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{"title":"Social-Hydrological Dynamics along the Yellow River Belt: A Temporal-Spatial Investigation of Regional Groundwater Use in a Source-to-Sink Manner.","authors":"Xintong Niu, Jingyu Liu, Yinmao Zhao, Xudong Wu, Man Guo","doi":"10.1007/s00267-025-02148-8","DOIUrl":"10.1007/s00267-025-02148-8","url":null,"abstract":"<p><p>As a key industrial production base in China, Yellow River Belt regions are faced with immense pressure on their groundwater resources. Revealing the socio-hydrological dynamics of groundwater resources in the context of regional economic integration is essential for formulating sustainable water use. As an important aspect to reflect the socio-hydrological dynamics of regions along the Yellow River Belt, this study adopted a source-to-sink manner to quantitatively track regional groundwater use and the virtual groundwater transfer via domestic supply chains. The results indicated that the Yellow River Belt regions accounted for nearly a quarter of the national total groundwater use embedded in intraregional trades within China. It was found that regions along the Yellow River Belt primarily exported groundwater use to the Yangtze River Delta and South coastal region, with significant contributions coming from sectors such as chemical & mineral manufacturing, food & tobacco and agriculture. Water-deficient regions such as Inner Mongolia and Henan were revealed to supply substantial amounts of virtual groundwater use to other regions along the Yellow River Belt, exacerbating groundwater pressure in these areas that were scarce of water resources. These findings underline the importance of establishing intraregional and interregional cooperation mechanisms in coordinating water resources and economic development within the regions along the Yellow River Belt.</p>","PeriodicalId":543,"journal":{"name":"Environmental Management","volume":" ","pages":"2031-2045"},"PeriodicalIF":2.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143676719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multidimensional landscape changes contribute significantly to vegetation distribution: The evidences from the Luo River Watershed in the eastern part of the Qinling Mountains, China.","authors":"Jin Wang, Jinman Wang, Jianing Zhang","doi":"10.1007/s00267-025-02168-4","DOIUrl":"10.1007/s00267-025-02168-4","url":null,"abstract":"<p><p>Assessment of vegetation characteristics plays an important role in monitoring ecosystem health and restoration status, and it is necessary to consider the response characteristics of vegetation assessment indicator (VAI) to multidimensional landscape structure. Therefore, this research constructed a framework for analyzing landscape structure from two dimensions of landscape element and landscape pattern, selected fractional vegetation cover (FVC) and net primary productivity (NPP) as VAI, determined the response degree and spatial correlation of VAI to landscape structure by using geographical detector and bivariate Moran's index, and finally obtained the change threshold of VAI based on the constraints of landscape pattern by building a cubic polynomial. FVC and NPP were significantly higher from 2001 to 2021, with the expansion of the high-value areas. Cropland and woodland were the dominant landscape elements. The spatial explanatory power of landscape element for VAI was better than that of landscape pattern characteristics, while the combined factors in landscape structure all explained VAI better than univariate. The response of FVC to landscape structure was more significant compared to NPP. The high value areas of FVC tended to occur in natural landscape elements. FVC showed spatial correlation and clustering characteristics with both PD and LPI. One or more thresholds existed in the response of FVC to changes in landscape pattern. The research results have important reference value in the optimization of landscape structure and vegetation restoration, and can provide practical guidance for the sustainable development of the ecosystem.</p>","PeriodicalId":543,"journal":{"name":"Environmental Management","volume":" ","pages":"1963-1978"},"PeriodicalIF":2.