中华临床营养杂志最新文献

{"title":"Application of upper arm totally implantable venous access ports in 34 patients with tumor","authors":"Liyu Wang, Lihua Shi, F. Zhu, Qinying Zhang, Lanqing Bi, Hui Zhang, F. Cao, Fen Guo, Lu Zhang, Yuannian Jiao, Mingyang Yu, Yinger Feng","doi":"10.3760/CMA.J.ISSN.1674-635X.2019.01.010","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-635X.2019.01.010","url":null,"abstract":"Objective \u0000To investigate the safety, feasibility and clinical application effect of upper arm totally implantable venous access port (TIVAP) inserted by the combination of oncologists and nurses in patients with tumor. \u0000 \u0000 \u0000Methods \u0000A total of 34 patients, who needed long-term transfusion treatment, were included in this study with upper arm TIVAP from March 2017 and December 2017. There were 20 males and 14 females. The median age was 63 (35~83) years. Upper arm TIVAP was implanted by both doctors and nurses into the patients with tumor, and the TIVAP related success rate, complications and patients satisfaction were recorded. \u0000 \u0000 \u0000Results \u000034 patients all succeeded in TIVAP implantation with the operation success rate of 100%. The average operation time was about 40 minutes (30 to 60 minutes) from the disinfecting cloth to the end of the suture. The operations of all patients were successful. After the operation two patients died of cancer progression, one patient had soft tissue infection around capsular bag, None of the patients had other complications such as blocked infusion, catheter shift, port reversal, and so on, and the incidence of complication was 2.94%(1/34). \u0000 \u0000 \u0000Conclusions \u0000Upper arm TIVAP has the advantages of safe puncture, shorter operation time, few intra-operative and post-operative complications and higher feasibility for operation by both oncologist and nurse, which can supplement the limitations and deficiencies of the chest wall port and PICC in a certain extent, therefore is a good choice for clinical application. \u0000 \u0000 \u0000Key words: \u0000Upper arm; Totally implantable access port; Cancer","PeriodicalId":9877,"journal":{"name":"Chinese Journal of Clinical Nutrition","volume":"27 1","pages":"57-61"},"PeriodicalIF":0.0,"publicationDate":"2019-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42544588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cooperation and subject analysis of the research of ω-3 unsaturated fatty acids","authors":"L. Wei, Jinhu Tian, Yue Sun","doi":"10.3760/CMA.J.ISSN.1674-635X.2019.01.006","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-635X.2019.01.006","url":null,"abstract":"Objective \u0000To learn the latest progress in the research of ω-3 unsaturated fatty acids and provide references for the related investigator through visualized analysis of the research of ω-3 unsaturated fatty acids published in our country. \u0000 \u0000 \u0000Methods \u0000China Biology Medicine disc was searched by computer from the beginning until December 31, 2017. Bibliographic Item Co-occurrence Mining System (BICOMS) was used to extract and summarize the data of age, author, organization, province and key words and to produce a co-occurrence matrix. NetDraw of Ucinet 6. 0 was employed to draw the social network diagram of the author, organization, province and key words. And cluster analysis of the key words was performed by gCLUTO 2.0. \u0000 \u0000 \u0000Results \u0000A total of 1 165 studies involving 30 provinces and cities, 854 research units, 3 789 authors and 1 016 significative key words were included. The cooperation of author, organization and province needed to be further strengthened. The study focused on 3 aspects: the effects of unsaturated fatty acids on apoptosis/lipid in mice/rats with related genes of diabetes/cardiovascular disease/coronary artery disease; meta-analysis of immunonutrition to improve tumor/inflammation/sepsis; effect of fish oil fat emulsion on interleukin/C reactive protein in pneumonia/lung injury. \u0000 \u0000 \u0000Conclusions \u0000The research of ω-3 unsaturated fatty acids develops rapidly in China, but it is mainly concentrated in a few centers of cooperation agencies. There is little cooperation among different provinces, cities, areas, and organizations and the research topics needs to be further expanded. \u0000 \u0000 \u0000Key words: \u0000ω-3 unsaturated fatty acids; Immunonutrition; Cooperation situation; Subject analysis","PeriodicalId":9877,"journal":{"name":"Chinese