Chinese Journal of Natural Medicines最新文献

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Platycodon grandiflorus polysaccharides combined with hesperidin exerted the synergistic effect of relieving ulcerative colitis in mice by modulating PI3K/AKT and JAK2/STAT3 signaling pathways 桔梗多糖联合橙皮苷通过调节PI3K/AKT和JAK2/STAT3信号通路发挥缓解小鼠溃疡性结肠炎的协同作用
IF 4 2区 医学
Chinese Journal of Natural Medicines Pub Date : 2025-07-01 DOI: 10.1016/S1875-5364(25)60913-7
Yang Liu , Quanwei Sun , Xuefei Xu , Mengmeng Li , Wenheng Gao , Yunlong Li , Ye Yang , Dengke Yin
{"title":"Platycodon grandiflorus polysaccharides combined with hesperidin exerted the synergistic effect of relieving ulcerative colitis in mice by modulating PI3K/AKT and JAK2/STAT3 signaling pathways","authors":"Yang Liu ,&nbsp;Quanwei Sun ,&nbsp;Xuefei Xu ,&nbsp;Mengmeng Li ,&nbsp;Wenheng Gao ,&nbsp;Yunlong Li ,&nbsp;Ye Yang ,&nbsp;Dengke Yin","doi":"10.1016/S1875-5364(25)60913-7","DOIUrl":"10.1016/S1875-5364(25)60913-7","url":null,"abstract":"<div><div>Ulcerative colitis (UC) is a chronic inflammatory disorder with a complex etiology, characterized by intestinal inflammation and barrier dysfunction. <em>Platycodon grandiflorus</em> polysaccharides (PGP), the primary component of <em>Platycodon grandiflorus</em>, and hesperidin (Hesp), a prominent active component in <em>Citrus aurantium</em> L. (CAL), have both demonstrated anti-inflammatory properties. This study aims to elucidate the underlying mechanism of the synergistic effect of PGP combined with Hesp on UC, focusing on the coordinated interaction between the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) and Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) signaling pathways. A mouse model of UC induced by dextran sulfate sodium (DSS) and a cell model using lipopolysaccharide (LPS)-induced RAW264.7/IEC6 cells were employed to investigate the <em>in vitro</em> and <em>in vivo</em> anti-inflammatory effects of PGP combined with Hesp on UC and its potential mechanism of action. The results indicated that compared to the effects of either drug alone, the combination of PGP and Hesp significantly modulated inflammatory factor levels, inhibited oxidative stress, regulated colonic mucosal immunity, suppressed apoptosis, and restored intestinal barrier function <em>in vitro</em> and <em>in vivo</em>. Further <em>in vitro</em> studies revealed that PGP significantly inhibited the PI3K/AKT signaling pathway, while Hesp significantly inhibited the JAK2/STAT3 signaling pathway. The use of inhibitors and activators targeting both pathways validated the synergistic effects of PGP combined with Hesp on the PI3K/AKT and JAK2/STAT3 signaling pathways. These findings suggest that PGP combined with Hesp exhibits a synergistic effect on DSS-induced colitis, potentially mediated through the phosphatase and tensin homolog (PTEN)/PI3K/AKT and interleukin-6 (IL-6)/JAK2/STAT3 signaling pathways.</div></div>","PeriodicalId":10002,"journal":{"name":"Chinese Journal of Natural Medicines","volume":"23 7","pages":"Pages 848-862"},"PeriodicalIF":4.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144604781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Withanolide derivatives from Physalis angulata var. villosa and their cytotoxic activities 长绒Physalis varululata vlolosa .绒毛中的Withanolide衍生物及其细胞毒活性
IF 4 2区 医学
Chinese Journal of Natural Medicines Pub Date : 2025-06-01 DOI: 10.1016/S1875-5364(25)60881-8
Peng Wang , Jue Yang , Yu Zhang , Jun Jin , Meijun Chen , Xiaojiang Hao , Chunmao Yuan , Ping Yi
