ACS Publications最新文献

{"title":"Nanospectroscopic Imaging of 2D Materials by Tip-Enhanced Raman Spectroscopy","authors":"Zhendong Dai,&nbsp;Qingqing Zhang,&nbsp;Yang Zhao,&nbsp;Youqi Li,&nbsp;Yu Huang,&nbsp;Zhaohua Li,&nbsp;Facai Wei and Feng Shao*,&nbsp;","doi":"10.1021/acs.jpcc.5c0163710.1021/acs.jpcc.5c01637","DOIUrl":"https://doi.org/10.1021/acs.jpcc.5c01637https://doi.org/10.1021/acs.jpcc.5c01637","url":null,"abstract":"<p >The precise physicochemical and morphological characterization of individual components or heterostructural aggregates at the nanoscale plays a critical role in advancing fundamental research and enabling functional applications, particularly in the field of 2D materials (2DMs). One of its primary objectives is to utilize techniques with exceptional resolution, sensitivity, and specificity to reveal the atomic and molecular structures, nanoscale defects, and interlayer interactions of 2DMs, thereby providing deeper insights into their performance and the underlying mechanisms of their potential applications. Among various analytical methods, tip-enhanced Raman spectroscopy (TERS) stands out due to its high spatial resolution, surface sensitivity, and adherence to surface selection rules, offering unique advantages for the nanospectroscopic imaging of 2DMs. This review begins by contextualizing 2DMs and TERS, highlighting the synergy between TERS capabilities and the characterization needs of 2DMs. We then systematically summarize recent breakthroughs in TERS-based nanoscale mapping of the chemical composition, structural heterogeneities, and interfacial interactions within 2DMs. Finally, we propose future directions for TERS development, emphasizing the integration of advanced probe engineering, hyperspectral imaging modalities, and data-science-driven analysis frameworks. We envision that such advancements will propel TERS toward becoming an indispensable tool for decoding the nanoscopic complexity of 2DMs, ultimately accelerating their translation into next-generation technologies.</p>","PeriodicalId":61,"journal":{"name":"The Journal of Physical Chemistry C","volume":"129 16","pages":"7591–7611 7591–7611"},"PeriodicalIF":3.3,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143863150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Many-Body Expansion for Metals: II. Nonadditive Terms in Clusters Composed of Metals with ns1, ns2, and ns2p1 Configurations","authors":"Demeter Tzeli*,&nbsp;Joani Mato and Sotiris S. Xantheas*,&nbsp;","doi":"10.1021/acs.jpca.5c0106610.1021/acs.jpca.5c01066","DOIUrl":"https://doi.org/10.1021/acs.jpca.5c01066https://doi.org/10.1021/acs.jpca.5c01066","url":null,"abstract":"<p >The many-body expansion (MBE) was applied to homometallic and heterometallic trimers of metals with n<i>s</i>¹, n<i>s</i>², and n<i>s</i>²<i>p</i>¹ configurations to investigate its convergence, the magnitude and nature (stabilizing/destabilizing) of the individual terms and seek an understanding of their variation across the different families of clusters. In particular, we examined the series of alkali metals (Li₃, Na₃, K₃, Li₂Na, LiNa₂), alkali metal borides (Li₂B and LiB₂), and alkaline earth metals (Be₃, Be₂Mg, BeMg₃, and Mg₃) trimers, as well as sodium clusters Na<i>_n</i>, <i>n</i> = 2–5. We found that there is no uniform contribution (stabilizing or destabilizing) across the series in the different families of trimers. For instance, the 2-B term stabilizes the ground states of the Na₃ (doublet), Na₄ (singlet), and Na₅ (doublet) clusters, and the 3-B term destabilizes them; however, the opposite holds for the quartet state of the Li₃, Li₂Na, LiNa₂, and Na₃ clusters (destabilizing 2-B, stabilizing 3-B). Substituting Li with B in the quartet state of Li₃ results in a significant reduction of the 3-B term amounting to 16% (Li₂B) and 5% (LiB₃) of the binding energy. On the contrary, the ground states of the alkaline earth metal clusters (Be₃, Be₂Mg, BeMg₃, and Mg₃) are stabilized by the 3-B term, while the 2-B term destabilizes them. Overall, we find that the 3-B terms significantly stabilize the high-spin multiplicity states of the n<i>s</i>¹ configurations and the low-spin states of the n<i>s</i>² configurations. Finally, as the size of the metal increases, the contribution of the 3-B term to the binding energy decreases due to the longer metal–metal bond distances.