中华行为医学与脑科学杂志最新文献

{"title":"Correlation of empathy with cognitive function in patients with cerebral small vessel disease","authors":"Chen Chen, Xiaojing Wang, Shanshan Cao, Jun Zhang, Q. Wei, Lei Zhang, Kai Wang","doi":"10.3760/CMA.J.CN371468-20190930-00702","DOIUrl":"https://doi.org/10.3760/CMA.J.CN371468-20190930-00702","url":null,"abstract":"Objective \u0000To explore the empathy of patients with cerebral small vessel disease (CSVD) and its relationship with cognitive functions. \u0000 \u0000 \u0000Methods \u0000A total of 35 patients with CSVD and 26 normal controls with matching gender, age and education were enrolled.The Chinese version of the interpersonal reactivity index (IRI-C) and the multifaceted empathy test(MET) were used to assess the empathy of the participants.The montreal cognitive assessment scale (MoCA), the Hamilton anxiety scale(HAMA), and the Hamilton depression scale (HAMD) were applied to assess participants' overall cognitive function and emotional state.SPSS 19.0 software was used to analyze the differences between the CSVD group and the control group, while the influencing factors of empathy were studied by Pearson correlation analysis. \u0000 \u0000 \u0000Results \u0000The total scores of IRI, perspective taking(PT), fantasy(FS) and empathy concern(EC) of CSVD patients ((37.25±11.71), (6.94±4.35), (9.45±4.68) and (16.40±4.34)) were lower than those of the control group ((50.61±11.07), (11.84±3.90), (13.23±5.01), (19.69±3.03)), and the differences were statistically significant (IRI score: t=4.506, P 0.05). The MET-C results showed that there was a difference in the correct number of empathic emotion recognition between the two groups(CVSD group: (25.08±6.77), control group: (32.30±3.42), t=4.978, P 0.05). Pearson correlation analysis showed that the total score of IRI and PT in the CSVD group were positively correlated with education level (r=0.374, 0.471, both P<0.05). PT was positively correlated with MoCA score (r=0.458, P=0.006). PD was positively correlated with HAMA score and HAMD score (r=0.521, 0.541, both P<0.05). The correct number of emotion recognition was positively correlated with education level (r=0.600, P<0.001) and MoCA score (r=0.665, P<0.001), and negatively correlated with HAMA score(r=-0.445, P<0.05) and HAMD score (r=-0.421, P<0.05). \u0000 \u0000 \u0000Conclusion \u0000The empathy of patients with CSVD is lower than that of the normal group, and it is manifested as a decline in cognitive empathy, which is positively related to the overall cognitive function. \u0000 \u0000 \u0000Key words: \u0000Cerebral small vessel disease; Empathy; Cognitive function","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"29 1","pages":"227-232"},"PeriodicalIF":0.0,"publicationDate":"2020-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44775673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The qualitative study of disease cognition, treatment compliance and community services evaluation of community patients with schizophrenia, family members and disease control personnels","authors":"Zhen-song Gao, Zehua Chen, Lijian Xu, Sai-Sai Guo, Shengjiao Zhang, Wenhua Zheng, Minji Wu","doi":"10.3760/CMA.J.CN371468-20200117-00995","DOIUrl":"https://doi.org/10.3760/CMA.J.CN371468-20200117-00995","url":null,"abstract":"Objective \u0000To investigate the evaluation of disease perception, treatment compliance and community follow-up services of community schizophrenia patients, family members and personnel in Shantou City, and to provide a reference basis for improving the quality of management treatment. \u0000 \u0000 \u0000Methods \u0000With the method of stratified sampling qualitative research, a community sample of 17 198 patients with schizophrenia in seven districts or county in Shantou City were sampled from February to August 2019, with 2 towns being drawn from each district or county, and 10 patients, 10 family members and 3 personnel were selected in each town. The evaluation of disease perception, treatment compliance and community follow-up services were investigated and analyzed. Respondents were eventually included in 137 patients, 138 family