Elsevier最新文献_第10页

If someone is wrong but sincere, is it a lie? The role of objective falsity, intention, and in children's understanding of lying. 如果有人错了但很真诚，那是谎言吗？客观的虚假性、意图和在儿童对说谎的理解中的作用。

IF 2 2区心理学

Journal of Experimental Child Psychology Pub Date : 2025-12-01 Epub Date: 2025-08-08 DOI: 10.1016/j.jecp.2025.106350

Katarzyna Cantarero, Magdalena Król, Daria Gruberska, Maria Michalik, Gabriela Sorsa, Julia Żamejć, Sergio Moreno-Ríos

{"title":"If someone is wrong but sincere, is it a lie? The role of objective falsity, intention, and in children's understanding of lying.","authors":"Katarzyna Cantarero, Magdalena Król, Daria Gruberska, Maria Michalik, Gabriela Sorsa, Julia Żamejć, Sergio Moreno-Ríos","doi":"10.1016/j.jecp.2025.106350","DOIUrl":"10.1016/j.jecp.2025.106350","url":null,"abstract":"This study investigates how objective reality (truth vs falsity), intention (honest vs dishonest) and motivation (prosocial vs self-serving) affect lie labelling and moral judgment of lies. Using a comic-based task, we conducted a study with 5-6-year-olds and 9-10-year-olds (N = 194). Participants were presented with scenarios where a protagonist made either prosocial or self-serving statements that were truthful or false, with honest or deceptive intent. Results showed that younger children were more likely to judge objectively false statements as lies, while older children placed greater emphasis on the protagonist's intention. Prosocial lies were evaluated more positively than self-serving lies. However, contrary to prior research, prosocial lies were not less likely to be labeled as lies, but unlike in previous studies children were informed about the honest or dishonest intentions, which could prevent them from interpreting self-serving motivation as dishonest intentions. Additionally, lies were based on factual statements rather than opinions. Results of this research contribute to theory of mind, moral development, and social cognition research, offering insights into how children distinguish between truth and deception. The study also introduces a novel, language-independent tool for assessing children's understanding of deception, which may have applications in cross-cultural research and educational settings.","PeriodicalId":48391,"journal":{"name":"Journal of Experimental Child Psychology","volume":"260 ","pages":"106350"},"PeriodicalIF":2.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144812591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bismuth based nanomaterials: Design, synthesis and applications in tumor synergistic therapy. 铋基纳米材料：设计、合成及其在肿瘤协同治疗中的应用。

IF 5.6 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2025-12-01 Epub Date: 2025-08-05 DOI: 10.1016/j.colsurfb.2025.114992

Qiupeng Zhang, Jie Tu, Yuqin Jiang, Huihui Wang, Weixian Xue, Chunyao Dong, Ruizhuo Ouyang, Yuqing Miao

引用次数: 0

Quaternized chitosan-coated PLGA nanoparticles co-deliver resveratrol and all-trans retinoic acid to enhance humoral immunity, cellular immunity and gastrointestinal mucosal immunity. 季铵盐化壳聚糖包被的PLGA纳米颗粒共同递送白藜芦醇和全反式维甲酸，增强体液免疫、细胞免疫和胃肠道粘膜免疫。

IF 5.6 2区医学

Colloids and Surfaces B: Biointerfaces Pub Date : 2025-12-01 Epub Date: 2025-08-05 DOI: 10.1016/j.colsurfb.2025.114994

Dan Yang, Nannan Wang, Lijuan Cao, Huimao Liu, Hanyan Cheng, Haitao Ma, Lixia Li, Yuanfeng Zou, Xinghong Zhao, Xun Zhou, Xu Song, Dongmei Zhang, Mingyue Li, Renyong Jia, Zhongqiong Yin