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143951702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"More connected, more collisions? Documenting nonlinear relationships between habitat connectivity and wildlife-vehicle collision hotspots.","authors":"Clara Dawson, Amy M Villamagna, Rebecca A Martin, Remington J Moll","doi":"10.1007/s00267-025-02188-0","DOIUrl":"10.1007/s00267-025-02188-0","url":null,"abstract":"<p><p>Road networks fragment wildlife habitat and impede wildlife connectivity, which leads to elevated wildlife-vehicle collision (WVC) risk and increased danger to humans and wildlife. Habitat connectivity has been linked to WVC hotspot location and intensity, but this relationship likely depends on landscape context and road characteristics, which may be nonlinear due to varying habitat availability. Our objective was to evaluate factors affecting WVC location and intensity across New Hampshire, USA, with a focus on habitat connectivity. We assessed the relationship between WVCs and five connectivity models using generalized additive models and compared connectivity effects to road and land cover characteristics. We found that a barrier-sensitive wildlife species connectivity model was the best predictor of WVC hotspots and had a strong, negative nonlinear relationship with collision intensity. We also found that a simple forest variable performed almost as well as the complex connectivity model. WVC hotspots did not differ from adjacent roads or regional roads in terms of connectivity, except that traffic volume was higher at hotspots. Our findings suggest that the relationship between habitat connectivity and WVCs depends on broader landscape context and likely exhibits nonlinearity. Our work also demonstrates that some connectivity models are better predictors of WVCs than others, emphasizing the role of species-specific habitat connectivity assessments. These results can inform WVC mitigation planning and enhance understanding of habitat connectivity's role in broader landscapes.</p>","PeriodicalId":543,"journal":{"name":"Environmental Management","volume":" ","pages":"2089-2102"},"PeriodicalIF":2.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AHNAK2 Regulates NF-κB/MMP-9 Signaling to Promote Pancreatic Cancer Progression.","authors":"Na-Na Tang, Rong-Bo Xu, Bo Jiang, Hai-Ling Zhang, Xiao-Song Wang, Dan-Dan Chen, Ji-Jun Zhu","doi":"10.1007/s10528-024-10844-z","DOIUrl":"10.1007/s10528-024-10844-z","url":null,"abstract":"<p><p>Early metastasis of pancreatic cancer (PaC) is a major cause of its high mortality rate. Previous studies have shown that AHNAK2 is involved in the progression of some tumors and is predicted to be an independent prognostic factor for PaC; however, the specific mechanisms through which AHNAK2 regulates PaC remain unclear. In this study, we examined the role of AHNAK2 in PaC and its potential molecular mechanisms. AHNAK2 mRNA and protein expression in PaC tissues and cells were measured using qRT-PCR and western blot analysis. After AHNAK2 knockdown using small interfering RNA, PaC cells were subjected to CCK-8 scratch, and Transwell assays to assess cell proliferation, migration, and invasion, respectively. Furthermore, the validation of the mechanistic pathway was achieved by western blot analysis. AHNAK2 mRNA and protein levels were up-regulated in PaC and silencing AHNAK2 significantly inhibited the proliferation, migration, and invasion of PaC cells. Mechanistically, AHNAK2 knockdown decreased the expression of phosphorylated p65, phosphorylated IκBα, and matrix metalloproteinase-9 (MMP-9), suggesting that activation of the NF-κB/MMP-9 signaling pathway was inhibited. Importantly, activation of NF-κB reversed the effects of AHNAK2 knockdown. Our findings indicate that AHNAK2 promotes PaC progression through the NF-kB/MMP-9 pathway and provides a theoretical basis for targeting AHNAK2 for the treatment of PaC.</p>","PeriodicalId":482,"journal":{"name":"Biochemical Genetics","volume":" ","pages":"2912-2924"},"PeriodicalIF":2.