Journal of Clinical Nutrition","volume":"27 1","pages":"33-41"},"PeriodicalIF":0.0,"publicationDate":"2019-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42204448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of blind bedside non-spiral nasointestinal tubes in critically ill patients","authors":"Jiakui Sun, Wen-hao Zhang, Xiang Wang, Shou-tao Yuan, Qian-Kun Shi, Y. Liu","doi":"10.3760/CMA.J.ISSN.1674-635X.2019.01.007","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-635X.2019.01.007","url":null,"abstract":"Objective \u0000To evaluate the effect of blind bedside non-spiral nasointestinal tubes in critically ill patients. \u0000 \u0000 \u0000Methods \u0000Patients requiring bedside nasointenstinal tubes in intensive care unit of Nanjing First Hospital from February 2017 to February 2018 were enrolled in this study. The placement of nasointenstinal tubes was conducted according to the reference procedure of our department, recording operation times, operation duration, position of the tube′s tip, expense and complications. \u0000 \u0000 \u0000Results \u0000A total of 53 patients received the bedside non-spiral nasointenstinal tubes which were conducted for 64 times. 51 patients(51/53, 94.4%) were successful in tube placement, 45 case-times(45/64, 70.3%) were successful at the first attempt, and 50 case-times(50/64, 78.1%) were successful at the second attempt in accumulation. The mean time of our procedure was (13.80±6.90) minutes, the mean insertion length was (99.55±8.35) cm, and the mean expense was (244.82±45.68) Yuan. No severe complications were observed. \u0000 \u0000 \u0000Conclusion \u0000Blind bedside placement of non-spiral nasointestinal tubes has high success rate and many advantages as short operation time, low expense and less complications, which is a good choice for early establishment of enteral feeding pathway and early supplement of enteral nutrition in critically ill patients. \u0000 \u0000 \u0000Key words: \u0000Nasointestinal tube; Blind bedside placement; Enteral nutrition; Critical illness","PeriodicalId":9877,"journal":{"name":"Chinese Journal of Clinical Nutrition","volume":"27 1","pages":"42-46"},"PeriodicalIF":0.0,"publicationDate":"2019-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69988039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal zinc metabolism and changes of metallothionein-1 and zinc transporter-1 in fetal congenital heart diseases","authors":"Che Jiang, Xin-ru Hong, Chaobin Liu, F. Chen, Xiaoyu He, Yulan Wang","doi":"10.3760/CMA.J.ISSN.1674-635X.2019.01.004","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-635X.2019.01.004","url":null,"abstract":"Objective \u0000To investigate maternal zinc metabolism and the changes of zinc-related factors as metallothionein-1(MT1) and zinc transporter-1(ZnT1) in certain types of congenital heart diseases (CHD). \u0000 \u0000 \u0000Methods \u0000Fifteen infants with interventricular septal defect, 12 infants with atrial septal defect and 7 infants with tetralogy of Fallot, together with their mothers were enrolled, and normal infants and their mothers were enrolled by a ratio of 1∶1 with the above three types of CHD diseases. General conditions of the mothers, along with their diets and zinc-containing drug supplementation during the pregnancy, were surveyed. Maternal blood zinc levels and serum alkaline phosphatase activities at gestation week 32 and delivery or induced abortion, and the protein and mRNA expressions of MT1 and ZnT1 in maternal serum and placental tissue at delivery or induced abortion were assayed. \u0000 \u0000 \u0000Results \u0000The general conditions were comparable between the CHD group and control group. The ratio of the mothers taking more zinc-rich food was significantly lower in the CHD group than in the control group. Circulating zinc levels in interventricular septal defect (73.55±5.79 μmol/L), atrial septal defect (72.66±5.82 μmol/L) and tetralogy of Fallot (68.72±6.72 μmol/L) groups were significantly lower than those in the control groups (82.77±7.88, 84.58±7.55 and 85.66±7.30 μmol/L) at delivery (P all <0.05). Similar change patterns were seen for serum alkaline phosphatase activities. The relative quantities of serum MT1 and ZnT1 proteins in interventricular septal defect (73.22±36.54 and 68.55±27.82), atrial septal defect (64.29±38.26 and 74.55±29.67) and tetralogy of Fallot (67.88±30.50 and 70.13±29.65) groups were significantly lower than those in their corresponding control