{"title":"FAM72A promotes cervical cancer progression by regulating the PI3K pathway","authors":"Qin wang, Hao Yu, Rui Huang","doi":"10.1007/s10142-025-01735-6","DOIUrl":"10.1007/s10142-025-01735-6","url":null,"abstract":"<div><p>Cervical cancer (CC) is a major malignancy and a serious threat to women’s health worldwide. The role of FAM72A in CC remains poorly defined. This study aimed to investigate its function in CC progression and its impact on the PI3K/AKT/mTOR pathway. FAM72A expression in CC was examined using TCGA-CESC and GEO (GSE63514) datasets, and then validated in CC tissues and cell lines. Functional assays assessed cell proliferation (CCK-8, EdU), invasion (Transwell), apoptosis (flow cytometry), and epithelial–mesenchymal transition (EMT; Western blot for E-cadherin/N-cadherin). The role of FAM72A in the PI3K/AKT/mTOR pathway was further evaluated by Western blot and pharmacological modulation with the activator 740 Y-P and the inhibitor LY294002. In vivo, a xenograft model with BALB/c nude mice was used to assess tumor growth, apoptosis (TUNEL staining), proliferation (Ki-67 IHC), and pathway activation (p-PI3K, p-AKT, and p-mTOR). FAM72A expression was upregulated in CC tissues and correlated with poor survival. Subgroup analysis showed that high FAM72A expression was associated with advanced FIGO stage, lymph node metastasis, and deep stromal invasion, indicating a link with aggressive clinical features. FAM72A silencing suppressed proliferation and invasion but promoted apoptosis, mainly through inhibition of the PI3K/AKT/mTOR pathway. Conversely, FAM72A overexpression enhanced these malignant traits. In vivo, FAM72A knockdown reduced tumor burden and altered EMT markers and PI3K/AKT/mTOR pathway activity. FAM72A promotes CC progression, at least in part, through activation of the PI3K/AKT/mTOR pathway, supporting its value as a potential therapeutic target.</p></div>","PeriodicalId":574,"journal":{"name":"Functional & Integrative Genomics","volume":"25 1","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145316298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comparative analysis with biosynthesized nanoparticles by reducing and capping of identified Pterocarpus Santalinus bioactive compounds","authors":"Swarna Kumari Kanthireegala, Lokesh Reddy Bandi, Sindu Kadapana, Dakshayani Lomada, Veeranjaneya Reddy Lebaka, Madhava C. Reddy, Suresh V. Chinni, Subash C.B. Gopinath","doi":"10.1007/s00339-025-08989-8","DOIUrl":"10.1007/s00339-025-08989-8","url":null,"abstract":"<div>\u0000 \u0000 <p>This research analyzed <i>Pterocarpus santalinus</i> leaf extract using LC-MS and identified 39 bioactive components, including isorhamnetin, kaempferol, quercetin, and trifolin. Silver and copper nanoparticles (PsAgNPs and PsCuONPs) were synthesized using reducing and capping of identified bioactive compounds and characterized using UV-Vis spectroscopy, XRD, FTIR, FESEM, TEM, Zeta potential, and DLS. PsAgNPs exhibited higher antibacterial activity against drug-resistant strains, with inhibition zones of 18 mm for <i>Escherichia coli</i> and 17 mm for <i>Staphylococcus aureus</i> at 100 µg/mL. In comparison, PsCuONPs showed inhibition zones of 16 and 14 mm at 175 µg/mL, respectively. PsAgNPs demonstrated antibacterial action at lower concentrations (MIC and MBC values at 50–75 µg/mL) compared to PsCuONPs (100 µg/mL). Both nanoparticles induced bacterial membrane perforation and cellular lysis, confirmed by FESEM. Additionally, PsAgNPs demonstrated superior anti-biofilm, antioxidant (DPPH: 6.97 µg/mL; ABTS: 3.92 µg/mL), and anti-inflammatory activities, inhibiting hemolysis (IC<sub>50</sub> = 4.17 µg/mL) and protein denaturation (IC<sub>50</sub> = 6.33 µg/mL) compared to PsCuONPs. Moreover, they displayed higher cytotoxicity against human breast cancer cell lines. This data suggests that PsAgNPs and PsCuONPs could be promising therapeutic molecules for antibacterial, anti-oxidative, anti-inflammatory, and anti-cancer applications.</p>\u0000 </div>","PeriodicalId":473,"journal":{"name":"Applied Physics A","volume":"131 11","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145316301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chiara Richiardi, Consolata Siniscalco, Matteo Garbarino, Maria Adamo