{"title":"Withanolide derivatives from Physalis angulata var. villosa and their cytotoxic activities","authors":"Peng Wang ,&nbsp;Jue Yang ,&nbsp;Yu Zhang ,&nbsp;Jun Jin ,&nbsp;Meijun Chen ,&nbsp;Xiaojiang Hao ,&nbsp;Chunmao Yuan ,&nbsp;Ping Yi","doi":"10.1016/S1875-5364(25)60881-8","DOIUrl":"10.1016/S1875-5364(25)60881-8","url":null,"abstract":"<div><div>A comprehensive phytochemical investigation of the leaves and twigs of <em>Physalis angulata.</em> var. <em>villosa</em> resulted in the isolation of 23 withanolide derivatives, including one novel 13,20-<em>γ</em>-lactone withanolide derivative (<strong>1</strong>) and three new withanolide derivatives (<strong>2</strong>−<strong>4</strong>). Architecturally, physalinin A (<strong>1</strong>) represents the first identified type B withanolide featuring a 13,20-<em>γ</em>-lactone moiety. The molecular structures of all isolates were elucidated using an integrated approach combining nuclear magnetic resonance (NMR) spectroscopy, mass spectrometry (MS), infrared (IR) spectroscopy, and quantum chemical calculations to confirm structural assignments. The antiproliferative activities of all isolated withanolides were evaluated against four human cancer cell lines (HEL, HCT-116, Colo320DM, and MDA-MB-231). Among them, eight derivatives (<strong>2</strong>, <strong>5</strong>–<strong>8</strong>, <strong>14</strong>, <strong>15</strong>, and <strong>23</strong>) exhibited significant inhibitory effects, with half-maximal inhibitory concentration (IC<sub>50</sub>) values of 0.18 ± 0.03 to 17.02 ± 0.21 μmol·L<sup>−1</sup>. Structure-activity relationship (SAR) analysis suggested that the presence of an epoxide ring enhances anticancer activity, potentially through increased reactivity or specific interactions with molecular targets involved in cancer progression. These findings underscore the pharmacological potential of withanolides as promising lead compounds for the development of novel anticancer therapeutics.</div></div>","PeriodicalId":10002,"journal":{"name":"Chinese Journal of Natural Medicines","volume":"23 6","pages":"Pages 762-768"},"PeriodicalIF":4.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144331322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Deciphering the therapeutic potential and mechanisms of Artemisia argyit essential oil on flagellum-mediated Salmonella infections 解读艾叶精油对鞭毛介导的沙门氏菌感染的治疗潜力和机制
IF 4 2区 医学
Chinese Journal of Natural Medicines Pub Date : 2025-06-01 DOI: 10.1016/S1875-5364(25)60890-9
Linlin Ding , Lei Xu , Na Hu , Jianfeng Wang , Jiazhang Qiu , Qingjie Li , Xuming Deng
{"title":"Deciphering the therapeutic potential and mechanisms of Artemisia argyit essential oil on flagellum-mediated Salmonella infections","authors":"Linlin Ding ,&nbsp;Lei Xu ,&nbsp;Na Hu ,&nbsp;Jianfeng Wang ,&nbsp;Jiazhang Qiu ,&nbsp;Qingjie Li ,&nbsp;Xuming Deng","doi":"10.1016/S1875-5364(25)60890-9","DOIUrl":"10.1016/S1875-5364(25)60890-9","url":null,"abstract":"<div><div>Salmonellosis represents a global epidemic, and the emergence of extensively drug-resistant (XDR) <em>Salmonella</em> and its sustained transmission worldwide constitutes a significant public health concern. Flagellum-mediated motility serves as a crucial virulence trait of <em>Salmonella</em> that guides the pathogen toward the epithelial surface, enhancing gut colonization. <em>Artemisia argyit</em> essential oil, a traditional herb extract, demonstrates efficacy in treating inflammation-related symptoms and diseases; however, its effects on flagellum assembly and expression mechanisms in anti-<em>Salmonella</em> activity remain inadequately explored. This study aimed to elucidate the mechanism by which <em>Artemisia argyit</em> essential oil addresses <em>Salmonella</em> infections. Network pharmacological analysis revealed that Traditional Chinese Medicine (TCM) <em>Artemisia argyit</em> exhibited anti-<em>Salmonella</em> infection potential and inhibited flagellum-dependent motility. The application of <em>Artemisia argyit</em> essential oil induced notable motility defects through the downregulation of flagellar and fimbriae expression. Moreover, it significantly reduced <em>Salmonella</em>-infected cell damage by interfering with flagellum-mediated <em>Salmonella</em> colonization. <em>In vivo</em> studies demonstrated that <em>Artemisia argyit</em> essential oil administration effectively alleviated <em>Salmonella</em> infection symptoms by reducing bacterial loads, inhibiting interleukin-1 beta (IL-1β), IL-6, and tumor necrosis factor-alpha (TNF-α) production, and diminishing pathological injury. Gas chromatography-mass spectrometry (GC-MS) analysis identified forty-three compounds in <em>Artemisia argyit</em> essential oil, with their corresponding targets and active ingredients predicted. Investigation of an <em>in vivo</em> model of <em>Salmonella</em> infection using the active ingredient demonstrated that alpha-cedrene ameliorated <em>Salmonella</em> infection. These findings suggest the potential application of <em>Artemisia argyit</em> essential oil in controlling <em>Salmonella</em>, the predominant food-borne pathogen.