中华临床营养杂志最新文献

{"title":"Bibliometric analysis of home enteral nutrition in China","authors":"Lei Shi, J. Gong, Yuan Liu, D. Mu, Xin Liao, Xiaoqing Zeng, Jiajie Yu","doi":"10.3760/CMA.J.ISSN.1674-635X.2019.02.003","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-635X.2019.02.003","url":null,"abstract":"Objective \u0000To analyze the current status of studies related to home enteral nutrition (HEN) in China, and provide scientific basis for the research and management of HEN in China. \u0000 \u0000 \u0000Methods \u0000We searched CNKI and WanFang Data since it built to January 1st, 2018. The included studies were screened and categorized by publication information, study type, subjects of the study, topic, interventions and outcomes. Descriptive analysis was conducted after extraction of information. \u0000 \u0000 \u0000Results \u0000A total of 153 studies were included, of which 37 were observational studies, 102 were experimental studies, 12 were case report, and 2 were exploring articles. Since 2012, the number of studies has been increasing. Most of the subjects were elderly people who were diagnosed with diseases of digestive system, head and neck tumors and diseases of nervous system. These studies were featured as small sample size and short intervention time, follow-ups by telephone and home visit, less than 1/4 providing professional nutrition support team, and outcomes mainly as complication, nutritional biochemical indices, anthropometric indices and prognosis. \u0000 \u0000 \u0000Conclusion \u0000HEN in China is still in its infancy. The number of relative studies is still small and quality of literatures is very low, but it has been increasing. At present, there are some problems in the implementation of HEN in China, such as lack of standardized management model and professional team, short-term intervention, and single follow-up mode. The elderly and patients with digestive disease, head and neck tumors and nervous disease are the key subjects; more professional nutrition support team and scientific management model should be established in the future. \u0000 \u0000 \u0000Key words: \u0000Home enteral nutrition; Bibliometric analysis","PeriodicalId":9877,"journal":{"name":"Chinese Journal of Clinical Nutrition","volume":"27 1","pages":"76-83"},"PeriodicalIF":0.0,"publicationDate":"2019-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43491042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitamin B12 status of vegetarians in Shanghai","authors":"Xueying Cui, Bian Wang, Youmei Wu, Luyao Xie, Q. Tang","doi":"10.3760/CMA.J.ISSN.1674-635X.2019.02.008","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-635X.2019.02.008","url":null,"abstract":"Objective \u0000To investigate the vitamin B12 status of vegetarians in Shanghai. \u0000 \u0000 \u0000Methods \u0000A total of 282 adult vegetarians and 282 omnivores matching by gender and age were recruited in Shanghai. Their dietary intakes were collected. The serum concentrations of vitamin B12, folate and homocysteine were tested. The red blood cell, hematocrit value, mean corpuscular volume and mean erythrocyte width were also examined. \u0000 \u0000 \u0000Results \u0000The daily average intake of dietary vitamin B12 was(0.46±1.01) μg/d in vegetarians and only (0.1±0.46) μg/d in vegans, which was lower than that of omnivores [(3.91±6.92)μg/d, F=50.57, P<0.01] . 137 omnivores and 274 vegetarians had less dietary vitamin B12 level than recommended nutrient intake (RNI) and the difference was statistically significant (χ2=114.77, P<0.01). 54.26% of vegetarians, 68.92% vegans, 49.04% ovo-lacto vegetarians and 15.60% omnivores had hyperhomocysteinemia and the differences between vegetarians and omnivores were statistically significant (all P<0.01). After adjusting the confounding factors the hematocrit value was higher in vegetarians, vegans and ovo-lacto vegetarians than in omnivores(27.42%±18.32%, 28.73%±18.19%, 26.95%±18.38% vs. 8.96%±16.59%, P<0.01). Vegans had lower red blood cell counts and higher hematocrit value and mean corpuscular volume than omnivores. \u0000 \u0000 \u0000Conclusion \u0000Vitamin B12 deficiency combined with an elevated level of homocysteine and red blood cell volume growth are common but serious issue in vegetarians, especially in vegans. \u0000 \u0000 \u0000Key words: \u0000Vegetarian; Vitamin B12; Red blood cell; Homocysteine; Folate","PeriodicalId":9877,"journal":{"name":"Chinese