Elsevier最新文献

{"title":"Multifunctional nanofiber-based electronic skin with moisture-wicking, piezoelectric motion sensing and thermochromic temperature response.","authors":"Jun Zhang, Jinke Guo, Kainan Guo, Qianyue Li, Shouzhi Yan, Tingxiao Li, Binjie Xin","doi":"10.1016/j.jcis.2025.138773","DOIUrl":"10.1016/j.jcis.2025.138773","url":null,"abstract":"<p><p>Electronic skin (e-skin) faces challenges in achieving long-term signal stability and wearability due to the poor breathability, sweat accumulation, and limited sensitivity. This paper reports a multifunctional nanofibrous e-skin (PTZ-PPPB-PPT) fabricated via layer-by-layer electrospinning, integrating a hydrophobic layer (PVDF-TrFE/ZnO), a piezoelectric enhancement layer (PAN/PVP/PDA@BTO), and a thermochromic layer (PAN/PVP/TCM). Benefited from the asymmetric wettability and hierarchical fiber structure, the device enables unidirectional sweat transport (contact angle reduces from 132.8° to 0° within 5.72 s) while blocking reverse osmosis (hydrostatic resistance of 40 mmH₂O). When the piezoelectric sensor operates under excessive sweating conditions, the unidirectional sweat transport maintains skin surface dryness, thereby ensuring stable piezoelectric output during movement. Notably, the E-skin achieves a high output voltage (40 V at 30 N with a sensitivity of 0.825 V/N), exhibits rapid response/recovery (100/80 ms). It also demonstrates reversible thermochromism (25-40 °C) for real-time temperature visualization. Additionally, the device ensures superior comfort during prolonged wear by maintaining exceptional air permeability (8.05 mm/s) and outstanding mechanical flexibility (187.75 % elongation at break). This multifunctional integrated E-skin synergizes sweat management with temperature visualization, holding promising potential for applications in wearable healthcare, human-computer interaction, and dynamic environmental monitoring.</p>","PeriodicalId":351,"journal":{"name":"Journal of Colloid and Interface Science","volume":"701 ","pages":"138773"},"PeriodicalIF":9.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144937889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Li₃PO₄-enriched solid electrolyte interphase on Si-based anode for enhanced Li⁺ transport and interfacial stability in lithium batteries.","authors":"Guang Ma, Chong Xu, Sai Che, Dongyuan Zhang, Shuang Liu, Junjie Fu, Gong Cheng, Ye Wang, Yang Sun, Chao Dong, Wenyue Gao, Yongfeng Li","doi":"10.1016/j.jcis.2025.138710","DOIUrl":"10.1016/j.jcis.2025.138710","url":null,"abstract":"<p><p>The structure and composition of the solid electrolyte interphase (SEI) exerts a significant influence on the fast-charging capability and stability of lithium-ion batteries (LIBs). However, elucidating the design principles governing anode interfacial structures and revealing the kinetics and mechanisms of Li⁺ transport remain challenging. SEI layer. Herein, we present an efficient synthesis strategy for fabricating LIBs anodes consisting of silicon nanoparticles coated with a Li₃PO₄-modified carbon shell (Si@C@LPO). Through a combination of comprehensive experimental investigations and density functional theory (DFT) calculations, we elucidate the influence of SEI layer enriched with various inorganic components on Li⁺ transport. The high adsorption energy of the LiPO₄-enriched SEI enhances its affinity for Li⁺ during the cycling process and suppresses solvent decomposition at the anode interface, thereby improving both fast-charging performance and electrode stability. Consequently, the Si@C@LPO anode exhibit a specific capacity of 605.67 mAh g^-1 at 8 A g^-1 and significantly enhanced cycling durability with a higher capacity retention of 73.3 % after 100 cycles at 1 A g^-1. This strategy establishes a clear correlation among SEI components, Li⁺ transport kinetics, and the design of interfacial structures in high performance LIBs anode materials.</p>","PeriodicalId":351,"journal":{"name":"Journal of Colloid and Interface Science","volume":"701 ","pages":"138710"},"PeriodicalIF":9.