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Metabolic engineering of Pichia pastoris as an industrial chassis enables biosynthesis of dopamine from methanol. 毕赤酵母作为工业底盘的代谢工程使甲醇生物合成多巴胺成为可能。
IF 9 1区 环境科学与生态学
Bioresource Technology Pub Date : 2025-11-01 Epub Date: 2025-06-29 DOI: 10.1016/j.biortech.2025.132915
Dexun Fan, Zijia Yuan, Huayang Tang, Pengcheng Ren, Shuangyan Han
{"title":"Metabolic engineering of Pichia pastoris as an industrial chassis enables biosynthesis of dopamine from methanol.","authors":"Dexun Fan, Zijia Yuan, Huayang Tang, Pengcheng Ren, Shuangyan Han","doi":"10.1016/j.biortech.2025.132915","DOIUrl":"10.1016/j.biortech.2025.132915","url":null,"abstract":"<p><p>Methanol, as a renewable and carbon-neutral single-carbon (C1) feedstock, has emerged as an ideal carbon source for green biomanufacturing due to its non-competition with food resources and scalability for industrial production. Here, we report the first efficient biosynthesis of dopamine from methanol through systematic metabolic engineering strategies in P. pastoris. Specifically, overexpressing high-activity tyrosine hydroxylase and enhancing shikimate pathway flux yielded 579 mg/L dopamine. To prevent degradation, key dopamine catabolic enzymes (PAS_chr1-4_0441) were knocked out. By reinforcing NADH regeneration and accelerating methanol assimilation, the titer increased to 1533 mg/L, an 84.2-fold increase from the first-generation strain. Finally, we optimized the fermentation process in a 15 L fermenter to minimize dopamine autoxidation, achieving a highest reported dopamine titer using methanol as the sole carbon source to date (12.2 g/L). This study not only validates methanol as a high-performance substrate for industrial microbiology, but also establishes a critical foundation for synthesizing dopamine and its derivatives from C1 feedstocks.</p>","PeriodicalId":258,"journal":{"name":"Bioresource Technology","volume":" ","pages":"132915"},"PeriodicalIF":9.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144537607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The changing prevalence of ADHD? A systematic review. ADHD患病率的变化？系统回顾。
IF 4.9 2区 医学
Journal of affective disorders Pub Date : 2025-11-01 Epub Date: 2025-05-18 DOI: 10.1016/j.jad.2025.119427
Alex F Martin, G James Rubin, M Brooke Rogers, Simon Wessely, Neil Greenberg, Charlotte E Hall, Angie Pitt, Poppy Ellis Logan, Rebecca Lucas, Samantha K Brooks
{"title":"The changing prevalence of ADHD? A systematic review.","authors":"Alex F Martin, G James Rubin, M Brooke Rogers, Simon Wessely, Neil Greenberg, Charlotte E Hall, Angie Pitt, Poppy Ellis Logan, Rebecca Lucas, Samantha K Brooks","doi":"10.1016/j.jad.2025.119427","DOIUrl":"10.1016/j.jad.2025.119427","url":null,"abstract":"<p><strong>Introduction: </strong>Understanding the prevalence of Attention Deficit Hyperactivity Disorder (ADHD) and changes in demand for related healthcare services is crucial for effective healthcare policy and resource allocation. Clinicians, teachers and charities have reported increasing demand for ADHD assessments in recent years, overwhelming support systems. This review synthesises post-2020 studies of ADHD prevalence and incidence.</p><p><strong>Methods: </strong>We conducted systematic searches in Web of Science, Embase, Medline, Global Health, and PsycInfo using terms relating to ADHD and prevalence. Additional sources included public health databases, Google, and study reference lists. Studies were included if they contained original data relating to general population rates of ADHD and we extracted data relating to methods of assessment and measures of prevalence and incidence. We followed PRISMA and synthesis without meta-analysis (SWiM) guidelines.