members and 41 personnel.The interviewees were conducted with semi-structured interviews, the data were collected according to traditional methods, and the descriptive statistical analysis was carried out with SPSS 12.0. \u0000 \u0000 \u0000Results \u0000(1)34.3% of patients and 32.6% of the family members were not fully aware of the disease.22.6% of the patients and 23.2% of the family members had a sense of ill shame. (2)26.3% of patients did not comply with treatment, 29.9% of patients had not insight, 53.3% of patients and 24.6% of family members on the side effects of drugs and addiction understood improperly, and, 35.0% of patients and 13.0% of the family had a misunderstanding of illness and using drugs. (3)29.2% of patients and 31.2% of their families were tired of taking long-term medication, 24.8% of patients and 21.0% of their families felt socially isolated, and, 17.5% felt unsupported and 18.8% of their families admitted that they did not care enough about patients. (4)31.4% of patients did not actively receive follow-up services, 37.2% of patients and 20.3% of family members did not cooperate with follow-up doctors, and, 21.2% of patients and 10.1% of family members were not satisfied with follow-up services. (5)The personnel of psychiatric care could basically grasp the conditions of patients in the jurisdiction and carried out follow-up services on a regular basis (90.2%), master emergency disposal methods (92.7%), and have carried out training (97.6%). However, the psychiatric practice of the personnel were lower than (58.5%) and most lying part-time (78.0%), the average length of service was 5.7±1.4 years. The personnel satisfaction with the community follow-up service was higher (95.1%), but most of them thought that the psychiatric care was more difficult (36.6%), and were dissatisfied with the multi-functional staff to undertake a number of public services (31.7%). \u0000 \u0000 \u0000Conclusion \u0000The management treatment project of mental disorders services in Shantou City show initial results.The patients were satisfied with the community follow-up service, but the patients and their families still have low level of cognition, poor compliance, obv","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"29 1","pages":"271-276"},"PeriodicalIF":0.0,"publicationDate":"2020-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44087254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Capacity of cognitive control in patients with cerebral small vessel disease","authors":"Zhiqi Wang, Jun Zhang, Q. Wei, Shanshan Cao, Wen Pan, Kai Wang","doi":"10.3760/CMA.J.CN371468-20190927-00695","DOIUrl":"https://doi.org/10.3760/CMA.J.CN371468-20190927-00695","url":null,"abstract":"Objective \u0000To evaluate the capacity of cognitive control(CCC) in patients with cerebral small vessel disease(CSVD) and explore the relationship between CCC and cognitive function in CSVD, and to assess the predict value of CCC on the occurrence of CSVD. \u0000 \u0000 \u0000Methods \u0000Twenty-two patients with CSVD and twenty-three healthy controls were enrolled.All of them completed the majority function task-masked (MFT-M) and a set of neuropsychological tests.Neuropsychological test was performed by Montreal cognitive assessment (MoCA), verbal fluency test (VFT), Chinese auditory learning test (CAVLT), symbol digit modalities test (SDMT), digital span (DS), Stroop color word test (SCWT), color trail test (CTT) and Modified Boston naming test (Modified BNT). The predict value of CCC for the occurrence of CSVD was assessed with logistic regression analysis. \u0000 \u0000 \u0000Results \u0000CCC of patients with CSVD was lower than that of healthy control ((2.97±0.72)bps vs (3.53±0.62)bps, t=-2.704, P=0.01). Between patients with CSVD and healthy control, there were significant differences in MoCA ((22.24±4.58 vs (24.86±2.42), t=-2.334, P=0.026), VFT-animal (12(6) vs 15(6), Z=-2.965, P=0.003), VFT-vegetables and fruits ((13.79±3.81) vs (18.27±4.13), t=-3.592, P=0.001), CAVLT-immediate ((7.45±2.18) vs (9.11±2.08), t=-2.502, P=0.017), CAVLT-short term delay ((7.20±3.32) vs (10.76±3.08), t=-3.564, P=0.001), CAVLT-long