Elsevier最新文献

{"title":"Advanced aptasensor technologies for sensitive detection of 17β-Estradiol.","authors":"Yanan Cao, Mingshu Zhou, Hua Li","doi":"10.1016/j.cca.2025.120534","DOIUrl":"10.1016/j.cca.2025.120534","url":null,"abstract":"<p><p>The detection of 17β-estradiol (E2), a potent endocrine-disrupting compound, is critical for both environmental monitoring and biomedical diagnostics. Traditional detection methods often suffer from limitations in sensitivity, selectivity, and cost-effectiveness. Aptasensors, which utilize aptamers as biorecognition elements, offer promising alternatives because of their high specificity, stability, and adaptability. This paper explores recent advancements in aptasensor technologies for E2 detection, highlighting optical, electrochemical, and surface-enhanced Raman scattering (SERS)-based platforms. The integration of nanomaterials such as gold nanoparticles, carbon dots, and conductive polymers significantly enhances sensor performance, achieving ultralow detection limits and broad dynamic ranges. By leveraging these innovations, aptasensors provide scalable solutions for real-time monitoring of E2 in environmental, food, and clinical samples, paving the way for improved endocrine regulation and public health safety.</p>","PeriodicalId":10205,"journal":{"name":"Clinica Chimica Acta","volume":" ","pages":"120534"},"PeriodicalIF":2.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144798322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasonic imaging of spherical solids embedded in ice.","authors":"Francesco Simonetti","doi":"10.1016/j.ultras.2025.107779","DOIUrl":"10.1016/j.ultras.2025.107779","url":null,"abstract":"<p><p>The transmission of compressional ultrasonic waves into a rigid and dense solid with a doubly-curved surface is impeded when the solid is placed in a liquid medium and its surface is irradiated with waves traveling through the liquid. Measurable power transmission is only possible when the incident ultrasonic beam is close to normal to the surface. This condition is difficult to realize when the waves are excited and detected by a linear array of transducers and limits the possibility of forming cross-sectional images of the solid from the array data. Here, it is shown that the interior of the solid can be imaged with enhanced fidelity if the water is frozen. The high speed of compressional waves in polycrystalline ice (approximately 4000 ms^-1) along with its rigid behavior ensure that ultrasonic waves can be transmitted through the surface over a broad range of angles of incidence. However, due to the double curvature, the rays that form the ultrasonic beam can be deflected outside the array azimuthal plane after entering the solid. Therefore, the two-dimensional images obtained from the linear array data may not be consistent with the fully three-dimensional structure of the ray paths. The analysis of this phenomenon for the special case of solid spheres reveals that the image, to a good approximation, corresponds to a section of the sphere that is parallel to the azimuthal plane and at a standoff distance from it. The distance increases with the angle that the normal to the surface forms relative to the azimuthal plane while it decreases as the velocity contrast between ice and the material of the sphere decreases. While this property is not expected to hold for more complex surfaces, the ray-based framework used in this study is applicable to more general surface configurations and can be used to correlate the images to the structure of the solid. These findings are relevant to the inspection of metallic components with complex geometry which represents a long-standing challenge in the field of nondestructive testing.</p>","PeriodicalId":23522,"journal":{"name":"Ultrasonics","volume":"157 ","pages":"107779"},"PeriodicalIF":4.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144822733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of dietary mineral intake with depression in overweight or obese adults: A cross-sectional study in the United States.","authors":"Siqiao Wang, Na Luo, Jiahui Jiang, Chenyi Zhu, Xiao Hu, Wei Xu, Zhourui Wu, Chen Li, Zhihui Xiao, Bei Ma, Lei Huang, Liming Cheng","doi":"10.1016/j.jad.2025.120080","DOIUrl":"10.1016/j.jad.2025.120080","url":null,"abstract":"<p><strong>Background: </strong>This study explored the association between mineral intake and depression in overweight/obese adults in the United States.</p><p><strong>Methods: </strong>A cross-sectional study was performed using data from the National Health and Nutrition Examination Survey (NHANES) from 2015 to 2018. Depression was evaluated using the PHQ-9 questionnaire. The participants were divided into overweight/obesity group and non-overweight/obesity group according to whether BMI ≥ 25 kg/m². Univariate and multivariate logistic regression was used to analyze the association between mineral intake and depression.