Elsevier最新文献

{"title":"From awareness to action: Tackling sleep issues in college students","authors":"Galit Levi Dunietz , Erica C. Jansen","doi":"10.1016/j.sleepx.2025.100171","DOIUrl":"10.1016/j.sleepx.2025.100171","url":null,"abstract":"","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"11 ","pages":"Article 100171"},"PeriodicalIF":0.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145938887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"On the maximum electrical power efficiency of a hydroelectric nanobubble-driven cell.","authors":"Francisco J Arias","doi":"10.1016/j.jcis.2026.140954","DOIUrl":"10.1016/j.jcis.2026.140954","url":null,"abstract":"<p><p>In recent decades, nanobubble technology has emerged as a disruptive approach with potential applications across a wide range of scientific and industrial fields. Although several theories have been proposed to explain the extraordinary longevity of nanobubbles-a behavior not predicted by classical models-this phenomenon remains the subject of active debate. Nevertheless, there is broad consensus that nanobubble stability primarily arises from strong surface electric charge associated with interfacial phenomena, leading to localized water dissociation in the vicinity of the nanobubble. The water dissociation driven by nanobubbles has prompted speculation regarding the possibility of power generation through a hydroelectric cell, potentially enabling an alternative long-term, large-scale energy storage pathway that has not yet been explored. However, despite its conceptual appeal, any quantitative estimation of the efficiency of such a system, if feasible at all, has not been established. Here, utilizing the linearized Poisson-Boltzmann (Debye-Hückel) approximation and first-order perturbations in the nanobubble surface potential, an analytical expression for the maximum efficiency of a hydroelectric nanobubble-driven cell is derived. It is shown that a maximum efficiency of  ≃ 12% can be achieved at best, with predicted current densities remaining within the same order of magnitude as those reported for conventional hydroelectric-cell systems based on nanoporous ferrites. The resulting efficiencies are sufficiently non-negligible to warrant further theoretical and experimental investigation.</p>","PeriodicalId":351,"journal":{"name":"Journal of Colloid and Interface Science","volume":"723 ","pages":"140954"},"PeriodicalIF":9.6,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148337292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A light-activated one-pot ERA/CRISPR-Cas12a assay for cost-effective dual-mode detection of HBV DNA.","authors":"Xuan Zhou, Lang Wang, XiaoZhen Peng, Mengzhao Liu, Yue Li, Fang Gui, Lanying Zhou, Zhongliang Deng","doi":"10.1016/j.talanta.2026.130329","DOIUrl":"10.1016/j.talanta.2026.130329","url":null,"abstract":"<p><p>Light-activatable CRISPR-Cas systems offer an effective strategy to overcome the kinetic incompatibility in one-pot nucleic acid assays; however, their practical application remains limited by high reagent cost, the lack of compatible reaction buffers, and reliance on instrument-dependent readout. In this work, we developed a cost-effective light-controlled one-pot ERA/CRISPR-Cas12a platform for rapid hepatitis B virus (HBV) DNA detection. NPOM-caged crRNA was employed to temporarily suppress Cas12a activity during amplification and to trigger target-dependent trans-cleavage by a brief 30 s UV irradiation. By replacing RPA with ERA, the per-reaction reagent cost of the one-pot assay was reduced from approximately US$6.0 to US$2.0, corresponding to a reduction of approximately 66.7%, while maintaining comparable analytical performance. In addition, a PEG-free unified buffer was established through systematic optimization, enabling efficient integration of ERA and Cas12a reactions in a sealed single-tube format. The proposed platform provided dual-mode readout through fluorescence and lateral flow assay (LFA), with a limit of detection of 1 copy μL^-1 and a total assay time of 30 min. Clinical evaluation using 79 serum samples showed a sensitivity of 100% for fluorescence readout and 96.3% for LFA, with excellent agreement with qPCR (Cohen's κ = 0.94 - 1.00). Owing to its low cost, high sensitivity, and operational simplicity, this platform represents a promising tool for rapid HBV molecular diagnosis in both centralized laboratories and resource-limited settings.</p>","PeriodicalId":435,"journal":{"name":"Talanta","volume":" ","pages":"130329"},"PeriodicalIF":6.7,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148676600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emotional processing biases in the longitudinal course of major depressive disorder.","authors":"Katharina Hierl, Liane Wollweber, Hannah Lemke, Leonie Esser, Cécile Abati, Dominik Grotegerd, Katharina Dohm, Anna Kraus, Elisabeth J Leehr, Hanne L Kjærstad, Philipp Kanske, Udo Dannlowski, Katharina Förster","doi":"10.1016/j.jad.2026.122362","DOIUrl":"10.1016/j.jad.2026.122362","url":null,"abstract":"<p><p>Negative biases in emotional processing are central to cognitive models of Major Depressive Disorder (MDD), yet it remains unclear whether negatively biased valence attribution covaries with