Martin Hébert, Gabriel Bellavance and Louis Barriault*,
{"title":"","authors":"Martin Hébert, Gabriel Bellavance and Louis Barriault*, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":57,"journal":{"name":"Journal of Organic Chemistry","volume":"90 26","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":3.3,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acs.joc.5c01012","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144548325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Atomic-Scale Control and In Situ Raman Probing of Hot Carrier Transport in Two-Dimensional Heterojunctions.","authors":"Jing-Liang Yang, Hong-Jia Wang, Xia-Guang Zhang, Gaoxiang Lin, Huijie Liu, Jing-Yu Wang, Jingyi Hu, Yanfeng Zhang, Xiaosi Qi, Weiwei Cai, Ye Yang, Hua Zhang, Jian-Feng Li","doi":"10.1021/acsnano.5c05497","DOIUrl":"https://doi.org/10.1021/acsnano.5c05497","url":null,"abstract":"<p><p>Chemical reactions triggered by plasmonic hot carriers attract growing attention due to their high activity and widely adjustable selectivity. However, precise control of hot carrier behaviors and catalytic reactions driven by them on the subnanometer scale remains challenging. Herein, the transportation of plasmonic hot carriers in two-dimensional (2D) van der Waals (vdW) heterojunctions consisting of graphene and MoS<sub>2</sub>, as well as its influence on photocatalytic reactions, has been in situ monitored by surface-enhanced Raman spectroscopy (SERS) with atomic layer accuracy. Direct spectral results prove that when the MoS<sub>2</sub> layer gradually moves closer to the top Au nanoparticles (NPs), the reduction reaction efficiency induced by hot electrons improves, while the oxidation process induced by hot holes is inhibited and vice versa. This originates from the redistribution of electromagnetic fields in the plasmonic nanogap as well as the change in the hot carrier generation and transfer efficiency with different MoS<sub>2</sub>/graphene vdW heterojunction stacking modes, as revealed by time-resolved transient absorption spectra (TAS), electromagnetic field simulations, and density functional theory (DFT). This work provides valuable insights to deepen the understanding of vdW heterojunction-modulated hot carrier behaviors and reveals the importance of precise photocatalyst design.</p>","PeriodicalId":21,"journal":{"name":"ACS Nano","volume":" ","pages":""},"PeriodicalIF":15.8,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144564150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nano LettersPub Date : 2025-07-04DOI: 10.1021/acs.nanolett.5c02793
Zhuoer Wang, Yitong Gai, Aiyou Hao, Pengyao Xing
{"title":"Dynamic Cyclodipeptide Clamps as Enantioselective Receptors toward Vitamin K1.","authors":"Zhuoer Wang, Yitong Gai, Aiyou Hao, Pengyao Xing","doi":"10.1021/acs.nanolett.5c02793","DOIUrl":"https://doi.org/10.1021/acs.nanolett.5c02793","url":null,"abstract":"<p><p>We report the design of folded cyclodipeptides that show dynamic and adaptive conformational transitions responding to solvents and enantioselective recognition of a biomolecule, vitamin K1 (VK1). Postmodification of phenylalanine-based cyclodipeptides with polycyclic aromatic hydrocarbons (pyrene, anthracene, and phenanthrene) produced chiral folded structures. Compared with other solvents, these cyclodipeptides exhibit ultrahigh sensitivity to dimethyl sulfoxide (DMSO), which induces a conformational transition from parallel to perpendicular dimerization. It leads to a reversed screw sense of the chromophores, facilitating tunable chiroptical properties. In a mixed DMSO/water system, the folded cyclodipeptides perform as efficient molecular clamps that recognize VK1 through charge-transfer complexation. Additionally, d,d- and l,l-configured cyclodipeptides displayed enantioselective recognition of VK1, as evidenced by differences in binding affinity, circularly polarized luminescence and self-assembled nanoarchitectures. This study provides approaches for artificial receptors and chiral sensing based on cyclopeptides.</p>","PeriodicalId":53,"journal":{"name":"Nano Letters","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144564174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Sustainable Synthesis of Pyrimidines by [NNO]-Pincer-Supported Nickel(II) Complexes via Dehydrogenative Annulation of Alcohols.","authors":"Pranesh Kavin Sekar, Anandaraj Pennamuthiriyan, Ramesh Rengan","doi":"10.1021/acs.joc.5c00821","DOIUrl":"https://doi.org/10.1021/acs.joc.5c00821","url":null,"abstract":"<p><p>An efficient strategy for the multicomponent synthesis of pyrimidine analogues has been demonstrated via acceptorless dehydrogenative annulation (ADA) of alcohols utilizing new Ni(II)-NNO pincer complexes as catalysts. The newly formed Ni(II) complexes (<b>C1</b>-<b>C4</b>) featuring N^N^O chelating hydrazone ligands are well established through analytical and spectral methods (FT-IR and NMR). Single-crystal X-ray diffraction analysis precisely reveals the NNO coordination fashion and square planar geometry around the metal center. The catalytic performance of the complexes is validated through the smooth and efficient synthesis of pyrimidine derivatives from the dehydrogenative coupling of primary alcohols, benzamidines/guanidines/acetamidines, and 1-phenylethanol and delivers the desired products up to 92% with a catalyst loading of 2 mol %. Time-dependent control experiments evidence the formation of probable intermediates such as aldehyde, ketone, and chalcone. The catalytic system displaces a variety of 2,4,6-trisubstituted pyrimidines (27 examples) and H<sub>2</sub>O and H<sub>2</sub> are the sole byproducts. Additionally, a successful gram-scale synthesis highlights the industrial applicability of this catalytic protocol.