</p><p><strong>Results: </strong>A total of 8204 adults were included in this study. Univariate logistic regression model showed the higher intake of phosphorus, magnesium, iron, zinc, copper, sodium, potassium, and calcium (all p < 0.001) in overweight/obese people was associated with lower depression risk. In non-overweight/obese individuals, multivariate models showed higher magnesium intake (Q3 vs. Q1: OR = 0.615, p = 0.042) and sodium intake (Q2-Q4 vs. Q1: p < 0.05) were associated with lower depression risk. The negative correlation between depression risk and the intake of phosphorus (Q2: p = 0.004), magnesium (Q2: p = 0.016; Q3: p = 0.009), iron (Q2: p = 0.019; Q3: p = 0.001), zinc (Q2: p = 0.003), copper (Q2: p = 0.001; Q3: p = 0.001; Q4: p = 0.025), sodium (Q2: p = 0.007), and potassium (Q2: p = 0.006) is more prominent in overweight/obese women.</p><p><strong>Conclusion: </strong>Appropriate mineral supplementation for overweight/obese individuals may reduce the depression risk, especially in women.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"120080"},"PeriodicalIF":4.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144955026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metformin's psychological benefits in Type 2 diabetes: A call for further exploration.","authors":"Xiaozhi Chen, Zhiqiang Zhang","doi":"10.1016/j.jad.2025.120171","DOIUrl":"10.1016/j.jad.2025.120171","url":null,"abstract":"","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"120171"},"PeriodicalIF":4.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144955104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identify key environmental factors and neglected genetic SNPs associated with obsessive-compulsive disorder by two-sample multivariate Mendelian randomization analysis.","authors":"Yongheng Wang, Weiye Qian, Haoyu Sun, Juan Zhao, Mingdao Mu, Zhiyuan Yang","doi":"10.1016/j.jad.2025.120181","DOIUrl":"10.1016/j.jad.2025.120181","url":null,"abstract":"<p><strong>Background: </strong>Obsessive-compulsive disorder (OCD) is a mental disorder characterized by recurrent, intrusive thoughts and repetitive behaviors. The association between environmental factors and OCD remains incompletely understood.</p><p><strong>Methods: </strong>We applied two-sample multivariate Mendelian randomization analysis by using single nucleotide polymorphisms (SNPs) as instrumental variables to analyze the possible associations between environmental factors and OCD.</p><p><strong>Results: </strong>Our results showed that depressive symptoms (p-value = 0.0004, OR = 3.234), neuroticism (p-value = 0.0001, OR = 2.502), and educational attainment (p-value = 0.021, OR = 1.467) are significant risk factors for OCD. Conversely, adventurousness (p-value = 0.044, OR = 0.669), eczema (p-value = 0.004, OR = 0.253), and subjective well-being (p-value = 0.002, OR = 0.304) appear to be significant protective factors. In addition, the heterogeneity test for these six environmental factors indicated no significant variations present in this study. The horizontal pleiotropy analysis showed that certain neglected SNPs impact OCD only indirectly through environmental factors, but do not directly influence this disease. By SNP-gene mapping analysis, 11 genes and 11 SNPs were present in those three risk factors. Metabolic pathway analysis showed that these genes were significantly enriched in the pathways of neurodevelopmental disorder.</p><p><strong>Conclusion: </strong>Our identification of these environmental factors and SNPs significantly advances the understanding of and potential treatments for OCD.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"120181"},"PeriodicalIF":4.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144992524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mentalization and Emotional-Cognitive Rigidity as predictors of esketamine's effects on Treatment-Resistant Depression: Findings from a prospective observational study.","authors":"Miriam Olivola, Filippo Mazzoni, Barbara Tarantino, Alessandro Guffanti, Matteo Marcatili, Federico Luigi Motta, Ranieri Domenico Cornaggia, Vassilis Martiadis, Tiziano Prodi, Pierluigi Politi, Natascia Brondino, Giovanni Martinotti, Massimo Clerici, Bernardo Dell'Osso","doi":"10.1016/j.jad.2025.120231","DOIUrl":"10.1016/j.jad.2025.120231","url":null,"abstract":"<p><strong>Introduction: </strong>Treatment-Resistant Depression (TRD) remains a major challenge in the management of Major Depressive Disorder (MDD). Esketamine, the S-enantiomer of ketamine and a glutamatergic modulator, has been approved by the FDA and EMA for TRD in 2019. Beyond its rapid antidepressant effects, esketamine may enhance neuroplasticity, facilitating the reconnection with emotional and cognitive processes, improving mentalization, social cognition and promoting resilience.