term delay ((7.30±3.16) vs (10.29±3.18), t=-3.012, P=0.005), SDMT ((15.95±5.49) vs (23.41±12.73), t=-2.513, P=0.018), CTT-A (85.17(42.60) vs 55.50(52.65), Z=-2.965, P=0.003), CTT-B ((200.69±71.35) vs (132.44±53.66), t=3.556, P=0.001), and CTT-B-A ((104.13±53.31) vs (65.20±35.98), t=2.819, P=0.007). But there was no significant difference in VFT-word begin with Chinese character\"water\"((3.68±2.63) vs (5.44±2.71), t=-1.940, P=0.061), CAVLT-recognition (14(3) vs 14(4), Z=-0.524, P=0.601), DS-forward (7.0(3.0) vs 5.5(2.0), Z=-0.152, P=0.880), DS-backward (4(1) vs 4(2), Z=-1.044, P=0.297), SCWT ((9.50±9.28) vs (5.94±10.47), t=1.123, P=0.268), Modified BNT (14.0(3.0) vs 13.5(3.0), Z=-0.727, P=0.467) between CSVD patients and healthy controls.In patients with CSVD, CCC was positively correlated with scores of MoCA (r=0.551, P=0.010) and also with DS-forward (r=0.532, P=0.013) and SCWT (r=-0.487, P=0.040). Logistic regression analysis showed that CCC was an important variable in predicting the possibility of CSVD (B=-1.318, P=0.019, OR=0.268, 95%CI (0.089-0.808)). \u0000 \u0000 \u0000Conclusion \u0000Compared with the healthy control, CCC in patients with CSVD decreases significantly and CCC is related to the cognitive impairment.CCC can predict the possibility of CSVD. \u0000 \u0000 \u0000Key words: \u0000Cognitive control capacity; Cerebral small vessel disease; Cognitive function","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"29 1","pages":"221-226"},"PeriodicalIF":0.0,"publicationDate":"2020-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46392508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between the dark triad and guilt proneness: the mediating role of basic psychological needs satisfaction","authors":"Liping Shi, Xueli Zhu, Tingting Zhan, Jiejing Yu, Jingjing Gu, Dan Shi, Yaoguo Geng","doi":"10.3760/CMA.J.CN371468-20190905-00603","DOIUrl":"https://doi.org/10.3760/CMA.J.CN371468-20190905-00603","url":null,"abstract":"Objective \u0000To explore the relationship between the dark triad, basic psychological needs satisfaction and guilty proneness. \u0000 \u0000 \u0000Methods \u0000Totally 595 college students were randomly selected from Zhengzhou University.They were tested with the dirty dozen(DD), the balanced measure of psychological needs scale(BMPN) and guilt-proneness-5(GP-5). SPSS 22.0 and AMOS 21.0 were used for data analysis, including descriptive analysis, correlation analysis and confirmatory factor analysis. Bootstrap measure was used for mediating effect test. \u0000 \u0000 \u0000Results \u0000(1)The correlation analysis showed that the dark triad (29(21, 37)), Machiavellianism (4(4, 8)) and psychopathy(5(4, 9)) were negatively correlated with guilty proneness (20(16, 23)), and the correlation coefficients were -0.10, -0.22 and -0.18 respectively(all P 0.01). The satisfaction of basic psychological needs (56(54, 60)) was positively correlated with guilty proneness (r=0.31, P<0.01). (2)The relationship between the dark triad and guilty proneness was partially mediated by basic psychological needs satisfaction, and the mediating effect accounted for 62.96%. \u0000 \u0000 \u0000Conclusion \u0000The dark triad influences guilty proneness through basic psychological needs satisfaction. \u0000 \u0000 \u0000Key words: \u0000The dark triad; Machiavellianism; Psychopathy; Guilty proneness; Basic psychological needs satisfaction","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"29 1","pages":"262-265"},"PeriodicalIF":0.0,"publicationDate":"2020-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49603546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychometric properties and applications of the system of quality of life instruments for cancer patients","authors":"C. Wan, Zheng Yang, Ting Wu, Jia-hong Luo, Qiong Meng, Gaofeng Li, Yingli Cun","doi":"10.3760/CMA.J.CN371468-20190827-00557","DOIUrl":"https://doi.org/10.3760/CMA.J.CN371468-20190827-00557","url":null,"abstract":"Objective \u0000To present briefly introductions and evaluations on the constructs, psychometric properties (reliability, validity, reactivity etc.) and applications of the system