</p>","PeriodicalId":57,"journal":{"name":"Journal of Organic Chemistry","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144564180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kanga Marius N'Gatta, Edja Florentin Assanvo, Joelle El Hayek, Nathalie Masquelez, Pelagie Kamgang Syapnjeu, Stefano Deabate, Valérie Bonniol, Laurence Soussan, Camilo Zamora-Ledezma, Jeevithan Elango, Valérie Flaud, David Boa, Chrystelle Salameh
{"title":"3D-Printed Polycaprolactone Scaffolds Reinforced with Cellulose Nanocrystals and Silver Nanoparticles for Bone Tissue Engineering.","authors":"Kanga Marius N'Gatta, Edja Florentin Assanvo, Joelle El Hayek, Nathalie Masquelez, Pelagie Kamgang Syapnjeu, Stefano Deabate, Valérie Bonniol, Laurence Soussan, Camilo Zamora-Ledezma, Jeevithan Elango, Valérie Flaud, David Boa, Chrystelle Salameh","doi":"10.1021/acsami.5c06504","DOIUrl":"https://doi.org/10.1021/acsami.5c06504","url":null,"abstract":"<p><p>Cellulose nanocrystals (CNC) have garnered significant attention in pharmaceutical and medical applications due to their biocompatibility, biodegradability, renewability, and strong surface reactivity. In this study, we designed 3D-printed bioactive composite scaffolds via fused deposition modeling (FDM), incorporating polycaprolactone (PCL), CNC derived from Ficus thonningii bark, and silver nanoparticles (AgNps) synthesized through <i>in situ</i> reduction of silver nitrate AgNO<sub>3</sub>. Energy-dispersive X-ray spectroscopy (EDX) confirmed AgNps incorporation, while scanning electron microscopy (SEM) revealed a highly porous, interconnected structure. The inclusion of CNC and AgNps enhanced PCL's biodegradability, hydrophilicity, and hydroxyapatite nucleation, all crucial for osteoconductivity. The scaffolds demonstrated mechanical properties suitable for bone regeneration, effective antibacterial activity against <i>Escherichia coli</i>, and cytocompatibility with Mesenchymal Stem Cells (MSCs). These findings highlight the potential of PCL/CNCx/AgNps scaffolds as advanced biomaterials for bone tissue engineering, since they offer enhanced resorbability, antibacterial protection, and structural adaptability.</p>","PeriodicalId":5,"journal":{"name":"ACS Applied Materials & Interfaces","volume":" ","pages":""},"PeriodicalIF":8.3,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144558350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yi-Tzai Chen, Rui Qi, Ang Cai, Bongsup P Cho, Deyu Li
{"title":"Conformation-Dependent Lesion Bypass and Mutagenicity of Bulky 2-Acetylaminofluorene-Guanine DNA Adduct in Epigenetically Relevant Sequence Contexts.","authors":"Yi-Tzai Chen, Rui Qi, Ang Cai, Bongsup P Cho, Deyu Li","doi":"10.1021/acs.chemrestox.5c00055","DOIUrl":"https://doi.org/10.1021/acs.chemrestox.5c00055","url":null,"abstract":"<p><p>DNA base cytosine can be modified epigenetically by adding a methyl group to form 5-methylcytosine (5mC). 5mC in DNA CpG islands plays a crucial role in mammalian cell development and epigenetic regulation. While 5mC does not block DNA replication and is not mutagenic, the biological consequences of 5mC affecting the flanking guanine with a bulky modification during DNA replication are not well understood. This paper examined the lesion bypass and mutagenicity of the 2-acetylaminofluorene-modified guanine DNA adduct (dG-AAF) in epigenetically relevant sequence contexts in <i>Escherichia coli</i>. The C/5mC context exhibited significantly different bypass and mutagenicity profiles for dG-AAF. The biological outcomes also varied depending on the nature of the 3' flanking base and the lesion bulkiness. In addition, we extensively observed a unique type of -1 G deletion when the lesion was flanked by 3' purines, possibly due to the formation of a stacked slipped mutagenic intermediate. However, there was no such deletion with 3' pyrimidines. Our findings provide a new perspective on the role of epigenetic markers in DNA replication and could help to develop methods to identify mutation patterns associated with specific mutational signatures or spectra in cancer.</p>","PeriodicalId":31,"journal":{"name":"Chemical Research in Toxicology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144558425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}