groups (166.31±67.43 and 97.67±30.22, 182.56±71.40 and 111.65±32.70, and 173.81±62.36 and 108.27±28.52, P<0.01 or P<0.05). The relative quantities of placental MT1 and ZnT1 proteins and mRNA expressions in interventricular septal defect (protein quantities 0.438±0.096 and 0.384±0.061, mRNA expressions 1.23±0.82 and 0.96±0.39), atrial septal defect (0.427±0.093 and 0.377±0.059, 1.17±0.70 and 0.85±0.40) and tetralogy of Fallot (0.414±0.111 and 0.336±0.066, 1.31±0.97 and 0.90±0.38) groups were significantly lower than those in their corresponding control groups (protein quantities 0.565±0.083 and 0.541±0.090, mRNA expressions 2.78±1.06 and 1.67±0.33; protein quantities 0.622±0.136 and 0.493±0.079, mRNA expressions 2.85±0.89 and 1.72±0.38; protein quantities 0.637±0.125 and 0.521±0.089, mRNA expressions 3.21±0.99 and 1.61±0.29; P<0.01 or P<0.05). \u0000 \u0000 \u0000Conclusion \u0000Mothers with their fetus of certain types of CHD are found zinc deficiency, and down-regulation of MT1 and ZnT1 expressions in the serum and placenta may involve in the pathogenesis of CHD when maternal zinc deficiency. \u0000 \u0000 \u0000Key words: \u0000Zinc deficiency; Congenital heart disease; Pregnancy; Metallothionein-1; Zinc transporter-1","PeriodicalId":9877,"journal":{"name":"Chinese Journal of Clinical Nutrition","volume":"27 1","pages":"18-25"},"PeriodicalIF":0.0,"publicationDate":"2019-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47449495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A systemic review on efficacy and safety of multi-oil fat emulsion injection in premature infant parenteral nutrition support based on the meta-analysis","authors":"Tian Zhang, Xueyang Wang, Q. Ni, Yi Ren","doi":"10.3760/CMA.J.ISSN.1674-635X.2018.06.006","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-635X.2018.06.006","url":null,"abstract":"Objective \u0000To systemically analyze the efficacy and safety of multi-oil fat emulsion injection (SMOF) in the premature infant parenteral nutrition support. \u0000 \u0000 \u0000Methods \u0000Databases including EMbase, PubMed, Cochrane Library, CNKI, VIP and Wanfang, were searched from libraries establishment to November 2017 for randomized controlled trials (RCTs) focusing on the efficacy and safety of SMOF in the premature infant parenteral nutrition support. All the literatures were retrieved and screened according to inclusion and exclusion criteria by two researchers. The software RevMan 5.3 was used for meta-analysis after the evaluation of methodology of quality. \u0000 \u0000 \u0000Results \u0000A total of 7 articles including 7 RCTs were enrolled. Meta-analysis showed that there were no significant differences in body length (OR=-0.25, 95% CI=-1.80-1.30, P=0.75), weight(OR=-0.12, 95% CI=-0.20-0.04, P=0.14), head circumference(OR=0.07, 95% CI=-0.83-0.96, P=0.88), low-density lipoprotein, high-density lipoprotein, direct bilirubin, serum creatinine(OR=-0.16, 95% CI=-0.59-0.26, P=0.45) between the infants receiving SMOF or Intralipid. But compared with the infants receiving Intralipid, hemoglobin(OR=-0.75, 95% CI=-1.49-0.00, P=0.05), red blood cells(OR=-0.23, 95% CI=-0.45-0.00, P=0.05) decreased in the infants receiving SMOF, and white blood cells(OR=1.91, 95% CI=0.46-3.37, P=0.01) increased. \u0000 \u0000 \u0000Conclusions \u0000SMOF can control the hemoglobin content in serum, reduce the risk and degree of jaundice in premature infant, with better safety. \u0000 \u0000 \u0000Key words: \u0000Multi-oil fat emulsion injection; Premature infant; Meta-analysis; Randomized controlled trials; Efficacy; Safety","PeriodicalId":9877,"journal":{"name":"Chinese Journal of Clinical Nutrition","volume":"26 1","pages":"354-360"},"PeriodicalIF":0.0,"publicationDate":"2018-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43171700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glutamine supplementation provides neuroprotection by inhibiting microglia-mediated neuroinflammatory response after traumatic brain injury in rats","authors":"Dandan Huang, Shasha Xie, Fan Pan","doi":"10.3760/CMA.J.ISSN.1674-635X.2018.06.009","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-635X.2018.06.009","url":null,"abstract":"Objective \u0000To investigate the effects and mechanisms of Glutamine(Gln) supplementation on neurobehavioral outcome, neuronal apoptosis, microglia polarization, and neuroinflammatory response after traumatic brain injury (TBI) in rats. \u0000 \u0000 \u0000Methods \u0000TBI animal models were