{"title":"Quaternized chitosan-coated PLGA nanoparticles co-deliver resveratrol and all-trans retinoic acid to enhance humoral immunity, cellular immunity and gastrointestinal mucosal immunity.","authors":"Dan Yang, Nannan Wang, Lijuan Cao, Huimao Liu, Hanyan Cheng, Haitao Ma, Lixia Li, Yuanfeng Zou, Xinghong Zhao, Xun Zhou, Xu Song, Dongmei Zhang, Mingyue Li, Renyong Jia, Zhongqiong Yin","doi":"10.1016/j.colsurfb.2025.114994","DOIUrl":"10.1016/j.colsurfb.2025.114994","url":null,"abstract":"Conventional vaccine adjuvants are limited by their mechanisms of action and administration routes, often failing to simultaneously elicit robust systemic and mucosal immune responses. This limitation compromises the establishment of dual protective barriers during early pathogen invasion. Therefore, we developed an innovative poly (lactic-co-glycolic acid) (PLGA) nanoparticle-based adjuvant system (Res/RA QCS NPs) featuring quaternized chitosan (QCS) surface modification for ovalbumin (OVA) delivery, co-encapsulating dual immunomodulators - resveratrol (Res) and all-trans retinoic acid (RA). The results showed that the Res/RA QCS NPs possessed excellent antigen adsorption capacity (adsorption rate of 93.87 ± 5.27 %) and significantly enhanced the recruitment of antigen-presenting cells (APCs) at the injection site and lymph node-targeting delivery. In vitro immunological evaluation further confirmed that OVA-Res/RA QCS NPs possessed excellent immune-enhancing properties, including: efficient antigen internalization, Dendritic Cells (DCs) maturation activation, enhanced cytokine secretion and mucosal homing ability. In vivo immunity experiments, OVA-Res/RA QCS NPs not only induced high levels of serum antigen-specific IgG antibodies and proliferation and activation of T cells in peripheral lymphoid tissues, but also stimulated the secretion of large amounts of antigen-specific IgA in the gastrointestinal mucosa, which realized the dual activation of systemic and mucosal immunity. This study provides an important theoretical and experimental basis for the development of novel vaccine adjuvants and immunotherapy strategies based on intestinal immunomodulation.","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"256 Pt 1","pages":"114994"},"PeriodicalIF":5.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144797767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structure-switching aptasensor for multiplex detection of antimalarial drugs via split T7 promoter-powered transcription generation of dual-color RNA aptamers. 通过分裂T7启动子转录生成双色RNA适体，用于抗疟药物多重检测的结构开关适体传感器。

IF 6.1 1区化学

Talanta Pub Date : 2025-12-01 Epub Date: 2025-05-29 DOI: 10.1016/j.talanta.2025.128386

Tiantian Chen, Qian Xiang, Xuemei Sang, Daxiu Li, Wenjiao Zhou, Fengfeng Xu

{"title":"Structure-switching aptasensor for multiplex detection of antimalarial drugs via split T7 promoter-powered transcription generation of dual-color RNA aptamers.","authors":"Tiantian Chen, Qian Xiang, Xuemei Sang, Daxiu Li, Wenjiao Zhou, Fengfeng Xu","doi":"10.1016/j.talanta.2025.128386","DOIUrl":"10.1016/j.talanta.2025.128386","url":null,"abstract":"Malaria remains a significant threat to global health, especially with the emergence of drug-resistant strains. Therefore, precise monitoring of antimalarial drug levels is crucial for assessing and managing drug resistance. Here, we report a multiplex aptasensor that enables simultaneous fluorescence detection of two antimalarial drugs (MQ and PQ) via split dsT7 promoter-mediated transcription of two-color light-up RNA aptamers. The detection mechanism relies on specific binding of target antimalarial drugs (MQ/PQ) to their aptamers, each triggering formation of intact dsT7 promoter to induce amplified transcription of its cognate RNA aptamer. The generated RNA aptamers bind their corresponding organic dyes (TO1-Biotin and MG) with high affinity, yielding 7.7-/25-fold fluorescence enhancement to enable ultrasensitive detection of MQ and PQ with limits of 0.71 ng/mL and 0.069 ng/mL, respectively. The method also exhibits high selectivity and low background signal. Furthermore, this label-free system achieves multiplexed detection of antimalarial drugs in 10-fold diluted human serum (recovery: 98.67-106.84 % for PQ and 99.89-106.19 % for MQ), demonstrating its real utility. This label-free system is adaptable to other biomarkers through aptamer replacement.","PeriodicalId":435,"journal":{"name":"Talanta","volume":"295 ","pages":"128386"},"PeriodicalIF":6.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144186166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Improved analytical workflow towards machine learning supported N-glycomics-based biomarker discovery. 改进了机器学习的分析工作流程，支持基于n -糖组学的生物标志物发现。

IF 6.1 1区化学

Talanta Pub Date : 2025-12-01 Epub Date: 2025-05-26 DOI: 10.1016/j.talanta.2025.128389

Agnes Vathy-Fogarassy, Veronika Gombas, Rebeka Torok, Gabor Jarvas, Andras Guttman