</p><p><strong>Objective: </strong>This prospective multicenter observational study aimed to evaluate esketamine's therapeutic impact on depressive symptoms and explore whether psychological and clinical factors-including mentalization, psychache, social cognition, suicidality, and cognitive-emotional rigidity-could predict treatment response, enabling a more personalized approach to TRD management.</p><p><strong>Methods: </strong>Thirty-six TRD patients treated with esketamine were assessed over a six-month follow-up period using psychometric measures of depression severity, suicidality, mentalization, social cognition, psychache, and cognitive-emotional rigidity.</p><p><strong>Results: </strong>A significant association emerged between mentalization deficits and depressive symptoms. Specifically, patients with poor baseline mentalization abilities exhibited higher Montgomery-Åsberg Depression Rating Scale (MADRS) scores both at baseline and throughout follow-up. In contrast, greater cognitive rigidity appeared to have a protective role, potentially mitigating negative thinking and providing emotional stability, which may enhance resilience to stressors.</p><p><strong>Conclusions: </strong>These findings highlight the importance of a personalized treatment approach in TRD. Esketamine may be particularly beneficial in reducing cognitive rigidity, improving mentalization, and breaking the cognitive inflexibility that contributes to sustained negative depressive thinking patterns. Further research is needed to refine patient stratification and optimize treatment strategies for individuals with TRD.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"120231"},"PeriodicalIF":4.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145000597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring why adolescents of disadvantaged family socio-economic status were more depressed than others: Serial mediations via personal psychological resources, loneliness, and school refusal functions.","authors":"Yanqiu Yu, Juliet Honglei Chen, Anise M S Wu, Guohua Zhang, Dong-Wu Xu, Xinwei Lyu, Deborah Baofeng Wang, Mengni Du, Joseph T F Lau","doi":"10.1016/j.jad.2025.120220","DOIUrl":"10.1016/j.jad.2025.120220","url":null,"abstract":"<p><strong>Background: </strong>Disadvantageous family socio-economic status (DFSES) is a potential source of disparity in adolescent mental health. This study investigated the association between DFSES and probable depression and its mediation mechanisms via personal psychological resources (hope and resilience), loneliness, and school refusal functions.</p><p><strong>Methods: </strong>A school-based anonymous survey was conducted among 8285 middle school students in China from February to March 2022; the response/eligible rate was 98.6 %/88.4 % (n = 8169/7321). The DFSES index counted the number of five unfavorable conditions (not living with both parents, either the father's or the mother's education level was primary school or below, self-reported poor/very poor household financial situation, and single-parent family). Probable depression was defined as the 9-item Patient Health Questionnaire score ≥ 10.</p><p><strong>Results: </strong>The prevalence of probable depression was 18.9 %. The proportions endorsing nil/1/2/≥3 DFSES conditions were 49.4 %/30.4 %/15.1 %/5.1 %. Adjusting for age and sex, DFSES was positively associated with probable depression. Such an association was fully mediated by three 2-step indirect paths (via personal psychological resources of hope and resilience, loneliness, and school refusal functions, respectively) and two 3-step serial mediation (via personal psychological resources then school refusal functions, and via loneliness and then school refusal); the mediation effect size ranged from 8.8 % to 23.5 %.</p><p><strong>Conclusions: </strong>DFSES was a significant factor of adolescent depression. Modifications of the personal psychological resources of hope and resilience, loneliness, and school refusal functions might mitigate such potentially harmful effects of DFSES. Future longitudinal and intervention studies are warranted to verify the findings and reduce adolescent depression.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"120220"},"PeriodicalIF":4.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145008269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meta-analysis of the association between prenatal antibiotic exposure and risk of childhood attention-deficit/hyperactivity disorder.","authors":"Jiali Fan, Shanshan Wu, Chengshuang Huang, Dongqiong Xiao, Fajuan Tang","doi":"10.1016/j.jad.2025.120168","DOIUrl":"10.1016/j.jad.2025.120168","url":null,"abstract":"<p><strong>Background: </strong>Studies examining the association between maternal antibiotic use during pregnancy and the risk of childhood attention-deficit/hyperactivity disorder (ADHD) have yielded inconsistent results. This meta-analysis synthesizes available evidence to establish a more comprehensive understanding of this association.