established using Feeney's method. Sixty Wistar rats were randomly divided into three groups: control group (Con), traumatic brain injury group (TBI), and glutamine supplementation group (TBI+ Gln). We measured rat behavioral outcomes by modified neurologic severity score (mNSS) tests at day 1, 3, 7 and 14 after TBI. Apoptotic neurons were determined by Nissl staining. The microglia polarization relatived protein (Iba-1, CD16, CD86) expressions in TBI cerebral cortices were determined by immunohistochemistry staining and western blotting, respectively. While, the serum levels of tumor necrosis factor-α(TNF-α), interleukin (IL)-1 and interferon (IFN)-γ were tested by enzyme linked immunosorbent Assay (ELISA). \u0000 \u0000 \u0000Results \u0000Compared with the Con group, the levels of neurobehavioral outcome, neurons apoptosis, microglia polarization and neuroinflammatory factors were significantly increased in the other two groups(P=0.00). Compared with the TBl group, glutamin supplementation improved neurobehavioral outcome[7 d: (10.74±0.25)points vs. (8.94±0.24) points, P=0.01; 14 d: (8.77±0.16)points vs. (7.43±0.13)points, P=0.03]. Meanwhile, glutamin supplementation suppressed the apoptotic rates of neurons [3 d: (80.18±8.38)% vs.(65.47±7.02)%, P=0.01; 7 d: (58.90±6.12)% vs.(42.73±4.88)%, P=0.01; 14 d: (39.56±2.95)% vs.(31.12±3.16)%, P=0.01], inhibited protein expressions of Iba-1 and CD16, and increased the protein expression of CD86, which promoted the phenotypic shift of microglia from M1 to M2 phenotype, inhibited microglial activation, and thus reduced TBI-induced neuroinflammatory factors [TNF-α: (125.42±12.81)pg/ml vs. (74.36±9.25)pg/ml, P=0.01; IL-1: (69.04±8.48)pg/ml vs. (34.73±3.92)pg/ml, P=0.01; TNF-α: (89.75±9.40)pg/ml vs. (45.62±6.64)pg/ml, P=0.02]. \u0000 \u0000 \u0000Conclusion \u0000Glutamine supplementation can markedly reduce neuron apoptosis and improve neurological outcomes after TBI, possibly mediated by promoting the phenotypic shift of microglia from M1 to M2 phenotype and thus reducing TBI-induced neuroinflammatory factors. \u0000 \u0000 \u0000Key words: \u0000Traumatic brain injury; Glutamine; Microglia; Inflammatory response; Neuroprotection","PeriodicalId":9877,"journal":{"name":"Chinese Journal of Clinical Nutrition","volume":"26 1","pages":"373-378"},"PeriodicalIF":0.0,"publicationDate":"2018-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48826315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of maternal high fat diet on intestinal barrier function in early life of offspring mice","authors":"Runxiang Xie, H. Cao, Xinyuan Huang, Tianyu Liu, Sinan Wang, Wenxiao Dong","doi":"10.3760/CMA.J.ISSN.1674-635X.2018.06.007","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-635X.2018.06.007","url":null,"abstract":"Objective \u0000To observe the effects of maternal high fat diet (MHFD) during pregnancy and lactation on intestinal barrier function in offspring mice. \u0000 \u0000 \u0000Methods \u0000C57BL/6 pregnant mice were divided into high fat diet (MHFD) group and normal diet group (MND) randomly and were given high fat diet and normal diet during pregnancy (3 weeks) and lactation (3 weeks) respectively. Both groups of offspring mice were naturally given and bodyweight of pups was monitored at birth and weekly. After weaning, the intestinal permeability of offspring mice was detected by fluorescein isothiocyanate conjugated-dextran method (FITC-D). Immunofluorescence was used to detect the expression of ZO-1 in intestinal tissues. HE staining was used to assess the villus length and crypt depth. The intestinal cell proliferation(expression of Ki-67)and Mucin 2(MUC2) were assessed by immunohistochemistry. PAS staining was used to evaluate the goblet cells. The expression of inflammatory cytokines including IL-1β, IL-6, and TNF-α in intestinal tissue were measured by real-time PCR. \u0000 \u0000 \u0000Results \u0000At the age of 2 and 3 weeks, the offspring in MHFD group were significantly heavier than those in MND group. HE staining showed no obvious microscopic inflammation in both groups of 3 weeks old offspring mice, however, the relative expression levels of IL-1β (1.95±0.53 vs. 1.13±0.15; t=3.65, P=0.005), IL-6(1.40±0.71 vs. 0.73±0.17; t=2.72, P=0.04), and TNF-α(1.63±0.53 vs. 1.04±0.12; t=2.64, P=0.02) mRNA were significantly higher in the MHFD group. Compared with the 3 weeks old offspring mice in MND group, MHFD significantly increased the permeability of intestine and decreased the