{"title":"Improved analytical workflow towards machine learning supported N-glycomics-based biomarker discovery.","authors":"Agnes Vathy-Fogarassy, Veronika Gombas, Rebeka Torok, Gabor Jarvas, Andras Guttman","doi":"10.1016/j.talanta.2025.128389","DOIUrl":"10.1016/j.talanta.2025.128389","url":null,"abstract":"The composition and function of glycans are very complex thus manual data interpretation of their structural elucidation is difficult. Capillary electrophoresis is one of the liquid phase separation techniques, which is most frequently used to address these challenging tasks. Combining high-resolution capillary electrophoresis with machine learning-supported data interpretation holds the promise to gain as much chemical and clinical information from the analyzed samples as possible. However, this combination requires significant technological improvements both in the analytical and the data processing aspects. In this study we report on the development of an automated, liquid-handling robot-based sample preparation method to obtain reproducible and N-glycome profiles by capillary electrophoresis for the subsequent machine learning-supported data interpretation, which was optimized for the special needs of the analysis. The resulting new glycoanalytical workflow was then tested for a demanding problem to predict the effectiveness of chemotherapy treatments of lung cancer patients ensuring the effective management of the disease. Our findings revealed that the achieved N-glycan data contained important clinical information to accurately predict patient response to chemotherapy with AUC values ranged from 0.8290 to 0.8410.","PeriodicalId":435,"journal":{"name":"Talanta","volume":"295 ","pages":"128389"},"PeriodicalIF":6.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144191343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancing anaerobic digestion of nitrogen-rich substrates through in situ ammonia recovery using tubular gas-permeable membranes. 通过管状透气膜原位氨回收提高富氮基质的厌氧消化。

IF 9 1区环境科学与生态学

Bioresource Technology Pub Date : 2025-12-01 Epub Date: 2025-08-05 DOI: 10.1016/j.biortech.2025.133063

João Fernando Ferri da Silva, Deisi Cristina Tápparo, Ana Claudia Lazaroto, Dagmara Beltrame de Asis, Igor Vinicius Machado Sophiatti, Flaviane Eva Magrini, Ricardo Luís Radis Steinmetz, Fabiane Goldschmidt Antes, Matias Vanotti, Suelen Paesi, Airton Kunz

{"title":"Enhancing anaerobic digestion of nitrogen-rich substrates through in situ ammonia recovery using tubular gas-permeable membranes.","authors":"João Fernando Ferri da Silva, Deisi Cristina Tápparo, Ana Claudia Lazaroto, Dagmara Beltrame de Asis, Igor Vinicius Machado Sophiatti, Flaviane Eva Magrini, Ricardo Luís Radis Steinmetz, Fabiane Goldschmidt Antes, Matias Vanotti, Suelen Paesi, Airton Kunz","doi":"10.1016/j.biortech.2025.133063","DOIUrl":"10.1016/j.biortech.2025.133063","url":null,"abstract":"This study evaluated ePTFE gas-permeable membranes (GPM) to mitigate ammonia inhibition during anaerobic digestion (AD). Two semi-continuous laboratory-scale reactors were operated with swine manure and urea as nitrogen sources. One reactor was equipped with GPM for in situ ammonia recovery, while the other served as a control. Initially, methane yield (MY) remained stable at ∼ 200 LCH4 kgVS-1. When free ammonia (FA) exceeded 500 mgN L-1, MY declined by 50 %, and microbial inhibition intensified. At 700 mgN L-1, inhibition reached 70 %, with increases in Clostridium_sensu_stricto_1, HN-HF0106, and Fastidiosipila. Methanosarcina remained dominant among archaea, showing greater tolerance to ammonium. After GPM activation, FA levels decreased and methane production recovered. The GPM system proved effective as both a preventive and corrective strategy, improving process stability and enabling ammonia recovery. These findings highlight the potential of GPM technology as a promising solution to enhance the robustness of AD treating nitrogen-rich substrates.","PeriodicalId":258,"journal":{"name":"Bioresource Technology","volume":" ","pages":"133063"},"PeriodicalIF":9.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144774422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Moderating and mediating effects of dysmenorrhea pain severity in the relationship between body mass index and body appreciation among adult women with primary dysmenorrhea. 痛经疼痛严重程度在成年女性原发性痛经患者身体质量指数和身体欣赏关系中的调节和中介作用

IF 4.9 2区医学

Journal of affective disorders Pub Date : 2025-12-01 Epub Date: 2025-07-12 DOI: 10.1016/j.jad.2025.119888

Guilherme Tavares de Arruda, Maria Eduarda Chinotti Batista da Silva, Pâmela Calixto de Moraes, Patricia Driusso, Mariana Arias Avila

