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{"title":"Effects of exercise on mental health in mice with circadian rhythm disruption.","authors":"Chunxiao He, Masahiro Wakayama, Hanlin Jiang, Tingrui Zhao, Yifan Zhang, Bin Liu, Hideki Moriyama","doi":"10.1016/j.jad.2025.119936","DOIUrl":"10.1016/j.jad.2025.119936","url":null,"abstract":"<p><strong>Background: </strong>Circadian rhythm disruptions are major contributors to anxiety and depression, potentially involving mechanisms like altered clock gene activity and midbrain dopamine system impairments. Exercise has been shown to play a significant role in maintaining the stability of the circadian rhythm and promoting mental health. This study aimed to investigate whether various exercise modes could alleviate mental health issues triggered by circadian rhythm disruption.</p><p><strong>Methods: </strong>A total of 48 male C57BL/6J mice were randomly divided into four groups: control group, circadian rhythm disruption group, aerobic exercise group with circadian rhythm disruption, and resistance exercise group with circadian rhythm disruption. Circadian rhythm disruption was induced by altering the light-dark cycle every three days, followed by four weeks of exercise intervention. The behavioral rhythms of mice were evaluated through sleep recording. Behavioral assessments, including the open field test, elevated plus maze, and forced swim test, were used to evaluate anxiety- and depression-like behaviors. The expression of clock genes and dopamine levels in the prefrontal cortex were analyzed using quantitative real-time PCR and enzyme-linked immunosorbent assay.</p><p><strong>Results: </strong>Exercise interventions significantly reduced anxiety- and depression-like behaviors in the mice. Aerobic and resistance exercise significantly maintained the circadian rhythmic expression pattern of the Bmal1 gene. Aerobic exercise increased dopamine levels in the prefrontal cortex.</p><p><strong>Conclusion: </strong>Exercise, especially aerobic exercise, effectively alleviates mental health challenges associated with circadian rhythm disruption by influencing clock gene expression and dopamine regulation in the prefrontal cortex. These findings provide evidence for the potential use of exercise interventions as therapeutic strategies for circadian rhythm-related mental health problems.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"119936"},"PeriodicalIF":4.9,"publicationDate":"2025-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144649531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does intimate partner violence mediate the association between adverse childhood experiences and internalizing symptomatology in women? A mediation meta-analysis.","authors":"Julia Martini, Audrey-Ann Deneault, Jenney Zhu, Nicole Racine, Pasco Fearon, Sheri Madigan, Jennifer M Jenkins","doi":"10.1016/j.jad.2025.119742","DOIUrl":"10.1016/j.jad.2025.119742","url":null,"abstract":"<p><p>Research is needed to elucidate the underlying mechanisms that link adverse childhood experiences (ACEs) and internalizing symptomatology in women. In the present study, we conducted a systematic review to assess whether intimate partner violence (IPV) mediated the association between ACEs and internalizing symptomatology in women. We utilized a novel statistical technique-meta-analytic structural equation modelling (MASEM)-to examine the path model by amalgamating effect sizes across all studies, thereby combining both meta-analytic and structural equation modelling approaches. A total of 25 studies (N = 30,737 women) were included in the MASEM. The average age of female participants was 30.4 years. Results indicated that IPV partially mediated the association between ACEs and internalizing symptomatology, explaining 16 % of the total effect. Tested moderators included sociodemographic factors (age, SES, single status, and minority status) and methodological factors, including IPV characteristics (IPV category and IPV timeline), psychopathology assessment method, and the number of ACEs items measured. None of the tested moderators significantly influenced the indirect pathway. Findings suggest that IPV is an important risk factor in explaining why ACEs are associated with internalizing symptomatology in women.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"119742"},"PeriodicalIF":4.9,"publicationDate":"2025-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetic resonance spectroscopy studies in children and adolescents with depression: A systematic review and meta-analysis.","authors":"Hong Zhou, Yao Gao, Tao Dong, Jie Wang, Zhi-Fen Liu","doi":"10.1016/j.jad.2025.119747","DOIUrl":"10.1016/j.jad.2025.119747","url":null,"abstract":"<p><strong>Background: </strong>Numerous studies have focused on the levels of brain metabolites in patients with depression. However, there are relatively few studies on magnetic resonance spectroscopy (MRS) of adolescent depression and the related neurobiological mechanisms lack consistent conclusions. To summarize the nature of brain metabolite changes in adolescents with depression, we conducted meta-analyses of metabolite levels in proton magnetic resonance spectroscopy (¹H-MRS) studies.</p><p><strong>Methods: </strong>We searched the PubMed, Cochrane Library, Scopus, Embase, and Web of Science databases from January 1965 to December 2023. Heterogeneity across studies was evaluated using the Q and I² tests, and the random-effects model was used for analysis. Subgroup analyses were also conducted to explore potential sources of inconsistency.</p><p><strong>Results: </strong>A total of 26 studies involving 465 adolescent patients with depression and 409 healthy controls (HC) were included in this systematic review. N-acetyl aspartate (NAA) levels (SMD: -0.20, 95%CI: -0.34 to -0.05) were decreased in adolescents with depression when all brain areas were combined. In the dorsolateral prefrontal cortex white matter region, right-sided NAA (SMD: -0.76, 95 % CI: -1.36 to -0.15) and left-sided choline (Cho) levels (SMD: -0.54, 95 % CI: -0.96 to -0.12) were decreased. The levels of NAA (SMD: -0.35, 95 % CI: -0.65 to -0.05), Cho (SMD: -0.34, 95 % CI: -0.67 to -0.00) and creatine (Cr) (SMD: -0.50, 95 % CI: -0.96 to -0.03) in the anterior cingulate cortex (ACC) are reduced. The NAA/Cr levels (SMD: -1.67, 95 % CI: -3.29 to -0.05) in the left prefrontal cortex (PFC) are decreased.