ACS Publications最新文献

{"title":"Discovery of Novel Bifunctional Agents as Potent Androgen Receptor Antagonists and Degraders for the Treatment of Enzalutamide-Resistant Prostate Cancer","authors":"Wenqiang Zhang,&nbsp;Hao Zhu,&nbsp;Zhuolin Chen,&nbsp;Hongmei Li,&nbsp;Xingru Chen,&nbsp;Yawen Fan,&nbsp;Xiaoyu Zhou,&nbsp;Yi Luo,&nbsp;Yan Zhang,&nbsp;Feng Tang,&nbsp;Xinhao Zhang,&nbsp;Yunrui Feng,&nbsp;Tao Lu,&nbsp;Xian Wei*,&nbsp;Yadong Chen*,&nbsp;Caiping Chen* and Yu Jiao*,&nbsp;","doi":"10.1021/acs.jmedchem.4c0304310.1021/acs.jmedchem.4c03043","DOIUrl":"https://doi.org/10.1021/acs.jmedchem.4c03043https://doi.org/10.1021/acs.jmedchem.4c03043","url":null,"abstract":"<p >Bifunctional agents that simultaneously antagonize and degrade various AR proteins more effectively block the AR signaling pathway, offering a promising strategy for the treatment of mCRPC patients. Herein, we report the discovery and development of a series of small-molecule AR degraders with 3,8-diazabicyclo[3.2.1]octan scaffold. The optimal compound <b>20i</b> exhibited potent AR antagonistic and degrading activities, effectively overcoming multiple resistance mechanisms and showing significant antiproliferative effects against enzalutamide-resistant PCa cell lines. Moreover, compound <b>20i</b> exhibited favorable oral pharmacokinetics and a good safety profile. In the 22Rv1 xenograft models, <b>20i</b> exhibited potent antitumor activity without obvious toxicity. Taken together, these results demonstrated that <b>20i</b> might be a potential candidate for the treatment of enzalutamide-resistant PCa.</p>","PeriodicalId":46,"journal":{"name":"Journal of Medicinal Chemistry","volume":"68 8","pages":"8330–8345 8330–8345"},"PeriodicalIF":6.8,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143863191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Probing Molecular Interactions between Barnacle Peptides and Polymers In Situ to Understand Bioadhesion","authors":"Zahra Asif Gandhi,&nbsp;Tieyi Lu,&nbsp;Wen Guo,&nbsp;Ralph Crisci,&nbsp;Jinpeng Gao,&nbsp;Michael C. Wilson,&nbsp;Christopher R. So,&nbsp;Pranab Sarker,&nbsp;Xiaoxue Qin,&nbsp;Tao Wei and Zhan Chen*,&nbsp;","doi":"10.1021/acs.jpclett.5c0068710.1021/acs.jpclett.5c00687","DOIUrl":"https://doi.org/10.1021/acs.jpclett.5c00687https://doi.org/10.1021/acs.jpclett.5c00687","url":null,"abstract":"<p >Biofouling poses a significant issue in the maritime industry, where the attachment of biofoulants to ships greatly affects operational costs, surface durability, and marine pollution. Barnacles and barnacle proteins are widely used as models to study the biofouling mechanisms. With a combined <i>in situ</i> experimental and simulation approach, this study elucidated the molecular interaction mechanisms between barnacle cement-derived peptides (BCPs) and a polymer. The results showed that the peptide-charged segment plays a significant role in interfacial interactions, facilitating the formation of antiparallel β-sheets within the simple domain. This study reports the first <i>in situ</i>, real-time observation of β-sheet formation in adsorbed BCPs at the buried solution–polymer interface, which will prove to be essential for understanding overall BCP aggregation and barnacle fouling mechanisms.</p>","PeriodicalId":62,"journal":{"name":"The Journal of Physical Chemistry Letters","volume":"16 16","pages":"4031–4037 4031–4037"},"PeriodicalIF":4.8,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143863179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring Laser-Induced Local Sintering in K(Y0.90Er0.05Yb0.05)3F10 Crystals through Luminescence Thermometry","authors":"Pablo Serna-Gallén,&nbsp;Miguel A. Hernández-Rodríguez,&nbsp;Julio Corredoira-Vázquez,&nbsp;Carlos D. S. Brites*,&nbsp;Héctor Beltrán-Mir,&nbsp;Eloísa Cordoncillo and Luís