{"title":"Moderating and mediating effects of dysmenorrhea pain severity in the relationship between body mass index and body appreciation among adult women with primary dysmenorrhea.","authors":"Guilherme Tavares de Arruda, Maria Eduarda Chinotti Batista da Silva, Pâmela Calixto de Moraes, Patricia Driusso, Mariana Arias Avila","doi":"10.1016/j.jad.2025.119888","DOIUrl":"10.1016/j.jad.2025.119888","url":null,"abstract":"Objective: To investigate whether dysmenorrhea severity moderates and/or mediates the association between body mass index (BMI) and body appreciation among women with primary dysmenorrhea (PD).Methods: Cross-sectional online study with 2026 women with PD. Participants were allocated into two groups according to their menstrual status: those who were menstruated and had current menstrual pain (CMP) and those who reported pain from their last menstrual period (LMP). We assessed bivariate relationships among BMI (Kg/cm2), pain severity (Numerical Rating Scale), and body appreciation (10-item Body Appreciation Scale), along with moderation and mediation for the same variables.Results: In the LMP group, BMI was significantly and negatively correlated with body appreciation (r = -0.249, p < 0.001). Moderation analysis indicated that the negative association between BMI and body appreciation was stronger at lower pain severity (β = -0.045, p < 0.001), whereas higher pain severity attenuated this effect. Furthermore, mediation analysis revealed that dysmenorrhea severity partially mediated the relationship between BMI and body appreciation (indirect effect β = -0.001, 95 % CI [-0.002, -0.001]), accounting for approximately 3 % of the total effect. No significant moderation or mediation effects were observed in the CMP group.Conclusions: Dysmenorrhea severity plays a dual role - acting as both moderator and mediator - in linking higher BMI to lower body appreciation. These findings underscore the importance of integrating pain management with interventions designed to improve body appreciation in women with PD. Future longitudinal studies should further clarify these relationships and underlying mechanisms.","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"119888"},"PeriodicalIF":4.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144637004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the individual contributions of the 8 adverse childhood experiences (ACEs) domains to substance use. 探索8种不良童年经历（ace）域对物质使用的个人贡献。

IF 4.9 2区医学

Journal of affective disorders Pub Date : 2025-12-01 Epub Date: 2025-07-14 DOI: 10.1016/j.jad.2025.119923

Fares Qeadan, Jacob France, William A Barbeau

{"title":"Exploring the individual contributions of the 8 adverse childhood experiences (ACEs) domains to substance use.","authors":"Fares Qeadan, Jacob France, William A Barbeau","doi":"10.1016/j.jad.2025.119923","DOIUrl":"10.1016/j.jad.2025.119923","url":null,"abstract":"Background: Traditionally, adverse childhood experiences (ACEs) are grouped together into a cumulative score to predict substance use.Objective: To determine the effect of individual ACE domains (physical, emotional, sexual abuse, exposure to domestic violence, parental separation, household incarceration, household substance use and household mental illness) on later life substance use.Participants and setting: BRFSS data from 2019 to 2022 were used to construct 3 cohorts analyzing 5 different substance use outcomes.Methods: Logistic regression models were constructed to determine adjusted odd ratios (aORs) of substance used for each ACE domain. Random forest models served for sensitivity analyses.Results: Effect sizes varied across ACE domains and substances. Household substance use was the strongest predictor, with the highest aORs for smoking (aOR = 1.336, 95 % CI [1.266-1.410]), e-cigarette use (aOR = 1.451, 95 % CI [1.317-1.597]), and binge drinking (aOR = 1.256, 95 % CI [1.181-1.335]). Emotional abuse was the second most influential domain, particularly associated with marijuana use (aOR = 1.475, 95 % CI [1.349-1.613]). In contrast, exposure to domestic violence showed no significant associations with any substance use outcome. Sensitivity analyses using random forest models validated these findings, emphasizing the differential contributions of individual ACE domains to substance use behaviors.Conclusions: These findings emphasize that ACEs are not all entirely equal, and a cumulative score does not represent the individual effect each ACE has on substance use outcomes. Tailoring interventions and policies toward addressing specific ACE domains could significantly reduce substance use rates in later life.","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"119923"},"PeriodicalIF":4.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144649532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating the extent to which targets are achieved in national suicide prevention strategies. 评估国家预防自杀战略实现目标的程度。

IF 4.9 2区医学

Journal of affective disorders Pub Date : 2025-12-01 Epub Date: 2025-08-06 DOI: 10.1016/j.jad.2025.120021