</p><p><strong>Methods: </strong>Observational studies published through October 2, 2024, were systematically searched from Cochrane Library, EMBASE, Web of Science, and PubMed databases. The Newcastle-Ottawa Scale was used to assess the quality of the included studies, and statistical analyses were performed using Stata version 15.0.</p><p><strong>Results: </strong>Nine studies encompassing 6,180,434 participants were included. Prenatal antibiotic exposure was associated with an increased risk of childhood ADHD (HR = 1.15; 95 % CI = 1.09-1.22, P < 0.0001; OR = 1.28; 95 % CI = 1.21-1.35, P < 0.001). Both mid-pregnancy (HR = 1.11; 95 % CI = 1.02-1.22, P = 0.282) and late-pregnancy (HR = 1.07; 95 % CI = 1.02-1.12, P = 0.521) antibiotic exposure was associated with an increased risk of ADHD. Repeated antibiotic exposures was associated with an increased risk further (twice: HR = 1.13; 95 % CI = 1.10-1.16, P = 0.856; ≥3 times: HR = 1.21; 95 % CI = 1.17-1.24, P = 0.166).</p><p><strong>Conclusion: </strong>This analysis identified a link between maternal antibiotic use during pregnancy and an increased risk of childhood ADHD. Large-scale, multicenter, well-designed prospective studies are needed to confirm these findings and adjust for potential confounders in evaluating the relationship between prenatal antibiotic exposure and childhood ADHD.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"120168"},"PeriodicalIF":4.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145008288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Authors' reply to letter to the editor: Clarifying context and scope in the replication of ASSIP in severe psychiatric inpatients.","authors":"Anna Monn, Tania Villar de Araujo, Christoph Hörmann, Golo Kronenberg, Georgios Schoretsanitis, Michael Rufer, Erich Seifritz, Birgit Kleim, Sebastian Olbrich","doi":"10.1016/j.jad.2025.120280","DOIUrl":"10.1016/j.jad.2025.120280","url":null,"abstract":"","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"120280"},"PeriodicalIF":4.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145023323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peripheral innate immune signature links migraine and depression: Identification of PTX3 and HP as shared diagnostic biomarkers.","authors":"Shuangyuan Hu, Zili Tang, Xu Ouyang, Shiqi Sun, Longyao Xu, Jing Yuan, Ling Zhao","doi":"10.1016/j.jad.2025.120311","DOIUrl":"10.1016/j.jad.2025.120311","url":null,"abstract":"<p><strong>Objective: </strong>To investigate convergent peripheral molecular mechanisms linking migraine and major depressive disorder (MDD) and to prioritize shared blood-based biomarkers.</p><p><strong>Methods: </strong>Peripheral blood transcriptomic datasets from migraine (PRJEB40032) and MDD (GSE98793) were integrated to identify shared differentially expressed genes (DEGs) and enriched pathways, with independent cohorts (migraine PRJEB67312; MDD GSE76826) used for validation. Candidate biomarkers were prioritized using machine learning (LASSO, SVM-RFE) and evaluated by receiver operating characteristic (ROC) curves. Immune cell infiltration was assessed using CIBERSORT, regulatory networks were reconstructed, and potential therapeutic compounds were predicted through DSigDB.</p><p><strong>Results: </strong>We identified 122 shared DEGs, enriched in innate immune activation with relative suppression of adaptive immune programs. Pentraxin 3 (PTX3) and haptoglobin (HP) were identified as diagnostic biomarkers, showing strong but variable performance. In training, PTX3 achieved AUCs of 0.912 (migraine) and 0.644 (MDD), while HP reached 0.767 and 0.661, respectively. The combined model yielded AUCs of 0.938 (training) and 0.736 (validation) for migraine, and 0.683 (training) and 0.775 (validation) for MDD, consistent with validation trends. Immune deconvolution showed increased neutrophils/monocytes across disorders, correlating positively with PTX3 and HP expression. Regulatory analysis implicated chromatin remodeling and inflammatory TFs, while drug repurposing analysis identified anti-inflammatory compounds such as withaferin A and myricetin.</p><p><strong>Conclusion: </strong>Our analysis identifies PTX3 and HP as blood-based biomarkers capturing a shared innate immune signature in migraine and MDD. These findings highlight convergent immune dysregulation and support biomarker-informed diagnostics and therapeutic strategies for comorbid migraine-depression.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"120311"},"PeriodicalIF":4.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145040161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}