</div></div>","PeriodicalId":10002,"journal":{"name":"Chinese Journal of Natural Medicines","volume":"23 6","pages":"Pages 714-726"},"PeriodicalIF":4.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144331317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bioactivity-guided discovery of antiviral templichalasins A‒C from the endophytic fungus Aspergillus templicola 从内生真菌templicola Aspergillus templichalasins A-C中生物活性导向的抗病毒药物的发现
IF 4 2区 医学
Chinese Journal of Natural Medicines Pub Date : 2025-06-01 DOI: 10.1016/S1875-5364(25)60880-6
Teng Cai , Jingzu Sun , Wenxuan Chen , Qiang He , Baosong Chen , Yulong He , Peng Zhang , Yanhong Wei , Hongwei Liu , Xiaofeng Cai
{"title":"Bioactivity-guided discovery of antiviral templichalasins A‒C from the endophytic fungus Aspergillus templicola","authors":"Teng Cai ,&nbsp;Jingzu Sun ,&nbsp;Wenxuan Chen ,&nbsp;Qiang He ,&nbsp;Baosong Chen ,&nbsp;Yulong He ,&nbsp;Peng Zhang ,&nbsp;Yanhong Wei ,&nbsp;Hongwei Liu ,&nbsp;Xiaofeng Cai","doi":"10.1016/S1875-5364(25)60880-6","DOIUrl":"10.1016/S1875-5364(25)60880-6","url":null,"abstract":"<div><div>The bioactivity-guided isolation of potentially active natural products has been widely utilized in pharmaceutical discovery. In this study, by screening fungal extracts against coxsackievirus B3 (CVB3), three new aspochalasins, templichalasins A‒C (<strong>1</strong>‒<strong>3</strong>), along with six known aspochalasins (<strong>4</strong>‒<strong>9</strong>) were isolated from an active extract derived from the endophytic fungus <em>Aspergillus templicola</em> LHWf045. Compound <strong>1</strong> features a unique 5/6/5/7/5 pentacyclic ring system, while compounds <strong>2</strong> and <strong>3</strong> possess unusual 5/6/6/7 tetracyclic skeletons. Their structures were characterized through extensive spectroscopic analyses, electronic circular dichroism (ECD) calculations, and single-crystal X-ray diffraction analysis. Additionally, we demonstrated that compound <strong>4</strong> can be readily converted into compounds <strong>1</strong>‒<strong>3</strong> under mild acidic conditions and proposed a plausible mechanism for this conversion. Bioactivity evaluation of compounds <strong>1</strong>‒<strong>9</strong> against CVB3 revealed the inhibitory effects of all compounds against the virus. Notably, compound <strong>9</strong> exhibited superior antiviral activity, surpassing the commercial drug ribavirin in selectivity index (SI) value.</div></div>","PeriodicalId":10002,"journal":{"name":"Chinese Journal of Natural Medicines","volume":"23 6","pages":"Pages 754-761"},"PeriodicalIF":4.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144331321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The potential therapeutic role of ginsenosides on fibrosis-associated diseases: a review on molecular mechanisms and call for further research 人参皂苷对纤维化相关疾病的潜在治疗作用:分子机制综述及进一步研究的展望
IF 4 2区 医学
Chinese Journal of Natural Medicines Pub Date : 2025-06-01 DOI: 10.1016/S1875-5364(25)60817-X
Mengguang Wei , Yue Zhang , Xiaomeng Sun , Lianwen Qi , Qun Liu