Manuel Canal-Rivero, Jane Pirkis, Matthew J Spittal, Angela Nicholas, Miguel Ruiz-Veguilla, Benedicto Crespo-Facorro, Angela Clapperton

{"title":"Evaluating the extent to which targets are achieved in national suicide prevention strategies.","authors":"Manuel Canal-Rivero, Jane Pirkis, Matthew J Spittal, Angela Nicholas, Miguel Ruiz-Veguilla, Benedicto Crespo-Facorro, Angela Clapperton","doi":"10.1016/j.jad.2025.120021","DOIUrl":"10.1016/j.jad.2025.120021","url":null,"abstract":"Background: Several countries have implemented National Suicide Prevention Strategies (NSPSs), some of which include specific targets relating to reductions in suicide and/or suicidal behaviour. This study aimed to: (1) identify the proportion of NSPSs that include targets; and (2) assess whether these targets were achieved.Methods: A comprehensive review of NSPSs was conducted using relevant databases to identify those with defined targets. Official agencies were consulted to verify target achievement and to gather data on suicidal behaviour.Results: We identified 54 national strategies for analysis, of which 27 (50 %) included specific, quantitative targets. Eleven of these strategies had passed their target date and had available data for assessment. Of these eleven, only two countries, Chile and Israel, achieved their targets. For the remaining nine, outcomes varied: non-statistically significant reductions were observed in Bulgaria and Panama. Ireland also saw a reduction that, while numerically surpassing its target, was not statistically significant. Rates remained stable in England, and increased in Northern Ireland, the United States, Scotland, and Uruguay.Limitations: Although the data were sourced from official records, potential biases may have affected the quality and accuracy of the analysis.Conclusions: A significant proportion of NSPSs lack specific targets and even among those that have specific targets, achieving these remains a challenge for many. However, the presence of specific targets could at least facilitate the identification of barriers hindering the attainment of these targets.","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"120021"},"PeriodicalIF":4.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144799170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Blood-based biomarkers in ketamine treatment: A blueprint for translational drug development in mood disorders. 氯胺酮治疗中的血液生物标志物：情绪障碍转化药物开发的蓝图。

IF 4.9 2区医学

Journal of affective disorders Pub Date : 2025-12-01 Epub Date: 2025-08-06 DOI: 10.1016/j.jad.2025.120016

Alan C Courtes, Gregory H Jones, Ioline D Henter, Lokesh Shahani, Gabriel R Fries, Mario F Juruena, Jair C Soares, Carlos A Zarate, Rodrigo Machado-Vieira

{"title":"Blood-based biomarkers in ketamine treatment: A blueprint for translational drug development in mood disorders.","authors":"Alan C Courtes, Gregory H Jones, Ioline D Henter, Lokesh Shahani, Gabriel R Fries, Mario F Juruena, Jair C Soares, Carlos A Zarate, Rodrigo Machado-Vieira","doi":"10.1016/j.jad.2025.120016","DOIUrl":"10.1016/j.jad.2025.120016","url":null,"abstract":"Over the past two decades, the N-methyl-d-aspartate receptor antagonist ketamine has emerged as a transformational, rapid-acting therapy for both unipolar and bipolar depression-particularly in treatment refractory cases. However, its specific mechanism of action remains unclear. Furthermore, although repeatable neuroimaging-based and electrophysiological biomarkers of treatment response to ketamine have been identified, they cannot provide specific molecular targets with which to advance precision psychiatry with rapid-acting antidepressants. This review explores blood-based biomarkers of ketamine response with an eye towards elucidating ketamine's intricate and varied antidepressant effects. Key findings indicate that ketamine modulates inflammatory, neurotrophic, and metabolic systems, and these changes are reflected in altered levels of biomarkers such as interleukin-6, brain-derived neurotrophic factor (BDNF), and plasma d-serine. Notably, the relationship between therapeutic efficacy and ketamine's metabolites, such as (2R,6R)-hydroxynorketamine, highlights the potential for metabolite-guided strategies and reciprocal translational research. In addition, the rapid temporal dynamics of biomarkers, particularly BDNF and inflammatory cytokines, underscore their potential as tools for monitoring treatment response and developing novel therapeutics. Despite these advances, limitations persist, including heterogeneous methodologies and small sample sizes across studies. The field requires a paradigm shift towards integrated biosignatures, combining multi-system biomarkers (i.e., neuroimaging, electrophysiological, and sleep biomarkers) with clinical outcomes. Such an approach has the potential to refine patient stratification, enhance drug development, and improve treatment monitoring.","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"120016"},"PeriodicalIF":4.9,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144804169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0