Correlation of total magnetic resonance imaging burden with homocysteine in patients with cerebral small vessel disease

中华行为医学与脑科学杂志 Pub Date : 2020-03-20 DOI:10.3760/CMA.J.CN371468-20191216-00913

Y. Ji, Zhenjie Teng, Xiangyu Li, Xiaosha Li, Peiyuan Lyu

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引用次数: 1

Abstract

Objective To explore the relationship between total MRI burden and serum homocysteine (Hcy) in patients with cerebral small vessel disease(CSVD), and to provide clues for disease prevention and treatment. Methods A total of 370 inpatients with CSVD from the neurology department of hospital were consecutively enrolled from September 2016 to December 2018.The clinical data, including serum homocysteine(Hcy) levels were collected.Brain MRI data were collected, including the severity of white matter hyperintensities(WMH), lacune infarcts(LI), cerebral microbleeds(CMBs), and enlarged perivascular spaces(ePVS) to evaluate the total load of CSVD.SPSS21.0 was applied to analyze the association between total CSVD burden and Hcy. Results (1)Compared with the patients with lower Hcy levels, the higher Hcy group had heavier total burdens of CSVD(P<0.01). (2)According to the total MRI burden scores of CSVD, all patients were further divided into low burden group(106 cases) and moderate-high burden group(264 cases). Multivariate logistic regression analysis showed that Hcy(OR=1.026, 95%CI: 1.003-1.049, P=0.026) was risk factor for increasing CSVD burden and hyperhomocysteinemia was a stronger predictor for total MRI burdens of CSVD(OR=3.202, 95%CI: 1.947-5.268, P<0.001). Conclusion Serum Hcy can be an independent risk factor for the total MRI burdens of CSVD.This finding provides a promising clue for the prediction and clinical management of CSVD. Key words: Cerebral small vessel disease; Risk factor; Magnetic resonance imaging; Homocysteine

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脑小血管病患者总磁共振成像负荷与同型半胱氨酸的相关性

目的探讨脑血管病(CSVD)患者MRI总负荷与血清同型半胱氨酸(Hcy)的关系，为该病的防治提供依据。方法选取2016年9月至2018年12月我院神经内科住院CSVD患者370例。收集临床资料，包括血清同型半胱氨酸(Hcy)水平。收集脑MRI数据，包括脑白质高信号(WMH)、腔隙性梗死(LI)、脑微出血(CMBs)和血管周围间隙扩大(ePVS)的严重程度，评估CSVD总负荷，应用spss21.0分析CSVD总负荷与Hcy的相关性。结果(1)与Hcy水平较低的患者相比，Hcy水平较高的患者CSVD总负担更重(P<0.01)。(2)根据CSVD MRI总负荷评分，将所有患者进一步分为低负荷组(106例)和中高负荷组(264例)。多因素logistic回归分析显示，Hcy(OR=1.026, 95%CI: 1.003 ~ 1.049, P=0.026)是增加CSVD负荷的危险因素，高同型半胱氨酸血症是CSVD MRI总负荷的较强预测因子(OR=3.202, 95%CI: 1.947 ~ 5.268, P<0.001)。结论血清Hcy是心血管疾病MRI总负荷的独立危险因素。这一发现为心血管疾病的预测和临床治疗提供了有希望的线索。关键词:脑血管病;风险因素;磁共振成像;同型半胱氨酸

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来源期刊

中华行为医学与脑科学杂志

自引率

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发文量

8131

期刊介绍： "Chinese Journal of Behavioral Medicine and Brain Science" (CN 37-1468/R, ISSN 1674-6554) is a national academic journal under the supervision of the National Health Commission, sponsored by the Chinese Medical Association and Jining Medical College. The journal was founded in June 1992 and was formerly known as "Chinese Journal of Behavioral Medicine" (1992-1993) and "Chinese Behavioral Medical Science" (1994-2008). In 2009, it was renamed "Chinese Journal of Behavioral Medicine and Brain Science" with the approval of the State Administration of Press, Publication, Radio, Film and Television. The purpose of "Chinese Journal of Behavioral Medicine and Brain Science" is to implement the health and health policies of the Party and the State, implement the principle of combining theory with practice and popularization and improvement, and reflect the major progress in the theory and practical application of behavioral medicine and brain science in my country. It publishes academic papers and scientific research results in the field of behavioral medicine and brain science in my country, and has columns such as monographs/reviews, basic research, clinical research, health prevention, methods and techniques, psychological behavior and evaluation, and systematic evaluation.