脑小血管病患者的认知控制能力

中华行为医学与脑科学杂志 Pub Date : 2020-03-20 DOI:10.3760/CMA.J.CN371468-20190927-00695

Zhiqi Wang, Jun Zhang, Q. Wei, Shanshan Cao, Wen Pan, Kai Wang

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The predict value of CCC for the occurrence of CSVD was assessed with logistic regression analysis. \n \n \nResults \nCCC of patients with CSVD was lower than that of healthy control ((2.97±0.72)bps vs (3.53±0.62)bps, t=-2.704, P=0.01). Between patients with CSVD and healthy control, there were significant differences in MoCA ((22.24±4.58 vs (24.86±2.42), t=-2.334, P=0.026), VFT-animal (12(6) vs 15(6), Z=-2.965, P=0.003), VFT-vegetables and fruits ((13.79±3.81) vs (18.27±4.13), t=-3.592, P=0.001), CAVLT-immediate ((7.45±2.18) vs (9.11±2.08), t=-2.502, P=0.017), CAVLT-short term delay ((7.20±3.32) vs (10.76±3.08), t=-3.564, P=0.001), CAVLT-long term delay ((7.30±3.16) vs (10.29±3.18), t=-3.012, P=0.005), SDMT ((15.95±5.49) vs (23.41±12.73), t=-2.513, P=0.018), CTT-A (85.17(42.60) vs 55.50(52.65), Z=-2.965, P=0.003), CTT-B ((200.69±71.35) vs (132.44±53.66), t=3.556, P=0.001), and CTT-B-A ((104.13±53.31) vs (65.20±35.98), t=2.819, P=0.007). But there was no significant difference in VFT-word begin with Chinese character\"water\"((3.68±2.63) vs (5.44±2.71), t=-1.940, P=0.061), CAVLT-recognition (14(3) vs 14(4), Z=-0.524, P=0.601), DS-forward (7.0(3.0) vs 5.5(2.0), Z=-0.152, P=0.880), DS-backward (4(1) vs 4(2), Z=-1.044, P=0.297), SCWT ((9.50±9.28) vs (5.94±10.47), t=1.123, P=0.268), Modified BNT (14.0(3.0) vs 13.5(3.0), Z=-0.727, P=0.467) between CSVD patients and healthy controls.In patients with CSVD, CCC was positively correlated with scores of MoCA (r=0.551, P=0.010) and also with DS-forward (r=0.532, P=0.013) and SCWT (r=-0.487, P=0.040). Logistic regression analysis showed that CCC was an important variable in predicting the possibility of CSVD (B=-1.318, P=0.019, OR=0.268, 95%CI (0.089-0.808)). \n \n \nConclusion \nCompared with the healthy control, CCC in patients with CSVD decreases significantly and CCC is related to the cognitive impairment.CCC can predict the possibility of CSVD. \n \n \nKey words: \nCognitive control capacity; Cerebral small vessel disease; Cognitive function","PeriodicalId":9940,"journal":{"name":"中华行为医学与脑科学杂志","volume":"29 1","pages":"221-226"},"PeriodicalIF":0.0000,"publicationDate":"2020-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Capacity of cognitive control in patients with cerebral small vessel disease\",\"authors\":\"Zhiqi Wang, Jun Zhang, Q. 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引用次数: 0

摘要

目的评价脑血管病(CSVD)患者的认知控制能力，探讨认知控制与认知功能的关系，评价认知控制对脑血管病发生的预测价值。方法选取22例CSVD患者和23例健康对照者。所有受试者均完成了多数功能任务屏蔽(MFT-M)和一组神经心理测试。神经心理测试采用蒙特利尔认知测验(MoCA)、语言流畅性测验(VFT)、汉语听觉学习测验(CAVLT)、符号数字模态测验(SDMT)、数字广度测验(DS)、Stroop颜色词测验(SCWT)、颜色轨迹测验(CTT)和改良波士顿命名测验(Modified Boston naming test)进行。采用logistic回归分析评估CCC对CSVD发生的预测价值。结果CSVD患者的CCC低于健康对照组((2.97±0.72)bps vs(3.53±0.62)bps, t=-2.704, P=0.01)。在CSVD患者和健康对照组之间，MoCA(22.24±4.58 vs(24.86±2.42)，t=-2.334, P=0.026)、vft -动物(12(6)vs 15(6)， Z=-2.965, P=0.003)、vft -蔬菜水果((13.79±3.81)vs(18.27±4.13)，t=-3.592, P=0.001)、cavlt -即时((7.45±2.18)vs(9.11±2.08)，t=-2.502, P=0.017)、cavlt -短期延迟((7.20±3.32)vs(10.76±3.08)，t=-3.564, P=0.001)、cavlt -长期延迟((7.30±3.16)vs(10.29±3.18)，t=-3.012, P=0.005)、cavlt -长期延迟((7.30±3.16)vs(10.29±3.18)，t=-3.012, P=0.005。SDMT((15.95±5.49)和(23.41±12.73),t = -2.513, P = 0.018), CTT-A(85.17(42.60)和55.50 (52.65),Z = -2.965, P = 0.003), CTT-B((200.69±71.35)和(132.44±53.66),t = 3.556, P = 0.001),和CTT-B-A((104.13±53.31)和(65.20±35.98),t = 2.819, P = 0.007)。但在以“水”字为首字的vft((3.68±2.63)vs(5.44±2.71)，t=-1.940, P=0.061)、cavlt识别(14(3)vs 14(4)， Z=-0.524, P=0.601)、DS-forward (7.0(3.0) vs 5.5(2.0)， Z=-0.152, P=0.880)、DS-backward (4(1) vs 4(2)， Z=-1.044, P=0.297)、SCWT((9.50±9.28)vs(5.94±10.47)，t=1.123, P=0.268)、改良BNT (14.0(3.0) vs 13.5(3.0)， Z=-0.727, P=0.467)方面，CSVD患者与健康对照组无显著差异。CSVD患者CCC与MoCA评分呈正相关(r=0.551, P=0.010)，与DS-forward评分呈正相关(r=0.532, P=0.013)，与SCWT评分呈正相关(r=-0.487, P=0.040)。Logistic回归分析显示，CCC是预测CSVD发生可能性的重要变量(B=-1.318, P=0.019, OR=0.268, 95%CI(0.089 ~ 0.808))。结论与健康对照组相比，CSVD患者的CCC明显降低，且与认知功能障碍有关。CCC可以预测CSVD发生的可能性。关键词:认知控制能力;脑血管病;认知功能