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144937794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phosphate ion functionalized Ni(OH)₂/Ni/MoO₂ composite for enhanced alkaline hydrogen evolution.","authors":"Yuyang Liu, Huiping You, Tiancheng Geng, Jing Zhang, Enlai Hu, Yining Zhang, Zhongwei Chen","doi":"10.1016/j.jcis.2025.138724","DOIUrl":"10.1016/j.jcis.2025.138724","url":null,"abstract":"<p><p>The development of efficient electrocatalysts for hydrogen evolution reaction (HER) is important in advancing sustainable energy technologies. This work introduces a phosphate ion modified Ni(OH)₂/Ni/MoO₂ (PNNM) composite, elaborately constructed by a one-pot electrodeposition method. The integration of heterostructure engineering and ion modification strategies significantly endows the composite with remarkable electrocatalytic performance. The prepared PNNM has excellent HER activity, with a low overpotential of 35 mV to achieve a current density of 10 mA cm^-2 and a favorable Tafel slope of 59.5 mV dec^-1. Meanwhile, PNNM also possesses prominently long-term durability with the current density retention rate of 90.1 % after 240 h. In-situ Raman, electrochemical analysis, and theoretical calculation results reveal that the enhanced HER activity of PNNM results from the moderated hydrogen adsorption strength, robust water adsorption, and accelerated water dissociation process. This study highlights the potential of PNNM as a promising candidate for scalable alkaline hydrogen generation, offering significant advancements in renewable energy applications.</p>","PeriodicalId":351,"journal":{"name":"Journal of Colloid and Interface Science","volume":"701 ","pages":"138724"},"PeriodicalIF":9.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144937909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clarifying conceptualization of emotional dysregulation: Differences with emotional lability during 4-month DBT skills training - A naturalistic study.","authors":"Amaury Durpoix, Martin Blay, Christophe Moog, Julie Rolling, Luisa Weiner, Laurence Lalanne, Sébastien Weibel","doi":"10.1016/j.jad.2025.120199","DOIUrl":"10.1016/j.jad.2025.120199","url":null,"abstract":"<p><strong>Introduction: </strong>Emotion dysregulation is common in many different psychiatric disorders and it can be effectively treated with the well-established Dialectical Behavioral Therapy (DBT). Despite its clinical relevance and increasing scientific interest, emotional dysregulation (ED) is sometimes conflated with emotional lability (EL). However, these constructs differ: ED involves top-down neurobiological processes, while EL involves bottom-up processes. As psychotherapy essentially influences top-down processes compared to pharmacotherapy, this study aimed to investigate whether ED is more sensitive to DBT than EL.</p><p><strong>Method: </strong>Our naturalistic study involved the 39 participants (sex ratio = 9 m/30w, mean age = 33.23) who completed questionnaires assessing ED (DERS-36) and EL (ALS-18) before then after transdiagnostic DBT skills training (DBT-ST). The diagnoses of participants included BPD (64 %), BD (23 %), ADHD (23 %), addiction (17 %) or eating disorder (17 %). DBT was performed in a transdiagnostic group over 4 months.</p><p><strong>Result: </strong>After DBT-ST, ED improved significantly with a medium effect size (d = 0.73), while EL showed no significant change (d = 0.13). The percentages of improvement on DERS were significantly higher than on ALS (p < 0.002, d = 0.50). The correlation between these both measures decreased during therapy from r = 0.37 to r = 0.32.</p><p><strong>Discussion: </strong>Our findings indicate that ED improved more than EL after DBT and that their correlation diminished during therapy. These results suggest that ED is a different process from EL and that ED is more sensitive to treatments like DBT Skills Training. To confirm these findings, further studies are needed ideally with larger sample size, long-term follow-up and a controlled design.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"120199"},"PeriodicalIF":4.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145006111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unravelling symptom-specific polygenic effects on maternal mental health during the perinatal period and postpartum.","authors":"Ludvig Daae Bjørndal, Robyn E Wootton, Omid V Ebrahimi, Giulia G Piazza, Laura Hegemann, Elizabeth C Corfield, Laurie J Hannigan, Jean-Baptiste Pingault, Ole A Andreassen, Alexandra Havdahl, Helga Ask","doi":"10.1016/j.jad.2025.120228","DOIUrl":"10.1016/j.jad.2025.120228","url":null,"abstract":"<p><strong>Background: </strong>While genetic factors are important influences on maternal mental health, few studies have used symptom-level analyses to examine how genetic liability is related to the experience of specific mental health problems in mothers. A symptom-level approach can account for disorder heterogeneity and delineate key associations between genetic liabilities and mental health.