Elsevier最新文献

{"title":"Suicidal ideation covaries with depressive severity during six-month real-world esketamine treatment in a cohort enriched for borderline personality disorder.","authors":"Vassilis Martiadis, Fabiola Raffone, Filippo Mazzoni, Arianna De Ciechi, Nicolaja Girone, Monica Macellaro, Giovanni Martinotti, Bernardo Dell'Osso, Miriam Olivola","doi":"10.1016/j.jad.2026.122405","DOIUrl":"10.1016/j.jad.2026.122405","url":null,"abstract":"","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"122405"},"PeriodicalIF":5.7,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148793419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Depolymerization of aquaporin-4 orthogonal array particles via the A25Q mutation does not cause behavioral deficits but confers resilience to chronic unpredictable mild stress.","authors":"Supratik Kundu, Yu Ai, Yue-Lin Huang, Jing-Cheng Lu, Tong Wu, Dan-Yue Shan, Yue Kong, Yi-Fan Zhao, Ao-Ran Sui, Dan-Dan Zhu, Tong-Hui Ma, Shao Li","doi":"10.1016/j.jad.2026.122376","DOIUrl":"10.1016/j.jad.2026.122376","url":null,"abstract":"<p><p>Aquaporin-4 (AQP4) formed orthogonal array particles (OAPs) is critical for brain water homeostasis and astrocytic function, but whether OAP structural integrity influences behavior or stress susceptibility is unknown. Using knock-in mice carrying the AQP4-A25Q mutation, which depolymerizes OAPs without altering AQP4 expression, we investigated baseline behavior and responses to chronic unpredictable mild stress (CUMS). Naïve AQP4-A25Q mice showed no anxiety- or depression-like behavior differences from wild-type (WT) mice, indicating OAP disassembly alone does not cause behavior deficit disorders. However, after CUMS, AQP4-A25Q mice exhibited significant resilience: reduced immobility in the tail suspension and forced swimming tests, preserved locomotor activity and central-zone exploration in the open field, and decreased anxiety-like responses in elevated plus maze compared to post stress WT mice. CUMS induced marked astrocytic (GFAP, S100β) and microglial (Iba-1, CD68) activation in WT hippocampus, but these responses were largely absent in mutants. Consistently, CUMS elevated pro-inflammatory cytokine (IL-1β, IL-6, TNF-α) in WT but not mutant mice. Although CUMS reduced the pAkt/Akt ratio in both genotypes, AQP4-A25Q mice maintained significantly higher pAkt levels after stress. Moreover, CUMS caused neuronal damage in WT hippocampus and cortex, whereas AQP4-A25Q mice were protected and even showed increased hippocampal neuronal density after stress. Collectively, OAP depolymerization does not intrinsically disrupt behavior but confers resilience to chronic stress by attenuating glial activation, neuroinflammation, and pAkt decline, preserving neuronal integrity. This identifies AQP4 OAP structure as a novel molecular determinant of stress susceptibility and highlights therapeutic potential for targeting OAP assembly in stress-related neuropsychiatric disorders.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"122376"},"PeriodicalIF":5.7,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148758441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Sustainable aviation fuel (SAF) from lignin: Pathways, catalysts, and challenges\" [Biores. Technol. 419 (2025) 132039].","authors":"Xianqing Lv, Chengke Zhao, Ning Yan, Xinbin Ma, Shixiang Feng, Li Shuai","doi":"10.1016/j.biortech.2026.135839","DOIUrl":"10.1016/j.biortech.2026.135839","url":null,"abstract":"","PeriodicalId":258,"journal":{"name":"Bioresource Technology","volume":" ","pages":"135839"},"PeriodicalIF":8.2,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148981883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Homogeneous catalytic oxidation of coconut shells to high-yield aromatic monomers and holocellulose in mild TMAH-imidazole\" [Bioresour. Technol. 464 (2027) 135857].","authors":"Chenjun He, Ruoruo Jiang, Yunxuan Wang, Heng Li, Arthur Ragauskas, Qiang Yu","doi":"10.1016/j.biortech.2026.135904","DOIUrl":"10.1016/j.biortech.2026.135904","url":null,"abstract":"","PeriodicalId":258,"journal":{"name":"Bioresource Technology","volume":" ","pages":"135904"},"PeriodicalIF":8.2,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149056641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physiology of the subconscious: Autonomic activation during sexual dreaming","authors":"Emmanuel Eroumé A Egom ,&nbsp;Bernadette Sandrine Lema ,&nbsp;Elijah-Bill Christopher Nguem Nguem","doi":"10.1016/j.sleepx.2026.100174","DOIUrl":"10.1016/j.sleepx.2026.100174","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate self-reported autonomic-like symptoms following sexual dreams in the SLEEP Study and characterize their perceived physiological patterns.