重症肌无力患者的认知功能特征

中华行为医学与脑科学杂志 Pub Date : 2020-03-20 DOI:10.3760/CMA.J.CN371468-20191015-00755

Jing Wang, Xin Li, Li-min Li, Lin-Jie Zhang, Li Yang

{"title":"重症肌无力患者的认知功能特征","authors":"Jing Wang, Xin Li, Li-min Li, Lin-Jie Zhang, Li Yang","doi":"10.3760/CMA.J.CN371468-20191015-00755","DOIUrl":null,"url":null,"abstract":"Objective \nTo evaluate the cognitive function characteristics in patients with myasthenia gravis(MG). \n \n \nMethods \nThe cognitive function of 83 MG patients and 39 healthy controls (HC) were evaluated by MMSE, California verbal learning test( CVLT), brief visuospatial memory test revised(BVMT-R), symbol digit modalities test(SDMT), benton judgment of line orientation test(BJLOT), paced auditory serial addition Test(PASAT) and verbal fluency test(VFT). The depression state was assessed by beck depression inventory (BDI). The results were compared between MG and HC groups.The effect of clinical characteristics such as disease type, comorbidities, course of disease, disease severity, and drug treatment on cognitive impairment in MG group was further analysed. \n \n \nResults \nThe scale scores of MMSE(28(26, 29), 29(28, 30)), CVLT, BVMT-R, SDMT((37.06±12.18), (47.54±14.91)) and PASAT((32.86±10.23), (37.00±8.82)) in MG were significantly lower than those in control group (P 0.05). Spearman correlation analysis showed that QMG scores were negatively correlated with SDMT scores(r=-0.234, P<0.05). MG-ADL scores were inversely correlated with total BVMT-R scores of three trials(r=-0.283, P<0.05). \n \n \nConclusion \nPatients with MG suffered from cognitive impairment, mainly in memory, attention, processing speed and visual memory, which supported the hypothesis of CNS involvement in MG.Dysfunction in some cognitive domains may be related to the disease severity.Clinicians need take morce attention to early assessment, developing long-term follow-ups and appropriate intervention. \n \n \nKey words: \nMyasthenia gravis; Neuropsychology; Cognitive function; Depression","PeriodicalId":9940,"journal":{"name":"中华行为医学与脑科学杂志","volume":"32 2","pages":"256-261"},"PeriodicalIF":0.0000,"publicationDate":"2020-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Cognitive function characteristics in patients with myasthenia gravis\",\"authors\":\"Jing Wang, Xin Li, Li-min Li, Lin-Jie Zhang, Li Yang\",\"doi\":\"10.3760/CMA.J.CN371468-20191015-00755\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Objective \\nTo evaluate the cognitive function characteristics in patients with myasthenia gravis(MG). \\n \\n \\nMethods \\nThe cognitive function of 83 MG patients and 39 healthy controls (HC) were evaluated by MMSE, California verbal learning test( CVLT), brief visuospatial memory test revised(BVMT-R), symbol digit modalities test(SDMT), benton judgment of line orientation test(BJLOT), paced auditory serial addition Test(PASAT) and verbal fluency test(VFT). The depression state was assessed by beck depression inventory (BDI). The results were compared between MG and HC groups.The effect of clinical characteristics such as disease type, comorbidities, course of disease, disease severity, and drug treatment on cognitive impairment in MG group was further analysed. \\n \\n \\nResults \\nThe scale scores of MMSE(28(26, 29), 29(28, 30)), CVLT, BVMT-R, SDMT((37.06±12.18), (47.54±14.91)) and PASAT((32.86±10.23), (37.00±8.82)) in MG were significantly lower than those in control group (P 0.05). Spearman correlation analysis showed that QMG scores were negatively correlated with SDMT scores(r=-0.234, P<0.05). MG-ADL scores were inversely correlated with total BVMT-R scores of three trials(r=-0.283, P<0.05). \\n \\n \\nConclusion \\nPatients with MG suffered from cognitive impairment, mainly in memory, attention, processing speed and visual memory, which supported the hypothesis of CNS involvement in MG.Dysfunction in some cognitive domains may be related to the disease severity.Clinicians need take morce attention to early assessment, developing long-term follow-ups and appropriate intervention. \\n \\n \\nKey words: \\nMyasthenia gravis; Neuropsychology; Cognitive function; Depression\",\"PeriodicalId\":9940,\"journal\":{\"name\":\"中华行为医学与脑科学杂志\",\"volume\":\"32 2\",\"pages\":\"256-261\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2020-03-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"中华行为医学与脑科学杂志\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3760/CMA.J.CN371468-20191015-00755\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"中华行为医学与脑科学杂志","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3760/CMA.J.CN371468-20191015-00755","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 1