{"title":"Unravelling decades of habitat dynamics in protected areas: A hierarchical approach applied to the Gran Paradiso National Park (NW Italy)","authors":"Chiara Richiardi, Consolata Siniscalco, Matteo Garbarino, Maria Adamo","doi":"10.1007/s10661-025-14669-0","DOIUrl":"10.1007/s10661-025-14669-0","url":null,"abstract":"<div><p>Habitat loss is the main threat to biodiversity at a global level, making habitat mapping an essential tool for the management of protected areas and for the conservation and monitoring, in line with Directive 92/43/EEC. Traditional mapping methods are resource-intensive, while remote sensing approaches depend on the availability of ground truth datasets. In this context, this study presents a novel framework for time series habitat classification. The approach leverages a single pre-existing habitat cartography and a limited set of ancillary data to derive a retrospective training dataset. The method was applied to analyse 39 years (1985–2023) of habitat and land cover changes in Gran Paradiso National Park (NW Italy). Annual seasonal composite images were generated for the growing and senescence seasons using an enhanced Best Available Pixel approach. Annually derived training datasets were used to classify hierarchically land cover and habitats via ensemble random forest models. Validation against high-resolution maps demonstrated the robustness of the approach. The method allows for long-term habitat monitoring even in data-sparse environments. The results reveal high stability of land cover (88% of the area) and significant trends in some vegetation types, including a decline in grasslands (− 10 ha year<sup>−1</sup>) and the expansion of shrublands (+ 10 ha year<sup>−1</sup>). The method proved to be reliable for large patches, less so for ecotones. Future research should explore its application across different landscapes. This work underscores the potential of remote sensing for long-term habitat monitoring, providing a cost-effective solution to support biodiversity preservation efforts.</p></div>","PeriodicalId":544,"journal":{"name":"Environmental Monitoring and Assessment","volume":"197 11","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s10661-025-14669-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145316367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Amirali Hariri, Atefeh Zarepour, Arezoo Khosravi, Mina Mirian, Siavash Iravani, Ali Zarrabi
{"title":"Engineering vascularized brain tumor organoids: bridging the gap between models and reality","authors":"Amirali Hariri, Atefeh Zarepour, Arezoo Khosravi, Mina Mirian, Siavash Iravani, Ali Zarrabi","doi":"10.1007/s10544-025-00773-y","DOIUrl":"10.1007/s10544-025-00773-y","url":null,"abstract":"<div><p>Traditional two-dimensional cultures and patient-derived xenografts fail to fully mimic the complexity of the tumor microenvironment, limiting their utility in drug discovery and personalized medicine. Recent breakthroughs in three-dimensional tumor modeling have led to the development of brain tumor organoids, patient-derived organoids, and bioengineered tumor-on-chip systems that offer more physiologically relevant platforms for studying glioblastoma biology and therapeutic response. One of the key advancements in these models is the incorporation of vascular networks to mimic the neurovascular unit and the blood-brain barrier (BBB). Various strategies such as co-culturing with endothelial cells, bio-printing vascularized scaffolds, and utilizing microfluidic platforms have been explored to enhance vascularization within glioblastoma organoids. These models have demonstrated improved nutrient and oxygen exchange, reduced hypoxia, and better maintenance of tumor heterogeneity. However, challenges remain in achieving fully functional capillary networks, BBB integrity, and immune cell integration. This review provides a comprehensive analysis of the latest advancements in brain tumor organoid research, focusing on vascularization strategies, their impact on tumor modeling, and their potential applications in drug screening and personalized therapy. We discussed the strengths and limitations of glioblastoma models, highlighted advanced bioengineering techniques for enhancing organoid complexity, and explored future directions for clinically relevant tumor organoids.