</p><p><strong>Results: </strong>Forty studies across 17 countries, with one study spanning 42 countries, were reviewed. No significant rise in ADHD prevalence was found, although incidence was found to vary during the COVID-19 pandemic. Only four of the included studies were at low risk of bias.</p><p><strong>Limitations: </strong>There are substantial limitations in the quality of the literature included in this review. Due to significant delays in reporting prevalence data, estimates from previous reviews may be inaccurate. There is a lack of healthcare data and no school-level data.</p><p><strong>Conclusions: </strong>Significant research gaps exist in determining ADHD prevalence and incidence. The highest quality findings do not suggest an increase in prevalence since 2020 but indicate some variability in incidence during the COVID-19 pandemic. Further research is urgently needed to guide clinical practice and public health policy.</p>","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"119427"},"PeriodicalIF":4.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corrigendum to "Fabrication of Cu2+-loaded phase-transited lysozyme nanofilm on bacterial cellulose: Antibacterial, anti-inflammatory, and pro-angiogenesis for bacteria-infected wound healing" [Carbohydrate Polymers 309 (2023) 120681]. “在细菌纤维素上制备Cu2+负载的相转移溶菌酶纳米膜：细菌感染伤口愈合的抗菌、抗炎和促血管生成”[碳水化合物聚合物309(2023)120681]的更正。
IF 12.5 1区 化学
Carbohydrate Polymers Pub Date : 2025-11-01 Epub Date: 2025-07-28 DOI: 10.1016/j.carbpol.2025.123951
Wei He, Xiaodong Wang, Tian Hang, Jing Chen, Zhichao Wang, Dina A Mosselhy, Jin Xu, Shitao Wang, Yudong Zheng
{"title":"Corrigendum to \"Fabrication of Cu<sup>2+</sup>-loaded phase-transited lysozyme nanofilm on bacterial cellulose: Antibacterial, anti-inflammatory, and pro-angiogenesis for bacteria-infected wound healing\" [Carbohydrate Polymers 309 (2023) 120681].","authors":"Wei He, Xiaodong Wang, Tian Hang, Jing Chen, Zhichao Wang, Dina A Mosselhy, Jin Xu, Shitao Wang, Yudong Zheng","doi":"10.1016/j.carbpol.2025.123951","DOIUrl":"https://doi.org/10.1016/j.carbpol.2025.123951","url":null,"abstract":"","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"367 ","pages":"123951"},"PeriodicalIF":12.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144858733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corrigendum to "Chitosan-poly(lactide-CO-glycolide)/poloxamer mixed micelles as a mucoadhesive thermo-responsive moxifloxacin eye drop to improve treatment efficacy in bacterial keratitis" [Carbohydrate Polymers 312 (2023) 120822]. “壳聚糖-聚（丙交酯- co -乙醇酸）/波洛沙姆混合胶束作为黏附热响应性莫西沙星滴眼液提高细菌性角膜炎治疗疗效”的更正[碳水化合物聚合物312(2023)120822]。
IF 12.5 1区 化学
Carbohydrate Polymers Pub Date : 2025-11-01 Epub Date: 2025-07-29 DOI: 10.1016/j.carbpol.2025.123953
Sanjay Ch, Sri Ganga Padaga, Balaram Ghosh, Sanhita Roy, Swati Biswas
{"title":"Corrigendum to \"Chitosan-poly(lactide-CO-glycolide)/poloxamer mixed micelles as a mucoadhesive thermo-responsive moxifloxacin eye drop to improve treatment efficacy in bacterial keratitis\" [Carbohydrate Polymers 312 (2023) 120822].","authors":"Sanjay Ch, Sri Ganga Padaga, Balaram Ghosh, Sanhita Roy, Swati Biswas","doi":"10.1016/j.carbpol.2025.123953","DOIUrl":"https://doi.org/10.1016/j.carbpol.2025.123953","url":null,"abstract":"","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"367 ","pages":"123953"},"PeriodicalIF":12.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144858732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Erratum to 'Simultaneous enantiomeric separation of linagliptin and clopidogrel by capillary electrophoresis for the individual, combined, and enantiomeric ecotoxicity evaluation on Pseudokirchneriella subcapitata' [Talanta (September 2025) 127992]. 毛细管电泳同时分离利格列汀和氯吡格雷对映体对亚capitata Pseudokirchneriella的单个、联合和对映体生态毒性评价[Talanta (September 2025) 127992]。
IF 5.6 1区 化学
Talanta Pub Date : 2025-11-01 Epub Date: 2025-05-16 DOI: 10.1016/j.talanta.2025.128204
