Springer最新文献_第4页

Quantitation of antibiotics in fresh fermentation medium by hydrophilic interaction chromatography mass spectrometry.

IF 3.8 2区化学

Analytical and Bioanalytical Chemistry Pub Date : 2025-04-01 Epub Date: 2025-02-21 DOI: 10.1007/s00216-025-05775-6

Nadia Marcon, Mathias Rüdt, Joachim Klein, Saša M Miladinović

引用次数: 0

Cost-effective, user-friendly detection and preconcentration of thrombin on a sustainable paper-based electrochemical platform.

IF 3.8 2区化学

Analytical and Bioanalytical Chemistry Pub Date : 2025-04-01 Epub Date: 2025-02-01 DOI: 10.1007/s00216-025-05764-9

Ada Raucci, Giuseppina Sorrentino, Sima Singh, Nicola Borbone, Giorgia Oliviero, Gennaro Piccialli, Monica Terracciano, Stefano Cinti

{"title":"Cost-effective, user-friendly detection and preconcentration of thrombin on a sustainable paper-based electrochemical platform.","authors":"Ada Raucci, Giuseppina Sorrentino, Sima Singh, Nicola Borbone, Giorgia Oliviero, Gennaro Piccialli, Monica Terracciano, Stefano Cinti","doi":"10.1007/s00216-025-05764-9","DOIUrl":"10.1007/s00216-025-05764-9","url":null,"abstract":"<p><p>Thrombin overexpression in serum serves as a critical biomarker and is implicated in several diseases associated with significant morbidity and mortality. Existing techniques for thrombin detection are time-consuming and require sophisticated equipment and extensive sample preparation procedures, which further delay the detection and increase the cost of the procedure. Early and accessible diagnosis at the point of care, especially in limited-resource countries, represents the first step of clinical interventions. To overcome these limitations, we have proposed an innovative, sustainable paper-based electrochemical detection platform for thrombin. In this work, a sustainable paper-based aptasensor was rationally designed, characterized, evaluated against conventional gold standard plastic-based substrates, and applied to human serum, yielding a detection limit of ~ 60 pM. The present method provides an efficient and user-friendly way for the detection of thrombin and potentially leading to better management and treatment outcomes for patients.</p>","PeriodicalId":462,"journal":{"name":"Analytical and Bioanalytical Chemistry","volume":" ","pages":"1863-1872"},"PeriodicalIF":3.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11914299/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143073231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Buried interface engineering with amphoteric ion for inverted perovskite solar cells

IF 2.5 4区材料科学

Applied Physics A Pub Date : 2025-04-01 DOI: 10.1007/s00339-025-08372-7

Liquan Zhang, Zhuo Chen, Jiayu Han, Tingfeng Wang, Chongyang Xu, Sheng Wu, Zhihai Liu

{"title":"Buried interface engineering with amphoteric ion for inverted perovskite solar cells","authors":"Liquan Zhang, Zhuo Chen, Jiayu Han, Tingfeng Wang, Chongyang Xu, Sheng Wu, Zhihai Liu","doi":"10.1007/s00339-025-08372-7","DOIUrl":"10.1007/s00339-025-08372-7","url":null,"abstract":"<div><p>The efficiency of perovskite solar cells (PSCs) primarily depends on the quality of the perovskite films. The buried interface, located at the bottom surface of the perovskite layer, significantly influences the performance of perovskite photovoltaics. This study utilizes cetyltrimethylammonium bromide (CTAB), an amphoteric organic salt, on the surface of poly(3,4-ethylenedioxythiophene): poly(styrene sulfonate) (PEDOT: PSS) to modify the bottom interface between the perovskite film and the hole transport layer. The ammonium group and bromine ion in CTAB can passivate vacancy defects at the PEDOT: PSS/perovskite interface, while the long carbon chain enhances the humidity stability of PEDOT: PSS. The application of CTAB significantly improved the photoelectric performance of PSCs, increasing the power conversion efficiency (PCE) from 15.16 to 17.30%, with excellent reproducibility. The unencapsulated device retained over 60% of its initial PCE after 400 h. As an emerging technology, modifying the buried interface of the perovskite film presents new strategies for achieving high-performance and long-lasting PSCs.</p></div>","PeriodicalId":473,"journal":{"name":"Applied Physics A","volume":"131 4","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143740868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Temperature-dependent kinetic analysis of direct air capture using a gravimetric approach in porous environments