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141305129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"E2F1 Facilitates the Proliferation and Stemness of Gastric Cancer Cells by Activating CDC25B Transcription and Modulating the MAPK Pathway.","authors":"Ming Liu, Chaobo Xu, Guoxiong Cheng, Zhengwei Chen, Xiaoming Pan, Yijun Mei","doi":"10.1007/s10528-024-10864-9","DOIUrl":"10.1007/s10528-024-10864-9","url":null,"abstract":"<p><p>Gastric cancer (GC) is a health problem that concerns people around the world. CDC25B is an essential cell cycle regulatory factor that is overexpressed in a variety of tumor cells. CDC25B plays a vital part in the progression and proliferation of malignant tumors. However, it is not yet clear that how CDC25B affects the stemness of GC cells. The study used bioinformatics to detect the expression of E2F1 and CDC25B in GC tissues and their correlation, as well as pathways enriched by CDC25B. We detected the expression of E2F1 and CDC25B in GC cell lines using quantitative reverse transcription polymerase chain reaction and tested the combination relationship between E2F1 and CDC25B using chromatin immunoprecipitation (ChIP) and dual-luciferase assays. We measured cell viability using CCK-8 assay, evaluated sphere-forming efficiency using sphere formation assay, and determined cell proliferation ability using colony formation assay. We also analyzed the expression of stemness markers and MAPK pathway-related proteins using western blot. In GC tissues and cells, CDC25B was upregulated. Silencing CDC25B could affect the MAPK pathway, thereby repressing the proliferation and stemness of GC cells. As predicted by bioinformatics, CDC25B had an upstream transcription factor, E2F1, which also had a high expression level in GC. Dual-luciferase and ChIP assays confirmed the combination relationship between the two. Rescue experiments uncovered that overexpression of CDC25B could reverse the impact induced by E2F1 knockdown on proliferation and stemness of cells. In conclusion, E2F1 could activate CDC25B transcription to regulate the MAPK pathway and enhance the proliferation and stemness of GC cells. We revealed a potential regulatory pathway of stemness of GC cells that was mediated by CDC25B, providing new ideas for improving and innovating GC treatment.</p>","PeriodicalId":482,"journal":{"name":"Biochemical Genetics","volume":" ","pages":"3428-3447"},"PeriodicalIF":2.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141562324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of HOXC Gene Family as Prognostic and Immune-Related Biomarkers in Breast Cancer Through mRNA Transcriptional Profile and Experimental Validation.","authors":"Xiongtao Cheng, Jie Luo, Jianxiong Cao","doi":"10.1007/s10528-024-10884-5","DOIUrl":"10.1007/s10528-024-10884-5","url":null,"abstract":"<p><p>Breast cancer (BC) is the most common malignancy in women worldwide, and more effective biomarkers are urgently needed for the prevention and treatment of BC. Our study aimed to investigate the role of the HOXC gene family (HOXCs) and its relationship with the immune response in BC. The differential expression of HOXCs and its clinical prognostic significance in BC were explored using bioinformatics analysis, and the cBioPortal database was used to evaluate the genetic mutation profile of the HOXCs in BC. The results indicated that the expression levels of HOXC4, 10, 11, 12, and 13 were significantly increased in BC tissues compared with the normal tissues, and expressions of these genes were closely associated with BC stage, among them, high expression levels of HOXC10 and HOXC13 predicted poor outcome in BC patients. In addition, to elucidate the essential role of HOXCs in the tumor microenvironment and immunotherapeutic response of BC, the impact of HOXCs on the regulation of immune infiltration in BC was comprehensively assessed. The result showed that HOXC10 and HOXC13 expressions were significantly positively linked with the infiltration levels of CD8+T cell and M1 macrophage, while they were negatively related to Mast and Natural killer cells, suggesting the important influence of HOXCs on regulating tumor immunity in BC patients. Lastly, the RT-qPCR assay was employed to validate HOXCs expression in samples of BC patients. In conclusion, HOXCs may be a promising prognostic indicator and could regulate the immune infiltration in BC patients, thus being a promising targeted immunotherapy for BC.</p>","PeriodicalId":482,"journal":{"name":"Biochemical Genetics","volume":" ","pages":"3448-3464"},"PeriodicalIF":2.