</div></div><div><h3>Methods</h3><div>In a cross-sectional online study, 301 female-identifying adults reported physical and emotional sensations experienced immediately after sexual dreams. We summarized symptom prevalence using descriptive statistics.</div></div><div><h3>Results</h3><div>Increased heart rate (57.4 %) and sweating (35.0 %) were most frequently reported, followed by anxiety (33.9 %) and muscle tension (23.0 %). A minority (20.8 %) reported no symptoms, indicating variability in perceived arousal or recall. Symptom patterns reflected common co-occurrence of self-reported cardiovascular-like and affective experiences.</div></div><div><h3>Discussion</h3><div>These findings suggest that sexual dreams are often accompanied by self-reported autonomic-like experiences, although these reports do not represent objective physiological measurements. This brief report isolates the symptom dimension of the SLEEP Study dataset—a component not analyzed in our prior <em>Sleep Research</em> publication—and highlights the potential value of self-reported responses for studying REM-linked emotional arousal.</div></div>","PeriodicalId":37065,"journal":{"name":"Sleep Medicine: X","volume":"11 ","pages":"Article 100174"},"PeriodicalIF":0.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146037873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of dispositional optimism and pessimism on the relationship between stressful life events and late-life depression.","authors":"Greg Roebuck, Mojtaba Lotfaliany, James Whittaker, Malcolm Forbes, Mohammadreza Mohebbi, John J McNeil, Robyn L Woods, Alice J Owen, Stephanie A Ward, Rosanne Freak-Poli, Danijela Gasevic, Heather Craig, Chenglong Yu, Paul Lacaze, Jessica E Green, Richard A Kanaan, Michael Berk","doi":"10.1016/j.jad.2026.122359","DOIUrl":"10.1016/j.jad.2026.122359","url":null,"abstract":"<p><strong>Background: </strong>Dispositional optimism is associated with a lower risk of depression. Optimism may protect against depression by conferring resilience to stressful life events. This study aimed to investigate the effects of dispositional optimism, and the related trait of dispositional pessimism, on the relationship between stressors and depression in older adults.</p><p><strong>Methods: </strong>This prospective cohort study used data from the ASPREE Longitudinal Study of Older Persons. Participants were aged ≥70 years and without known cardiovascular disease, dementia, independence-limiting physical disability and depression. Optimism and pessimism were measured using the Life Orientation Test-Revised. Incident depression was defined as a score ≥ 8 on the 10-item Center for Epidemiological Studies Depression Scale. The experience of 10 different types of stressors was assessed.</p><p><strong>Findings: </strong>10,791 participants were followed for a median (IQR) period of 3.5 (2.8-5.0) years. After adjusting for sociodemographic, lifestyle and medical factors and genetic predisposition to depression (using a polygenic score), optimism was associated with a lower risk of depression (HR, 0.92; 95% CI 0.90-0.93). Pessimism (HR, 1.07; 95% CI 1.06-1.08) and stressful life events (HR, 1.17; 95% CI 1.14-1.21) were associated with a higher depression risk. Neither optimism nor pessimism was associated with differences in the strength of the relationship between stressors and depression (p ≥ 0.499).</p><p><strong>Conclusions: </strong>Optimism was associated with a lower risk of late-life depression. However, it was not associated with lower vulnerability to the depressogenic effects of stressful life events. These findings raise questions regarding whether optimism confers resilience to stressors in older adults.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"122359"},"PeriodicalIF":5.7,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148689317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive trajectories in the nine months following recent-onset major depressive disorder.","authors":"Alexandra Stainton, Caroline X Gao, Georgina D Thomas, Myriam Zhou, Robert Hester, Shayden Bryce, Katharine Chisholm, Siân Lowri Griffiths, Lana Kambeitz-Ilankovic, Julian Wenzel, Carolina Bonivento, Paolo Brambilla, Mariam Iqbal, Theresa K Lichtenstein, Marlene Rosen, Linda A Antonucci, Eleonora Maggioni, Joseph Kambeitz, Stefan Borgwardt, Anita Riecher-Rössler, Christina Andreou, André Schmidt, Frauke Schultze-Lutter, Eva Meisenzahl, Stephan Ruhrmann, Raimo K R Salokangas, Christos Pantelis, Rebekka Lencer, Olga Bienek, Georg Romer, Udo Dannlowski, Alessandro Bertolino, Rachel Upthegrove, Dominic B Dwyer, Nikolaos Koutsouleris, Stephen J Wood, Kelly Allott","doi":"10.1016/j.jad.2026.122371","DOIUrl":"10.1016/j.jad.2026.122371","url":null,"abstract":"<p><strong>Background: </strong>Specific cognitive difficulties are common in major depressive disorder, impacting functioning and quality of life. Yet, the timing of their emergence and longitudinal course remains poorly understood. This study aimed to characterise longitudinal cognitive functioning following recent onset depression and its association with changes in depressive symptoms.