Springer最新文献

{"title":"Adolescent M-CSF Administration Provides Durable Protection Against Trauma-Induced PTSD-Like Phenotypes in Male Mice Through Microglia-Dependent Mechanisms","authors":"Fu Li,&nbsp;Minxiu Ye,&nbsp;Lijuan Tong,&nbsp;Chao Huang,&nbsp;Xing Xu,&nbsp;Jie Peng","doi":"10.1007/s11064-026-04915-3","DOIUrl":"10.1007/s11064-026-04915-3","url":null,"abstract":"<div><p>Post-traumatic stress disorder (PTSD) is a severe psychiatric condition for which effective preventive strategies are lacking. Innate immune preconditioning has shown promise for the prevention of PTSD, yet the transient nature of such protection when induced in adulthood poses a substantial limitation. Using male C57BL/6J mice, we tested whether administration of macrophage colony-stimulating factor (M-CSF, 100 µg/kg, intraperitoneally) during adolescence, a developmental period characterized by heightened microglial plasticity, could establish enduring resilience against trauma-induced PTSD-like behaviors. Mice received a single M-CSF injection at postnatal day 28 (PND28) and were subsequently subjected to single prolonged stress (SPS/FS) at 4, 16, or 32 weeks thereafter, with behavioral and molecular assessments conducted at PND70, PND154, and PND266, respectively. Our results showed that adolescent M-CSF exposure substantially prevented SPS/FS-induced anxiety-like behaviors assessed by the elevated plus maze and open field test, and SPS/FS-induced fear-like behaviors evaluated by contextual and cued fear conditioning tests, at all three post-administration intervals. Concurrently, M-CSF pretreatment prevented SPS/FS-induced interleukin-1β (<i>Il-1β</i>), <i>Il-6</i>, and tumor necrosis factor-α (<i>Tnf-α</i>) mRNA expression within the hippocampus and medial prefrontal cortex across all time points examined. These protective phenotypes were eliminated when microglial function was pharmacologically inhibited or when microglia were depleted before M-CSF administration, establishing that microglial integrity at the time of adolescent immune challenge is required for the establishment of long-term resilience. Taken together, these findings demonstrate that a single developmental immune intervention confers lifelong protection against SPS/FS-induced PTSD-like behaviors through microglia-dependent mechanisms, introducing a vaccine-like paradigm for the prevention of PTSD.</p></div>","PeriodicalId":719,"journal":{"name":"Neurochemical Research","volume":"51 6","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149219410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Bernhard Blümich: On the Occasion of His 70th Birthday","authors":"Matthew Augustine,&nbsp;Peter Blümler,&nbsp;Jeffrey Reimer","doi":"10.1007/s00723-026-01866-4","DOIUrl":"10.1007/s00723-026-01866-4","url":null,"abstract":"","PeriodicalId":469,"journal":{"name":"Applied Magnetic Resonance","volume":"57 11-12","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149222699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nonequivalent Macrophase Separation and Polyelectrolyte Complex Formation in the Lignosulfonate–Chitosan System","authors":"T. N. Lugovitskaya,&nbsp;U. R. Sharipova,&nbsp;D. Yu. Berseneva,&nbsp;M. A. Gladysheva,&nbsp;D. A. Rogozhnikov","doi":"10.1134/S1061933X26600594","DOIUrl":"10.1134/S1061933X26600594","url":null,"abstract":"<p>The interpolymer interaction in the lignosulfonate (LS)–chitosan (ChTS) system, in which ChTS is dissolved in aspartic acid (ChTS·Asp), has been studied, and the colloid-chemical regularities of macrophase separation accompanied by the formation of a water-insoluble polyelectrolyte complex (PEC) have been determined. The data on the concentration dependences of molar conductivity and pH have been used to show that LS and ChTS·Asp solutions exhibit polyelectrolyte properties. On the basis of the potentiometrically controlled dosed mixing of polyelectrolyte solutions in two different orders, the cloud points have been determined and an empirical phase state diagram has been plotted for the LS–ChTS·Asp systems. It has been found that, when the LS solution is added to the ChTS·Asp solution, the turbidity onset is observed at conditional analytical ratio <i>n</i>(<span>({text{SO}}_{3}^{ - })</span>)/<i>n</i>(<span>({text{NH}}_{3}^{ + })</span>) = 0.015–0.567, i.e., in the region of an analytical excess of ChTS amino groups. At the reverse mixing order, when the ChTS·Asp solution is added to the LS solution, the initial turbidity is recorded at ratio <i>n</i>(<span>({text{SO}}_{3}^{ - })</span>)/<i>n</i>(<span>({text{NH}}_{3}^{ + })</span>) = 6.30–7.03, which corresponds to an analytical excess of LS sulfonate groups. Hence, the transition of the system to the macrophase separation is not caused by the achievement of a conditional charge equivalence of the functional groups and essentially depends on the order of component addition, the local composition of the medium, and the concentration and kinetic factors. Water-insoluble PEC has been isolated from the LS–ChTS·Asp systems and characterized using FTIR spectroscopy, thermogravimetric analysis, and scanning electron microscopy. Taken together, the obtained data indicate the formation of an LS–ChTS interpolymer complex with involvement of electrostatic interactions between <span>({text{SO}}_{3}^{ - })</span> groups of LS and <span>({text{NH}}_{3}^{ + })</span> groups of protonated ChTS, as well as hydrogen bonding. It has been found that the phase behavior of the system is governed not only by the charge ratio of the components, but also by the mixing order and the conformational and associative features of the natural polyelectrolytes in an aqueous medium.