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141589314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolomic Approach to Identify the Potential Metabolites from Alpinia malaccensis for Treating SARS-CoV-2 Infection.","authors":"Esrat Jahan, Tanoy Mazumder, Tarek Hasan, Khondoker Shahin Ahmed, Muhammed Amanat, Hemayet Hossain, Sumaiya Jannat Supty, Israt Jahan Liya, Md Sadikur Rahman Shuvo, A F M Shahid Ud Daula","doi":"10.1007/s10528-024-10869-4","DOIUrl":"10.1007/s10528-024-10869-4","url":null,"abstract":"<p><p>The advent of the new coronavirus, leading to the SARS-CoV-2 pandemic, has presented a substantial worldwide health hazard since its inception in the latter part of 2019. The severity of the current pandemic is exacerbated by the occurrence of re-infection or co-infection with SARS-CoV-2. Hence, comprehending the molecular process underlying the pathophysiology of sepsis and discerning possible molecular targets for therapeutic intervention holds significant importance. For the first time, 31 metabolites were tentatively identified by GC-MS analysis from Alpinia malaccensis. On the other hand, five phenolic compounds were identified and quantified from the plant in HPLC-DAD analysis, including (-) epicatechin, rutin hydrate, rosmarinic acid, quercetin, and kaempferol. Nine GC-MS and five HPLC-identified metabolites had shown interactions with 45 and 30 COVID-19-associated human proteins, respectively. Among the proteins, PARP1, FN1, PRKCA, EGFR, ALDH2, AKR1C3, AHR, and IKBKB have been found as potential therapeutic targets to mitigate SARS-CoV-2 infection. KEGG pathway analysis also showed a strong association of FN1, EGFR, and IKBKB genes with SARS-CoV-2 viral replication and cytokine overexpression due to viral infection. Protein-protein interaction (PPI) analysis also showed that TP53, MMP9, FN1, EGFR, and NOS2 proteins are highly related to the genes involved in COVID-19 comorbidity. These proteins showed interaction with the plant phytoconstituents as well. As the study offers a robust network-based procedure for identifying biomolecules relevant to COVID-19 disease, A. malaccensis could be a good source of effective therapeutic agents against COVID-19 and related viral diseases.</p>","PeriodicalId":482,"journal":{"name":"Biochemical Genetics","volume":" ","pages":"3287-3312"},"PeriodicalIF":2.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141490369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Forensic Characterization, Genomic Variability and Ancestry Analysis of Six Populations from Odisha Using mtDNA SNPs and Autosomal STRs.","authors":"Jaison Jeevan Sequeira, Muktikanta Panda, Shivani Dixit, Ramkishan Kumawat, Mohammed S Mustak, Awdhesh Narayan Sharma, Gyaneshwer Chaubey, Pankaj Shrivastava","doi":"10.1007/s10528-024-10887-2","DOIUrl":"10.1007/s10528-024-10887-2","url":null,"abstract":"<p><p>Located on India's eastern coast, Odisha is known for its diverse tribes and castes. In the early days of genome sequencing technology, researchers primarily studied the Austroasiatic communities inhabiting this region to reconstruct the ancient origins and dispersal of this broad linguistic group. However, current research has shifted towards identifying population and individual-specific genome variation for forensic applications. This study aims to analyze the forensic efficiency and ancestry of six populations from Odisha. We assessed the SF mtDNA-SNP60™ PCR Amplification Kit by comparing it with PowerPlex® Fusion 6C System, a widely used autosomal STR (aSTR) kit, in an Indian cohort. Although the mtDNA SNP kit showed low discriminating power for individuals of a diverse population, it could identify deep lineage divergence. Also, we utilized mitochondrial and autosomal variation information to analyze the ancestry of six endogamous ethnic groups in Odisha. We observe two extremities-populations with higher West Asian affinity and those with East Asian affinity. This observation is in congruence with the existing information of their tribal and non-tribal affiliation. When compared with neighbouring populations from Central and Eastern India, multivariate analysis showed that the Brahmins clustered separately or with the Gopala, Kaibarta appeared as an intermediate, Pana and Kandha clustered with the Gonds, and Savara with the Munda tribes. Our findings indicate significant deep lineage stratification in the ethnic populations of Odisha and a gene flow from West and East Asia. The artefacts of unique deep lineage in such a diverse population will help in improving forensic identification. In addition, we conclude that the SF mtDNA-SNP60 PCR Amplification Kit may be used only as a supplementary tool for forensic analysis.