摘要

目的探讨重症肌无力（MG）患者的认知功能特点。方法采用MMSE、California言语学习测试（CVLT）、短时视觉空间记忆修正测试（BVMT-R）、符号数字模态测试（SDMT）、benton判断线定向测试（BJLOT）、起搏听觉序列加法测试（PASAT）和语言流利度测试（VFT）对83例MG患者和39例健康对照（HC）的认知功能进行评价。抑郁状态采用贝克抑郁量表（BDI）进行评估。比较MG组和HC组的结果。进一步分析了MG组的疾病类型、合并症、病程、疾病严重程度和药物治疗等临床特征对认知障碍的影响。结果MMSE（28（26，29），29（28，30））、CVLT、BVMT-R、SDMT（（37.06±12.18），（47.54±14.91））和PASAT（（32.86±10.23）的量表得分，Spearman相关分析显示，QMG评分与SDMT评分呈负相关（r=-0.234，P<0.05），MG-ADL评分与三项试验的BVMT-r总分呈负相关，r=-0.283，P<0.05，处理速度和视觉记忆，这支持了中枢神经系统参与MG的假设。某些认知领域的功能障碍可能与疾病的严重程度有关。临床医生需要注意早期评估，制定长期随访和适当的干预措施。关键词：重症肌无力；神经心理学；认知功能；抑郁症

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Cognitive function characteristics in patients with myasthenia gravis

Objective To evaluate the cognitive function characteristics in patients with myasthenia gravis(MG). Methods The cognitive function of 83 MG patients and 39 healthy controls (HC) were evaluated by MMSE, California verbal learning test( CVLT), brief visuospatial memory test revised(BVMT-R), symbol digit modalities test(SDMT), benton judgment of line orientation test(BJLOT), paced auditory serial addition Test(PASAT) and verbal fluency test(VFT). The depression state was assessed by beck depression inventory (BDI). The results were compared between MG and HC groups.The effect of clinical characteristics such as disease type, comorbidities, course of disease, disease severity, and drug treatment on cognitive impairment in MG group was further analysed. Results The scale scores of MMSE(28(26, 29), 29(28, 30)), CVLT, BVMT-R, SDMT((37.06±12.18), (47.54±14.91)) and PASAT((32.86±10.23), (37.00±8.82)) in MG were significantly lower than those in control group (P 0.05). Spearman correlation analysis showed that QMG scores were negatively correlated with SDMT scores(r=-0.234, P<0.05). MG-ADL scores were inversely correlated with total BVMT-R scores of three trials(r=-0.283, P<0.05). Conclusion Patients with MG suffered from cognitive impairment, mainly in memory, attention, processing speed and visual memory, which supported the hypothesis of CNS involvement in MG.Dysfunction in some cognitive domains may be related to the disease severity.Clinicians need take morce attention to early assessment, developing long-term follow-ups and appropriate intervention. Key words: Myasthenia gravis; Neuropsychology; Cognitive function; Depression

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

中华行为医学与脑科学杂志

自引率

0.00%

发文量

8131

期刊介绍： "Chinese Journal of Behavioral Medicine and Brain Science" (CN 37-1468/R, ISSN 1674-6554) is a national academic journal under the supervision of the National Health Commission, sponsored by the Chinese Medical Association and Jining Medical College. The journal was founded in June 1992 and was formerly known as "Chinese Journal of Behavioral Medicine" (1992-1993) and "Chinese Behavioral Medical Science" (1994-2008). In 2009, it was renamed "Chinese Journal of Behavioral Medicine and Brain Science" with the approval of the State Administration of Press, Publication, Radio, Film and Television. The purpose of "Chinese Journal of Behavioral Medicine and Brain Science" is to implement the health and health policies of the Party and the State, implement the principle of combining theory with practice and popularization and improvement, and reflect the major progress in the theory and practical application of behavioral medicine and brain science in my country. It publishes academic papers and scientific research results in the field of behavioral medicine and brain science in my country, and has columns such as monographs/reviews, basic research, clinical research, health prevention, methods and techniques, psychological behavior and evaluation, and systematic evaluation.