of Quality of Life Instruments for Cancer Patients QLICP(V1.0) including 12 kinds of scales for patients with head and neck cancer, brain cancer, lung cancer, breast cancer, esophageal cancer, gastric cancer, colorectal cancer, liver cancer, cervical cancer, ovarian cancer, leukemia and lymphoma. \u0000 \u0000 \u0000Methods \u0000Based on our measuring data from relevant patients at hospitals, the constructs, characteristics and psychometrics of the system above were analyzed and presented. Internal consistency reliability for each domain and the overall scale was assessed using Cronbach's alpha coefficient, and test-retest reliability through calculating the Pearson correlation coefficient between the first and second assessments. The criterion-related validity was evaluated by correlating corresponding domains of two instruments. Responsiveness was assessed through comparing the mean difference between the pre-treatment and post-treatments with standardized response mean (SRM). The use agreements and literature reviews of this system were used to understand the applications of 12 kinds measurement scales. \u0000 \u0000 \u0000Results \u0000The quality of life scales for 12 kinds of cancer patients of the system QLICP(V1.0) have good construct( 5 domains, 11-15 facets), reliability, validity and a certain degree of responsiveness. The internal consistency reliability Cronbach's α coefficients for the overall scale of QLICP in different cancers was from 0.67 to 0.92, and the test-retest reliability (correlation coefficient) was from 0.61 to 0.99. The criterion-related validity (correlation coefficient) was for the overall scale of QLICP in different cancers was from 0.28 to 0.89, and the responsiveness SRM was from 0.25 to 1.28. And also they were widely used in clinical practice and relevant studies for the corresponding cancers. \u0000 \u0000 \u0000Conclusion \u0000The system QLICP(V1.0) is of outstanding characteristics with all psychometrics meeting requirements and better construct (clear hierarchical structure with items→ facets→ domains→ overall ), and can be used widely in clinical practice further. \u0000 \u0000 \u0000Key words: \u0000Quality of life; Cancer; Instrument system","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"29 1","pages":"277-283"},"PeriodicalIF":0.0,"publicationDate":"2020-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46677835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of endocannabinoid and its metabolic enzymes with severity in children with autism spectrum disorder","authors":"Dexin Li, Ling Li, M. Zou, Yu Liu, Shuang Xie, Caihong Sun","doi":"10.3760/CMA.J.CN371468-20190905-00595","DOIUrl":"https://doi.org/10.3760/CMA.J.CN371468-20190905-00595","url":null,"abstract":"Objective \u0000To explore the relationship between endocannabinoid (eCB) and its metabolic enzymes and severity of autism spectrum disorder (ASD), and to provide a theoretical basis for the study of the etiology and pathogenesis of ASD. \u0000 \u0000 \u0000Methods \u0000A case-control study was conducted to collect 58 ASD children who underwent rehabilitation training at the Children's Developmental Behavior Research Center of Harbin Medical University and the provincial autism rehabilitation facility from December 2017 to December 2018 as the ASD group.According to the principle of gender and age 1∶1 matching, 58 normal children were selected as control group in Heilongjiang Province.Liquid chromatography-tandem mass spectrometry (LC-MS/MS) and real-time quantitative PCR (RT-qPCR) were used to detect eCB of ASD group and control group, including anandamide (AEA), 2-arachidonoylglycerol (2-AG), palmitoylethanolamide (PEA), oleoylethanolamide (OEA) and its metabolic enzymes: n-acylphosphatidylethanolamine-specific phospholipase D (NAPE-PLD), fatty acid amide hydrolase (FAAH), monoacylglycerol lipase (MAGL) and diacylglycerol lipase (DAGL) mRNA expression levels.Pearson correlation was used to analyze the level of eCB and ASD children's severity. \u0000 \u0000 \u0000Results \u0000The levels of AEA, OEA and PEA in ASD children ((10.10±2.6)nmol/L, (24.30±5.60)nmol/L, (15.92±2.28)nmol/L) were