expression of ZO-1 in membrane. The number of Ki-67 positive cells (18.00±4.74 vs. 24.60±4.17; t=3.31, P=0.004) in each villus, goblet cells (14.70±2.91 vs. 28.10±4.95; t=7.38, P<0.001) and MUC2 positive cells (20.60±3.13 vs. 30.00±3.33; t=6.50, P<0.001) in each crypt were significantly lower than those in MND group. \u0000 \u0000 \u0000Conclusion \u0000Maternal high fat diet in early life of offspring mice can induce intestinal low grade inflammation and lead to the disruption of intestinal mucosal barrier in offspring mice, which may be involved in the progeny diseases. \u0000 \u0000 \u0000Key words: \u0000Early life; High fat diet; Inflammation; Intestinal mucosal barrier","PeriodicalId":9877,"journal":{"name":"Chinese Journal of Clinical Nutrition","volume":"26 1","pages":"361-365"},"PeriodicalIF":0.0,"publicationDate":"2018-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42584393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research on the application of gastrointestinal ultrasound combined with gas-water alternating injection in the positioning of nasointestinal tube for severe patients","authors":"Xiaokang Xing, Man Li","doi":"10.3760/CMA.J.ISSN.1674-635X.2018.06.005","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-635X.2018.06.005","url":null,"abstract":"Objective \u0000To assess the value of bedside gastrointestinal ultrasound combined with gas-water alternate injection on nasointestinal tube positioning in critically ill patients. \u0000 \u0000 \u0000Methods \u0000A total of 62 critically ill patients requiring post-pyloric enteral nutrition admitted to the intensive care unit in our Hospital from May 1, 2017 to December 1, 2017 were enrolled. Nasointestinal tubes were blindly inserted in a bedside setting. Then, we evaluated the nasointestinal tube position using both an ultrasound with gas-water alternate injection and the traditional auscultation method after gas perfusion. Abdominal X-ray imaging was also performed in all cases as the gold standard, and the sensitivities, specificities, positive predictive values, negative predictive values, and accuracies of the tested methods were obtained. \u0000 \u0000 \u0000Results \u0000Sixty-two patients were confirmed by X-ray, wherein 55 were successfully catheterized and 7 were ectopic. The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of ultrasound-assisted gas-water injection were 90.9%, 100%, 100%, 58.3%, and 91.9%, respectively, which were all higher than those of traditional gas perfusion auscultation (P<0.05). \u0000 \u0000 \u0000Conclusion \u0000The bedside gastrointestinal ultrasound with gas-water alternate injections for nasointestinal tube positioning in critically ill patients has a certain clinical value. \u0000 \u0000 \u0000Key words: \u0000Intensive care; nasointestinal tube; Ultrasonography; gastrointestinal","PeriodicalId":9877,"journal":{"name":"Chinese Journal of Clinical Nutrition","volume":"26 1","pages":"349-353"},"PeriodicalIF":0.0,"publicationDate":"2018-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42140485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of nasogastric feeding tube placed by endoscopy to give enteral nutrient solution in the pediatric intensive diseases","authors":"Min Lian, R. Wu, Yu Jin","doi":"10.3760/CMA.J.ISSN.1674-635X.2018.06.004","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-635X.2018.06.004","url":null,"abstract":"Objective \u0000To investigate the efficacy and safety of nasogastric feeding tube placed by endoscopy to give enteral nutrient solution in the pediatric intensive diseases. \u0000 \u0000 \u0000Methods \u0000A retrospective analysis of 30 children with serious illness who were given enteral nutrient solution through the nasogastric feeding tube placed by endoscopy from January 2013 to May 2016 in our hospital was conducted including 12 boys and 18 girls aging from 2 months to 14 years with the mean as (6.86±3.44) years old. Catheterization condition including catheter insertion time after hospitalization, catheter maintenance time, hospital stay and retention time after discharge, postoperative complications after catheterization, prognostic indications including anal exhaust and defecation time, blood urine amylase and returning to normal time, and changes of the indicators for nutrition including total protein, albumin, prealbumin, retinol binding protein were analyzed. \u0000 \u0000 \u0000Results \u0000Catheter insertion time after hospitalization was (16.13±10.51) days, catheter