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":490,"journal":{"name":"Biomedical Microdevices","volume":"27 4","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145316566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Running gravitational constant induced dark energy as a solution to (sigma _8) tension","authors":"Tilek Zhumabek, Azamat Mukhamediya, Hrishikesh Chakrabarty, Daniele Malafarina","doi":"10.1140/epjc/s10052-025-14917-0","DOIUrl":"10.1140/epjc/s10052-025-14917-0","url":null,"abstract":"<div><p>We consider a modified gravity model with a running gravitational constant coupled to a varying dark energy fluid and test its imprint on the growth of structure in the universe. Using redshift space distortion (RSD) measurement results, we show a tension at the <span>(3 sigma )</span> level between the best fit <span>(Lambda )</span>CDM and the corresponding parameters obtained from the Planck data. Unlike many modified gravity-based solutions that overlook scale dependence and model-specific background evolution, we study this problem in the broadest possible context by incorporating both factors into our investigation. We performed a full perturbation analysis to demonstrate a scale dependence in the growth equation. Fixing the scale to <span>(k = 0.1 h)</span> Mpc<span>(^{-1})</span> and introducing a phenomenological functional form for the varying Newton coupling <i>G</i> with only one free parameter, we conduct a likelihood analysis of the RSD selected data. The analysis reveals that the model can bring the tension level within <span>(1 sigma )</span> while maintaining the deviation of <i>G</i> from Newton’s gravitational constant at the fifth order.\u0000</p></div>","PeriodicalId":788,"journal":{"name":"The European Physical Journal C","volume":"85 10","pages":""},"PeriodicalIF":4.8,"publicationDate":"2025-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1140/epjc/s10052-025-14917-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145316369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fuad Ameen, Dabeer Hussain Mir, Ashiwin Vadiveloo, Jameelah Alabdulatif, Ibrahim Arif
{"title":"Adsorptive elimination of fluoride ions from water: kinetic and thermodynamic assessment of Chara vulgaris biomass","authors":"Fuad Ameen, Dabeer Hussain Mir, Ashiwin Vadiveloo, Jameelah Alabdulatif, Ibrahim Arif","doi":"10.1007/s10661-025-14718-8","DOIUrl":"10.1007/s10661-025-14718-8","url":null,"abstract":"<div><p>Fluoride ion contamination in drinking water poses a considerable environmental and health risk. Thus, novel sustainable and economic removal techniques are needed. This study examined the biosorption of fluoride ions from aqueous solutions utilizing the dead biomass of the green alga <i>Chara vulgaris</i> as an adsorbent. First, the biomass was studied for its structural and functional characteristics using Fourier transform infrared spectroscopy (<i>FTIR</i>), scanning electron microscopy (<i>SEM</i>), transmission electron microscopy (<i>TEM</i>), X-ray diffraction (<i>XRD</i>), and Brunauer–Emmett–Teller (<i>BET</i>) techniques. The optimal conditions for the biosorption were studied experimentally. Dead <i>Chara vulgaris</i> biomass achieved fluoride removal efficiency of 91% under optimal conditions (pH 2, 35 °C, 0.4 g adsorbent dose, and 300 min contact time). The surface characteristics and functional groups of the algal biomass were assessed to enable effective fluoride adsorption via a spontaneous, exothermic mechanism. The examination of fluoride biosorption indicated that the process was best explained by a Langmuir model with a high fit (<i>R</i><sup>2</sup> = 0.99). It shows that fluoride adheres to the surface in a monolayer. The kinetics of the process followed the pseudo-second-order model (<i>R</i><sup>2</sup> = 0.98), with the internal movement of particles being of lesser significance. The findings indicate that dead <i>Chara vulgaris</i> biomass can be used as an efficient material for fluoride removal, making it highly beneficial for purifying natural water and treating industrial effluent.