"DENG Wanyu ,&nbsp;CHEN Fu ,&nbsp;ZHAO Yue ,&nbsp;ZHOU Ming ,&nbsp;GUO Min","doi":"10.1016/S1875-5364(23)60505-9","DOIUrl":"https://doi.org/10.1016/S1875-5364(23)60505-9","url":null,"abstract":"<div><p>Chronic hepatitis B (CHB) infections caused by the hepatitis B virus (HBV) continue to pose a significant global public health challenge. Currently, the approved treatments for CHB are limited to interferon and nucleos(t)ide analogs, both of which have their limitations, and achieving a complete cure remains an elusive goal. Therefore, the identification of new therapeutic targets and the development of novel antiviral strategies are of utmost importance. Natural products (NPs) constitute a class of substances known for their diverse chemical structures, wide-ranging biological activities, and low toxicity profiles. They have shown promise as potential candidates for combating various diseases, with a substantial number demonstrating anti-HBV properties. This comprehensive review focuses on the current applications of NPs in the fight against HBV and provides a summary of their antiviral mechanisms, considering their impact on the viral life cycle and host hepatocytes. By offering insights into the world of anti-HBV NPs, this review aims to furnish valuable information to support the future development of antiviral drugs.</p></div>","PeriodicalId":10002,"journal":{"name":"Chinese Journal of Natural Medicines","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138453523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mulberry leaf flavonoids activate BAT and induce browning of WAT to improve type 2 diabetes via regulating the AMPK/SIRT1/PGC-1α signaling pathway","authors":"CHENG Long ,&nbsp;SHI Lu ,&nbsp;HE Changhao ,&nbsp;WANG Chen ,&nbsp;LV Yinglan ,&nbsp;LI Huimin ,&nbsp;AN Yongcheng ,&nbsp;DUAN Yuhui ,&nbsp;DAI Hongyu ,&nbsp;ZHANG Huilin ,&nbsp;HUANG Yan ,&nbsp;FU Wanxin ,&nbsp;SUN Weiguang ,&nbsp;ZHAO Baosheng","doi":"10.1016/S1875-5364(23)60481-9","DOIUrl":"https://doi.org/10.1016/S1875-5364(23)60481-9","url":null,"abstract":"<div><p>Mulberry (<em>Morus alba</em> L.) leaf is a well-established traditional Chinese botanical and culinary resource. It has found widespread application in the management of diabetes. The bioactive constituents of mulberry leaf, specifically mulberry leaf flavonoids (MLFs), exhibit pronounced potential in the amelioration of type 2 diabetes (T2D). This potential is attributed to their ability to safeguard pancreatic β cells, enhance insulin resistance, and inhibit α-glucosidase activity. Our antecedent research findings underscore the substantial therapeutic efficacy of MLFs in treating T2D. However, the precise mechanistic underpinnings of MLF’s anti-T2D effects remain the subject of inquiry. Activation of brown/beige adipocytes is a novel and promising strategy for T2D treatment. In the present study, our primary objective was to elucidate the impact of MLFs on adipose tissue browning in <em>db/db</em> mice and 3T3-L1 cells and elucidate its underlying mechanism. The results manifested that MLFs reduced body weight and food intake, alleviated hepatic steatosis, improved insulin sensitivity, and increased lipolysis and thermogenesis in <em>db/db</em> mice. Moreover, MLFs activated brown adipose tissue (BAT) and induced the browning of inguinal white adipose tissue (IWAT) and 3T3-L1 adipocytes by increasing the expressions of brown adipocyte marker genes and proteins such as uncoupling protein 1 (<em>UCP1</em>) and beige adipocyte marker genes such as transmembrane protein 26 (<em>Tmem26</em>), thereby promoting mitochondrial biogenesis. Mechanistically, MLFs facilitated the activation of BAT and the induction of WAT browning to ameliorate T2D primarily through the activation of AMP-activated protein kinase (AMPK)/sirtuin 1 (SIRT1)/peroxisome proliferator-activated receptor-gamma coactivator 1α (PGC-1α) signaling pathway. These findings highlight the unique capacity of MLF to counteract T2D by enhancing BAT activation and inducing browning of IWAT, thereby ameliorating glucose and lipid metabolism disorders. As such, MLFs emerge as a prospective and innovative browning agent for the treatment of T2D.</p></div>","PeriodicalId":10002,"journal":{"name":"Chinese Journal of Natural Medicines","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138453526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SBC (Sanhuang Xiexin Tang combined with Baihu Tang plus Cangzhu) alleviates NAFLD by enhancing mitochondrial biogenesis and ameliorating inflammation in obese patients and mice","authors":"REN Zhitao ,&nbsp;XIAO Gemin ,&nbsp;CHEN Yixin ,&nbsp;WANG Linli ,&nbsp;XIANG Xiaoxin ,&nbsp;YANG Yi ,&nbsp;WEN Siying ,&nbsp;XIE Zhiyong ,&nbsp;LUO Wenhui ,&nbsp;LI Guowei ,&nbsp;ZHENG Wenhua ,&nbsp;QIAN Xiaoxian ,&nbsp;HAI Rihan ,&nbsp;YANG Liansheng ,&nbsp;ZHU Yanhua ,&nbsp;CAI Mengyin ,&nbsp;YE Yinong ,&nbsp;SHI Guojun ,&nbsp;CHEN Yanming","doi":"10.1016/S1875-5364(23)60469-8","DOIUrl":"https://doi.org/10.1016/S1875-5364(23)60469-8","url":null,"abstract":"<div><p>In the context of non-alcoholic fatty liver disease (NAFLD), characterized by dysregulated lipid metabolism in hepatocytes, the quest for safe and effective therapeutics targeting lipid metabolism has gained paramount importance. Sanhuang Xiexin Tang (SXT) and Baihu Tang (BHT) have emerged