maintenance time (21.35±9.62) days, hospitalization time after catheterization (20.10±8.96) days and hospital stay (36.23±14.20) days. 10 cases (33.3%) maintained the catheter for (11.10±4.65) days after the discharge. The anal exhaust time was (2.84±3.32) days and the defecation time (4.55±3.35) days; The urinary amylase significantly deceased three days after catheterization compared with that of one day before catheterization (P=0.047); Serum total protein, albumin, prealbumin and retinol binding protein increased three days after catheterization compared with that of one day before catheterization, but the difference was not statistically significant (P>0.05). 5 children (17%) had complications including 3 children of abdominal distension and 2 children of vomiting. \u0000 \u0000 \u0000Conclusions \u0000Nasogastric feeding tube placed by endoscopy to give enteral nutrient solution in the pediatric intensive diseases can improve the intestinal and pancreatic function, recover their nutritional status to some extent and be controlled safely. However, the waiting time for catheterization and the hospital stay after catheterization are relatively long. The implementation of this technology and the awareness of its safety need be strengthened. \u0000 \u0000 \u0000Key words: \u0000Endoscopy; Nasogastric feeding tube; Enteral nutrition; Children","PeriodicalId":9877,"journal":{"name":"Chinese Journal of Clinical Nutrition","volume":"26 1","pages":"344-348"},"PeriodicalIF":0.0,"publicationDate":"2018-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42871989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects and mechanism of epigallocatechin gallate on white adipose tissue angiogenesis in high fat diet rats","authors":"Jialu Wang, Kudelaiti Maidinayi, Wenjing Tang, Li-ping Lu, R. Xu, Y. Wan","doi":"10.3760/CMA.J.ISSN.1674-635X.2018.06.008","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-635X.2018.06.008","url":null,"abstract":"Objective \u0000To investigate the effects and mechanism of (-)-epigallocatechin-3-gallate (EGCG) on white adipose tissue angiogenesis in high fat diet rats. \u0000 \u0000 \u0000Methods \u0000Twenty-four male weaning SD rats were randomly divided into normal control group, high fat diet group and EGCG intervention group, 8 rats in each group. Normal control group were fed with normal diet, high-fat diet group were fed with high-fat diet, EGCG intervention group were fed with high-fat diet along with intragastric administration of 200 mg/(kg·d) EGCG. After 8 weeks, the rats were sacrificed. The adipocyte size and vascular density of the abdominal adipose tissue in rats in each group were observed under the microscope.The serum vascular endothelial growth factor (VEGF) concentration was detected by Elisa Kit. RT-PCR was used to detect the expression of VEGF, nuclear factor E2 (Nrf2), heme oxygenase-1 (HO-1), catalase (CAT), SOD, GPx, interleukin-6(IL-6) and monocyte chemoattractant protein-1 (MCP-1) mRNA. \u0000 \u0000 \u0000Results \u0000The adipocyte size, number of vascular/each adipocyte, serum VEGF concentration and VEGF mRNA expression in adipose tissue of high fat diet group were significantly higher than those of normal control group (all P<0.05). EGCG can significantly reduce the above indicators of high fat diet group (all P<0.05). The expression of Nrf2, HO-1, SOD, GPx and CAT mRNA in adipose tissue of EGCG group was significantly higher than those in high fat diet group and normal control group (all P<0.05). The expression of MCP-1 and IL-6 mRNA in adipose tissue of EGCG group was significantly lower than that in high fat diet group (all P<0.05). \u0000 \u0000 \u0000Conclusion \u0000EGCG can decrease the production of serum VEGF, vascular density and the expression of VEGF mRNA in white adipose tissue of high fat diet rats, and inhibit the angiogenesis in white adipose tissue possibly due to its up-regulation of Nrf2/HO-1 pathway to increase the expression of antioxidant enzymes (SOD, CAT, GPx), reduce ROS production and decrease the inflammatory response. \u0000 \u0000 \u0000Key words: \u0000(-)-Epigallocatechin-3-gallate; High fat diet; White adipose tissue; Angiogenesis; Vascular endothelial growth factor","PeriodicalId":9877,"journal":{"name":"Chinese Journal of Clinical Nutrition","volume":"26 1","pages":"366-372"},"PeriodicalIF":0.0,"publicationDate":"2018-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47628320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}