</p></div>","PeriodicalId":544,"journal":{"name":"Environmental Monitoring and Assessment","volume":"197 11","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145316431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gabriel Christian de Farias Morais, Caio Patrício de Souza Sena, Gabriel Vinícius Rolim Silva, Guilherme Bastos Alves, Davi Serradella Vieira, Shopnil Akash, Md. Aktaruzzaman, Al-Anood M. Al-Dies, Umberto Laino Fulco, Jonas Ivan Nobre Oliveira
{"title":"Comprehensive evaluation of potential EBOV inhibitors using advanced molecular modeling techniques: implications for anti-Ebola therapeutics and rational drug design","authors":"Gabriel Christian de Farias Morais, Caio Patrício de Souza Sena, Gabriel Vinícius Rolim Silva, Guilherme Bastos Alves, Davi Serradella Vieira, Shopnil Akash, Md. Aktaruzzaman, Al-Anood M. Al-Dies, Umberto Laino Fulco, Jonas Ivan Nobre Oliveira","doi":"10.1186/s43094-025-00902-7","DOIUrl":"10.1186/s43094-025-00902-7","url":null,"abstract":"<div><h3>Background</h3><p>Ebola virus (EBOV) causes severe hemorrhagic fever outbreaks with high mortality rates, and currently there are no approved antiviral drugs. In this study, in silico (computational) techniques were applied to evaluate six small-molecule inhibitors—Latrunculin A, LJ001, CA-074, CA-074Me, U18666A, and Apilimod—focusing on drug-likeness, ADMET profiles, molecular docking, quantum chemical descriptors, and molecular dynamics simulations.</p><h3>Results</h3><p>Among the tested compounds, CA-074 proved to be the most promising candidate as it exhibited strong binding affinity to Cathepsin B (− 40.87 kcal/mol), an endosomal cysteine protease crucial for Ebola virus entry, as well as favorable ADMET properties and safety indicators such as absence of the human Ether-à-go-go-Related Gene (hERG) inhibition and mutagenic potential. CA-074 fulfilled the Lipinski and Veber rules with low plasma protein binding and a high unbound fraction, indicating improved bioavailability. The quantum descriptors indicated high chemical stability and low reactivity. Molecular dynamics confirmed the stability of the CA-074–Cathepsin B complex over 300 ns, with persistent hydrogen bonds and low flexibility in the binding pocket.</p><h3>Conclusion</h3><p>CA-074 has the potential to be a leading candidate for the treatment of EBOV. The comprehensive in silico strategy provides a valuable framework for accelerating early-stage antiviral drug discovery.</p></div>","PeriodicalId":577,"journal":{"name":"Future Journal of Pharmaceutical Sciences","volume":"11 1","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://fjps.springeropen.com/counter/pdf/10.1186/s43094-025-00902-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145316564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Food BiophysicsPub Date : 2025-10-20DOI: 10.1007/s11483-025-10037-0
Erlane da Rocha Fernandes, Jefferson Henrique Tiago Barros, Patrícia Martins Guarda, Emerson Adriano Guarda
{"title":"The Use of Ionic Liquids and Deep Eutectic Solvents in the Extraction of Phytochemicals with Bioactive Properties: A Review","authors":"Erlane da Rocha Fernandes, Jefferson Henrique Tiago Barros, Patrícia Martins Guarda, Emerson Adriano Guarda","doi":"10.1007/s11483-025-10037-0","DOIUrl":"10.1007/s11483-025-10037-0","url":null,"abstract":"<div><p>Innovative solvents like Ionic Liquids (ILs), Deep Eutectic Solvents (DES), and more recently, Natural Deep Eutectic Solvents (NaDES) have emerged as promising alternatives to conventional organic solvents for the extraction of bioactive compounds from plants. These solvents have gained attention due to their efficiency, lower environmental impact, and potential to enhance the selectivity of target compound extraction. Despite significant advancements in this field, a literature review revealed a lack of systematic reviews on the application