</p>","PeriodicalId":521,"journal":{"name":"Colloid Journal","volume":"88 5","pages":"763 - 775"},"PeriodicalIF":1.6,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149222689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Secondary Flows and Hydraulic Resistance in a Rectangular Channel with Spatially Inhomogeneous Discrete Roughness","authors":"R. R. Shakirov,&nbsp;I. A. Davletshin,&nbsp;N. I. Mikheev","doi":"10.1134/S1063785026700926","DOIUrl":"10.1134/S1063785026700926","url":null,"abstract":"<p>Spanwise heterogeneous surface roughness can induce secondary flows of Prandtl’s second kind, which significantly affect momentum and heat transfer. Despite a large number of numerical studies of such flows, experimental data remain rather limited. In this paper, an experimental study of turbulent flow in a rectangular channel with walls formed by alternating smooth sections and strips of discrete roughness is performed. The fields of mean velocities and turbulence characteristics are obtained using the SIV method, and the structure of secondary flows is reconstructed. Measurements of hydraulic resistance are carried out for various surface configurations and Reynolds numbers. It is shown that heterogeneous roughness leads to the formation of large-scale secondary flows in the form of counter-rotating vortices with a transverse velocity of up to 5% of the main flow velocity. A correlation between the intensity of secondary flows and the hydraulic resistance coefficient is revealed, indicating a significant role of secondary circulation in momentum transfer mechanisms in the channel.</p>","PeriodicalId":784,"journal":{"name":"Technical Physics Letters","volume":"52 9","pages":"476 - 483"},"PeriodicalIF":0.8,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149222773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bidirectional Regulatory Mechanisms of T cell-microglia Interactions in Cerebral Ischemic Disease: Molecular Crosstalk, Experimental Techniques and Therapeutic Implications","authors":"Yuxiao Zheng,&nbsp;Jialin Cheng,&nbsp;Fawei Li,&nbsp;Zilin Ren,&nbsp;Congai Chen,&nbsp;Zehan Zhang,&nbsp;Xin Lan,&nbsp;Chuxin Zhang,&nbsp;Yang Zhao,&nbsp;Jinhua Han,&nbsp;Jiaming Li,&nbsp;Fafeng Cheng,&nbsp;Qingguo Wang,&nbsp;Changxiang Li,&nbsp;Xueqian Wang","doi":"10.1007/s11064-026-04916-2","DOIUrl":"10.1007/s11064-026-04916-2","url":null,"abstract":"<div><p>Cerebral ischemic diseases, such as ischemic stroke (IS) and vascular dementia (VaD), are major causes of neurological disability and mortality. Neuroinflammation acts as a pivotal driver of secondary brain injury, mediated by intricate bidirectional interactions between peripheral T cells and central nervous system (CNS)-resident microglia. This review delineates the molecular mechanisms underlying T cell-microglia crosstalk in cerebral ischemia, emphasizing their dual roles in exacerbating neurotoxicity and promoting repair. Direct interactions involve antigen presentation via MHC-TCR engagement and co-stimulatory checkpoints (e.g., CD80/CD86-CD28, PD-L1-PD-1), which regulate T cell activation and microglial polarization. Direct signaling through cytokines (IFN-γ, IL-4, IL-17, IL-10) further modulates microglial phenotypes: Th1/Th17 cells drive pro-inflammatory M1 polarization via STAT1/NF-κB pathways, while Tregs/Th2 cells induce anti-inflammatory M2 states through STAT6/SMAD signaling. Spatial transcriptomics and single-cell omics reveal spatiotemporal dynamics of these interactions, identifying STAT1/STAT6 imbalance as a critical determinant of neuroinflammatory outcomes. Advanced methodologies, including two-photon intravital microscopy and microfluidic blood-brain barrier (BBB) models, enable real-time visualization of immune cell trafficking and synaptic communication. Therapeutically, targeting immune checkpoints (CTLA-4, PD-1) or cytokine pathways (e.g., IL-4 mimetics) shows promise in recalibrating neuroimmune responses. However, challenges such as blood-brain barrier impermeability to biologics and interspecies immune heterogeneity necessitate innovative delivery strategies. This review integrates molecular, cellular, and technological insights to propose a framework for precision immunomodulation. By elucidating context-dependent signaling nodes and leveraging emerging tools, the study underscores the potential of harnessing T cell-microglia crosstalk to mitigate neuroinflammation and enhance neural repair, offering transformative avenues for stroke and dementia therapy.