Laura García-Cansino, Karina Boltes, María Luisa Marina, María Ángeles García
{"title":"Erratum to 'Simultaneous enantiomeric separation of linagliptin and clopidogrel by capillary electrophoresis for the individual, combined, and enantiomeric ecotoxicity evaluation on Pseudokirchneriella subcapitata' [Talanta (September 2025) 127992].","authors":"Laura García-Cansino, Karina Boltes, María Luisa Marina, María Ángeles García","doi":"10.1016/j.talanta.2025.128204","DOIUrl":"10.1016/j.talanta.2025.128204","url":null,"abstract":"","PeriodicalId":435,"journal":{"name":"Talanta","volume":" ","pages":"128204"},"PeriodicalIF":5.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144085598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corrigendum to "Development of a universal one-pot CRISPR assay based on multifunctional tagged primer eliminating unstable crRNA input and PAM dependency for point-of-care detection of bacterial infections" [Biosens. Bioelectron. 287 (2025) 117718]. “基于多功能标记引物消除不稳定的crRNA输入和PAM依赖，用于即时检测细菌感染的通用一罐CRISPR测定的开发”的勘误表[Biosens]。生物电子学学报，2004,12(2):357 - 357。
IF 10.7 1区 生物学
Biosensors and Bioelectronics Pub Date : 2025-11-01 Epub Date: 2025-07-04 DOI: 10.1016/j.bios.2025.117742
Xiaofan Zhu, Jingran Jiao, Qun Ni, Li Yao, Yule Zhang, Kaiyong Liu, Lin Huang, Qingli Bo, Panzhu Qin
{"title":"Corrigendum to \"Development of a universal one-pot CRISPR assay based on multifunctional tagged primer eliminating unstable crRNA input and PAM dependency for point-of-care detection of bacterial infections\" [Biosens. Bioelectron. 287 (2025) 117718].","authors":"Xiaofan Zhu, Jingran Jiao, Qun Ni, Li Yao, Yule Zhang, Kaiyong Liu, Lin Huang, Qingli Bo, Panzhu Qin","doi":"10.1016/j.bios.2025.117742","DOIUrl":"10.1016/j.bios.2025.117742","url":null,"abstract":"","PeriodicalId":259,"journal":{"name":"Biosensors and Bioelectronics","volume":" ","pages":"117742"},"PeriodicalIF":10.7,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144564200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ferrocene derivatives constructed Prussian blue analogs for colorimetric detection of hydrogen peroxide and glucose. 二茂铁衍生物构建的普鲁士蓝类似物用于过氧化氢和葡萄糖的比色检测。
IF 10.7 1区 生物学
Biosensors and Bioelectronics Pub Date : 2025-11-01 Epub Date: 2025-06-25 DOI: 10.1016/j.bios.2025.117714
Yue Tong, Qian Liu, Dan Yang, Chunze Zhang, Yi Xiao, Mengying Shi, Meng Meng, Huixia Di, Hongmei Gao, Rimo Xi, Yongmei Yin
{"title":"Ferrocene derivatives constructed Prussian blue analogs for colorimetric detection of hydrogen peroxide and glucose.","authors":"Yue Tong, Qian Liu, Dan Yang, Chunze Zhang, Yi Xiao, Mengying Shi, Meng Meng, Huixia Di, Hongmei Gao, Rimo Xi, Yongmei Yin","doi":"10.1016/j.bios.2025.117714","DOIUrl":"10.1016/j.bios.2025.117714","url":null,"abstract":"<p><p>This study reports the rational design of ferrocene-derived Prussian blue analogs (PBAs) as a new class of nanozymes with enhanced catalytic properties. Capitalizing on its high peroxidase-like activity, we developed a colorimetric assay for detecting hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) and glucose, which exhibited high stability, sensitivity, and accuracy in biological samples such as serum. Furthermore, by leveraging the reversible structural dynamics of Fc(COOH)<sub>2</sub>-PBA, we engineered a dual-mode colorimetric assay for visual quantitation of H<sub>2</sub>O<sub>2</sub> and glucose in complex samples, including cells, tissues, and cerebrospinal fluid. The distinct colorimetric response of this system demonstrates promising potential for point-of-care testing applications. Our findings provide mechanistic insights into the structure-activity relationships of nanozymes and will facilitate the development of application-targeted nanozymes for disease diagnostics.</p>","PeriodicalId":259,"journal":{"name":"Biosensors and Bioelectronics","volume":" ","pages":"117714"},"PeriodicalIF":10.7,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144493209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corrigendum to "Is 'minimally adequate treatment' really adequate? investigating the effect of mental health treatment on quality of life for children with mental health problems" [J. Affect. Disord. 276 (2020) 327-334]. “‘最低限度的适当治疗’真的足够吗？”心理健康治疗对有心理健康问题儿童生活质量的影响研究[J]。影响。[j].科学通报，2014(5):327-334。