{"title":"The potential therapeutic role of ginsenosides on fibrosis-associated diseases: a review on molecular mechanisms and call for further research","authors":"Mengguang Wei ,&nbsp;Yue Zhang ,&nbsp;Xiaomeng Sun ,&nbsp;Lianwen Qi ,&nbsp;Qun Liu","doi":"10.1016/S1875-5364(25)60817-X","DOIUrl":"10.1016/S1875-5364(25)60817-X","url":null,"abstract":"<div><div>Fibrosis is characterized as an aberrant reparative process involving the direct replacement of damaged or deceased cells with connective tissue, leading to progressive architectural remodeling across various tissues and organs. This condition imposes a substantial burden, resulting in considerable morbidity and mortality. Ginseng (<em>Panax ginseng</em> C. A. Meyer), renowned for its medicinal properties, has been incorporated as a key component in Chinese patent medicines to mitigate fibrotic diseases. Ginsenosides, the primary bioactive compounds in ginseng, have garnered significant attention. Over the past five years, extensive research has explored the pharmaceutical potential of ginsenosides in diverse organ fibrosis conditions, including liver, myocardial, renal, and pulmonary fibrosis. Studies have elucidated that ginsenosides demonstrate potential effects on inflammatory responses stemming from parenchymal cell damage, myofibroblast activation leading to extracellular matrix (ECM) production, and myofibroblast apoptosis or inactivation. Additionally, potential downstream targets and pathways associated with these pathological processes have been identified as being influenced by ginsenosides. This review presents a comprehensive overview of the efficacious treatments utilizing ginsenosides for various tissue fibrosis types and their potential anti-fibrotic mechanisms. Furthermore, it offers a reference for the development of novel candidate drugs for future organ fibrosis therapies.</div></div>","PeriodicalId":10002,"journal":{"name":"Chinese Journal of Natural Medicines","volume":"23 6","pages":"Pages 673-686"},"PeriodicalIF":4.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144331397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intervention of natural products targeting novel mechanisms after myocardial infarction 针对心肌梗死新机制的天然产物干预
IF 4 2区 医学
Chinese Journal of Natural Medicines Pub Date : 2025-06-01 DOI: 10.1016/S1875-5364(25)60816-8
Guangjie Tai , Renhua Liu , Tian Lin , Jiancheng Yang , Xiaoxue Li , Ming Xu
{"title":"Intervention of natural products targeting novel mechanisms after myocardial infarction","authors":"Guangjie Tai ,&nbsp;Renhua Liu ,&nbsp;Tian Lin ,&nbsp;Jiancheng Yang ,&nbsp;Xiaoxue Li ,&nbsp;Ming Xu","doi":"10.1016/S1875-5364(25)60816-8","DOIUrl":"10.1016/S1875-5364(25)60816-8","url":null,"abstract":"<div><div>Myocardial infarction is a cardiovascular disease (CVD) with high morbidity and mortality, which can trigger a cascade of cardiac pathophysiological changes, including fibrosis, inflammation, ischemia-reperfusion injury (IRI), and ventricular remodeling, ultimately leading to heart failure (HF). While conventional pharmacological treatments and clinical reperfusion therapy may enhance short-term prognoses and emergency survival rates, both approaches have limitations and adverse effects. Natural products (NPs) are extensively utilized as therapeutics globally, with some demonstrating potentially favorable therapeutic effects in preclinical and clinical pharmacological studies, positioning them as potential alternatives to modern drugs. This review comprehensively elucidates the pathophysiological mechanisms during myocardial infarction and summarizes the mechanisms by which NPs exert cardiac beneficial effects. These include classical mechanisms such as inhibition of inflammation and oxidative stress, alleviation of cardiomyocyte death, attenuation of cardiac fibrosis, improvement of angiogenesis, and emerging mechanisms such as cardiac metabolic regulation and histone modification. Furthermore, the review emphasizes the modulation by NPs of novel targets or signaling pathways in classical mechanisms, including other forms of regulated cell death (RCD), endothelial-mesenchymal transition, non-coding ribonucleic acids (ncRNAs) cascade, and endothelial progenitor cell (EPC) function. Additionally, NPs influencing a particular mechanism are categorized based on their chemical structure, and their relevance is discussed. Finally, the current limitations and prospects of NPs therapy are considered, highlighting their potential for use in myocardial infarction management and identifying issues that require urgent attention.</div></div>","PeriodicalId":10002,"journal":{"name":"Chinese Journal of Natural Medicines","volume":"23 6","pages":"Pages 658-672"},"PeriodicalIF":4.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144331402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Oroxylin A inhibits UVB-induced non-melanoma skin cancer by regulating XPA degradation Oroxylin A通过调节XPA降解抑制uvb诱导的非黑色素瘤皮肤癌