IF 3 4区工程技术

Adsorption Pub Date : 2025-04-01 DOI: 10.1007/s10450-025-00615-6

Yongqiang Wang, Dan Zhao, Gang Kevin Li

{"title":"Temperature-dependent kinetic analysis of direct air capture using a gravimetric approach in porous environments","authors":"Yongqiang Wang, Dan Zhao, Gang Kevin Li","doi":"10.1007/s10450-025-00615-6","DOIUrl":"10.1007/s10450-025-00615-6","url":null,"abstract":"<div><p>Adsorption kinetics has been regarded as one of the most critical factors determining the productivity and economic feasibility of direct air capture (DAC) of CO<sub>2</sub>, but has received relatively little attention compared with adsorption thermodynamics. One commonly used method for kinetics investigation is thermogravimetric analysis (TGA) which suffers from gas diffusion limitations and often underestimates adsorption rates. Here, a modified TGA system equipped with a porous self-made crucible was employed to address the gas diffusion challenges and analyze the kinetic behaviors of three polymeric chemisorbents, including Lewatit VP OC 1065, for DAC. The obtained adsorption kinetics were successfully applied to simulate and describe the breakthrough behaviors in a fixed-bed column. The CO<sub>2</sub> adsorption/desorption kinetics of chemisorbents with different amine structures or loadings were measured at various temperatures and described through the linear driving force model. The present work offers a reliable and fast kinetics analysis approach for DAC, paving the way for accurately collecting the kinetics parameters used for guiding further adsorbent and process design.</p><h3>Graphic abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":458,"journal":{"name":"Adsorption","volume":"31 4","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10450-025-00615-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143740852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A study on comprehensive anti-calcification treatment technology for bioprosthetic valves

IF 3.4

International Journal of Mechanical and Materials Engineering Pub Date : 2025-04-01 DOI: 10.1186/s40712-025-00263-2

Yongkai Zhang, Yumiao Wang, Jie Hao, Haiyang Wei, Yana Meng, Xinwei Yang, Shengshou Hu, Jianye Zhou

{"title":"A study on comprehensive anti-calcification treatment technology for bioprosthetic valves","authors":"Yongkai Zhang, Yumiao Wang, Jie Hao, Haiyang Wei, Yana Meng, Xinwei Yang, Shengshou Hu, Jianye Zhou","doi":"10.1186/s40712-025-00263-2","DOIUrl":"10.1186/s40712-025-00263-2","url":null,"abstract":"<div><h3>Background</h3><p>Calcification is the primary cause of bioprosthetic material degradation, triggered by various factors. Although many studies have proposed different anti-calcification methods, most of them focus on a single target and modify it, while the treated tissue is still stored in glutaraldehyde, re-exposing them to calcification-prone environments, thus failing to achieve ideal clinical application.</p><h3>Methods</h3><p>Decellularization was performed using surfactants Triton X-100, sodium dodecyl sulfate (SDS), and sodium deoxycholate (SDC) to remove cellular membrane phospholipid fragments. Sodium bisulfite (SBS) was then used to neutralize unbound aldehyde groups. Finally, the treated tissue was stored in a 75% glycerol solution. A series of biomechanical properties of the treated bovine pericardium were evaluated in vitro, and its anti-calcification properties were assessed through a 6-month in vivo implantation study using a sheep model.</p><h3>Results</h3><p>Compared with the glutaraldehyde-treated control group, the tissues treated with the new comprehensive anti-calcification method showed no significant changes in tensile strength or elongation at break. Additionally, no adverse effects on coagulation or hemolysis were observed, and the use of surfactants showed no significant cytotoxicity. Subcutaneous implantation in rats and mitral valve implantation in sheep model showed significantly improved anti-calcification performance compared to the glutaraldehyde control group.</p><h3>Conclusion</h3><p>This study proposes a comprehensive anti-calcification treatment method, which includes removing cellular debris, reducing phospholipids, neutralizing residual aldehyde groups, and storing the tissue in glycerol. This approach offered a new avenue for further research in the field and significant potential for clinical application.</p></div>","PeriodicalId":592,"journal":{"name":"International Journal of Mechanical and Materials Engineering","volume":"20 1","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://jmsg.springeropen.com/counter/pdf/10.1186/s40712-025-00263-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143740897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Threatening the Near–Threatened: Microplastics in Jerdon's Catfish (Mystus malabaricus), Endemic to the Global Biodiversity Hotspot, the Western Ghats of India

IF 3.8 4区环境科学与生态学

Water, Air, & Soil Pollution Pub Date : 2025-04-01 DOI: 10.1007/s11270-025-07914-2

Pradeep Kumkar, Chandani R. Verma, Martin Lexa, Sachin M. Gosavi, Sanjay S. Kharat, Lukáš Kalous