depressive symptoms or represents a more stable vulnerability. In this longitudinal study, we examined emotional valence ratings during a subliminal affective priming task in n = 232 MDD patients and n = 496 healthy controls (HC's) across multiple follow-up assessments, yielding 1395 observations. Multilevel models tested effects of depressive symptom severity, diagnostic group (MDD vs. HC), affective prime (happy, sad, neutral), and their interactions. To separate within-person fluctuations from between-person differences, depressive symptom severity was decomposed (Mundlak within-between specification). Exploratory analyses examined whether long-term symptom trajectory clusters were associated with emotional bias. Greater depressive symptom severity was associated with more negative valence ratings. Within-between analyses indicated that this association was primarily driven by within-person symptom fluctuations, indicating more negative ratings when symptom severity exceeded individual average. In contrast, diagnostic group, prime condition, and symptom severity × prime interactions did not significantly predict valence ratings, and no group differences emerged between HC's and remitted MDD patients. Exploratory trajectory analyses suggested that patients with recurrent symptom patterns may show more negative valence ratings, although cluster stability was limited and findings should be interpreted cautiously. Overall, the results suggest that negative valence attribution in MDD is more closely linked to current depressive symptom severity than to diagnostic status alone. Longitudinal approaches separating within- and between-person processes may help clarify when negative biases emerge and persist during depression progression.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"122362"},"PeriodicalIF":5.7,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148701309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evening meal timing irregularity is associated with higher depressive symptoms in Iranian adults: A cross-sectional study.","authors":"Vida Dankoob, Amirreza Ostevari, Bahareh Jabbarzadeh-Ganjeh, Amin Mirrafiei, Reyhane Norouziasl, Shadi Ghaemi, Negar Bafkar, Mahsa Firouzi, Aliyu Tijani Jibril, Amirreza Aghvamiamoli, Kurosh Djafarian, Alireza Bahrami, Sakineh Shab-Bidar","doi":"10.1016/j.jad.2026.122404","DOIUrl":"10.1016/j.jad.2026.122404","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to examine the association between irregular meal timing and symptoms of depression, anxiety, and stress among Iranian adults.</p><p><strong>Methods: </strong>This cross-sectional study included 450 apparently healthy adults (aged 20-59 years; 53.8% female) recruited via convenience sampling. Dietary data were collected using three non-consecutive 24-h recalls to assess meal timing irregularity, defined as day-to-day variability and deviation from participants' habitual meal timing, using composite phase deviation (CPD) scores for breakfast, lunch, and dinner. Mental health outcomes were measured with the Depression Anxiety Stress Scales short form. Covariates included sleep quality (Pittsburgh Sleep Quality Index), chronotype (Morningness-Eveningness Questionnaire), physical activity (International Physical Activity Questionnaire), anthropometrics, and sociodemographics. Associations were examined using multivariable logistic regression for binary outcomes and linear regression for continuous scores, adjusting for confounders. Linear regression analyses included participants with complete data for all model variables (n = 404).</p><p><strong>Results: </strong>No significant associations emerged between meal timing irregularity tertiles and binary mental health outcomes (all adjusted P-trend>0.05). However, in linear regression models, dinner irregularity was independently associated with higher depressive symptom scores (B = 1.08, 95% CI 0.32-1.85, P = 0.006), but not stress (P = 0.336) and anxiety (P = 0.388). Breakfast and lunch irregularities showed no significant associations.</p><p><strong>Conclusions: </strong>Dinner timing irregularity may be associated with higher depressive symptom scores in this sample of Iranian adults. Future prospective and intervention studies are needed to clarify temporality and underlying mechanisms.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"122404"},"PeriodicalIF":5.7,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148793190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The spatiotemporal-specific regulation of cell wall-related proteins promotes the secretion of pigments in Antarctic fungi Geomyces sp. wnf-18c.","authors":"Jiawen Du, Long Liu, Jiawen Gao, Xiaofeng Zhu, Lingkai Kong, Ting Cui, Menghao Cai, Xuemei Li, Yunxia Zhao, Xinyu Lu, Nengfei Wang, Shusheng Zhang","doi":"10.1016/j.biortech.2026.135614","DOIUrl":"10.1016/j.biortech.2026.135614","url":null,"abstract":"<p><p>The polar environment harbors extremely rich and valuable natural product resources. In this study, a strain of Antarctic fungus, Geomyces sp. wnf-18c, in Antarctic soil was isolated in a laboratory. This fungus produces a purplish-red pigment whose hue closely resembles that of the high-end pigment carminic acid. However, approximately 50 % of the