</p></div>","PeriodicalId":719,"journal":{"name":"Neurochemical Research","volume":"51 6","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149219465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monte Carlo Analysis of Ga2O3 Damage from Alpha Particle Radiation","authors":"Daotian Shi,&nbsp;Chuanyang Liu,&nbsp;Qing Sun,&nbsp;Jingjing Liu,&nbsp;Xinjiang Wang,&nbsp;Huakui Hu","doi":"10.1134/S1063785026600626","DOIUrl":"10.1134/S1063785026600626","url":null,"abstract":"<p>In this study, we used the Monte Carlo method to simulate the interaction of alpha particles with Ga₂O₃ and assess radiation damage. The findings show that alpha particles are primarily stopped by electrons, with ionization dominating energy dissipation, while phonon and vacancy‑related losses contribute negligibly. Over the investigated energy range, ionization loss increased with radiation energy, while both phonon and vacancy losses decreased. At a radiation energy of 2.05 MeV, ionization accounts for 99.41% of the total energy loss, while phonon excitation and vacancy formation contribute only 0.03 and 0.52%, respectively. As the radiation energy increased from 2.05 to 5.48 MeV, the peak energy absorbed by Ga and O atoms decreased from 0.81 and 0.84 eV to 0.62 eV, respectively. Alpha particles in Ga₂O₃ have a spatial distribution similar to a tadpole. The calculated maximum values were 0.0347 for displacement per atom (DPA), 1.63 × 10²¹ cm^–3 for V_Ga concentration, and 1.65 × 10²¹ cm^–3 for V_O concentration. These results demonstrate that alpha particle irradiation causes substantial damage in Ga₂O₃, posing a critical threat to both material integrity and device functionality.</p>","PeriodicalId":784,"journal":{"name":"Technical Physics Letters","volume":"52 9","pages":"493 - 500"},"PeriodicalIF":0.8,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149222571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Theoretical Estimation of the Heat Transfer Coefficient in a Plane Channel","authors":"N. D. Bogdanov,&nbsp;I. A. Davletshin","doi":"10.1134/S106378502670094X","DOIUrl":"10.1134/S106378502670094X","url":null,"abstract":"<p>The heat transfer coefficient in a plane channel was estimated theoretically. In the framework of assumptions made in the present research, a correlation in the form of Lyon’s integral was obtained for energy equation. It was employed for analytical estimation of heat transfer coefficient in laminar flows and liquid metal flows, in which molecular heat transfers prevail over turbulent one. The computational results comply with the literature.</p>","PeriodicalId":784,"journal":{"name":"Technical Physics Letters","volume":"52 9","pages":"467 - 471"},"PeriodicalIF":0.8,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149222572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Water/AOT/Isopropyl Myristate Reverse Microemulsions as Media for Biocatalytic Reactions","authors":"N. V. Sautina,&nbsp;D. O. Sagdeev,&nbsp;O. I. Gnezdilov,&nbsp;Yu. G. Galyametdinov","doi":"10.1134/S1061933X26600466","DOIUrl":"10.1134/S1061933X26600466","url":null,"abstract":"<p>This work examines the possibility of controlling biocatalytic reactions in self-organizing systems using cytochrome C as a catalyst. It is known that it can accelerate biological processes acting as a catalyst for cellular respiration. Microemulsions based on sodium bis(2-ethylhexyl)sulfosuccinate (AOT) are of significant interest as nanosized transport and reaction systems in biocatalysis, as they are capable of stabilizing enzymes while maintaining their functional activity. In this study, three-component water/AOT/isopropyl myristate systems with different compositions and degrees of hydration have been obtained. They have the structure of water-in-oil microemulsions with droplet sizes of 4.2–8.7 nm, as well as the structure of liquid crystals. The structure-related phase transformations in the systems under consideration have been studied upon increasing AOT concentration from microemulsions to a liquid crystalline mesophase. It has been found that the incorporation of cytochrome C into the microemulsions results in its good solubilization, which leads to a slight decrease in droplet sizes and their narrower distribution in the system. The UV–Vis and luminescence spectroscopy data have shown the occurrence of the adsorption interaction between the protein and the polar groups of AOT. The applicability of the obtained systems to biocatalysis has been investigated using the example of guaiacol oxidation with hydrogen peroxide in the presence of cytochrome C. To controllably increase the yield of the catalytic reaction product in the microemulsion, hydrophilic Cd_0.9Mn_0.1S/ZnS quantum dots stabilized with mercaptopropionic acid have been added to the microemulsion. It has been found that the yield of tetraguaiacol in the reaction increases in direct proportion to the concentration of the introduced quantum dots. Thus, the catalytic processes can be accelerated or slowed down using the microemulsions as reaction media.