lower than those in the control group ((13.46±3.04)nmol/L, (27.85± 6.89)nmol/L, (17.87±2.67)nmol/L, t=-6.612, -3.99, -4.779, P 0.05). The level of PEA in the ASD group was negatively correlated with the total score of the autism behavior checklist (ABC) (r=-0.288, P<0.05). \u0000 \u0000 \u0000Conclusion \u0000There may be metabolic abnormalities in eCB and its metabolic enzymes in ASD children, and the level of eCB is related with the severity of ASD. \u0000 \u0000 \u0000Key words: \u0000Autism spectrum disorder; Endocannabinoid; Liquid chromatography-tandem mass spectrometry","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"29 1","pages":"245-249"},"PeriodicalIF":0.0,"publicationDate":"2020-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41869520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of total magnetic resonance imaging burden with homocysteine in patients with cerebral small vessel disease","authors":"Y. Ji, Zhenjie Teng, Xiangyu Li, Xiaosha Li, Peiyuan Lyu","doi":"10.3760/CMA.J.CN371468-20191216-00913","DOIUrl":"https://doi.org/10.3760/CMA.J.CN371468-20191216-00913","url":null,"abstract":"Objective \u0000To explore the relationship between total MRI burden and serum homocysteine (Hcy) in patients with cerebral small vessel disease(CSVD), and to provide clues for disease prevention and treatment. \u0000 \u0000 \u0000Methods \u0000A total of 370 inpatients with CSVD from the neurology department of hospital were consecutively enrolled from September 2016 to December 2018.The clinical data, including serum homocysteine(Hcy) levels were collected.Brain MRI data were collected, including the severity of white matter hyperintensities(WMH), lacune infarcts(LI), cerebral microbleeds(CMBs), and enlarged perivascular spaces(ePVS) to evaluate the total load of CSVD.SPSS21.0 was applied to analyze the association between total CSVD burden and Hcy. \u0000 \u0000 \u0000Results \u0000(1)Compared with the patients with lower Hcy levels, the higher Hcy group had heavier total burdens of CSVD(P<0.01). (2)According to the total MRI burden scores of CSVD, all patients were further divided into low burden group(106 cases) and moderate-high burden group(264 cases). Multivariate logistic regression analysis showed that Hcy(OR=1.026, 95%CI: 1.003-1.049, P=0.026) was risk factor for increasing CSVD burden and hyperhomocysteinemia was a stronger predictor for total MRI burdens of CSVD(OR=3.202, 95%CI: 1.947-5.268, P<0.001). \u0000 \u0000 \u0000Conclusion \u0000Serum Hcy can be an independent risk factor for the total MRI burdens of CSVD.This finding provides a promising clue for the prediction and clinical management of CSVD. \u0000 \u0000 \u0000Key words: \u0000Cerebral small vessel disease; Risk factor; Magnetic resonance imaging; Homocysteine","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"29 1","pages":"233-238"},"PeriodicalIF":0.0,"publicationDate":"2020-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43150702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of white matter microstructural changes with executive function impairment in patients with white matter lesions","authors":"Yanling Ma, Hongyan Chen, Jinfang Wang, Na Ye, Shinan Wang, Li Feng, Yue-xiu Li, Qingli Shi, Weili Jia, Yumei Zhang","doi":"10.3760/CMA.J.CN371468-20190924-00678","DOIUrl":"https://doi.org/10.3760/CMA.J.CN371468-20190924-00678","url":null,"abstract":"Objective \u0000To explore abnormal microstructural changes of white matter in patients with white matter lesions(WML) using diffusion tensor imaging(DTI), and to determine the association of such abnormalities of DTI parameters with executive function. \u0000 \u0000 \u0000Methods \u0000Totally 34 patients with WML were recruited from the department of Neurology, Beijing Tiantan Hospital, Capital Medical University from March 2012 to May 2019.All patients with WML were scored with Hamilton depression scale (HAMD) and Hamilton anxiety scale (HAMA), and assessed with Montreal cognitive assessment (MoCA) and clinical dementia rating(CDR). They were divided into WML-cognitive normal group, WML-vascular cognitive impairment-non dementia group