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Capacity of cognitive control in patients with cerebral small vessel disease

Objective To evaluate the capacity of cognitive control(CCC) in patients with cerebral small vessel disease(CSVD) and explore the relationship between CCC and cognitive function in CSVD, and to assess the predict value of CCC on the occurrence of CSVD. Methods Twenty-two patients with CSVD and twenty-three healthy controls were enrolled.All of them completed the majority function task-masked (MFT-M) and a set of neuropsychological tests.Neuropsychological test was performed by Montreal cognitive assessment (MoCA), verbal fluency test (VFT), Chinese auditory learning test (CAVLT), symbol digit modalities test (SDMT), digital span (DS), Stroop color word test (SCWT), color trail test (CTT) and Modified Boston naming test (Modified BNT). The predict value of CCC for the occurrence of CSVD was assessed with logistic regression analysis. Results CCC of patients with CSVD was lower than that of healthy control ((2.97±0.72)bps vs (3.53±0.62)bps, t=-2.704, P=0.01). Between patients with CSVD and healthy control, there were significant differences in MoCA ((22.24±4.58 vs (24.86±2.42), t=-2.334, P=0.026), VFT-animal (12(6) vs 15(6), Z=-2.965, P=0.003), VFT-vegetables and fruits ((13.79±3.81) vs (18.27±4.13), t=-3.592, P=0.001), CAVLT-immediate ((7.45±2.18) vs (9.11±2.08), t=-2.502, P=0.017), CAVLT-short term delay ((7.20±3.32) vs (10.76±3.08), t=-3.564, P=0.001), CAVLT-long term delay ((7.30±3.16) vs (10.29±3.18), t=-3.012, P=0.005), SDMT ((15.95±5.49) vs (23.41±12.73), t=-2.513, P=0.018), CTT-A (85.17(42.60) vs 55.50(52.65), Z=-2.965, P=0.003), CTT-B ((200.69±71.35) vs (132.44±53.66), t=3.556, P=0.001), and CTT-B-A ((104.13±53.31) vs (65.20±35.98), t=2.819, P=0.007). But there was no significant difference in VFT-word begin with Chinese character"water"((3.68±2.63) vs (5.44±2.71), t=-1.940, P=0.061), CAVLT-recognition (14(3) vs 14(4), Z=-0.524, P=0.601), DS-forward (7.0(3.0) vs 5.5(2.0), Z=-0.152, P=0.880), DS-backward (4(1) vs 4(2), Z=-1.044, P=0.297), SCWT ((9.50±9.28) vs (5.94±10.47), t=1.123, P=0.268), Modified BNT (14.0(3.0) vs 13.5(3.0), Z=-0.727, P=0.467) between CSVD patients and healthy controls.In patients with CSVD, CCC was positively correlated with scores of MoCA (r=0.551, P=0.010) and also with DS-forward (r=0.532, P=0.013) and SCWT (r=-0.487, P=0.040). Logistic regression analysis showed that CCC was an important variable in predicting the possibility of CSVD (B=-1.318, P=0.019, OR=0.268, 95%CI (0.089-0.808)). Conclusion Compared with the healthy control, CCC in patients with CSVD decreases significantly and CCC is related to the cognitive impairment.CCC can predict the possibility of CSVD. Key words: Cognitive control capacity; Cerebral small vessel disease; Cognitive function

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中华行为医学与脑科学杂志

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期刊介绍： "Chinese Journal of Behavioral Medicine and Brain Science" (CN 37-1468/R, ISSN 1674-6554) is a national academic journal under the supervision of the National Health Commission, sponsored by the Chinese Medical Association and Jining Medical College. The journal was founded in June 1992 and was formerly known as "Chinese Journal of Behavioral Medicine" (1992-1993) and "Chinese Behavioral Medical Science" (1994-2008). In 2009, it was renamed "Chinese Journal of Behavioral Medicine and Brain Science" with the approval of the State Administration of Press, Publication, Radio, Film and Television. The purpose of "Chinese Journal of Behavioral Medicine and Brain Science" is to implement the health and health policies of the Party and the State, implement the principle of combining theory with practice and popularization and improvement, and reflect the major progress in the theory and practical application of behavioral medicine and brain science in my country. It publishes academic papers and scientific research results in the field of behavioral medicine and brain science in my country, and has columns such as monographs/reviews, basic research, clinical research, health prevention, methods and techniques, psychological behavior and evaluation, and systematic evaluation.