D. Carlos*,&nbsp;","doi":"10.1021/acs.jpcc.5c0108010.1021/acs.jpcc.5c01080","DOIUrl":"https://doi.org/10.1021/acs.jpcc.5c01080https://doi.org/10.1021/acs.jpcc.5c01080","url":null,"abstract":"<p >Laser-induced heating is a groundbreaking tool across various fields, including medicine and micro/nanoscale material processing. Techniques such as laser ablation and sintering play pivotal roles in material processing. Laser sintering, in particular, drives critical processes, including particle coalescence, crystallinity enhancement, and densification, with precise temperature control essential to regulate sintering kinetics, grain boundary mobility, and phase stability. Luminescence thermometry is a promising approach for studying laser sintering, offering localized and real-time temperature measurements that surpass the limitations of traditional methods. This study explores laser-induced sintering in K(Y_0.90Er_0.05Yb_0.05)₃F₁₀ upconversion powder under 980 nm excitation at power densities of up to 275 W cm^–2. A pronounced transition from a nonemissive to a highly emissive regime is observed, driven by particle growth and enhanced crystallinity of the α-KY₃F₁₀ phase, as evidenced by X-ray diffraction and thermal analysis. Postirradiation, the transformed powder functions as a Boltzmann primary luminescent thermometer, enabling accurate temperature measurements up to 615 ± 32 °C. XRD data from the irradiated powder confirm the structural integrity of the α-KY₃F₁₀ phase, showing no new phase formation below 700 °C. By integrating local laser sintering with Boltzmann primary luminescent thermometry, this work demonstrates a scalable and robust method for real-time, localized temperature monitoring during sintering processes. These findings have significant implications for advancing additive manufacturing and other laser-based material processing techniques.</p>","PeriodicalId":61,"journal":{"name":"The Journal of Physical Chemistry C","volume":"129 16","pages":"7823–7831 7823–7831"},"PeriodicalIF":3.3,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143863197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Terpolymerization of Oxetane, CO2, and Isothiocyanates with Bifunctional Catalysts: Synthesis and Degradability of Poly(thioimidocarbonate-trimethylene carbonate)s","authors":"Io Yamamoto,&nbsp;Satoshi Muranaka,&nbsp;Keiichi Hirose and Tadashi Ema*,&nbsp;","doi":"10.1021/acsapm.5c0041510.1021/acsapm.5c00415","DOIUrl":"https://doi.org/10.1021/acsapm.5c00415https://doi.org/10.1021/acsapm.5c00415","url":null,"abstract":"<p >Bifunctional Al^III porphyrins catalyzed the terpolymerization reactions of oxetane, CO₂, and isothiocyanates to synthesize poly(thioimidocarbonate-trimethylene carbonate)s, PTIC–PTMC, for the first time. In addition to the target polymers, three interesting sulfur-containing cyclic byproducts were obtained and fully identified by spectroscopic methods including X-ray crystallography. These byproducts were useful for the understanding of reaction behaviors of reactive intermediates, such as the O/S exchange reaction and the backbiting reaction. The time course of the terpolymerization reaction indicated that phenyl isothiocyanate was consumed much faster than CO₂. This trend is opposite to our previous observation that CO₂ reacted with cyclohexene oxide faster than phenyl isothiocyanate. This opposite trend is due to the difference in the selectivity-determining step in the catalytic cycles. The ring-opening of oxetane is the selectivity-determining step owing to the small ring strain of oxetane in the present case, while the reaction of an alkoxide ion with heteroallene (CO₂ or isothiocyanates) is the selectivity-determining step in the previous case with the epoxide. UV light irradiation, heat treatment, or acid treatment selectively degraded the PTIC units without decomposing the PTMC units, giving a cyclic <i>S</i>-thiocarbamate compound, 3-phenyl-1,3-thiazinan-2-one. The polymers with different substituents had a glass transition temperature (<i>T</i>_g) in the range of −11 to 30 °C. It is likely that most terpolymers had a gradient character in composition, although some of them had block-like structures. The polymers with different substituents had a 10% weight loss temperature (<i>T</i>_d¹⁰) in the range of 221 to 264 °C, among which the terpolymer with the <i>p</i>-tolyl group possessing the highest PTMC content showed the highest <i>T</i>_d¹⁰ value.