</p><p><strong>Methods: </strong>Three waves of data (30 weeks of gestation, 6 and 18 months postpartum) from the Norwegian Mother, Father and Child Cohort Study (MoBa) were used to assess item-level associations between genetic liabilities to depression, anxiety, neuroticism and positive affect, and maternal mental health phenotypes (i.e., symptoms of anxiety, depression, positive and negative affect) using a network analysis approach. Sample sizes ranged from 46,537 to 59,308 mothers.</p><p><strong>Results: </strong>PGSs exhibited both phenotype-specific associations (e.g., depression PGS linked with hopelessness, anxiety PGS linked with worry) and cross-phenotype (e.g., depression PGS linked with nervousness, positive affect PGS inversely related to anxiety and depressive symptoms) relationships, with partial correlations ranging between r = -0.025 and r = 0.024. Some PGS-phenotype associations were consistent (e.g., depression PGS linked with feeling like screaming or banging on something across all waves) and others inconsistent (e.g., anxiety PGS linked with nervousness only at 6 months postpartum) across the perinatal and postpartum periods.</p><p><strong>Conclusions: </strong>Our findings highlight symptom-level associations between PGSs and maternal mental health, which may be obscured when global measures of mental health (e.g., overall scores) are used. Identifying symptom-specific PGS associations could advance current understanding of aetiological influences on maternal mental health.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"120228"},"PeriodicalIF":4.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145006153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perinatal depressive symptoms and child temperament at two years: The moderating role of child sleep duration.","authors":"Katherine Silang, Sarah R Horn, Gerald F Giesbrecht, Andrew Szeto, Deinera Exner-Cortens, Kyle Dewsnapp, James Wonkyu Jung, Elizabeth Keys, Catherine Lebel, Lianne Tomfohr-Madsen","doi":"10.1016/j.jad.2025.120253","DOIUrl":"10.1016/j.jad.2025.120253","url":null,"abstract":"<p><strong>Background: </strong>Perinatal depression has been linked to higher negative affectivity (NA) in children, though the strength of this association is variable. Infant sleep, a known protective factor, may moderate this relationship though this has not been tested.</p><p><strong>Objective: </strong>To examine whether within-person changes in depressive symptoms across pregnancy and postpartum were linked to child NA, and whether infant sleep duration moderated these effects.</p><p><strong>Methods: </strong>This study analyzed secondary data from 3906 postpartum individuals recruited during the COVID-19 pandemic (2020-2021). Online surveys were administered at enrollment (<35 weeks' gestation), 6-, 12-, and 24 months postpartum, capturing demographic information, depressive symptoms, child NA (24 months), delivery outcomes, and infant sleep duration (12 months). A generalized linear model (GLM) tested the effects of within-person changes in perinatal depressive symptoms and chronic depressive symptom levels on child NA. The moderating role of infant sleep duration was also assessed.</p><p><strong>Results: </strong>Reductions in depressive symptoms from pregnancy to postpartum were associated with lower child NA, but only at sufficient infant sleep duration (B = -0.01, p = .040, f² = 0.002). Chronic perinatal depressive symptoms were associated with greater child NA (B = 0.03, p < .001, f² = 0.06); this risk was attenuated at longer infant sleep duration.</p><p><strong>Conclusion: </strong>Child NA was shaped by both chronic levels and within-person patterns of depressive symptoms. Infant sleep duration buffered risk of chronic depressive symptoms, and amplified the protective effects of patterns of symptom reduction, underscoring infant sleep duration as a key intervention target.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"120253"},"PeriodicalIF":4.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145008214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Childhood emotional abuse and suicidal ideation intensity: The serial effects of rejection sensitivity, thwarted belongingness, and perceived burdensomeness.","authors":"Sarah L Brown, Shelby M Nichols, Andrew J Lodge, Lori N Scott","doi":"10.1016/j.jad.2025.120252","DOIUrl":"10.1016/j.jad.2025.120252","url":null,"abstract":"<p><strong>Background: </strong>Rejection sensitivity (hypersensitivity and reactivity to threats of rejection due to previous rejection experiences) could provide insight into the role of childhood emotional abuse and associated interpersonal risk factors in the development of suicide ideation (SI).