</p><p><strong>Conclusions: </strong>Our results suggest that the reduction in NAA levels throughout the brain regions, especially in the prefrontal cortex, among adolescent patients with depression may be due to neuronal loss. The decrease in Cr concentration indicates that using relative creatine concentration may affect the study results. The PFC and ACC may play an important role in adolescent depression.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"119747"},"PeriodicalIF":4.9,"publicationDate":"2025-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between folate intake and suicidal ideation: NHANES 2005-2018 and Mendelian randomization.","authors":"Ling Feng, Shandie Li, Chaorui Li","doi":"10.1016/j.jad.2025.119730","DOIUrl":"10.1016/j.jad.2025.119730","url":null,"abstract":"<p><strong>Background: </strong>Previous findings indicated that there was an association between folate intake and suicidal behaviors. Nevertheless, whether folate intake influences suicidal ideation remains inconclusive. Consequently, this research focuses on investigating the link between folate intake and suicidal ideation.</p><p><strong>Methods: </strong>The data utilized came from the National Health and Nutrition Examination Survey (NHANES) database, with a coverage period of 2005-2018. We examined the correlation between folate intake and suicidal ideation by applying weighted logistic regression, restricted cubic spline (RCS) models, and subgroup analysis. Mendelian randomization (MR) was utilized as an instrumental variable method to evaluate the potential causality.</p><p><strong>Results: </strong>The NHANES analysis revealed a non-linear inverse relationship between folate intake and suicidal ideation (P for nonlinear: 0.014). After adjusting for all covariates, participants in the fourth quartile of folate intake demonstrated a 38 % diminished risk of suicidal ideation relative to those in the first quartile, for each incremental unit of folate intake (OR: 0.62, 95%CI: 0.44-0.89). Subgroup analysis revealed that the relationship between folate intake and suicidal ideation remained consistent across gender, race, smoking status, diabetes, hypertension and depression (P for interaction>0.05). Nevertheless, the Mendelian randomization (MR) analysis was unable to show causality between folate intake and suicidal ideation (OR: 0.944, 95%CI: 0.788-1.131, P: 0.533).</p><p><strong>Conclusions: </strong>An inverse connection was observed between folate intake and suicidal ideation, but no causal relationship was established.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"119730"},"PeriodicalIF":4.9,"publicationDate":"2025-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144336602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor: \"Association between oral microbiome and depression: A population-based study\".","authors":"Shiyuan Wu, Muze Huang","doi":"10.1016/j.jad.2025.119897","DOIUrl":"10.1016/j.jad.2025.119897","url":null,"abstract":"","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"119897"},"PeriodicalIF":4.9,"publicationDate":"2025-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144626386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Multichannel nerve conduit based on chitosan derivates for peripheral nerve regeneration and Schwann cell survival\" [Carbohydrate Polymers 301 (2023) 120327].","authors":"Zhiwen Jiang, Yijie Zhang, Yanting Wang, Shuo Wang, Jing Chang, Wanshun Liu, Baoqin Han","doi":"10.1016/j.carbpol.2025.123952","DOIUrl":"https://doi.org/10.1016/j.carbpol.2025.123952","url":null,"abstract":"","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"367 ","pages":"123952"},"PeriodicalIF":12.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144858734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Evaluating the impact of adjunct bright light therapy on subjective sleep quality in major depressive disorder\" [J. Affect. Disord. 348 (2024) 175-178].","authors":"Lorenzo Fregna, Francesco Attanasio, Cristina Colombo","doi":"10.1016/j.jad.2025.119688","DOIUrl":"10.1016/j.jad.2025.119688","url":null,"abstract":"","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"119688"},"PeriodicalIF":4.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144333196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"A versatile chitosan nanogel capable of generating AgNPs in-situ and long-acting slow-release of Ag⁺ for highly efficient antibacterial\" [Carbohydr. Polym., 2021, 257, 117636].","authors":"Mengni Fan, Jingxing Si, Xiaogang Xu, Linfu Chen, Junpeng Chen, Chao Yang, Jingwu Zhu, Lihuang Wu, Jiang Tian, Xiaoyi Chen, Xiaozhou Mou, Xiaojun Cai","doi":"10.1016/j.carbpol.2025.123950","DOIUrl":"https://doi.org/10.1016/j.carbpol.2025.123950","url":null,"abstract":"","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"367 ","pages":"123950"},"PeriodicalIF":12.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144858731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"A CRISPR-Cas12a-mediated dual-mode luminescence and colorimetric nucleic acid biosensing platform based on upconversion nanozyme\" [Biosens. Bioelectron. 270 (2025) 116963].","authors":"Jiaxiang Yan, Bohan Yin, Qin Zhang, Chuanqi Li, Jiareng Chen, Yingying Huang, Jianhua Hao, Changqing Yi, Yu Zhang, Siu Hong Dexter Wong, Mo Yang","doi":"10.1016/j.bios.2025.117738","DOIUrl":"10.1016/j.bios.2025.117738","url":null,"abstract":"","PeriodicalId":259,"journal":{"name":"Biosensors and Bioelectronics","volume":" ","pages":"117738"},"PeriodicalIF":10.7,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144566883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Increased prevalence of depression, anxiety, and adjustment and somatoform disorders in transsexual individuals\" [J. Affect. Disord. 274 (2020) 482-485].","authors":"Marcel Konrad, Karel Kostev","doi":"10.1016/j.jad.2025.119812","DOIUrl":"10.1016/j.jad.2025.119812","url":null,"abstract":"","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"119812"},"PeriodicalIF":4.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144591214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}