</p>","PeriodicalId":59,"journal":{"name":"The Journal of Physical Chemistry A","volume":"129 16","pages":"3648–3662 3648–3662"},"PeriodicalIF":2.7,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143863177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual Dynamic Network Cross-Linked Recyclable, Self-Healing Biobased Elastomer with Electromagnetic Shielding and Photothermal Conversion Properties","authors":"Xinyu Wang,&nbsp;Xin Wang,&nbsp;Shuyang Xing,&nbsp;Wei Kuang* and Huilin Tian*,&nbsp;","doi":"10.1021/acsapm.5c0047910.1021/acsapm.5c00479","DOIUrl":"https://doi.org/10.1021/acsapm.5c00479https://doi.org/10.1021/acsapm.5c00479","url":null,"abstract":"<p >The incorporation of biobased materials into elastomers represents a critical approach to mitigating carbon emissions and combating environmental degradation. Epoxy natural rubber (ENR), Curdlan(CD), and other bioderived polymers have attracted considerable attention for their potential in developing self-healing and recyclable elastomeric composites. In this study, a novel biobased elastomer integrating dynamic boroxine bonds and β-hydroxy-ester networks was synthesized through the reaction between the epoxy groups of ENR, the amino groups of 3-aminophenylboronic acid (APBA), and the carboxyl groups of tartaric acid (TA). The resulting material exhibited exceptional mechanical properties, including a tensile strength of 9.07 MPa, and achieved an 84.4% self-healing efficiency within 1 h. Notably, the elastomer demonstrated a peak electromagnetic interference shielding effectiveness of 39.72 dB in the X-band (8.2–12.4 GHz), coupled with shape memory functionality and photothermal conversion capabilities (absorbing ∼95% of visible-near-infrared light). These multifunctional characteristics position the material as a promising candidate for next-generation biobased electronic shielding components, particularly in the emerging field of sustainable materials for smart devices.</p>","PeriodicalId":7,"journal":{"name":"ACS Applied Polymer Materials","volume":"7 8","pages":"5180–5188 5180–5188"},"PeriodicalIF":4.4,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143867518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetically Triggered Drug-Release System and Magnetic Caged Calcium Using Iron Oxide Nanoparticles and Hydrogels","authors":"Satoshi Okada*,&nbsp;Yuka Takashima and Hiroyuki Nakamura*,&nbsp;","doi":"10.1021/acsapm.5c0065210.1021/acsapm.5c00652","DOIUrl":"https://doi.org/10.1021/acsapm.5c00652https://doi.org/10.1021/acsapm.5c00652","url":null,"abstract":"<p >Magnetic field-responsive materials have been utilized as drug carriers that release payload drugs under a magnetic field, allowing precise spatiotemporal control of drug release. These materials also have potential as chemical tools that can regulate signal transduction in deep regions of the body. However, they have typically been specialized either as drug carriers or as chemical tools. To address these challenges, we developed here a versatile alternating magnetic field (AMF)-responsive platform consisting of polymer-coated iron oxide nanoparticles (PCIOs) and thermoresponsive hydrogels based on poly(<i>N</i>-isopropylacrylamide) (PNIPAM). We demonstrated that PCIOs could increase the medium temperature from 22 to 45 °C within 5 min under an AMF of 16 mT and 386 kHz, resulting in the release of the neutral drug model PM-546 from the PNIPAM-based hydrogel under physiological conditions. The combination system was further utilized as a chemical tool for controlling extracellular calcium ions (Ca²⁺), which are crucial for membrane potential regulation, bone resorption, cytokine induction, and intestinal homeostasis. The chemical tool, termed