</p><p><strong>Methods: </strong>Longitudinal data from the PRONIA (Personalised Prognostic Tools for Early Psychosis Management) cohort recruited from ten European sites were used to evaluate trajectory differences between Healthy Controls (HC) and individuals experiencing recent onset depression (ROD). Linear mixed effect models were used with group-by-time interaction term for trajectory differences between baseline and nine-month follow-up, and the associations between changes in depression symptoms and cognitive functioning among ROD.</p><p><strong>Results: </strong>The sample comprised 420 participants (ROD, N = 151; HC, N = 269) aged 15-40 years (M = 25.4, SD = 6.1; 55% female). Two distinct group-level cognitive trajectories were observed. First, a similar trajectory (i.e., no difference) to HC in visual memory, attention span, verbal learning and memory, visuospatial working memory, emotion recognition, and processing speed. A stable deficit trajectory was observed in mental flexibility, auditory verbal working memory, phonetic and semantic verbal fluency among the ROD group. Analysis within ROD group suggested that these outcomes were unrelated to reductions in depressive symptoms. Changes in visual memory, visuospatial working memory, sustained attention, and processing speed were associated with changes in depressive symptoms, despite being unrelated to baseline variations in depressive symptoms, possibly suggesting a sensitivity to state effects of illness, regardless of baseline severity.</p><p><strong>Conclusions: </strong>Specific cognitive difficulties are already evident at the first depressive episode and may endure in the short-medium term, irrespective of depressive course. Tailored treatment addressing cognition should be provided early to promote cognitive health and functional recovery.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"122371"},"PeriodicalIF":5.7,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148712585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antipsychotic medication and the prevention of psychiatric emergencies in difficult-to-treat adolescent depression.","authors":"Linnea Sepe-Forrest, Richard F Meraz, Zheng Chang, Michael D Morse, Tanya E Froehlich, Brian M D'Onofrio, Patrick D Quinn","doi":"10.1016/j.jad.2026.122386","DOIUrl":"10.1016/j.jad.2026.122386","url":null,"abstract":"<p><strong>Objectives: </strong>It is unclear how antipsychotic medications affect acute healthcare use among adolescents with depression. We compared risk of psychiatric emergencies between adolescents with difficult-to-treat depression initiating new antipsychotic versus antidepressant medications.</p><p><strong>Methods: </strong>This cohort study employed a target trial emulation framework using Optum's de-identified Clinformatics® Data Mart Database between 2009 and 2021. We compared risk of emergency visits or inpatient encounters with mental health diagnoses (i.e. psychiatric emergencies) following new atypical antipsychotic versus secondary antidepressant prescription fills among adolescents (10-19 years old) with depression. All adolescents had filled SSRI prescriptions within one year prior to initiating a secondary medication and had no FDA-approved indications for pediatric antipsychotic use.</p><p><strong>Results: </strong>Among youth with depression and SSRI receipt, there were 3710 incident antipsychotic users (63.7% female) and 28,527 secondary antidepressant users (71.7% female). Within 1 year of initiation, antipsychotic medications were associated with a higher risk of psychiatric emergencies (propensity-score weighted HR = 1.59; 95% CI = 1.46, 1.72) compared with secondary antidepressant medications. The weighted cumulative incidence of psychiatric emergencies was 38.7% (95% CI = 34.8%, 42.7%) for antipsychotic and 24.5% (95% CI = 23.7%, 25.3%) for secondary antidepressant users. Comparable results were observed for emergencies involving suicidality and in a series of sensitivity analyses.