Elsevier最新文献_第10页

Establishment of MS LOC platform and its pilot application in clinical lipidomics. MS LOC 平台的建立及其在临床脂质组学中的试点应用。

IF 5.6 1区化学

Talanta Pub Date : 2025-04-01 Epub Date: 2024-12-07 DOI: 10.1016/j.talanta.2024.127314

Xiaoming Chen, Shuo Cao, Liye Tao, Runlan Yan, Sheng Cao, Jingwen Hao, Yuelin Yi, Chunyan Luan, Jianmin Wu, Yue Gao, Xiao Liang

{"title":"Establishment of MS LOC platform and its pilot application in clinical lipidomics.","authors":"Xiaoming Chen, Shuo Cao, Liye Tao, Runlan Yan, Sheng Cao, Jingwen Hao, Yuelin Yi, Chunyan Luan, Jianmin Wu, Yue Gao, Xiao Liang","doi":"10.1016/j.talanta.2024.127314","DOIUrl":"10.1016/j.talanta.2024.127314","url":null,"abstract":"Lipidomics has demonstrated significant potential for disease diagnosis and prediction. The development and optimization of a robust mass spectrometry (MS) platform for lipidome analysis is critically important, as it can facilitate biomarker discovery, cohort testing, and performance evaluation in clinical lipidomics studies. In this work, we developed a high-throughput and reliable platform, termed MS Lab on a Chip (MS LOC), which integrates the MetArray chip, an automated lipidomics pretreatment protocol, and the reflectron matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) instrument. The MetArray chip, produced through a mass production process, exhibited exceptional stability as an MS substrate. The integration of automated lipid pretreatment and MS detection processes ensures high throughput, stability and efficiency during sample preparation. The analysis of various lipid standards and different types of biological samples enabled comprehensive investigation of lipid features and annotation using the MS LOC. Furthermore, a small cohort study, consisting of hepatocellular carcinoma (HCC) and non-HCC groups, was conducted on this platform, providing preliminary validation of its performance and suggesting that this platform offers a comprehensive protocol for clinical lipidomics testing.","PeriodicalId":435,"journal":{"name":"Talanta","volume":"285 ","pages":"127314"},"PeriodicalIF":5.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142845537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The coordination effect of organic ligands in Ce-MOF brings about atomically dispersed Fe in CeO₂ for TAC detection in commercial samples. Ce-MOF 中有机配体的配位效应使 Fe 原子分散在 CeO2 中，用于检测商业样品中的 TAC。

IF 5.6 1区化学

Talanta Pub Date : 2025-04-01 Epub Date: 2024-12-16 DOI: 10.1016/j.talanta.2024.127405

Lulu Cui, Houshen Li, Weijie Shi, Yingying Jing, Shuhong Sun, Shiyun Ai, Zeyi Guo

引用次数: 0

Organic photoelectrochemical transistor based on titanium dioxide nanorods for detection of Microcystin-LR. 基于二氧化钛纳米棒的有机光电化学晶体管用于检测微囊藻毒素-LR。

IF 5.6 1区化学

Talanta Pub Date : 2025-04-01 Epub Date: 2024-12-16 DOI: 10.1016/j.talanta.2024.127401

Jiahe Chen, Jiaxin Lv, Yue Liu, Jia-Hao Chen, Xue Wang, Hong Zhou

引用次数: 0

A sequence-activatable dual-locked fluorescent probe for simultaneous detection of hypochlorous acid and peroxynitrite during drug-induced liver injury. 用于同时检测药物性肝损伤中次氯酸和过氧亚硝酸盐的序列激活双锁荧光探针。

IF 5.6 1区化学

Talanta Pub Date : 2025-04-01 Epub Date: 2024-12-16 DOI: 10.1016/j.talanta.2024.127408

Caiyun Liu, Tingyi Yan, Xinyu Cai, Hanchuang Zhu, Peng Zhang, Xueting Liu, Xiaodi Rong, Kun Wang, Yao Wang, Wei Shu, Baocun Zhu