</p>","PeriodicalId":521,"journal":{"name":"Colloid Journal","volume":"88 5","pages":"786 - 798"},"PeriodicalIF":1.6,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149222634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamic Game-theoretical Models of Innovation Management in Universities Taking into Account Opportunistic behavior","authors":"V. Yu. Kalachev,&nbsp;G. A. Ougolnitsky,&nbsp;A. B. Usov","doi":"10.1134/S1064562426700146","DOIUrl":"10.1134/S1064562426700146","url":null,"abstract":"<p>The article studies the issues of innovation implementation in universities. A three-level hierarchically organized model is proposed to describe the process of innovation implementation in universities. The model includes agents (followers, in whose role teachers act), supervisors (subjects of middle-level management, universities) and a principal (leader, the state). The principal (the state) is the first to announce its behavior strategy. Supervisors choose their management strategies when the principal’s choice is already known, but the agents’ choice is not yet known. Agents (teachers) make their choice when the management strategies of the other subjects are already known. Supervisors, like agents, make their choice independently of each other. The principal subsidizes the innovative development of higher education institutions by allocating funds for the development of new electronic courses. The new electronic courses being developed are considered as innovative products that contribute to the innovative development of higher education institutions. Supervisors receive subsidies from the principal for the development and implementation of innovative products. They determine the required volume of new courses issued by agents. Agents develop new electronic training courses for subsequent sale and implementation in the educational process. Supervisors keep part of the subsidies received from the principal for themselves, and transfer part to agents. Agents receive subsidies, the amount of which depends on the demand for the courses they develop, and manage the quality of the courses they develop, improving their qualifications. The possibility of corruption in the system is provided for and methods for combating it are defined. Lower and middle management entities may be subject to corruption. Agents may offer bribes to supervisors, in exchange for which they inflate the portion of subsidies transferred to agents. An analysis is conducted of how the presence of corruption affects the innovative development of universities. Thus, a dynamic three-level model is constructed, in which the dynamics are described by a difference equation reflecting the change in the general innovative level of the education system depending on the agents’ controls. Algorithms for constructing a solution for different combinations of Stackelberg games with and without feedback on control between the state and universities and between universities and teachers are indicated. In a non-antagonistic game of universities among themselves, as in a game of teachers, a Nash equilibrium is built. The results of numerical experiments are presented, their analysis is given. A number of meaningful conclusions and recommendations are made.</p>","PeriodicalId":531,"journal":{"name":"Doklady Mathematics","volume":"113 3","pages":"102 - 110"},"PeriodicalIF":0.8,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149222777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation Technology for Autonomous Navigation Methods of Unmanned Aerial Vehicles Based on SLAM Algorithms","authors":"P. A. Ukhov,&nbsp;K. A. Stenin","doi":"10.1134/S1064562426700122","DOIUrl":"10.1134/S1064562426700122","url":null,"abstract":"<p>The article proposes a technology for validating autonomous navigation methods for unmanned aerial vehicles based on simultaneous mapping and localization (SLAM) algorithms. The proposed technology is based on experimental studies using real flight data and includes the design of validation scenarios, synchronization and spatial alignment of trajectories, as well as the calculation of a set of quantitative metrics characterizing global and local accuracy, drift accumulation, and the stability of the navigation solution. As a demonstration example, the technology was evaluated using the VINS-Fusion visual-inertial algorithm using recordings of real UAV flights. The obtained results show that the proposed approach allows comparing different SLAM solutions under the same conditions and identifying flight modes that are most sensitive to error accumulation.</p>","PeriodicalId":531,"journal":{"name":"Doklady Mathematics","volume":"113 3","pages":"84 - 94"},"PeriodicalIF":0.8,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149222779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}