从金丝桃中发现抗肝缺血/再灌注损伤的生物活性多环聚丙烯化酰基间苯三酚

IF 4.9 2区医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE

Chinese Journal of Natural Medicines Pub Date : 2025-09-01 DOI:10.1016/S1875-5364(25)60975-7

Bo Tao , Xiangli Zhao , Zhengyi Shi , Jie Li , Yulin Duan , Xiaosheng Tan , Gang Chen , Changxing Qi , Yonghui Zhang

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引用次数: 0

摘要

肝缺血/再灌注损伤（IRI）仍然是肝脏手术后移植物功能障碍的重要并发症。作为对肝保护天然产物的持续研究的一部分，从桃金丝桃中分离出了五种以前未报道的同形adaman烷型多环聚戊烯酰酰基间苯三酚（PPAPs），命名为hyperhomanons A-E(1 - 5)，和一种已知的类似物hypersampsone O(6)。其中，化合物6对cocl2诱导的肝细胞缺氧损伤具有有效的保护作用。此外，在血管闭塞引起的小鼠肝脏IRI模型中，6预处理可显著减轻肝损伤，减少肝细胞凋亡。这项研究首次确定PPAPs是开发针对肝脏IRI的治疗药物的有希望的支架，强调了它们作为缺血性肝病药物开发先导化合物的潜力。

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Discovery of bioactive polycyclic polyprenylated acylphloroglucinol from Hypericum patulum that protects against hepatic ischemia/reperfusion injury

Hepatic ischemia/reperfusion injury (IRI) remains a critical complication contributing to graft dysfunction following liver surgery. As part of an ongoing search for hepatoprotective natural products, five previously unreported homoadamantane-type polycyclic polyprenylated acylphloroglucinols (PPAPs), named hyperhomanoons A–E (1−5), and one known analog, hypersampsone O (6), were isolated from Hypericum patulum. Among these, compound 6 demonstrated potent protective effects against CoCl₂-induced hypoxic injury in hepatocytes. Furthermore, in a murine model of hepatic IRI induced by vascular occlusion, pretreatment with 6 markedly alleviated liver damage and reduced hepatocyte apoptosis. This study is the first to identify PPAPs as promising scaffolds for the development of therapeutic agents targeting hepatic IRI, underscoring their potential as lead compounds in drug discovery efforts for ischemic liver diseases.

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来源期刊

Chinese Journal of Natural Medicines INTEGRATIVE & COMPLEMENTARY MEDICINE-PHARMACOLOGY & PHARMACY

CiteScore

7.50

自引率

4.30%

发文量

2235

期刊介绍： The Chinese Journal of Natural Medicines (CJNM), founded and sponsored in May 2003 by China Pharmaceutical University and the Chinese Pharmaceutical Association, is devoted to communication among pharmaceutical and medical scientists interested in the advancement of Traditional Chinese Medicines (TCM). CJNM publishes articles relating to a broad spectrum of bioactive natural products, leading compounds and medicines derived from Traditional Chinese Medicines (TCM). Topics covered by the journal are: Resources of Traditional Chinese Medicines; Interaction and complexity of prescription; Natural Products Chemistry (including structure modification, semi-and total synthesis, bio-transformation); Pharmacology of natural products and prescription (including pharmacokinetics and toxicology); Pharmaceutics and Analytical Methods of natural products.