含有1,3-二氧六环的酮肟的合成、性质及抗凝血和抗血小板活性的研究

IF 1.7 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Russian Chemical Bulletin Pub Date : 2025-08-16 DOI:10.1007/s11172-025-4701-8

Ya. S. Artamonova, A. I. Poptsov, Yu. G. Borisova, A. A. Golovanov, G. Z. Raskildina, S. S. Zlotsky, R. M. Sultanova

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引用次数: 0

摘要

研究了含1,3-二氧六环的酮肟与烷基卤化物、双功能化合物和酰化剂的改性反应，并研究了起始化合物和产物的抗凝血和抗血小板活性。合成的醚类、酯类和氨基甲酸酯具有与乙酰水杨酸水平相当的抗凝血活性，而含有环缩醛基团的苯氨基甲酰肟在促聚集活性和增强血小板聚集方面与乙胺酸钠相当。

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Synthesis, properties, and study of anticoagulant and antiplatelet activity of ketoximes containing the 1,3-dioxane moiety

Modification of ketoximes containing 1,3-dioxane moiety in reactions with alkyl halides, bifunctional compounds, and acylation agents was studied, and anticoagulation and antiplatelet activity of both starting compounds and products was investigated. The synthesized ethers, esters, and carbamates showed anticoagulant activity at the level of acetylsalicylic acid, whereas phenylcarbamoyl oxime containing a cycloacetal group was found to be comparable to sodium etamsylate in pro-aggregation activity and enhancement of platelet aggregation.

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来源期刊

Russian Chemical Bulletin 化学-化学综合

CiteScore

2.70

自引率

47.10%

发文量

257

审稿时长

3-8 weeks

期刊介绍： Publishing nearly 500 original articles a year, by leading Scientists from Russia and throughout the world, Russian Chemical Bulletin is a prominent international journal. The coverage of the journal spans practically all areas of fundamental chemical research and is presented in five sections: General and Inorganic Chemistry; Physical Chemistry; Organic Chemistry; Organometallic Chemistry; Chemistry of Natural Compounds and Bioorganic Chemistry.