IF 4 2区 医学
Chinese Journal of Natural Medicines Pub Date : 2025-06-01 DOI: 10.1016/S1875-5364(25)60893-4
Renjie Dou , Jiarui Sun , Hang Yang , Yufen Zheng , Kang Yuan , Lei Qiang , Run Ma , Yunyao Liu
{"title":"Oroxylin A inhibits UVB-induced non-melanoma skin cancer by regulating XPA degradation","authors":"Renjie Dou ,&nbsp;Jiarui Sun ,&nbsp;Hang Yang ,&nbsp;Yufen Zheng ,&nbsp;Kang Yuan ,&nbsp;Lei Qiang ,&nbsp;Run Ma ,&nbsp;Yunyao Liu","doi":"10.1016/S1875-5364(25)60893-4","DOIUrl":"10.1016/S1875-5364(25)60893-4","url":null,"abstract":"<div><div>Oroxylin A (OA), a natural compound extracted from <em>Scutellaria baicalensis</em>, demonstrates preventive potential against ultraviolet B (UVB)-induced non-melanoma skin cancer (NMSC), the most prevalent cancer worldwide with increasing incidence. Utilizing SKH-1 hairless mice exposed to UVB, this study showed that OA delayed NMSC onset and alleviated acute skin damage. Mechanistic investigations revealed its dual action: inhibiting inflammation and enhancing nucleotide excision repair (NER) by stabilizing XPA, a crucial deoxyribonucleic acid (DNA) repair protein. This stabilization occurred through OA’s interaction with glucose-regulated protein 94 (GRP94), which disrupted murine double minute 2 (MDM2)-mediated XPA ubiquitination and proteasomal degradation. By maintaining XPA levels, OA expedited photoproduct clearance and diminished genomic instability, ultimately impeding NMSC development. These findings suggest OA as a promising chemopreventive agent targeting the GRP94/MDM2-XPA axis to counteract UVB-induced carcinogenesis.</div></div>","PeriodicalId":10002,"journal":{"name":"Chinese Journal of Natural Medicines","volume":"23 6","pages":"Pages 742-753"},"PeriodicalIF":4.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144331320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advancements and applications in radiopharmaceutical therapy 放射性药物治疗的进展与应用
IF 4 2区 医学
Chinese Journal of Natural Medicines Pub Date : 2025-06-01 DOI: 10.1016/S1875-5364(25)60887-9
Shiya Wang , Mingyi Cao , Yifei Chen , Jingjing Lin , Jiahao Li , Xinyu Wu , Zhiyue Dai , Yuhan Pan , Xiao Liu , Xian Liu , Liang-Ting Lin , Jianbing Wu , Ji Liu , Qifeng Zhong , Zhenwei Yuan
{"title":"Advancements and applications in radiopharmaceutical therapy","authors":"Shiya Wang ,&nbsp;Mingyi Cao ,&nbsp;Yifei Chen ,&nbsp;Jingjing Lin ,&nbsp;Jiahao Li ,&nbsp;Xinyu Wu ,&nbsp;Zhiyue Dai ,&nbsp;Yuhan Pan ,&nbsp;Xiao Liu ,&nbsp;Xian Liu ,&nbsp;Liang-Ting Lin ,&nbsp;Jianbing Wu ,&nbsp;Ji Liu ,&nbsp;Qifeng Zhong ,&nbsp;Zhenwei Yuan","doi":"10.1016/S1875-5364(25)60887-9","DOIUrl":"10.1016/S1875-5364(25)60887-9","url":null,"abstract":"<div><div>Radiopharmaceuticals operate by combining radionuclides with carriers. The radiation energy emitted by radionuclides is utilized to selectively irradiate diseased tissues while minimizing damage to healthy tissues. In comparison to external beam radiation therapy, radionuclide drugs demonstrate research potential due to their biological targeting capabilities and reduced normal tissue toxicity. This article reviews the applications and research progress of radiopharmaceuticals in cancer treatment. Several key radionuclides are examined, including <sup>223</sup>Ra, <sup>90</sup>Y, Lutetium-177 (<sup>177</sup>Lu), <sup>212</sup>Pb, and Actinium-225 (<sup>225</sup>Ac). It also explores the current development trends of radiopharmaceuticals, encompassing the introduction of novel radionuclides, advancements in imaging technologies, integrated diagnosis and treatment approaches, and equipment-medication combinations. We review the progress in the development of new treatments, such as neutron capture therapy, proton therapy, and heavy ion therapy. Furthermore, we examine the challenges and breakthroughs associated with the clinical translation of radiopharmaceuticals and provide recommendations for the research and development of novel radionuclide drugs.