{"title":"Threatening the Near–Threatened: Microplastics in Jerdon's Catfish (Mystus malabaricus), Endemic to the Global Biodiversity Hotspot, the Western Ghats of India","authors":"Pradeep Kumkar, Chandani R. Verma, Martin Lexa, Sachin M. Gosavi, Sanjay S. Kharat, Lukáš Kalous","doi":"10.1007/s11270-025-07914-2","DOIUrl":"10.1007/s11270-025-07914-2","url":null,"abstract":"<div><p>Microplastic contamination in freshwater fish poses a significant global threat but remains underexplored in biodiversity hotspots like the Western Ghats of India, where rivers exhibit elevated microplastic levels. This study investigates microplastic contamination in the endemic and near-threatened bagrid catfish, <i>Mystus malabaricus</i>, sampled from the Ulhas River, Maharashtra. Microplastics were isolated and analysed for physical attributes (size, shape, colour) using light microscopy and for chemical composition through µ-Raman spectroscopy. Our findings indicate that 50% of the catfish contained microplastics, averaging 2.54 ± 0.41 particles per fish, with five morphotypes identified, predominantly transparent and grey films made of polyethylene (89.3%) and polypropylene (10.7%). The observed characteristics of microplastics reflect a direct relationship to secondary anthropogenic sources, revealing inadequacies in regional waste management infrastructure. This contamination may adversely affect fish development and pose risks to fish consumers and artisanal fisheries. We propose mitigation strategies based on the findings of this and previous studies on the Ulhas River.</p></div>","PeriodicalId":808,"journal":{"name":"Water, Air, & Soil Pollution","volume":"236 5","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143740722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pre-analytic assessment of dried blood and dried plasma spots: integration in mass spectrometry-based metabolomics and lipidomics workflow.

IF 3.8 2区化学

Analytical and Bioanalytical Chemistry Pub Date : 2025-04-01 Epub Date: 2025-02-05 DOI: 10.1007/s00216-025-05760-z

Eleonora Bossi, Simone Serrao, Pierluigi Reveglia, Antonietta Ferrara, Marta Nobile, Elena Limo, Gaetano Corso, Giuseppe Paglia

{"title":"Pre-analytic assessment of dried blood and dried plasma spots: integration in mass spectrometry-based metabolomics and lipidomics workflow.","authors":"Eleonora Bossi, Simone Serrao, Pierluigi Reveglia, Antonietta Ferrara, Marta Nobile, Elena Limo, Gaetano Corso, Giuseppe Paglia","doi":"10.1007/s00216-025-05760-z","DOIUrl":"10.1007/s00216-025-05760-z","url":null,"abstract":"<p><p>Microsampling, especially dried blood spots (DBS), emerged in recent years as a viable alternative to conventional blood collection since it is rapid, simple, minimally invasive, and has user-friendly characteristics. Moreover, DBS are able to avoid analyte degradation thanks to their great stability. Due to their versatility, clinical applications with DBS have increased, including mass spectrometry-based metabolomics and lipidomics studies. In this work, we evaluated and optimized extraction protocols testing five different extraction solutions to perform metabolomics and lipidomics studies on the same spot considering three commercially available microsampling devices, Capitainer, Whatman, and Telimmune. Parallelly, we also evaluated the short-term stability of the three devices at room temperature for up to 5 days. Our results showed that pure methanol was the best compromise to simultaneously extract from the same spot both the lipidome and polar metabolome. However, we also propose a two-step protocol combining methanol and water extraction that improves polar metabolite extraction and shows improved reproducibility in Capitainer and Whatman. Short-term stability results highlighted that both polar metabolites and lipids were stable for up to 6 days using the Capitainer device, while with Whatman and Telimmune, some significant variations were observed after 3 days for some classes of metabolites/lipids, suggesting the need for cold-chain storage when working with these devices.</p>","PeriodicalId":462,"journal":{"name":"Analytical and Bioanalytical Chemistry","volume":" ","pages":"1791-1805"},"PeriodicalIF":3.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11913995/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143187882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fluorescence paper sensor meets magnetic affinity chromatography: discovering potent neuraminidase inhibitors in herbal medicines.

IF 3.8 2区化学

Analytical and Bioanalytical Chemistry Pub Date : 2025-04-01 Epub Date: 2025-01-31 DOI: 10.1007/s00216-025-05761-y

Fen Ma, Weibiao Wang, Mei Wang, Weiman Zhang, Shuxian Zhang, Gidion Wilson, Yuping Sa, Yue Zhang, Guoning Chen, Xueqin Ma