</p>","PeriodicalId":7,"journal":{"name":"ACS Applied Polymer Materials","volume":"7 8","pages":"5116–5126 5116–5126"},"PeriodicalIF":4.4,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143867628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dearomative Ring-Opening of N-Fused Heteroarenes: Access to Tetrasubstituted Alkenes and Ketimines","authors":"Qianling Wu,&nbsp;Xiaojing Wang and Qijian Ni*,&nbsp;","doi":"10.1021/acs.joc.5c0043510.1021/acs.joc.5c00435","DOIUrl":"https://doi.org/10.1021/acs.joc.5c00435https://doi.org/10.1021/acs.joc.5c00435","url":null,"abstract":"<p >We report a novel and efficient strategy for constructing tetrasubstituted alkenes and α-iminonitriles from 3-aminoindolizines and 3-aminoimidazo[1,2-<i>a</i>]pyridines. This approach involves a dearomative ring-opening of <i>N</i>-fused heteroaromatic amines coupled to a DDQ-mediated oxidative process under mild, metal-free conditions. The methodology demonstrates broad substrate scope, excellent functional group tolerance, and scalability, offering a versatile platform for synthesizing complex alkenes and nitrile-containing frameworks.</p>","PeriodicalId":57,"journal":{"name":"Journal of Organic Chemistry","volume":"90 16","pages":"5720–5724 5720–5724"},"PeriodicalIF":3.3,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143867520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Printable Two-Dimensional Nanomaterials: Approaching Low-Cost Electrodes for High-Efficiency Li/Na-Ion Batteries and Photodetectors","authors":"Ruei-Hong Cyu,&nbsp;Chuan-Hsun Wang,&nbsp;Arumugam Manikandan,&nbsp;Shu-Chi Wu,&nbsp;Shin-Yi Tang,&nbsp;Po-Wen Chiu*,&nbsp;Ray-Hua Horng* and Yu-Lun Chueh*,&nbsp;","doi":"10.1021/acsanm.5c0059010.1021/acsanm.5c00590","DOIUrl":"https://doi.org/10.1021/acsanm.5c00590https://doi.org/10.1021/acsanm.5c00590","url":null,"abstract":"<p >Molybdenum disulfide (MoS₂)/graphene composites have garnered significant attention as promising materials for high-performance electrodes and optoelectronic devices owing to their exceptional electrochemical and photodetection properties. However, the fabrication of these composite electrodes remains challenging, primarily due to the low yield, suboptimal quality, and structural stability of MoS₂ and graphene, which pose significant barriers to their practical applications. Here, a high-performance inkjet-printed flexible electrode based on a MoS₂-graphene heterostructure is demonstrated. The process parameters during ejection and the adhesion force between inkjet-printed film and the substrate have been systematically studied. As a result, it allows the rapid and cost-effective production of robust anodes for lithium-ion batteries (LIBs), sodium-ion batteries (SIBs), and high-performance photodetectors. The graphene-MoS₂ NF anodes demonstrate remarkable specific capacities of 856 mAh g^–1 after 450 cycles for LIBs and 505 mAh g^–1 after 650 cycles for SIBs at 0.6 A g^–1, exhibiting superior cycling stability and rate capability compared to doctor-blade-coated anodes. The enhanced stability is attributed to the inkjet printing’s precise layer-by-layer deposition, leading to better interfacial adhesion and reduced structural degradation during cycling. Moreover, the photodetectors, featuring MoS₂ nanosheets (NSs) as the channel and graphene as the electrode, achieve enhanced photocurrents and high on/off ratios with the flexible devices maintaining excellent performance after over 500 bending cycles. These findings underscore the potential of inkjet-printed graphene-MoS₂ heterostructures for scalable, durable, and multifunctional applications in energy storage and optoelectronics, showcasing the advantages of high uniformity and rapid low-cost fabrication.