{"title":"A sequence-activatable dual-locked fluorescent probe for simultaneous detection of hypochlorous acid and peroxynitrite during drug-induced liver injury.","authors":"Caiyun Liu, Tingyi Yan, Xinyu Cai, Hanchuang Zhu, Peng Zhang, Xueting Liu, Xiaodi Rong, Kun Wang, Yao Wang, Wei Shu, Baocun Zhu","doi":"10.1016/j.talanta.2024.127408","DOIUrl":"10.1016/j.talanta.2024.127408","url":null,"abstract":"Drug-induced liver injury (DILI) is a crucial factor that poses a significant threat to human health. DILI process leads to the changes of reactive oxygen species and reactive nitrogen species content in cells, which leads to oxidative and nitrosative stress in cells. However, the high reactivity of hypochlorous acid (HOCl) and peroxynitrite (ONOO⁻), combined with a lack of in situ imaging techniques, has hindered a detailed understanding of their roles in DILI. Therefore, this paper reports a novel sequence-activatable dual-locked molecular probe HA-P3 for the identification and imaging of two DILI-related biomarkers. First, HA-P3 selectively reacts with reactive oxygen species HOCl to leave the recognition receptor diethyl thiocarbamate to form HA-P2. Subsequently, HA-P2 reacts with ONOO⁻, liberating the fluorophore 4-hydroxy-1,8-naphthalimide, which emits a strong fluorescence signal. The two-step reaction effectively reduces the probability of false positive in predicting DILI. HA-P3 achieved the sensitive detection of HOCl and ONOO- in different cells and zebrafish. Furthermore, HA-P3 can distinguish between normal liver cells and hepatoma cells and monitored the elevated levels of HOCl and ONOO⁻ during acetaminophen (APAP)-induced cellular damage. It is worth noting that in the APAP-induced mouse model, the positive correlation between HOCl and ONOO- and DILI was revealed, providing strong direct evidence for the relationship between oxidative/nitrosative stress and DILI.","PeriodicalId":435,"journal":{"name":"Talanta","volume":"285 ","pages":"127408"},"PeriodicalIF":5.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142891203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Calibration-free disposable electrochemical sensor with co-facing electrodes for viscosity monitoring of plasma samples. 免校准的一次性电化学传感器，共面向电极，用于等离子体样品的粘度监测。

IF 5.6 1区化学

Talanta Pub Date : 2025-04-01 Epub Date: 2024-11-28 DOI: 10.1016/j.talanta.2024.127290

Angel A J Torriero, Megan J Fitz, Ashwin K V Mruthunjaya

{"title":"Calibration-free disposable electrochemical sensor with co-facing electrodes for viscosity monitoring of plasma samples.","authors":"Angel A J Torriero, Megan J Fitz, Ashwin K V Mruthunjaya","doi":"10.1016/j.talanta.2024.127290","DOIUrl":"10.1016/j.talanta.2024.127290","url":null,"abstract":"Plasma viscosity measurement is crucial in clinical diagnostics, providing insights into blood rheology and health status. Traditional methods, such as capillary and rotational viscometers, require large sample volumes and complex calibration. This study presents a novel disposable electrochemical sensor with co-facing electrodes for viscosity monitoring of plasma samples. The sensor independently determines the diffusion coefficient (D) of the electroactive test molecule ferrocyanide, eliminating the need for calibration curves. This enables the subsequent calculation of the solution's viscosity via the Stokes-Einstein relation. The sensor's performance was validated against a standard quartz-crystal microbalance method, demonstrating high accuracy and reliability. It maintained consistent measurements despite the presence of common electroactive plasma interferents such as ascorbic acid (≤160 μM), dopamine (<9.0 nM), uric acid (<1.0 mM), and urea (<15.6 mM). Although these interferents impacted D at concentrations exceeding twice the maximum levels typically present in plasma, the sensor exhibited robust performance under normal physiological conditions and standard interferent concentrations. The sensor offers rapid response times of less than 20 s, requires only 7 μL of sample, and is cost-effective, making it suitable for point-of-care applications. Bland-Altman plot analysis confirmed its precision, showing a mean difference of 0.00877 and narrow limits of agreement compared to the standard method used.","PeriodicalId":435,"journal":{"name":"Talanta","volume":"285 ","pages":"127290"},"PeriodicalIF":5.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142790863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to "Electrically-driven drug delivery into deep cutaneous tissue by conductive microneedles for fungal infection eradication and protective immunity" [Biomaterials 314 (2025) 122908]. “通过导电微针将电驱动药物输送到皮肤深层组织，用于真菌感染根除和保护性免疫”[生物材料314(2025)122908]的勘误表。

IF 12.8 1区医学

Biomaterials Pub Date : 2025-04-01 Epub Date: 2024-11-28 DOI: 10.1016/j.biomaterials.2024.122973

Sumanta Ghosh, Mengjia Zheng, Jiahui He, Yefeng Wu, Yaming Zhang, Weiping Wang, Jie Shen, Kelvin W K Yeung, Prasanna Neelakantan, Chenjie Xu, Wei Qiao

引用次数: 0

Multi-sample analytical workflow for the determination of isoprostanes in oral fluid: A new tool for non-invasive evaluation of oxidative stress. 测定口腔液中异前列腺素的多样品分析工作流程：无创评估氧化应激的新工具。

IF 5.6 1区化学

Talanta Pub Date : 2025-04-01 Epub Date: 2024-12-09 DOI: 10.1016/j.talanta.2024.127358

Francesco Bartolini, Martina Croce, Francesco Della Valle, Camilla Montesano, Federico Fanti, Dario Compagnone, Manuel Sergi