IF 4.9 2区 医学
Journal of affective disorders Pub Date : 2025-11-01 Epub Date: 2025-06-20 DOI: 10.1016/j.jad.2025.119691
Jemimah Ride, Li Huang, Melissa Mulraney, Harriet Hiscock, David Coghill, Michael Sawyer, Emma Sciberras, Kim Dalziel
{"title":"Corrigendum to \"Is 'minimally adequate treatment' really adequate? investigating the effect of mental health treatment on quality of life for children with mental health problems\" [J. Affect. Disord. 276 (2020) 327-334].","authors":"Jemimah Ride, Li Huang, Melissa Mulraney, Harriet Hiscock, David Coghill, Michael Sawyer, Emma Sciberras, Kim Dalziel","doi":"10.1016/j.jad.2025.119691","DOIUrl":"10.1016/j.jad.2025.119691","url":null,"abstract":"","PeriodicalId":14963,"journal":{"name":"Journal of affective disorders","volume":" ","pages":"119691"},"PeriodicalIF":4.9,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corrigendum to "Enhanced bioactivity of honeysuckle-Cassia seeds extracts through Lactobacillus acidophilus and Bacillus subtilis co-fermentation: Impact on alcoholic liver disease and gut microbiota" [Food Chem. 486 (2025) 144463]. “通过嗜酸乳杆菌和枯草芽孢杆菌共同发酵增强金银花-决明子提取物的生物活性：对酒精性肝病和肠道微生物群的影响”[食品化学，486(2025)144463]的更正。
IF 8.5 1区 农林科学
Food Chemistry Pub Date : 2025-10-15 Epub Date: 2025-06-27 DOI: 10.1016/j.foodchem.2025.145200
Mengtian Zhou, Yingao Zhang, Zeyi Song, Shuping Tang, Zhaoxue Liu, Meixia Pang, Di Zhang, Xiaoyan Wu, Xindi Yu, Pengze Wang, Ying Wei
{"title":"Corrigendum to \"Enhanced bioactivity of honeysuckle-Cassia seeds extracts through Lactobacillus acidophilus and Bacillus subtilis co-fermentation: Impact on alcoholic liver disease and gut microbiota\" [Food Chem. 486 (2025) 144463].","authors":"Mengtian Zhou, Yingao Zhang, Zeyi Song, Shuping Tang, Zhaoxue Liu, Meixia Pang, Di Zhang, Xiaoyan Wu, Xindi Yu, Pengze Wang, Ying Wei","doi":"10.1016/j.foodchem.2025.145200","DOIUrl":"10.1016/j.foodchem.2025.145200","url":null,"abstract":"","PeriodicalId":318,"journal":{"name":"Food Chemistry","volume":" ","pages":"145200"},"PeriodicalIF":8.5,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144511308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corrigendum to "Mechanically and functionally strengthened tissue adhesive of chitin whisker complexed chitosan/dextran derivatives based hydrogel" [Carbohydr. Polym. 237 (2020) 116138]. “几丁质须络合壳聚糖/葡聚糖衍生物基水凝胶的机械和功能强化组织粘合剂”的勘误[碳水化合物]。高分子学报，237(2020):116138。
IF 12.5 1区 化学
Carbohydrate Polymers Pub Date : 2025-10-15 Epub Date: 2025-06-18 DOI: 10.1016/j.carbpol.2025.123886
Jianhui Pang, Shichao Bi, Tiantian Kong, Xin Luo, Zhongzheng Zhou, Kaijin Qiu, Liang Huang, Xiguang Chen, Ming Kong
{"title":"Corrigendum to \"Mechanically and functionally strengthened tissue adhesive of chitin whisker complexed chitosan/dextran derivatives based hydrogel\" [Carbohydr. Polym. 237 (2020) 116138].","authors":"Jianhui Pang, Shichao Bi, Tiantian Kong, Xin Luo, Zhongzheng Zhou, Kaijin Qiu, Liang Huang, Xiguang Chen, Ming Kong","doi":"10.1016/j.carbpol.2025.123886","DOIUrl":"https://doi.org/10.1016/j.carbpol.2025.123886","url":null,"abstract":"","PeriodicalId":261,"journal":{"name":"Carbohydrate Polymers","volume":"366 ","pages":"123886"},"PeriodicalIF":12.5,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144740775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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