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 16","pages":"8133–8143 8133–8143"},"PeriodicalIF":5.3,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsanm.5c00590","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143867580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparation and Properties of Dual Cross-Linking Acrylic Pressure-Sensitive Adhesives for Flexible Displays","authors":"Ran Zong,&nbsp;Xinli Hu,&nbsp;Shuangyi Liu,&nbsp;Aosheng Zhong and Baoqing Shentu*,&nbsp;","doi":"10.1021/acsapm.5c0026910.1021/acsapm.5c00269","DOIUrl":"https://doi.org/10.1021/acsapm.5c00269https://doi.org/10.1021/acsapm.5c00269","url":null,"abstract":"<p >Aiming to satisfy the requirements of pressure-sensitive adhesives (PSAs) for flexible displays, 2-[[[6-[3-(6-methyl-4-oxo-1,4-dihydropyrimidin-2-yl)ureido]hexyl]carbamoyl] oxy]ethyl acrylate (Upy-HDI-HEA) was synthesized, and a series of dual cross-linking EHA-<i>co</i>-HEA copolymers with multiple hydrogen bonds were prepared. The effects of the Upy-HDI-HEA content on the EHA-<i>co</i>-HEA copolymers’ chemical structure, thermal properties, viscoelasticity, mechanical properties, and adhesion performance were comprehensively investigated via in situ Fourier transform infrared (FT-IR), differential scanning calorimetry (DSC), mechanical testing, and adhesion testing. The multiple hydrogen bonds acting as strong physical cross-linking enhance the deformation resistance of EHA-<i>co</i>-HEA copolymers. Moreover, compared to chemical cross-linking, the multiple hydrogen bonds allow for a certain degree of unhindered movement and energy dissipation, which benefits the flexibility and peel resistance of EHA-<i>co</i>-HEA copolymers. Consequently, relatively low storage moduli and glass transition temperatures were observed in all EHA-<i>co</i>-HEA copolymers. Young’s modulus, recovery rate, and cyclic stability of EHA-<i>co</i>-HEA copolymers increase with the rising Upy-HDI-HEA content. Also, the loop tack, 180° peel strength, and shear strength of EHA-<i>co</i>-HEA copolymers significantly improved, showing a better adhesion performance than commercial PSAs.</p>","PeriodicalId":7,"journal":{"name":"ACS Applied Polymer Materials","volume":"7 8","pages":"5025–5033 5025–5033"},"PeriodicalIF":4.4,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143867517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HMAMP: Designing Highly Potent Antimicrobial Peptides Using a Hypervolume-Driven Multiobjective Deep Generative Model","authors":"Li Wang,&nbsp;Yiping Liu*,&nbsp;Xiangzheng Fu*,&nbsp;Xiucai Ye,&nbsp;Junfeng Shi,&nbsp;Gary G. Yen,&nbsp;Quan Zou,&nbsp;Xiangxiang Zeng and Dongsheng Cao,&nbsp;","doi":"10.1021/acs.jmedchem.4c0307310.1021/acs.jmedchem.4c03073","DOIUrl":"https://doi.org/10.1021/acs.jmedchem.4c03073https://doi.org/10.1021/acs.jmedchem.4c03073","url":null,"abstract":"<p >Antimicrobial peptides (AMPs) have exhibited unprecedented potential as biomaterials in combating multidrug-resistant bacteria, prompting the proposal of many excellent generative models. However, the multiobjective nature of AMP discovery is often overlooked, contributing to the high attrition rate of drug candidates. Here, we propose a novel approach termed hypervolume-driven multiobjective AMP design (HMAMP), which prioritizes the simultaneous optimization of multiattribute AMPs. By synergizing reinforcement learning and a gradient descent