</p><p><strong>Objective: </strong>The current study examined SI among at-risk young adults using an integrated model of rejection sensitivity and suicide risk, as conceptualized by the interpersonal theory of suicide. We hypothesized that childhood emotional abuse would be indirectly prospectively associated with increases in SI intensity at 4-month follow-up (a cognitive-affective reaction to rejection) through greater rejection sensitivity and greater perceptions of rejection (thwarted belongingness [TB] and perceived burdenensomeness [PB]), in serial.</p><p><strong>Participants and setting: </strong>Participants were 148 young adult men and women (ages 18-35) with SI and/or suicidal behaviors within the past 4 months. Participants were recruited as part of a larger one-year longitudinal study of suicide risk in a transdiagnostic sample of young adults.</p><p><strong>Methods: </strong>PROCESS serial mediation procedures were used to test the hypothesis that emotional abuse would be indirectly associated with increased SI intensity at 4-month follow-up through rejection sensitivity and TB or PB, in serial.</p><p><strong>Results: </strong>Results indicated that childhood emotional abuse was prospectively associated with elevated SI intensity in adulthood through the indirect effects of rejection sensitivity and PB (std. est. = 0.04; 95 % CI = -0.03, 0.11) but not TB.</p><p><strong>Conclusion: </strong>Greater emotional abuse in childhood was associated with a greater sensitivity to rejection, which may perpetuate a cycle that increases risk for SI throughout adolescence and adulthood.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"120252"},"PeriodicalIF":4.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145008290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transdiagnostic homogeneity, and diagnostic-specific biomarkers among major depressive disorder, bipolar disorder and schizophrenia during 40 Hz auditory steady-state response: a normative modeling analysis.","authors":"Sitong Chen, Xinmeng Guo, Xiaoya Liu, Shuang Liu, Dong Ming","doi":"10.1016/j.jad.2025.120189","DOIUrl":"10.1016/j.jad.2025.120189","url":null,"abstract":"<p><strong>Background: </strong>Abnormal gamma-band auditory steady-state response (gamma-ASSR) power has been reported in major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia (SZ), but distinguishing between these disorders based solely on power remains challenging. Directed functional connectivity (DFC), which captures topological patterns of causal information flow, may provide more diagnostic-specific markers. However, conventional case-control framework often disregards the substantial individual heterogeneity, yielding unreliable biomarkers.</p><p><strong>Methods: </strong>An adapted framework integrating DFC heterogeneity with normative modeling was developed. 52 MDD, 33 BD, 39 SZ patients and 107 healthy controls (HC) participated in the 40 Hz-ASSR task. The normative model was established using data from 71 HC to define the population baseline. Thereafter, deviation Z-scores and the proportion of extreme deviations in DFC were calculated.</p><p><strong>Results: </strong>The DFC deviations showed high individual heterogeneity at most DFCs, with fewer than 2.6 % of individuals exhibiting extreme deviations at the same time point. However, a small proportion of DFC deviations with high overlap were embedded within common connectivity pathways in three disorders, particularly in the frontal and parietal regions. Furthermore, distinct diagnostic-specific patterns were identified: MDD mainly exhibited right temporal-frontal alterations, BD showed a parietal-driven temporo-occipital loop, and SZ presented a midline-centered pyramidal topology linking bilateral temporal-occipital regions. The Z-scores of DFC involved in these diagnostic-specific patterns achieved a maximum accuracy of 99.43 % with the K-nearest neighbors (KNN) algorithm.</p><p><strong>Conclusions: </strong>These findings offer novel insights into gamma-ASSR alterations and provide a robust framework for transdiagnostic and disorder-specific identification across MDD, BD, and SZ.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"120189"},"PeriodicalIF":4.