Elsevier最新文献

{"title":"Dual-mode sensor innovation based on light-harvesting and nanozyme integrated Cu-MOF loaded Cu₂O label.","authors":"Man Xu, Zheng Wang, Yingzhuo Shen, Meijuan Zhao, Xiaoya Hu, Hongbo Li, Wei Liu, Qin Xu","doi":"10.1016/j.talanta.2025.128012","DOIUrl":"10.1016/j.talanta.2025.128012","url":null,"abstract":"<p><p>Integrating photoelectrochemical (PEC) and colorimetric dual-mode shed light on \"all-in-one\" sensing platform for high sensitivity, in situ visualization and self-validating measurement. Its attainment depends on the capabilities of light harvesting and colorimetric signal generation from bi-functional tags, which remains challenging. Herein, Cu-MOF loaded Cu₂O (Cu₂O@Cu-MOF) was deliberately prepared and employed as the PEC- colorimetric signal reporter with tail-made stable photo-current and peroxidase mimic activity. A thin layer of Zr-MOF was deliberately encapsulated onto Cu₂O@Cu-MOF for the immobilization of aptamer (Apt) which can be captured by the magnetic AuNPs/Fe₃O₄ nanoparticles through duplex-specific hybrid. In the presence of target analyte, PEC- colorimetric signal reporter was quantitatively released from the magnetic AuNPs/Fe₃O₄ after one-step convenient magnetic separation, facilitating photocurrent response by the photo-induced excitation and colorimetric response by catalyzing the oxidation of 3,3',5,5'-tetramethylbenzidine (TMB). In a proof-of-concept experiment, a customized PEC- colorimetric dual-mode sensor platform based on Cu₂O@Cu-MOF reporter has achieved an ultrasensitive response for bisphenol A (BPA), exhibiting sub-picomole (PEC signal) and sub-nanomole (colorimetric signal) detection limits, respectively. Our dual-mode sensor platform strategy aims to extend to high-sensitivity and visual analysis in fields of in vitro diagnosis, environmental monitoring, and food safety.</p>","PeriodicalId":435,"journal":{"name":"Talanta","volume":"292 ","pages":"128012"},"PeriodicalIF":5.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143741911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative analysis of plastic blends based on virtual mid-infrared spectroscopy combined with chemometric methods.","authors":"Jian Yang, Yu-Peng Xu, Xiao-Li Chu","doi":"10.1016/j.talanta.2025.128006","DOIUrl":"10.1016/j.talanta.2025.128006","url":null,"abstract":"<p><p>Developing efficient and accurate quantitative analysis methods for plastic blends holds significant value for resource recycling and environmental monitoring. Mid-infrared (MIR) spectroscopy, combined with chemometric techniques, has demonstrated excellent performance in plastic blend quantification. However, obtaining mid-infrared spectral data for a large number of plastic blends to calibrate the model remains challenging. This study proposes an innovative approach that utilizes pure plastic MIR spectra and the Beer-Lambert law to generate virtual plastic blend spectra. Four experimental groups (A-D) were designed, incorporating both real and virtual spectra to systematically evaluate the method's effectiveness. Experiment group A established a baseline model using real spectra, while experiment groups B, C, and D respectively validated the applicability and generalization capability of models based on virtual spectra, as well as their potential applications in MIR hyperspectral imaging (MIR-HSI), respectively. The study further explores feature band selection, model construction, evaluation, and interpretation. The results demonstrate that this method can efficiently predict the mass percentages of components in ternary plastic blends. In experimental group C, partial least squares regression (PLSR), one-dimensional convolutional neural network (CNN1D), and two-dimensional convolutional neural network based on Gramian Angular Field (GAF-CNN2D) models-trained on 208 virtual plastic blend spectra-were employed to predict the mass percentages of 66 ternary plastic blends composed of polyethylene (PE), polypropylene (PP), and polystyrene (PS). The prediction coefficients of determination (R_T²) reached 0.9872, 0.9879, and 0.9944, respectively, indicating exceptional predictive