algorithm rooted in the hypervolume maximization concept, HMAMP effectively biases generative processes and mitigates the pattern collapse issue. Comparative experiments show that HMAMP significantly outperforms state-of-the-art methods in effectiveness and diversity. A knee-based decision strategy is then employed to fast screen candidates with favorable physicochemical properties, aligning with the enhanced antimicrobial activity and reduced side effects. Molecular visualization further elucidates structural and functional properties of the AMPs. Overall, HMAMP is an effective approach to traverse large and complex exploration spaces to search for idealism-realism trade-off AMPs.</p>","PeriodicalId":46,"journal":{"name":"Journal of Medicinal Chemistry","volume":"68 8","pages":"8346–8360 8346–8360"},"PeriodicalIF":6.8,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143863190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ortho-Hydroxy-Substituted Diaryliodonium Salts Enabled Intramolecular Aryliodonium Rearrangement in Synthesis of Ortho-Iodo Diaryl Ethers","authors":"Taiyou Liu,&nbsp;Cheng Pan,&nbsp;Limin Wang,&nbsp;Zhen-Jiang Xu and Jianwei Han*,&nbsp;","doi":"10.1021/acs.joc.4c0317910.1021/acs.joc.4c03179","DOIUrl":"https://doi.org/10.1021/acs.joc.4c03179https://doi.org/10.1021/acs.joc.4c03179","url":null,"abstract":"<p >A new family of <i>ortho</i>-hydroxy-substituted diaryliodonium salts was synthesized with 1-acetoxy-2-iodobenzenes, in which the acetyl group was cleaved in a one-pot synthesis. The <i>ortho</i>-hydroxyl-substituted diaryliodonium salts underwent further intramolecular aryl migration reaction, giving <i>ortho</i>-iodo diaryl ethers either with or without the presence of bases.</p>","PeriodicalId":57,"journal":{"name":"Journal of Organic Chemistry","volume":"90 16","pages":"5435–5443 5435–5443"},"PeriodicalIF":3.3,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143867579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discovery of a Potent and Selective Protein Arginine Methyltransferase 5 (PRMT5) PROTAC Degrader","authors":"Yue Zhong,&nbsp;Huensuk Kim,&nbsp;Chao Qian,&nbsp;Ling Xie,&nbsp;Xian Chen,&nbsp;Yan Xiong,&nbsp;Jacqueline Hu,&nbsp;Matthew Chen,&nbsp;Ernesto Guccione,&nbsp;Yudao Shen* and Jian Jin*,&nbsp;","doi":"10.1021/acs.jmedchem.5c0019810.1021/acs.jmedchem.5c00198","DOIUrl":"https://doi.org/10.1021/acs.jmedchem.5c00198https://doi.org/10.1021/acs.jmedchem.5c00198","url":null,"abstract":"<p >Protein arginine methyltransferase 5 (PRMT5) plays crucial roles in the regulation of various biological processes through the mono- and symmetric dimethylation of protein substrates. PRMT5 is overexpressed in various human cancers and its overexpression is associated with poor prognosis. We previously reported the first-in-class PRMT5 degrader, MS4322, which is also the only von Hippel-Lindau (VHL)-recruiting PRMT5 degrader to date. Here, we performed structure–activity relationship (SAR) studies exploring various linkers and ligands of VHL and PRMT5, which resulted in the best-in-class PRMT5 degrader, MS115 (compound <b>10</b>). Compound <b>10</b> potently and selectively degraded PRMT5 and its coactivator, MEP50, in concentration-, time-, and ubiquitin-proteasome system-dependent manners. It displayed much improved PRMT5/MEP50 degradation potency over MS4322, which translated to better antiproliferative effect in both breast and prostate cancer cells. Overall, we discovered a highly potent and selective PRMT5/MEP50 complex degrader, which is an invaluable chemical biology tool and a potential cancer therapeutic.</p>","PeriodicalId":46,"journal":{"name":"Journal of Medicinal Chemistry","volume":"68 8","pages":"8543–8563 8543–8563"},"PeriodicalIF":6.8,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143863178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}