Leveraging microbial natural products for pharmaceutical innovation: a vision of inspiration and future prospects

IF 4.9 2区医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE

Chinese Journal of Natural Medicines Pub Date : 2025-09-01 DOI:10.1016/S1875-5364(25)60971-X

Junbiao Yang , Jiwen Wang , Mengqun Liu , Xuzhe Zhou , Dong Feng , Hanxiang Jiang , Xinna Liu , Lu Chen , Ying Wang

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引用次数: 0

Abstract

Microorganisms, abundant in nature, are prolific producers of a diverse array of natural products (NPs) that are fundamental in the development of innovative therapeutics. Despite their significant potential, the field faces considerable challenges, including the continuous emergence of potential health threats, as well as novel pathogen strains and viruses. The advent and implementation of advanced technologies, such as culture strategies, genomics mining, and artificial intelligence (AI), are facilitating a paradigm shift in pharmaceutical research, introducing innovative methodologies and perspectives. The development and maturation of these technologies have enhanced the exploration of microbial-derived NPs, thereby advancing pharmaceutical research and development. This review synthesizes recent developments in this context, emphasizing their applications in pharmaceutical discovery and development. Through systematic analysis and synthesis, it provides objective insights into the promising prospects and future direction of this essential field.

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利用微生物天然产物进行药物创新：灵感和未来前景的愿景

自然界中丰富的微生物是多种天然产物（NPs）的多产生产者，这些天然产物是创新疗法发展的基础。尽管潜力巨大，但该领域面临着相当大的挑战，包括不断出现潜在的健康威胁，以及新的病原体菌株和病毒。先进技术的出现和实施，如培养策略、基因组学挖掘和人工智能（AI），正在促进制药研究的范式转变，引入创新的方法和观点。这些技术的发展和成熟促进了对微生物源性NPs的探索，从而推动了药物研究和开发。本文综述了这方面的最新进展，强调了它们在药物发现和开发中的应用。通过系统的分析和综合，对这一重要领域的前景和未来发展方向提供了客观的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chinese Journal of Natural Medicines INTEGRATIVE & COMPLEMENTARY MEDICINE-PHARMACOLOGY & PHARMACY

CiteScore

7.50

自引率

4.30%

发文量

2235

期刊介绍： The Chinese Journal of Natural Medicines (CJNM), founded and sponsored in May 2003 by China Pharmaceutical University and the Chinese Pharmaceutical Association, is devoted to communication among pharmaceutical and medical scientists interested in the advancement of Traditional Chinese Medicines (TCM). CJNM publishes articles relating to a broad spectrum of bioactive natural products, leading compounds and medicines derived from Traditional Chinese Medicines (TCM). Topics covered by the journal are: Resources of Traditional Chinese Medicines; Interaction and complexity of prescription; Natural Products Chemistry (including structure modification, semi-and total synthesis, bio-transformation); Pharmacology of natural products and prescription (including pharmacokinetics and toxicology); Pharmaceutics and Analytical Methods of natural products.