pigment remains within the fungal hyphae, restricting subsequent separation and extraction. In this study, the deletion of the key cell wall protein-encoding genes CHS3 and AGS1 enhanced pigment secretion. It also considerably inhibited the strain's growth, making it difficult to substantially increase the total pigment yield. To overcome these hurdles, the xylose-inducible system from Trichoderma reesei was heterologously expressed in Antarctic fungi, and the CRISPR-Cas9 system was placed under the control of this induction system. The exogenous addition of xylose as a signal to initiate genetic editing achieved the spatiotemporal regulation of the target gene-activating gene editing that restricts growth only after the completion of the strain's growth phase. The spatiotemporal regulation of key cell wall proteins significantly mitigated growth inhibition, greatly enhanced pigment secretion, and raised the total pigment yield. This discovery advances our understanding of the spatiotemporal specificity and dynamic regulation of microorganisms, offering novel strategies for exploiting polar microbial resources and reducing industrial production costs.</p>","PeriodicalId":258,"journal":{"name":"Bioresource Technology","volume":" ","pages":"135614"},"PeriodicalIF":8.2,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148760457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Remission outcomes with bupropion versus selective serotonin reuptake inhibitors in major depressive disorder with comorbid obesity: A propensity-matched cohort analysis.","authors":"Farah Khorassani, Justin Schneider, Jonathan Prunean, Gemma Espejo","doi":"10.1016/j.jad.2026.122398","DOIUrl":"10.1016/j.jad.2026.122398","url":null,"abstract":"<p><p>Observational and secondary analyses of clinical trials evaluating efficacy of antidepressants suggest that medications with noradrenergic and dopaminergic mechanisms of action may be more effective in managing symptoms of major depressive disorder (MDD) in obese patients than medications that are purely serotonergic. The purpose of this study is to compare the efficacy of bupropion versus SSRIs in patients without a documented antidepressant trial with comorbid MDD and obesity. This was a retrospective, propensity-score matched, observational study utilizing a global cohort within the TriNetX database. Adults aged 18 or over with a major depressive episode and obesity were grouped into two cohorts: 1) exposure to bupropion and 2) exposure to SSRIs. Patients with antidepressant exposure prior to the index event were excluded. Both cohorts were propensity matched based on 16 covariates. The primary outcome was remission of a major depressive episode. Secondary outcomes included evaluating socioeconomic and psychosocial differences between the groups. Each cohort yielded 165,629 patients. The primary endpoint analysis indicated a small but statistically significant difference in MDD remission rates in favor of bupropion with an absolute risk rate of 8.5% compared to 7.9% in the SSRI group (Risk Ratio [RR] 1.07, 95% CI 1.05-1.10, p < 0.0001). Binary outcomes were summarized using risk differences and risk ratios and compared between cohorts using chi-square tests. Our findings suggest bupropion monotherapy was associated with a small but statistically significant higher remission rate compared with SSRIs but further prospective studies using objective remission indicators are needed.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"122398"},"PeriodicalIF":5.7,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148793373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"10-year trends of particle size distributions and equivalent black carbon at the Environmental-Climate Observatory (ECO) in Lecce (Italy).","authors":"Daniele Contini, Daniela Cesari, Marianna Conte, Adelaide Dinoi","doi":"10.1016/j.envpol.2026.129234","DOIUrl":"10.1016/j.envpol.2026.129234","url":null,"abstract":"<p><p>This study investigates the long-term (2015-2024) inter-annual and seasonal trends of PM_2.5, coarse particles (PM_10-2.5), particle number size distribution (PNSD, 10-10,000 nm), and equivalent black carbon (eBC) at the ECO Observatory in Lecce (Southern Italy) measured with online instruments. Organic (OC) and elemental (EC) carbon were analysed offline to evaluate the Mass Absorption Cross-section (MAC). Results showed a clear decoupling between fine and coarse mass fractions. PM_2.5 decreased significantly by -2.58% yr^-1, consistent with a reduction of local anthropogenic combustion sources. Conversely, PM_10-2.5 remained stable due to the strong influence of natural Saharan dust events, which impacted 13.2% of the monitored days and induced opposite seasonal patterns between the two size fractions. eBC concentrations exhibited a statistically significant decline of -3.17% yr^-1, consistent with European urban background trends. The mass absorption cross-section remained stable (12.4 ± 2.4 m²g^-1). The reduction of absorption and a stable MAC suggest that the decrease of absorption is due to a decrease of eBC consistent with a decrease of combustion emissions. Seasonally, the eBC/PM₁₀ ratio increases from 2.8% in summer to 4.2% in winter, tracking PM_2.5 variations and highlighting the impact of wintertime emissions and boundary layer dynamics. Total particle number concentration (PNC) decreased by -2.99% yr^-1, primarily driven by reductions in the Aitken and accumulation modes. While submicron particles peaked in winter due to combustion, the coarse mode peaked in summer due to dust. The nucleation mode lacked inter-annual seasonality because summer nucleation countered winter traffic inputs. Diurnal variations were governed by boundary layer dynamics, except for the nucleation mode, which peaked midday due to photochemical new particle formation events happening, on average, in 25% of the days.