{"title":"Multi-sample analytical workflow for the determination of isoprostanes in oral fluid: A new tool for non-invasive evaluation of oxidative stress.","authors":"Francesco Bartolini, Martina Croce, Francesco Della Valle, Camilla Montesano, Federico Fanti, Dario Compagnone, Manuel Sergi","doi":"10.1016/j.talanta.2024.127358","DOIUrl":"10.1016/j.talanta.2024.127358","url":null,"abstract":"Oxidative stress is a pathological condition that contributes to the onset of various diseases. In this way, studying oxidative stress could lead to significant discoveries in the field of therapeutic and preventive medicine. Lipid peroxidation is the most significant event in the oxidative stress process and the gold standard biomarkers for endogenous oxidative damage to lipids are isoprostanes (IsoPs). This project aims to develop a reliable analytical method for the liquid-liquid microextraction technique, parallel artificial liquid membrane extraction (PALME) and LC-MS/MS analysis. PALME allowed to obtain a significant enrichment factor and, at the same time, a good sample purification by removing compounds that cause signal suppression, thereby reducing matrix effect. The chromatographic and mass spectrometric conditions have been fine tuned to improve the sensitivity of the method and therefore obtaining very low LOD and LOQ values. The recovery values obtained for the analytes are slightly above 50 %, except for 6-keto Prostaglandin F1A (24 %). Matrix effects were ≤ -10 %, with LODs ranging between 1 and 5 pg mL-1. The developed method is characterized by high sensitivity and low consumption of organic solvents, according to the principles of Green Analytical Chemistry and enables the determination of basal levels of IsoPs in oral fluid by processing 96 samples simultaneously.","PeriodicalId":435,"journal":{"name":"Talanta","volume":"285 ","pages":"127358"},"PeriodicalIF":5.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142823735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Outer-surface covering of nanochannels with hydrogel for anti-protein-interference on the ion current. 用水凝胶覆盖纳米通道的外表面，以防止蛋白质干扰离子流。

IF 5.6 1区化学

Talanta Pub Date : 2025-04-01 Epub Date: 2024-12-09 DOI: 10.1016/j.talanta.2024.127367

Xueting Sun, Xiaojin Zhang, Tingting Cao, Suqing Huang, Yu Dai, Fan Xia

引用次数: 0

Product-induced catalytic amplification strategy based on DNA tetrahedron for detection of miRNA-21 in colorectal cancer. 基于DNA四面体的产物诱导催化扩增策略检测结直肠癌miRNA-21。

IF 5.6 1区化学

Talanta Pub Date : 2025-04-01 Epub Date: 2024-12-12 DOI: 10.1016/j.talanta.2024.127354

Kaihang Yu, Zhiyi Wu, Lizhu Yang

引用次数: 0

Shades of red: A chemical exploration of pigments and dyes in 19th century postage stamps by a multi-analytical methodology. 红色的阴影：用多种分析方法对19世纪邮票上的颜料和染料进行化学探索。

IF 5.6 1区化学

Talanta Pub Date : 2025-04-01 Epub Date: 2024-12-17 DOI: 10.1016/j.talanta.2024.127409

Simone C R Ferreira, M Conceição Oliveira, Alberto A C C Pais, J Sérgio Seixas de Melo

{"title":"Shades of red: A chemical exploration of pigments and dyes in 19th century postage stamps by a multi-analytical methodology.","authors":"Simone C R Ferreira, M Conceição Oliveira, Alberto A C C Pais, J Sérgio Seixas de Melo","doi":"10.1016/j.talanta.2024.127409","DOIUrl":"10.1016/j.talanta.2024.127409","url":null,"abstract":"A total of 57 European, Canadian and North American postage stamps, all in red shades, were analyzed with the main goal of unraveling which pigments or dyes were used to produce the red color in the period dated from 1841 to 1899. Both non-destructive techniques, including X-Ray Fluorescence (XRF), Fiber Optics Reflectance Spectra (FORS), and Steady State Fluorescence Spectroscopy, and destructive methods such as High-Performance Liquid Chromatography coupled with Diode-Array Detection (HPLC-DAD) and Electrospray Ionization High-Resolution Mass Spectrometry (ESI-HRMS), were utilized for a comprehensive analysis. The examined red shades were identified as originating from either a single pigment or dye, or a combination of both. XRF analysis detected red lead/litharge in 14 postage stamps, vermilion in 8 and iron oxide in 4. The mapping results obtained by this technique were shown to be very important in the determination of inorganic pigments. Most specimens contained a natural organic dye, with carminic acid being the most prevalent, appearing in 30 samples. In contrast, alizarin was identified in only 3 of the examined postage stamps. A synthetic dye, eosin Y, first synthesised by Heinrich Caro in 1871, was detected in 11 stamps and suggested by FORS and steady-state fluorescence in 6 others printed from 1879 onwards. HPLC-HRMS provided more detailed information on the natural colorant. In 19 samples both organic and inorganic dyes or pigments were found to coexist. It has been shown that spectroscopic techniques, when used with an appropriate database, can play a role in suggesting the presence of certain compounds that are subsequently detected by other techniques.","PeriodicalId":435,"journal":{"name":"Talanta","volume":"285 ","pages":"127409"},"PeriodicalIF":5.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142885022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0