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145008298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring ADHD through the Lens of temperament: The TEMPS-A connection.","authors":"Josleen Al Barathie, Mariam El-Jamal, Elie G Karam","doi":"10.1016/j.jad.2025.120251","DOIUrl":"10.1016/j.jad.2025.120251","url":null,"abstract":"<p><strong>Background: </strong>Temperament has been increasingly studied in relation to neurodevelopmental disorders, including Attention-Deficit/Hyperactivity Disorder (ADHD). This study examines the association between ADHD and affective temperament traits using the Temperament Scale of Memphis, Pisa, Paris, and San Diego (TEMPS-A) in a clinical outpatient sample in Beirut, Lebanon.</p><p><strong>Methods: </strong>This cross-sectional study included 2,564 psychiatric outpatients aged 15 or older who completed the TEMPS-A. ADHD diagnosis was determined through clinical assessments based on the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5) criteria. Statistical analyses included descriptive comparisons and multivariate logistic regression, with temperament trait scores categorized based on Lebanese population norms.</p><p><strong>Results: </strong>Participants had an average age of 38.53 years, with females comprising 52.3 % of the sample. Bivariate analyses showed ADHD was associated with higher cyclothymic (CT), hyperthymic (HT), and irritable (IT) temperament trait scores. After adjusting for age, gender, and comorbidities, only IT remained a significant risk factor for ADHD (OR = 2.73, 95 % CI: 1.23-6.09), while depressive temperament trait (DT) emerged as a protective factor (OR = 0.38, 95 % CI: 0.17-0.87).</p><p><strong>Conclusion: </strong>Our findings highlight the complex relationship between temperament traits and ADHD. IT was a significant risk factor, while DT unexpectedly appeared protective. These results underscore the need for further investigation into temperament traits as a diagnostic and therapeutic consideration in ADHD.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"120251"},"PeriodicalIF":4.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145008305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longer-term effects of modernized collaborative care for depression on multiple mental health factors (eIMPACT): A randomized controlled trial.","authors":"Michelle K Williams, Aubrey L Shell, Wei Wu, Krysha L MacDonald, Christopher M Callahan, John I Nurnberger, Christopher A Crawford, Matthew D Schuiling, Jesse C Stewart","doi":"10.1016/j.jad.2025.120272","DOIUrl":"10.1016/j.jad.2025.120272","url":null,"abstract":"<p><strong>Background: </strong>Integrating digital mental health into collaborative care could address multiple mental health factors. To determine the longer-term effects of modernized collaborative care for depression on overlapping mental health factors, we analyzed data from the eIMPACT trial.</p><p><strong>Methods: </strong>Primary care patients with depression and elevated cardiovascular disease risk (N = 216, Mage: 59 years, 78 % female, 50 % Black, 46 % with income <$10,000/year) were randomized to 12 months of the eIMPACT intervention (modernized collaborative care involving internet cognitive-behavioral therapy [iCBT], telephonic CBT, and/or select antidepressants) or usual primary care for depression. Depressive symptoms (Hopkins Symptom Checklist-20 [SCL-20] and Patient Health Questionnaire-9 [PHQ-9]), anxiety symptoms (Generalized Anxiety Disorder-7 [GAD-7]), hostility/anger/aggression (Buss-Perry Aggression Questionnaire [BPAQ]), and trait positive affect (Positive and Negative Affect Schedule-Positive Affect Subscale [PANAS-PA]) were measured at 0, 6, 12, and 24 months.</p><p><strong>Results: </strong>Compared to the usual care group, the intervention group exhibited significant improvements across all outcomes. The intervention group advantage increased over the treatment period, peaked at post-treatment (12 months: SCL-20 d_adj = -0.57, PHQ-9 d_adj = -0.63, GAD-7 d_adj = -0.50, BPAQ d_adj = -0.17, PANAS-PA d_adj = 0.41), and decreased over the follow-up period (24 months: SCL-20 d_adj = -0.24, PHQ-9 d_adj = -0.29, GAD-7 d_adj = -0.20, BPAQ d_adj = 0.06, PANAS-PA d_adj = 0.17).</p><p><strong>Conclusions: </strong>Modernized collaborative care improved multiple mental health factors, highlighting the feasibility and longer-term benefits of blending collaborative care and digital mental health across racial, education, and income groups. Future implementation of such interventions could promote equitable access to high-quality care.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov Identifier: NCT02458690.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"120272"},"PeriodicalIF":4.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145033272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}