</p>","PeriodicalId":311,"journal":{"name":"Environmental Pollution","volume":" ","pages":"129234"},"PeriodicalIF":7.2,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149035958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nocturnal sleep-related scratching disorder as a possible variant of NREM arousal disorder: Clinical features and polysomnographic study of four newly reported cases","authors":"María Fernanda Gómez Morales ,&nbsp;Nicole Cresp Sinning ,&nbsp;Carlos H. Schenck","doi":"10.1016/j.sleepx.2025.100168","DOIUrl":"10.1016/j.sleepx.2025.100168","url":null,"abstract":"<div><div>A clinical variant of NREM arousal disorder is described manifesting with predominantly injurious, and exclusively sleep-related scratching without any conscious awareness, and without a history of dermatologic disease. Four patients were clinically evaluated and underwent videopolysomnography (vPSG). Case 1, a 30-year-old woman had a 20-yr history of non-injurious arm scratching/rubbing during sleep. vPSG: forearm rubbing against the chin during N2/N3. Two years later she developed restless bladder symptoms and leg movements before sleep onset. Serum ferritin level: 20.7 Intravenous iron therapy resulted in full control of bedtime leg movements, restless bladder symptoms, and nocturnal scratching. Case 2, a 28-year-old married man had a 1.5-yr history of perianal scratching with excoriations/bleeding during sleep, without other parasomnia. Medical and dermatologic evaluations were negative. vPSG: arousal index of 34/hr, with multiple episodes of perianal scratching. Paroxetine, 20 mg with clonazepam as (0.5–1.0 mg) at bedtime induced 50 % efficacy. Case 3, a 26-year-old African-American female had NREM parasomnias, vigorous sleep-related scratching with keloid formation, and major depression. Medical history was negative. vPSG: arousal index: 28/hr, without abnormal behaviors. Multiple sleep latency test (MSLT): mean sleep latency, 3.6 min, no REM sleep. Idiopathic hypersomnia and NREM parasomnias were diagnosed. Sleep-related scratching and NREM parasomnias responded fully to bedtime clonazepam, 0.5 mg. Case 4, a 50-year-old female had longstanding injurious sleep-related scratching, sleep terrors, and sleep bruxism. vPSG: 55 % sleep efficiency; arousal index: 25/hr, without abnormal behaviors or apneas. MSLT: no objective sleepiness. These cases of sleep-related scratching disorder represent a heterogeneous presumed variant of NREM arousal disorder with various comorbidities, and with full/partial control from diverse therapies.</div></div>","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"11 ","pages":"Article 100168"},"PeriodicalIF":0.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145798229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construction of phosphorus and cobalt co-modified tubular carbon nitride with dual reaction sites for boosted imidacloprid degradation.","authors":"Binyuan Chen, Hao Zeng, Ben Zhang, Jin Zheng, Ling Li, Zhanpeng Zhou, Rongdi Tang, Yaocheng Deng","doi":"10.1016/j.jcis.2026.140997","DOIUrl":"10.1016/j.jcis.2026.140997","url":null,"abstract":"<p><p>Polymeric carbon nitride demonstrates considerable potential for the degradation of imidacloprid (IMI) in aquatic environments; however, its practical application is limited by a scarcity of active sites and the rapid recombination of photogenerated charge carriers. To address these limitations, a phosphorus (P) and cobalt (Co) co-modified tubular carbon nitride photocatalyst (Co-PTCN) with dual reaction sites was successfully synthesized. This catalyst achieved 90% removal of IMI within one hour under visible light irradiation at pH 7.5. Comprehensive characterization confirmed that the tubular morphology promotes the formation of dual reaction sites, wherein Co sites functioning as oxidation centers and P sites serving as oxygen activation and reduction centers. The enhanced separation efficiency of photogenerated charge carriers was corroborated by theoretical calculations and transient photovoltage measurements. Proposed degradation pathways of IMI were elucidated, and toxicity predictions indicated a decreasing trend in toxicity throughout the degradation process. This work provides new perspectives for feasibly constructing dual-reaction-site photocatalysts and offers theoretical support for the degradation mechanisms of IMI.</p>","PeriodicalId":351,"journal":{"name":"Journal of Colloid and Interface Science","volume":"723 ","pages":"140997"},"PeriodicalIF":9.6,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148315063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}