</p>","PeriodicalId":482,"journal":{"name":"Biochemical Genetics","volume":" ","pages":"3497-3516"},"PeriodicalIF":2.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141747070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive review of dermatological and cosmeceutical manifestations of thermal water and future insights.","authors":"Shamsa Kanwal, Enass Y Osman, Imen Khiari","doi":"10.1007/s00484-025-02937-0","DOIUrl":"10.1007/s00484-025-02937-0","url":null,"abstract":"<p><p>Balneotherapy is a widely accepted and well-practiced treatment modality for dermatological diseases in many countries worldwide. The use of balneotherapy approaches for skin disease management is continuously increasing, but the mechanism by which thermal water affects the treatment of different dermatological conditions has not been fully explored. This comprehensive review seeks to consolidate scientific findings regarding the effects of thermal water in the treatment of different skin diseases, such as psoriasis, atopic dermatitis, acne, ichthyosis, and lichen planus, as well as its cosmeceutical effects, drawing from both in vitro and in vivo research. This review analyzed both in vitro and in vivo studies to validate the anti-inflammatory, immunomodulatory, and antioxidant potential of thermal water in dermatology. Thermal water exhibits these properties, making it beneficial for treating various skin conditions and enhancing cosmeceutical effects.\" Many studies have strongly demonstrated the therapeutic benefits of different thermal waters for the successful treatment of many skin diseases, and these materials have been incorporated into cosmetics for skin hydration and anti-aging and anti-wrinkle effects. The physicochemical and microbial characteristics of thermal water contribute to its therapeutic properties, with sulfurous water being particularly effective due to their favorable mineral composition and antioxidative effects.Although the cosmetic properties of thermal water are well described, further research is needed to identify specific mineral and microbial profiles for incorporation into cosmetic products and to integrate advanced technologies and approaches to increase the effectiveness of formulated products. Should aim to clarify the underlying mechanisms of action of thermal waters, investigate optimal treatment protocols, and assess their long-term efficacy. Longitudinal clinical trials are also needed to assess the long-term benefits and safety of these treatments, paving the way for standardized protocols in dermatological care.</p>","PeriodicalId":588,"journal":{"name":"International Journal of Biometeorology","volume":" ","pages":"1783-1817"},"PeriodicalIF":3.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144148972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"地球科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a reference material for simultaneous quantitative determination of multiple veterinary drug residues.","authors":"Cheng Ma, Chengping Wu, Yunhua Gao, Lianhua Dong, Jiayi Yang, Hailan Chen","doi":"10.1007/s00216-025-05952-7","DOIUrl":"10.1007/s00216-025-05952-7","url":null,"abstract":"<p><p>Excessive use of multiple veterinary drugs can lead to the accumulation of residues in food derived from animals, thereby posing potential risks to human health and the environment. Accurate quantification of residues from multiple veterinary drugs is essential for ensuring effective monitoring and regulatory compliance. In this study, a robust high-performance liquid chromatography coupled with diode array detection (HPLC-DAD) method was developed for the simultaneous determination of six veterinary drug residues, including florfenicol (FF), thiamphenicol (TAP), difloxacin (DIF), sulfadimidine (SDM), trimethoprim (TMP), and fenvalerate (FEN). This method was subsequently applied to quantify the multiple veterinary reference material (MVRM). Using the MVRM with assigned values, the varying performance of pre-treatment methods for multiple veterinary drugs in meat samples was evaluated, which may result in differing quantitative outcomes. The application of MVRM is helpful for ensuring food safety and safeguarding human health.</p>","PeriodicalId":462,"journal":{"name":"Analytical and Bioanalytical Chemistry","volume":" ","pages":"4373-4382"},"PeriodicalIF":3.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144300863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}