as prominent candidates for treating metabolic disorders. SXT combined with BHT plus Cangzhu (SBC) has been used clinically for Weihuochisheng obese patients. This retrospective analysis focused on assessing the anti-obesity effects of SBC in Weihuochisheng obese patients. We observed significant reductions in body weight and hepatic lipid content among obese patients following SBC treatment. To gain further insights, we investigated the effects and underlying mechanisms of SBC in HFD-fed mice. The results demonstrated that SBC treatment mitigated body weight gain and hepatic lipid accumulation in HFD-fed mice. Pharmacological network analysis suggested that SBC may affect lipid metabolism, mitochondria, inflammation, and apoptosis—a hypothesis supported by the hepatic transcriptomic analysis in HFD-fed mice treated with SBC. Notably, SBC treatment was associated with enhanced hepatic mitochondrial biogenesis and the inhibition of the c-Jun N-terminal kinase (JNK)/nuclear factor-kappa B (NF-κB) and extracellular signal-regulated kinase (ERK)/NF-κB pathways. In conclusion, SBC treatment alleviates NAFLD in both obese patients and mouse models by improving lipid metabolism, potentially through enhancing mitochondrial biogenesis. These effects, in turn, ameliorate inflammation in hepatocytes.</p></div>","PeriodicalId":10002,"journal":{"name":"Chinese Journal of Natural Medicines","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138453527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Six new coumarins from the roots of Toddalia asiatica and their anti-inflammatory activities","authors":"HE Haoxuan ,&nbsp;LI Niping ,&nbsp;FAN Yunqi ,&nbsp;HUANG Qian ,&nbsp;SONG Jianguo ,&nbsp;LV Lixia ,&nbsp;LIU Fen ,&nbsp;WANG Lei ,&nbsp;WANG Qi ,&nbsp;GU Jihong","doi":"10.1016/S1875-5364(23)60480-7","DOIUrl":"https://doi.org/10.1016/S1875-5364(23)60480-7","url":null,"abstract":"<div><p>We reported the discovery of six novel coumarins, toddasirins A–F (<strong>1</strong>–<strong>6</strong>), each endowed with modified isoprenyl or geranyl side chains, derived from the roots of <em>Toddalia asiatica</em>. Comprehensive structural elucidation was achieved through multispectroscopic analyses, single-crystal X-ray diffraction experiments, and advanced quantum mechanical electronic circular dichroism (ECD) calculations. Furthermore, the anti-inflammatory activity of these compounds was assessed. Notably, compounds <strong>1</strong>–<strong>3</strong> and <strong>6</strong> demonstrated notable inhibitory effects on nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW 264.7 cells, with 50% inhibitory concentration (IC₅₀) values of 3.22, 4.78, 8.90, and 4.31 μmol·L⁻¹, respectively.</p></div>","PeriodicalId":10002,"journal":{"name":"Chinese Journal of Natural Medicines","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138453529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of Bulbocodin D and C as novel STAT3 inhibitors and their anticancer activities in lung cancer cells","authors":"HE Xinyu ,&nbsp;FU Jiarui ,&nbsp;LYU Wenyu ,&nbsp;HUANG Muyang ,&nbsp;MO Jianshan ,&nbsp;CHENG Yaxin ,&nbsp;XU Yulian ,&nbsp;ZHENG Lijun ,&nbsp;ZHANG Xiaolei ,&nbsp;QI Lu ,&nbsp;ZHANG Lele ,&nbsp;ZHENG Ying ,&nbsp;HUANG Mingqing ,&nbsp;NI Lin ,&nbsp;LU Jinjian","doi":"10.1016/S1875-5364(23)60521-7","DOIUrl":"https://doi.org/10.1016/S1875-5364(23)60521-7","url":null,"abstract":"<div><p>Cancer stands as one of the predominant causes of mortality globally, necessitating ongoing efforts to develop innovative therapeutics. Historically, natural products have been foundational in the quest for anticancer agents. Bulbocodin D (BD) and Bulbocodin C (BC), two bibenzyls derived from <em>Pleione bulbocodioides</em> (Franch.) Rolfe, have demonstrated notable <em>in vitro</em> anticancer activity. In human lung cancer A549 cells, the IC_50s for BD and BC were 11.63 and 11.71 μmol·L⁻¹, respectively. BD triggered apoptosis, as evidenced by an upsurge in Annexin V-positive cells and elevated protein expression of cleaved-PARP in cancer cells. Furthermore, BD and BC markedly inhibited the migratory and invasive potentials of A549 cells. The altered genes identified through RNA-sequencing analysis were integrated into the CMap dataset, suggesting BD’s role as a potential signal transducer and activator of transcription 3 (STAT3) inhibitor. SwissDock and MOE analyses further revealed that both BD and BC exhibited a commendable binding affinity with STAT3. Additionally, a surface plasmon resonance assay confirmed the direct binding affinity between these compounds and STAT3. Notably, treatment with either BD or BC led to a significant reduction in p-STAT3 (Tyr 705) protein levels, regardless of interleukin-6 stimulation in A549 cells. In addition, the extracellular signal-regulated kinase (ERK) was activated after BD or BC treatment. An enhancement in cancer cell mortality was observed upon combined treatment of BD and U0126, the MEK1/2 inhibitor. In conclusion, BD and BC emerge as promising novel STAT3 inhibitors with potential implications in cancer therapy.</p></div>","PeriodicalId":10002,"journal":{"name":"Chinese Journal of Natural Medicines","volume":null,"pages":null},"PeriodicalIF":4.6,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138453528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}