{"title":"Fluorescence paper sensor meets magnetic affinity chromatography: discovering potent neuraminidase inhibitors in herbal medicines.","authors":"Fen Ma, Weibiao Wang, Mei Wang, Weiman Zhang, Shuxian Zhang, Gidion Wilson, Yuping Sa, Yue Zhang, Guoning Chen, Xueqin Ma","doi":"10.1007/s00216-025-05761-y","DOIUrl":"10.1007/s00216-025-05761-y","url":null,"abstract":"<p><p>Given the inherent complexity of natural medicines, finding a straightforward and efficient method for identifying active ingredients remains a significant challenge, yet it is of paramount importance. Influenza virus neuraminidase (NA), a primary target for anti-influenza drug development, plays a crucial role in the infection process, making it essential to develop rapid and facile methods for screening NA inhibitors. Herein, we developed a novel and efficient analytical technique for the identification of NA inhibitors from complex herbal medicines by integrating dual sensing with affinity chromatography. This approach simplifies the experimental process and highlights the benefits of being quicker, more sensitive, and cost-effective. Regarding the biosensing section, the innovative concept of a 4-methylumbelliferyl-N-acetylneuraminic acid-NA-based fluorescence paper sensor strategy enables the rapid detection of NA inhibitors in complex herbal samples. In affinity chromatography, bioactive compounds were precisely captured, separated, and identified. The efficacy and reliability of the developed method were confirmed using both negative and positive controls. Then, the method was applied to screen for NA inhibitors in 20 different herbal medicines. The results revealed that Bupleurum chinense DC. exhibited the most pronounced inhibitory effect on NA. Subsequent analysis utilizing affinity chromatography identified three bioactive compounds, namely saikosaponin a, saikosaponin d, and baicalin, as the active agents responsible for this inhibitory effect, with IC<sub>50</sub> values of 177.3 μM, 262.9 μM, and 241.4 μM, respectively. Molecular docking studies further indicated that these three bioactive compounds exhibit a strong binding affinity with NA. This research provides novel insights into the screening of enzyme inhibitors within herbal medicines.</p>","PeriodicalId":462,"journal":{"name":"Analytical and Bioanalytical Chemistry","volume":" ","pages":"1819-1832"},"PeriodicalIF":3.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143073372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Self-protective DNAzyme-based dual-responsive three-way Y-probe for simultaneous determination of multiple pathogenic bacteria.

IF 3.8 2区化学

Analytical and Bioanalytical Chemistry Pub Date : 2025-04-01 Epub Date: 2025-02-17 DOI: 10.1007/s00216-025-05782-7

Bowen Li, Xinru Ren, Yijing Xiao, Weiqing Sun, Meili Yang, Tsing-Ao Pang, Rui Zhu, Zhiqiang Guo, Yu Wang, Su Liu, Jiadong Huang

{"title":"Self-protective DNAzyme-based dual-responsive three-way Y-probe for simultaneous determination of multiple pathogenic bacteria.","authors":"Bowen Li, Xinru Ren, Yijing Xiao, Weiqing Sun, Meili Yang, Tsing-Ao Pang, Rui Zhu, Zhiqiang Guo, Yu Wang, Su Liu, Jiadong Huang","doi":"10.1007/s00216-025-05782-7","DOIUrl":"10.1007/s00216-025-05782-7","url":null,"abstract":"<p><p>Foodborne pathogens, a major cause of foodborne illness due to their high virulence, pose a serious threat to public health. Consequently, identification of foodborne pathogens is essential for the prevention and treatment of foodborne infections. Consequently, there is an immediate need to establish a highly specific and precise approach for the concurrent detection of several foodborne pathogens. Herein, we developed a DNAzyme-based self-protecting dual-response nanoprobe for the simultaneous detection of two foodborne pathogens. The technique utilizes nanostructures to achieve logical signal input and output. In the presence of the target pathogen, the pathogen binds to the arch probe and releases the activation chain, which in turn activates a strand-displacement reaction and DNAzyme for signal amplification, producing different output signals to complete the simultaneous detection of multiple pathogens. The limits of detection for E. coli O157:H7 and S. typhimurium were determined to be 3.7 cfu/mL and 3.2 cfu/mL, with a measurement response time of 2 h. This approach enables ultrasensitive, specific, and simultaneous detection of two foodborne pathogens and is applicable for identifying foodborne pathogens in actual biological samples. The fluorescence detection of foodborne pathogens with a three-way Y-probe and DNAzyme coupling represents a novel approach for the concurrent identification of several foodborne diseases.</p>","PeriodicalId":462,"journal":{"name":"Analytical and Bioanalytical Chemistry","volume":" ","pages":"1779-1790"},"PeriodicalIF":3.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143439726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Getting the Most Out of Your Meeting Abstract: An Editor's Perspective. 充分利用会议摘要：编辑的视角。

IF 2.5 4区医学

Journal of Medical Toxicology Pub Date : 2025-04-01 Epub Date: 2025-03-07 DOI: 10.1007/s13181-025-01066-9

Mark B Mycyk

引用次数: 0