magnetic caged calcium, was constructed by replacing the drug carrier gel with a thermoresponsive Ca²⁺-binding gel based on PNIPAM coated by poly(methacrylic acid). This gel reversibly adsorbed Ca²⁺ in a submillimolar range as the temperature increased from 25 to 45 °C. The magnetic caged calcium significantly decreased [Ca²⁺] by 0.18 ± 0.06 mM under the AMF exposure for 1 h. These results indicate that the PCIO–hydrogel combination serves as a foundation for AMF-induced drug-release systems operating under physiological conditions and for magnetic caged systems regulating extracellular calcium, leading to broad applications in both medical applications and fundamental studies of signal transduction in deep tissues in the future.</p>","PeriodicalId":7,"journal":{"name":"ACS Applied Polymer Materials","volume":"7 8","pages":"5250–5258 5250–5258"},"PeriodicalIF":4.4,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143867476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2′-FL in Dairy Matrices Attenuates Allergic Symptoms in Mice by Reducing BLG Hypersensitivity and Modulating Gut Microecology","authors":"Xintong Chen,&nbsp;Fan Yang,&nbsp;Tianliang Bai,&nbsp;Yong Wu,&nbsp;Shuangyan Zheng,&nbsp;Ping Tong,&nbsp;Hongbing Chen and Xin Li*,&nbsp;","doi":"10.1021/acs.jafc.4c1160610.1021/acs.jafc.4c11606","DOIUrl":"https://doi.org/10.1021/acs.jafc.4c11606https://doi.org/10.1021/acs.jafc.4c11606","url":null,"abstract":"<p >2′-Fucosyllactose (2′-FL), an industrial breast milk oligosaccharide, is approved for use in infant formula and may reduce cow’s milk protein allergenicity. To investigate whether glycosylation products of 2′-FL in dairy products (2′-FL-β-LG) increase its sensitization, we cross-linked β-LG with 2′-FL and used it to sensitize Balb/c mice, comparing it with nonglycosylated β-LG. Both 2′-FL-β-LG sensitization and oral 2′-FL intervention reduced allergic symptoms, specific antibodies (IgE, IgG, and IgG2a), inflammatory cytokine levels, and intestinal damage. 2′-FL also shifted T-cell differentiation, reduced cell surface expression of DC receptors, and enhanced gut microbial diversity. Oral 2′-FL showed the greatest efficacy, suggesting its potential for lowering milk allergenicity in formula.</p>","PeriodicalId":41,"journal":{"name":"Journal of Agricultural and Food Chemistry","volume":"73 16","pages":"9606–9617 9606–9617"},"PeriodicalIF":5.7,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143858665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hydrodealkenylative C(sp3)–C(sp2) Bond Fragmentation Using Isayama–Mukaiyama Peroxidation","authors":"Jeremy H. Dworkin,&nbsp;Zhuoxi M. Chen,&nbsp;Kathleen C. Cheasty,&nbsp;Aris V. Rubio and Ohyun Kwon*,&nbsp;","doi":"10.1021/jacs.5c0054010.1021/jacs.5c00540","DOIUrl":"https://doi.org/10.1021/jacs.5c00540https://doi.org/10.1021/jacs.5c00540","url":null,"abstract":"<p >Advancements in radical capture strategies have expanded the range of products accessible from alkenes through dealkenylative synthesis. These methods, however, are still limited, as they rely on ozonolysis to generate the key peroxide intermediates from alkenes. Ozonolysis has several limitations. It is not compatible with alkenes containing electron-rich aromatics. It is also inapplicable to certain alkene substitution patterns in the context of dealkenylative synthesis. Additionally, it struggles with sterically hindered alkenes, internal nucleophiles and electrophiles, and allylic alcohols. In this paper, using Isayama–Mukaiyama peroxidation (IMP), we address the limitations of ozonolysis to rescue previously inaccessible alkene substrates and broaden the applicability of dealkenylative functionalization. In particular, we apply IMP in hydrodealkenylation and describe a novel radical hydrogenation condition─employing catalytic [Fe^III], catalytic benzenethiol, and γ-terpinene in refluxing methanol─to resolve β-scission issues associated with IMP-generated alkyl silylperoxides.