</div></div>","PeriodicalId":10002,"journal":{"name":"Chinese Journal of Natural Medicines","volume":"23 6","pages":"Pages 641-657"},"PeriodicalIF":4.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144331401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Harmonizing tradition and technology: Liposomal nanocarriers unlocking the power of natural herbs in Traditional Chinese Medicine 调和传统与技术:脂质体纳米载体释放天然中药的力量
IF 4 2区 医学
Chinese Journal of Natural Medicines Pub Date : 2025-06-01 DOI: 10.1016/S1875-5364(25)60889-2
Ibrahim Shaw , Aaron Albert Aryee , Yimer Seid Ali , George Frimpong Boafo , Jingjing Tian , Ronald Mlambo , Songwen Tan , Chuanpin Chen
{"title":"Harmonizing tradition and technology: Liposomal nanocarriers unlocking the power of natural herbs in Traditional Chinese Medicine","authors":"Ibrahim Shaw ,&nbsp;Aaron Albert Aryee ,&nbsp;Yimer Seid Ali ,&nbsp;George Frimpong Boafo ,&nbsp;Jingjing Tian ,&nbsp;Ronald Mlambo ,&nbsp;Songwen Tan ,&nbsp;Chuanpin Chen","doi":"10.1016/S1875-5364(25)60889-2","DOIUrl":"10.1016/S1875-5364(25)60889-2","url":null,"abstract":"<div><div>Natural herbs demonstrate significant therapeutic potential in managing chronic and complex diseases; however, their clinical application faces limitations due to low bioavailability, instability, toxicity, and herb-drug interactions. Furthermore, insufficient standardized evidence and global acceptance impede their widespread adoption. Liposomes, nanocarriers consisting of a phospholipid bilayer enclosing an aqueous core, present a promising approach for enhancing the pharmacokinetics and therapeutic efficacy of herbal compounds. These adaptable systems can encapsulate both hydrophilic and hydrophobic agents, enabling targeted drug delivery and enhanced stability. Moreover, liposomes can be modified to carry diagnostic and imaging agents, enabling precise disease detection and monitoring. While liposomes offer potential as an innovative delivery technology for herbal remedies, their application in Traditional Chinese Medicine (TCM) remains relatively unexplored. TCM, with its holistic, energy-based approach to health and organ function, presents distinct challenges regarding formulation and delivery. This review examines the therapeutic potential of herbal medicines, emphasizing how liposomes address delivery challenges within the TCM framework. It also investigates the integration of TCM with Western medical practices, demonstrating how liposomal systems may bridge these approaches. The review analyzes key formulation techniques for TCM-loaded liposomes, particularly the microfluidic method, which demonstrates superior control over particle size and encapsulation efficiency compared to conventional methods. The analysis addresses barriers to integrating liposomal delivery systems with TCM, including physicochemical properties, scalability issues, and regulatory challenges. Finally, this review provides strategic recommendations for overcoming these obstacles and identifies future research directions to maximize the potential of liposomal technology in enhancing TCM therapies.</div></div>","PeriodicalId":10002,"journal":{"name":"Chinese Journal of Natural Medicines","volume":"23 6","pages":"Pages 700-713"},"PeriodicalIF":4.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144331404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diphenylemestrins A−E: diketopiperazine-diphenyl ether hybrids from Aspergillus nidulans Diphenylemestrins A−E:双酮哌嗪-二苯醚杂交种
IF 4 2区 医学
Chinese Journal of Natural Medicines Pub Date : 2025-06-01 DOI: 10.1016/S1875-5364(25)60891-0
Aimin Fu , Qin Li , Yang Xiao , Jiaxin Dong, Yuanyang Peng, Yu Chen, Qingyi Tong, Chunmei Chen, Yonghui Zhang, Hucheng Zhu
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