of these solvents in plant bioactive extraction, over the past five years. Therefore, this study aims to compare ILs, DES, and NaDES in terms of efficiency, applicability, usability, and environmental impact, providing a comprehensive overview of the trends and challenges in this emerging field. The PRISMA methodology was used for article selection, resulting in a total of 77 studies analyzed. The findings indicate a growing number of studies on the use of DES and NaDES, whereas research on ILs for this purpose remains relatively scarce within the investigated period. Furthermore, an increasing trend in combined extraction methods was observed, with a particular emphasis on ultrasound-assisted extraction (UAE) and microwave-assisted extraction (MAE), which have shown promising effects when used alongside these solvents to enhance bioactive compound extraction. This review contributes to a deeper understanding of the emerging role of DES and NaDES in plant bioactive extraction and highlights the need for further investigations on ILs, particularly within the context of sustainable and cost-effective extraction methodologies.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":564,"journal":{"name":"Food Biophysics","volume":"20 4","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145316303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Study on Integrability of (2+1)-Dimensional Bidirectional Sawada-Kotera Equation and Interaction of Lump-Type Solutions","authors":"Jiangying Huo, Taogetusang Bao","doi":"10.1007/s10773-025-06158-4","DOIUrl":"10.1007/s10773-025-06158-4","url":null,"abstract":"<div>\u0000 \u0000 <p>In this paper, we investigate the integrability problem of the (2+1)-dimensional bidirectional Sawada-Kotera (bSK) equation. Through analyzing the model, we explore the characteristics of nonlinear dynamics. The Bell polynomial method is one of the most useful tools for studying the integrability of nonlinear evolution equations. Using this method, we derive the Bäcklund transformation, Lax pair, infinite many conservation laws, and nonlinear superposition formula of solutions for the (2+1)-dimensional bSK equation. Then, we constructed the lump-type solutions and soliton solutions of the equation respectively by utilizing its bilinear form and the nonlinear superposition formula of solutions. The dynamic behaviors of the lump-type solutions, lump-kink solutions, and interaction solutions of the model were deduced via the mathematical symbolic computation system Mathematica, the extended three-wave method, and the homo-clinic test method, with the relationship between local waves in physics being elaborated.</p>\u0000 </div>","PeriodicalId":597,"journal":{"name":"International Journal of Theoretical Physics","volume":"64 11","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145316559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Investigation of the effect of calcite (CaCO3) grade on impact strength and crushability properties","authors":"Mahmut Suat Delibalta","doi":"10.1007/s10064-025-04540-4","DOIUrl":"10.1007/s10064-025-04540-4","url":null,"abstract":"<div><p>This paper examines the impact strength and crushability properties of different calcite (CaCO<sub>3</sub>) grades. For this purpose, mineralogical, physical, chemical and physicomechanical laboratory tests were carried out on 12 different rocks. Correlations between four different mechanical tests (aggregate crushing value (ACV), aggregate impact value (AIV), impact strength index (ISI), crushability index (CI)) and the color properties (L, Ry C/2, R-457, E-313) of the rocks were revealed. As a result, significant correlations were obtained between the color properties and the strength and crushability properties of calcite rocks. The best relationship (R<sup>2</sup> = 0.72) was obtained between R-457 and ACV.</p></div>","PeriodicalId":500,"journal":{"name":"Bulletin of Engineering Geology and the Environment","volume":"84 11","pages":""},"PeriodicalIF":4.2,"publicationDate":"2025-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145316435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}