and WML-Dementia group.The Stroop color and word test (SCWT), trail making test-A (TMTA), digit symbol test and verbal fluency test were carried out to evaluate executive function.In addition, the healthy elderly without WML lesions were selected as the control group after they were examined by MRI, and all brains of the subjects went through DTI with Siemens 3.0 T MR.The data were collected and analyzed by voxel based analysis (VBA). The anisotropy and mean diffusion coefficient of DTI in the region of interest (ROI) and other regions in the brain were studied in the four groups, and their correlation with scores of executive function in WML patients was analyzed. \u0000 \u0000 \u0000Results \u0000(1)In these executive function test, there were significant differences between the patients with cognitive impairment (WML-VAD group, WML-VCIND group) and normal cognition group(WML-CN group, NC group), such as SCWT(B)(65.54±6.24 vs 43.67±0.95, 76.75±2.13 vs 43.67±0. 95, 65.54±6.24 vs 43.66±1.81, 76.75±2.13 vs 43.66±1.81), SCWT(C)(88.58±6.76 vs 61.63±1.31, 96.37±1.47 vs 61 63±1.31, 88.58±6.76 vs 66.31±8.19, 96.37±1.47 vs 66.31±8.19), TMTA(40.47±2.76 vs 30.92±0.47, 44.24±1.43 vs 30.92±0.47, 44.24±1.43 vs 31.99±2.07, 40.47±2.76 vs 31.99±2.07), TMTB(88.66±6.55 vs 80.34±0.61, 96.70±1.72 vs 80.34±0.61, 88.66±6.55 vs 83.10±5.91, 96.70±1.72 vs 83. 10±5.91), Digit Symbol Test(39.25±5.63 vs 47.00±2.55, 31.27±3.93 vs 47.00±2.5, 39.25±5.63 vs 48.86±4.34, 31.27±3.93 vs 48.86±4.34) and Verbal Fluency Test(8.94±1.00 vs 11.71±0.47, 6.64±0.81 vs 11.71±0.47, 8.94±1.00 vs 10.86±0.69, 6.64±0.81 vs 10.86±0.69) scores (P<0.05); In the patients with cognitive impairment, there were significant differences between WML-VAD group and WML-VCIND group, such as SCWT(B), SCWT(C), TMTA, TMTB, digit symbol test and verbal fluency test scores (P<0.05); There were significant differences between WML-CN patients and NC group in the scores of SCWT (C), verbal fluency test(P<0.05). (2)FA values in the genu of corpus callosum and the inferior longitudinal fasciculus were negatively correlated with the time of SCWT (B), SCWT (C) and the TMTA(r=-0.436--0.471), but positively correlated with the scores of digit symbol test and verbal fluency test(r=0.428-0.573). MD values in the genu of corpus callosu","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"29 1","pages":"239-244"},"PeriodicalIF":0.0,"publicationDate":"2020-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45543035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect and possible mechanism of sevoflurane exposure on electroencephalographic seizures and long-term cognitive function in neonatal rats","authors":"Jie Wang, Baofeng Yang, Zheng Yang, Ningtao Li, Mingyang Sun, Jiaqiang Zhang","doi":"10.3760/CMA.J.CN371468-20190921-00661","DOIUrl":"https://doi.org/10.3760/CMA.J.CN371468-20190921-00661","url":null,"abstract":"Objective \u0000To investigate the effect of sevoflurane anesthesia on electroencephalographic (EEG) seizures and long-term behavior and possible mechanism in neonatal rats. \u0000 \u0000 \u0000Methods \u0000A total of 141 postnatal days 4-6 Sprague-Dawley rats (66 male, 75 female) were divided into 3 groups (n=47 in each group) according to random number table method: control group, sevoflurane group, and NKCC1 inhibitor group, with 22 males and 25 females in each group. Rats in the control group were fed in normal cage without anesthesia; rats in the sevoflurane group were anesthetized with 2.1% sevoflurane for 6 hours; rats in the NKCC1 blocker group received intraperitoneal injection of 1.82 mg / kg bumetanide 30 minutes before anesthesia with 2.1% sevoflurane. The rats in the control group and sevoflurane group were injected subcutaneously with the same dose of DMSO at the same time when the NKCC1 blocker group received the drug intervention, so as to eliminate the influence caused by the solvent. The rats were observed for 30 minutes after recovery from anesthesia and then continued to breastfeed normally. Some of the new born rats received EEG monitoring from 9 to 11 days after being raised; the other rats received EPM and PPI respectively at 