accuracy. Experimental group D further demonstrated that, even under Gaussian noise interference and limited spectral range, the strategy of fusing mid-wave infrared and long-wave infrared bands allowed the PLSR and GAF-CNN2D models to maintain high performance in predicting the mass percentages of 66 ternary blends of PE, PP, and PS, with R_T² values of 0.9852 and 0.9895, respectively. This suggests that the proposed method holds potential for applications in MIR-HSI and is promising for real-time online analysis. Finally, this study proposes a more widely applicable and optimized quantitative analysis application scheme based on virtual plastic blend spectra, aiming to enable rapid and precise determination of unknown plastic blends.</p>","PeriodicalId":435,"journal":{"name":"Talanta","volume":"292 ","pages":"128006"},"PeriodicalIF":5.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143741921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Imidazole-triggered in situ fluorescence reaction system for quantitatively determination of dopamine from multiple sources.","authors":"Yifei Ma, Lijie Zhang, Hong Yang, Shanshan Zhu, Jinhua Liu","doi":"10.1016/j.talanta.2025.127975","DOIUrl":"10.1016/j.talanta.2025.127975","url":null,"abstract":"<p><p>Highly selective and sensitive determination of dopamine (DA) from multiple sources remains a persistent and significant challenge. Here, we develop an imidazole-triggered in situ fluorescence reaction system for highly selective and sensitive determination of DA from various sources (human, horse, dog, rabbit, and mouse). The system operates by catalyzing the oxidation of DA with 1,5-Dihydroxynaphthalene (1,5-DHA) through a Lewis base formed by imidazole, leading to the rapid generation of yellow azamonardine fluorescent compounds (AFC). Notably, the system demonstrates minimal background noise and a high signal-to-noise ratio of up to 300-fold with a determination limit of 33.33 pM, making it 10-100 times more sensitive than conventional enzyme-linked immunosorbent assay (ELISA) methods. Moreover, selectivity tests reveal that our system can effectively distinguish between several common interfering substances, even at concentrations as low as 10 nM. The developed system shows promising results in detecting DA from diverse sources (humans, horses, dogs, rabbits, and mice), including urine samples from clinical patients, exhibiting good agreement with traditional ELISA kits. Therefore, the established in situ fluorescence reaction system holds great potential for the determination of DA-related disorders due to its impressive analytical capabilities.</p>","PeriodicalId":435,"journal":{"name":"Talanta","volume":"292 ","pages":"127975"},"PeriodicalIF":5.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143741914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monitoring variations in mitochondrial hydrogen sulfide using two-photon cyclometalated iridium(III) complex probe: A new strategy for ischemia-reperfusion drug discovery and efficacy evaluation.","authors":"Peng Du, Tianao Zhang, Ying Wu, Zongping Yu, Chaolong Liu","doi":"10.1016/j.talanta.2025.128021","DOIUrl":"10.1016/j.talanta.2025.128021","url":null,"abstract":"<p><p>Hepatic ischemia-reperfusion injury (HIRI) is one of the main causes of liver insufficiency and failure after liver surgery. However, the effectiveness of current methods of treating HIRI is generally limited. Previous studies have shown that hydrogen sulfide (H₂S) has a beneficial effect on HIRI, and an appropriate concentration of H₂S can significantly reduce HIRI by protecting the mitochondria. Therefore, establishing an accurate imaging platform for monitoring variations in mitochondrial H₂S is an effective strategy for anti-HIRI drug discovery and efficacy evaluation. To this end, a cyclometalated iridium(III) complex-based probe, Cym-Ir-EDB, was developed for detecting mitochondrial H₂S in HIRI. Cym-Ir-EDB possesses good sensitivity, high selectivity, negligible cytotoxicity, and excellent mitochondrial-targeting ability, rendering it a promising imaging tool for analyzing variations in mitochondrial H₂S in HIRI cells. Using Cym-Ir-EDB as a probe, anti-HIRI drugs were screened from isothiocyanates by monitoring variations in mitochondrial H₂S in HIRI cells, for the first time. Moreover, the dynamics of mitochondrial H₂S in HIRI cells were visualized and the response of HIRI to treatment with the screened erucin was monitored. The findings indicate that Cym-Ir-EDB can serve as a useful imaging platform for the precise imaging of mitochondrial H₂S in HIRI, thereby contributing to anti-HIRI drug discovery and efficacy evaluation.