</p>","PeriodicalId":49,"journal":{"name":"Journal of the American Chemical Society","volume":"147 16","pages":"13531–13544 13531–13544"},"PeriodicalIF":14.4,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143858668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discovery of Dual PD-L1/HDAC3 Inhibitors for Tumor Immunotherapy","authors":"Zhijie Wang,&nbsp;HaiQi He,&nbsp;Xiaotong Liao,&nbsp;Lin Yuan,&nbsp;Shuding Sun,&nbsp;Chenglong Xu,&nbsp;Xixiang Yang,&nbsp;Qinru Zang,&nbsp;Xiaopeng Peng*,&nbsp;Jianjun Chen* and Xia Guo*,&nbsp;","doi":"10.1021/acs.jmedchem.4c0252910.1021/acs.jmedchem.4c02529","DOIUrl":"https://doi.org/10.1021/acs.jmedchem.4c02529https://doi.org/10.1021/acs.jmedchem.4c02529","url":null,"abstract":"<p >Targeting programmed cell death protein-1 (PD-1)/programmed cell death-ligand 1 (PD-L1) pathway has been considered as one of the most promising strategies for tumor immunotherapy. However, single-target PD-1/PD-L1 inhibitors frequently exhibit limited efficacy, highlighting the urgent need for new therapies. Herein, a series of dual PD-L1/HDAC3 inhibitors were developed through a pharmacophore fusion strategy for the first time. Among them, compound <b>PH3</b> was identified as the most promising dual PD-L1/HDAC3 inhibitor, with potent PD-1/PD-L1 inhibitory activity (IC₅₀ = 89.4 nM) and selective HDAC3 inhibitory activity (IC₅₀ = 107 nM). Moreover, <b>PH3</b> exhibited superior <i>in vitro</i> antitumor activities and <i>in vitro</i> immune activation effects. Additionally, <b>PH3</b> showed potent and dose-dependent antitumor efficacy in the B16-F10 melanoma mouse model without obvious toxicity. Furthermore, <b>PH3</b> increased the infiltration of CD3⁺CD8⁺ and CD3⁺CD4⁺ cells in the tumor microenvironment. Collectively, <b>PH3</b> represented a novel dual PD-L1/HDAC3 inhibitor deserving further investigation as a tumor immunotherapy agent.</p>","PeriodicalId":46,"journal":{"name":"Journal of Medicinal Chemistry","volume":"68 8","pages":"8046–8064 8046–8064"},"PeriodicalIF":6.8,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143863089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Electron Spin, Chirality, and Charge Dynamics in Promoting the Persistence of Nascent Nucleic Acid–Peptide Complexes","authors":"Pratik Vyas*,&nbsp;Kakali Santra,&nbsp;Naupada Preeyanka,&nbsp;Anu Gupta,&nbsp;Orit Weil-Ktorza,&nbsp;Qirong Zhu,&nbsp;Norman Metanis,&nbsp;Jonas Fransson,&nbsp;Liam M. Longo and Ron Naaman*,&nbsp;","doi":"10.1021/acs.jpcb.5c0115010.1021/acs.jpcb.5c01150","DOIUrl":"https://doi.org/10.1021/acs.jpcb.5c01150https://doi.org/10.1021/acs.jpcb.5c01150","url":null,"abstract":"<p >Primitive nucleic acids and peptides likely collaborated in early biochemistry. What forces drove their interactions and how did these forces shape the properties of primitive complexes? We investigated how two model primordial polypeptides associate with DNA. When peptides were coupled to a ferromagnetic substrate, DNA binding depended on the substrate’s magnetic moment orientation. Reversing the magnetic field nearly abolished binding despite complementary charges. Inverting the peptide chirality or just the cysteine residue reversed this effect. These results are attributed to the chiral-induced spin selectivity (CISS) effect, where molecular chirality and electron spin alter a protein’s electric polarizability. The presence of CISS in simple protein–DNA complexes suggests that it played a significant role in ancient biomolecular interactions. A major consequence of CISS is enhancement of the kinetic stability of protein–nucleic acid complexes. These findings reveal how chirality and spin influence bioassociation, offering insights into primitive biochemical evolution and shaping contemporary protein functions.