60 and 70 days after being raised. \u0000 \u0000 \u0000Results \u0000The results of EEG showed that, compared with the control group, the number of epileptic waves((0.429±0.787), (1.571±0.787), t=2.753, P 0.05). Compared with male rats, the average duration of female rats in sevoflurane group decreased ((6.392±3.374), (2.515±2.992), t=3.044, P 0.05). Comparison between male and female rats: compared with male rats in sevoflurane group, the female rats in sevoflurane group had a longer open arm stay time in EPM experiment (P<0.05), the difference was statistically significant. \u0000 \u0000 \u0000Conclusion \u0000Sevoflurane anesthesia for 6 hours can significantly increase the generation of epileptic waves in EEG of male newborn rats, and cause behavioral abnormalities in adult male rats, which may be related to NKCC1.And male rats are more vulnerable to the negative effects of sevoflurane anesthesia on brain nerve development. \u0000 \u0000 \u0000Key words: \u0000Sevoflurane; Neonatal anesthesia; Bumetanide; Gender; Electroencephalo-graphic; Behaviour; Rat","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"29 1","pages":"215-220"},"PeriodicalIF":0.0,"publicationDate":"2020-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48328179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of behavioral intervention on the prognosis of patients with carotid artery stenting","authors":"Zhaoying Wu, Baojun Qiao, Hui Yan, Chen Chen, Shuhu Zhou, Yanlei Hao","doi":"10.3760/CMA.J.CN371468-20191120-00885","DOIUrl":"https://doi.org/10.3760/CMA.J.CN371468-20191120-00885","url":null,"abstract":"Objective \u0000To explore the effects of behavior intervention on patients with ischemic cerebrovascular disease recurrence, carotid artery stenosis recurrence, and quality of life after carotid artery stenting implantation. \u0000 \u0000 \u0000Methods \u0000Sixty patients with carotid stenosis who underwent stenting surgery between January 2017 and July 2018 in Affiliated Hospital of Jining Medical University were recruited.The subjects were randomly divided into behavioral intervention group and control group.The control group was routinely followed up after carotid artery stenting implantation.The behavioral intervention group added home visit, education, guidance of the control and detection of risk factors for cerebrovascular disease of stent implantation. \u0000 \u0000 \u0000Results \u0000After 12 months of intervention, the incidence of ischemic cerebrovascular disease and the recurrence rate of carotid restenosis in the behavioral intervention group(6.7%, 3.3%) were significantly lower than those in the control group(30.0%, 20.0%) (both P<0.05). Six months after the intervention and 12 months after the intervention, the self-management ability score (intervention group: six months after the intervention (171.20±18.43), 12 months after the intervention (179.90±14.34); control group: six months after the intervention (160.77±13.43); 12 months after the intervention (164.27±14.85)) and quality of SS-QOL score (intervention group: 6 months after intervention (188.47±16.25), 12 months after intervention (203.17±13.84); control group: 6 months after intervention (170.67±15.82); 12 months after intervention (183.80±18.19)of the intervention group were higher than that of the control group, the difference is statistically significant (all P<0.05). \u0000 \u0000 \u0000Conclusion \u0000Behavioral intervention after carotid artery stenting implantation can effectively reduce the incidence of stroke and the recurrence rate of carotid stenosis and improve the prognosis of patients.The mechanism may be related with that the behavioral intervention can improve the self-management ability and the quality of life of patients with carotid stenosis. \u0000 \u0000 \u0000Key words: \u0000Behavioral intervention; Carotid stenosis stent implantation; Recurrence of carotid stenosis; Prognosis","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"29 1","pages":"250-255"},"PeriodicalIF":0.0,"publicationDate":"2020-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43714816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}