</p>","PeriodicalId":435,"journal":{"name":"Talanta","volume":"292 ","pages":"128021"},"PeriodicalIF":5.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143741917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"L-borneol regulates rno-miR-127/PODXL2 to promote hair follicle stem cells to repair skin wounds\" [Int. Immunopharmacol. 158 (2025) 114847].","authors":"Zike Liu, Baolin Ye, Haoxiang Ye, Qing Zhong, Jiecheng Kong, Xianxi Zhou, Chunmei Ma, Aijun Liu","doi":"10.1016/j.intimp.2025.115097","DOIUrl":"10.1016/j.intimp.2025.115097","url":null,"abstract":"","PeriodicalId":13859,"journal":{"name":"International immunopharmacology","volume":" ","pages":"115097"},"PeriodicalIF":4.8,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144336419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction notice to \"Methyl helicterilate ameliorates alcohol-induced hepatic fibrosis by modulating TGF-β1/Smads pathway and mitochondria-dependent pathway\" [Int. Immunopharmacol. 75 (2019) 105759].","authors":"Shujuan Wen, Yuanyuan Wei, Xiaolin Zhang, Facheng Bai, Shimei Tan, Jinlan Nie, Jinbin Wei, Xing Lin","doi":"10.1016/j.intimp.2025.115091","DOIUrl":"10.1016/j.intimp.2025.115091","url":null,"abstract":"","PeriodicalId":13859,"journal":{"name":"International immunopharmacology","volume":" ","pages":"115091"},"PeriodicalIF":4.8,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction notice to \"Cyanorona-20: The first potent anti-SARS-CoV-2 agent\" [Int. Immunopharmacol. 98 (2021) 107831].","authors":"Amgad M Rabie","doi":"10.1016/j.intimp.2025.114980","DOIUrl":"10.1016/j.intimp.2025.114980","url":null,"abstract":"","PeriodicalId":13859,"journal":{"name":"International immunopharmacology","volume":" ","pages":"114980"},"PeriodicalIF":4.8,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction notice to \"Modulation of cytokine and β-defensin 2 expressions in human gingival fibroblasts infected with Chlamydia pneumoniae\" [Int. Immunopharmacol. 8(9) (2008) 1239-1247].","authors":"Antonietta Rizzo, Rossella Paolillo, Elisabetta Buommino, Alfonso Galeota Lanza, Luigi Guida, Marco Annunziata, Caterina Romano Carratelli","doi":"10.1016/j.intimp.2025.114981","DOIUrl":"10.1016/j.intimp.2025.114981","url":null,"abstract":"","PeriodicalId":13859,"journal":{"name":"International immunopharmacology","volume":" ","pages":"114981"},"PeriodicalIF":4.8,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"FABP5+ macrophages contribute to lipid metabolism dysregulation in type A aortic dissection\" [Int. Immunopharmacol. 143(Part 2) (2024) 113438].","authors":"Xin Chen, Ruoshi Chen, Yuefeng Wu, Anfeng Yu, Fei Wang, Chenxi Ying, Yifei Yin, Xiaofan Chen, Liang Ma, Yufei Fu","doi":"10.1016/j.intimp.2025.115126","DOIUrl":"10.1016/j.intimp.2025.115126","url":null,"abstract":"","PeriodicalId":13859,"journal":{"name":"International immunopharmacology","volume":" ","pages":"115126"},"PeriodicalIF":4.8,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144496150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of concern: \"Therapeutic effects of hyperbaric oxygen in a rat model of endothelin-1-induced focal cerebral ischemia\" [BRAIN RES, Volume 1153 (2007) 204-213].","authors":"Zhen-Xing Huang, Zhi-Min Kang, Guo-Jun Gu, Guang-Neng Peng, Liu Yun, Heng-Yi Tao, Wei-Gang Xu, Xue-Jun Sun, John H Zhang","doi":"10.1016/j.brainres.2025.149683","DOIUrl":"https://doi.org/10.1016/j.brainres.2025.149683","url":null,"abstract":"","PeriodicalId":9083,"journal":{"name":"Brain Research","volume":"1861 ","pages":"149683"},"PeriodicalIF":2.7,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}