</p>","PeriodicalId":60,"journal":{"name":"The Journal of Physical Chemistry B","volume":"129 16","pages":"3978–3987 3978–3987"},"PeriodicalIF":2.8,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acs.jpcb.5c01150","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143863211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of 11B4C Interlayers in Enhancing Fe/Si Multilayer Performance for Polarized Neutron Mirrors","authors":"Anton Zubayer*,&nbsp;Fredrik Eriksson,&nbsp;Martin Falk,&nbsp;Marcus Lorentzon,&nbsp;Justinas Palisaitis,&nbsp;Christine Klauser,&nbsp;Gyula Nagy,&nbsp;Philipp M. Wolf,&nbsp;Eduardo Pitthan,&nbsp;Radek Holeňák,&nbsp;Daniel Primetzhofer,&nbsp;Gavin B.G. Stenning,&nbsp;Artur Glavic,&nbsp;Jochen Stahn,&nbsp;Samira Dorri,&nbsp;Per Eklund,&nbsp;Jens Birch and Naureen Ghafoor,&nbsp;","doi":"10.1021/acs.jpcc.5c0006810.1021/acs.jpcc.5c00068","DOIUrl":"https://doi.org/10.1021/acs.jpcc.5c00068https://doi.org/10.1021/acs.jpcc.5c00068","url":null,"abstract":"<p >This study investigates the effects of incorporating ¹¹B₄C interlayers into Fe/Si multilayers, with a focus on interface quality, reflectivity, polarization, and magnetic properties for polarizing neutron optics. It is found that the introduction of 1–2 Å ¹¹B₄C interlayers significantly improves the interface sharpness, reducing interface width and preventing excessive Si diffusion into the Fe layers. X-ray reflectivity and polarized neutron reflectivity measurements show enhanced reflectivity and polarization, with a notable increase in polarization for 30 Å period multilayers. The inclusion of interlayers also helps prevent the formation of iron-silicides, improving both the magnetic properties and neutron optical performance. However, the impact of interlayers is less pronounced in thicker-period multilayers (100 Å), primarily due to the ratio between layer and interface widths. These results suggest that ¹¹B₄C interlayers offer a promising route for optimizing Fe/Si multilayer performance in polarizing neutron mirrors.</p>","PeriodicalId":61,"journal":{"name":"The Journal of Physical Chemistry C","volume":"129 16","pages":"7921–7930 7921–7930"},"PeriodicalIF":3.3,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acs.jpcc.5c00068","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143863196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Salamandamide Lipodipeptides Are Biosynthetic Intermediate Shunt Products of the Nonamodular Nonribosomal Peptide Assembly Lines of the Viscosin Family","authors":"Keshab Bhattarai,&nbsp;Thomas Majer,&nbsp;Manuela Haussmann,&nbsp;Dieter Schollmeyer,&nbsp;Markus Kramer,&nbsp;Feyisara Eyiwumi Oni,&nbsp;Monica Höfte,&nbsp;Rabea Voget,&nbsp;Michael Gütschow,&nbsp;Natalia Ruetalo,&nbsp;Michael Schindler,&nbsp;Jan Straetener,&nbsp;Tatjana Wannenwetsch,&nbsp;Heike Brötz-Oesterhelt,&nbsp;Ryan Karongo,&nbsp;Benedikt Masberg,&nbsp;Michael Lämmerhofer,&nbsp;Rosanna Catherine Hennessy,&nbsp;Carly R. Muletz-Wolz and Harald Gross*,&nbsp;","doi":"10.1021/acs.jnatprod.5c0008410.1021/acs.jnatprod.5c00084","DOIUrl":"https://doi.org/10.1021/acs.jnatprod.5c00084https://doi.org/10.1021/acs.jnatprod.5c00084","url":null,"abstract":"<p >Chemical investigation of a salamander-mucus-associated <i>Pseudomonas tolaasii</i> strain led to the isolation and chemical characterization of salamandamide A, a new lipo-dipeptide, along with known lipopeptides of the pseudodesmin and tolaasin class. Genome mining revealed that no specific gene cluster codes for the biosynthesis of salamandamide A. Stereochemical analyses and mutagenesis experiments linked the biosynthesis of the lipo-dipeptide salamandamide A to the NRPS gene cluster of the lipo-nonapeptide pseudodesmin. Further chemical investigations showed that this finding appears to be a broader concept and that all nonamodular NRPS gene clusters of the viscosin family were capable to produce, beside the expected lipo-nonapeptide, the corresponding lipo-dipeptide as a shunt product which also led to the discovery of salamandamide B from <i>Pseudomonas lactis</i> SS101.</p>","PeriodicalId":47,"journal":{"name":"Journal of Natural Products ","volume":"88 4","pages":"1012–1022 1012–1022"},"PeriodicalIF":3.3,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acs.jnatprod.5c00084","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143867627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}