</p><p><strong>Conclusions: </strong>Our findings do not provide support for a protective effect of atypical antipsychotic medications compared with secondary antidepressant medications for the prevention of psychiatric emergencies in youth with difficult-to-treat depression.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"122386"},"PeriodicalIF":5.7,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148760160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"X-ray fluorescence analysis of contemporary metal sculptures.","authors":"Leonardo S G Teixeira, Gianni Gallello, Miguel de la Guardia","doi":"10.1016/j.talanta.2026.130167","DOIUrl":"10.1016/j.talanta.2026.130167","url":null,"abstract":"<p><p>A portable X-ray fluorescence spectrometer (pXRF) has been employed to study the composition of contemporary metal sculptures. The equipment calibration was verified against a reference material and by using circulating coins with compositions declared by central banks. It was shown that coins can serve as a cheaper alternative for verifying the accuracy of XRF measurements. The analyses of 14 sculptures revealed that the same object can exhibit parts with markedly different compositions, particularly when these parts are independent and perform different functions within the artwork. On the other hand, a tendency towards compositional homogeneity was observed across the main body of the same artwork, consistent with the use of a single metal alloy in the sculpture's manufacture. Furthermore, it was not possible to establish unequivocal compositional characteristics for works attributed to the same artist, and it was found that certified limited-edition sculptures exhibited high-quality bronze, whereas other works did not adhere to a specific metal-alloy standard, reflecting different manufacturing processes. It has been confirmed that compositional analysis of sculptures using pXRF can be important for the certification and authentication of these artworks, as well as for evaluating material quality and potential restorations.</p>","PeriodicalId":435,"journal":{"name":"Talanta","volume":"310 ","pages":"130167"},"PeriodicalIF":6.7,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148306411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wastewater nutrients valorization into biostimulant via engineered polyphosphate-accumulating bacterium.","authors":"Xiaotong Ge, Xue Li, Zihao Fan, Xin Wang, Mengmeng Wang, Jingyun Yin, Xiaohua Song, Liyu Pan, Yuhu Zheng, Liuyan Yang","doi":"10.1016/j.biortech.2026.135607","DOIUrl":"10.1016/j.biortech.2026.135607","url":null,"abstract":"<p><p>Phosphorus (P) and nitrogen (N) are critical nutrients increasingly lost to wastewater streams. Existing methods focus on removal rather than recycling, and are poorly equipped for valorization. Building on our group's prior work engineering Citrobacter freundii (CPP) overexpressing ppk for enhanced P removal, we demonstrate here that CPP simultaneously valorizes both P and N from real municipal wastewater into intracellular polyphosphate (polyP) and spermidine (Spd). Under optimized conditions, CPP accumulated intracellular polyP and Spd at 247.56 mg/g and 102.71 mg/g, representing 2.44- and 2.99-fold increases over pre-optimization levels, with corresponding P and N valorization rates reaching 76.76% and 51.16%, respectively, substantially exceeding the productivity of conventional polyphosphate-accumulating organisms. Driven by the co-accumulation, polyP and Spd phase-separated into insoluble granules termed stabilisomes with diameters of up to 181 nm and a composition of 44.6% polyP and 20.5% Spd, which maintained intracellular homeostasis and sustaining their continuous co-production. Leveraging the sustained co-production of polyP and Spd, the product value far exceeds that of conventional single-nutrient recovery techniques. Calculations indicate that the heat-inactivated CPP-derived biostimulant (CPPB) has a unit production cost of approximately ¥1.97/g. Applied as a foliar spray at 1.8 g/L, increased Brassica chinensis dry weight by 121.14% and plant height by 31.08%, outperforming commercial microbial fertilizers tested. This work establishes a practical biorefinery route for simultaneous P and N valorization from municipal wastewater, advancing the transition toward a circular bioeconomy.</p>","PeriodicalId":258,"journal":{"name":"Bioresource Technology","volume":"462 ","pages":"135607"},"PeriodicalIF":8.2,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148756983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}