Journal of Clinical Nutrition","volume":"27 1","pages":"107-112"},"PeriodicalIF":0.0,"publicationDate":"2019-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49133679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of nutrition intake method with adaptive viscosity on nutritional status of laryngeal cancer patients with dysphagia after surgery and radiotherapy","authors":"Lei Yu, F. Fang","doi":"10.3760/CMA.J.ISSN.1674-635X.2019.02.009","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-635X.2019.02.009","url":null,"abstract":"Objective \u0000To investigate the effect of nutrition intake method with adaptive viscosity on nutritional status of laryngeal cancer patients with dysphagia after surgery and radiotherapy (RT). \u0000 \u0000 \u0000Methods \u000077 laryngeal carcinoma patients with dysphagia after surgery and radiotherapy were divided randomly into two groups by a random number table as study group (SG, n=39) and control group (CG, n=38). The CG received routine diet instruction and swallowing training, while the SG received oral nutritional supplementation with adaptive viscosity in additon. The body weight, body mass index (BMI), hemoglobin, albumin, prealbumin and scores of nutritional status at the end and 3 months after RT were compared between the two groups. \u0000 \u0000 \u0000Results \u0000There were 34 patients (87.2%) and 32 patients (84.2%) with nutritional status scores more than or equal to 2 at the end of RT in the two groups. At 3 months after RT, the body weight, BMI, hemoglobin, albumin, prealbumin, daily intake and nutritional status scores in the study group were significantly higher than those at the end of RT and those in the control group [(61.28±11.16) vs. (51.82±7.36), (56.44±10.69)kg; (20.57±6.13) vs. (18.81±4.43), (19.47±5.36)kg/m2; (134.87±17.86) vs. (114.68±15.25), (123.58±19.34)g/L; (40.74±7.54) vs. (36.77±5.27), (37.94±8.47)g/L; (312.83±35.83) vs. (271.56±32.82), (290.73±41.38)g/L; (2 047±126) vs. (1 512±143), (1 589±138)kcal; (2.36±0.93) vs. (3.70±1.80), (3.14±1.26); P all<0.05]. The level of the body weight and hemoglobin in the control group at 3 months after RT were significantly higher than those at end of RT [(56.44±10.69) vs. (51.56±8.34)kg, P=0.025; (123.58±19.34) vs. (113.36±16.56)g/L, P=0.023]. During 3 months, the rate of pulmonary infection was 1 (2.5%) in the study group and 6 (15.8%) in the control group and the difference was statistically significant (χ2=4.073, P=0.044). \u0000 \u0000 \u0000Conclusion \u0000Nutrition intake method with adaptive viscosity can effectively improve the nutritional status of laryngeal cancer patients with dysphagia after surgery and radiotherapy and reduce the infection rate of lung. \u0000 \u0000 \u0000Key words: \u0000Laryngeal neoplasm; Dysphagia; Nutrition intake method; Viscosity; Nutritional status","PeriodicalId":9877,"journal":{"name":"Chinese Journal of Clinical Nutrition","volume":"27 1","pages":"113-117"},"PeriodicalIF":0.0,"publicationDate":"2019-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44124140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of data normalization in the analysis and screening of the nutritional status and malnutrition risks in pediatric patients with acute lymphoblastic leukemia","authors":"Xiu-ling Yang, Jie Yan, Changlu Pan, Wenli Zhao","doi":"10.3760/CMA.J.ISSN.1674-635X.2019.02.006","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-635X.2019.02.006","url":null,"abstract":"Objective \u0000To evaluate the nutrional status and malnutrition risks of hospitalized children with acute lymphoblastic leukemia (ALL), provide nutrition support for subsequent treatment, lower nutritional risks and improve therapeutic effects; to complete the statistical analysis of height and weight across age through data normalization. \u0000 \u0000 \u0000Methods \u0000A total of 592 children diagnosed ALL from August 2014 to September 2016 at Beijing Children's Hospital were enrolled, and the directly measured height and weight which reflected the nutritional status of children were collected and normalized. Nutritional risk screening was completed by STAMP screening tool and the nutritional status was evaluated by three Z scores HAZ<-2, WAZ<-2 and WHZ<-2. The effects of nutrition intervention were investigated by weight, hemoglobin and albumin changes between before and after L-asp treatment. \u0000 \u0000 \u0000Results \u0000The Z score test showed that there was no significant difference between the nutritional status of pretreatment ALL patients(0.34% growth retardation, 2.36% lower body weight, 0.17% emaciation) and normal healthy children (3% malnutrition); after comparing the STAMP nutritional risk assessment and t test results for children with ALL, it was found that the proportion of children with high malnutrition risk ( score≥4 ) was 9.71%, which had a strong correlation with body mass index; the children with body mass index less than 0.80(50% children having malnutrition) or greater than 1.30(20% children having malnutrition) had a higher risk of malnutrition, and the body mass indexof the high-risk group(0.852 kg/m2) were significantly lower than that of the low risk group(1.051 kg/m2, score≤3 ); there were significant differences in height and weight between children with STAMP≤3 and STAMP≥4 (all P<0.05) Nutritional interventions made no significant weight change during treatment; For children with STAMP≤3 and STAMP≥4 in L-asp treatment, the hemoglobin value changed from (87.46±19.27)g/L to (95.12±13.51)g/L and (101.55±21.97)g/L to (95.05±11.22)g/L respectively (all P=0.001); The albumin of children with STAMP≤3 changed from (40.63±4.149)g/L to (41.20±5.266)g/L in treatment and that of children with STAMP≥4 changed from (40.96±8.429)g/L to (42.17±3.574)g/L in treatment(P=0.20, 0.05). \u0000 \u0000 \u0000Conclusion \u0000There are no obvious indications of malnutrition in children with ALL, but nearly 10 % of them have malnutrition risks. Special dietary guidance is needed during the treatment. Nutrition intervention is effective in the treatment of L-asp. Normalized data is more convenient to use in statistical analysis with more accurate results, which can be used as a supplementary method for cross-age group statistical analysis of children's height, weight and other parameters. \u0000 \u0000 \u0000Key words: \u0000Malnutrition; Risk screening; Evaluation; Data normalization","PeriodicalId":9877,"journal":{"name":"Chinese Journal of Clinical Nutrition","volume":"27 1","pages":"96-100"},"PeriodicalIF":0.0,"publicationDate":"2019-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42735500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroprotective effect of glutamine supplementation by inhibiting oxidative stress and promoting autophagy responses after traumatic brain injury in rats","authors":"Shukai Wu, Xiangrong Chen, Yasong Li, L. Luo","doi":"10.3760/CMA.J.ISSN.1674-635X.2019.02.004","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-635X.2019.02.004","url":null,"abstract":"Objective \u0000To investigate the effects and mechanisms of glutamine(Gln) supplementation on oxidative stress, autophagy response and neurobehavioral outcome after traumatic brain injury (TBI) in rats. \u0000 \u0000 \u0000Methods \u0000TBI animal models were established using Feeney's method. Eighty SD rats were randomly divided into 4 groups: sham operation group (group Sham), Sham + glutamine supplementation group (group Sham+ GLN), traumatic brain injury group (group TBI), and TBI + glutamine supplementation group (group TBI+ GLN). We measured rat behavioral outcomes by modified neurologic severity score (mNSS) tests at day 1, 3, 7 and 14 after TBI. The apoptosis neurons in TBI cerebral cortex were determined by TUNEL staining. The expression of reactive oxygen species (ROS) was tested by ROS kits. Oxidative stress and autophagy related cytokines (HO-1, NQO1, Nrf2, LC3-Ⅱ and Beclin-1) were tested with Western blotting. \u0000 \u0000 \u0000Results \u0000Compared with the TBI group, the neurological function was improved[(9.79±0.43)vs.(8.43±0.30), F=6.775, P=0.010] and the apoptosis rate decreased(19.88% ±1.60% vs. 15.35% ±1.28%, P=0.013) in the TBI+ GLN group after 7-day treatment. Compared with the Sham group, the protein expression of ROS increased(P=0.000), and the expression of anti-oxidative stress factors (HO-1, NQO1) and Nrf2 pathway significantly decreased in the TBI group. After glutamine supplementation was given, the expression of ROS decreased and the expressions of HO-1 and NQO1 increased. The Nrf2 pathway and autophagy response also were activated with the expressions of Nrf2, LC3-Ⅱ and Beclin-1 increasing. \u0000 \u0000 \u0000Conclusion \u0000Glutamine supplementation can markedly reduce neuron apoptosis and improve neurological outcomes after TBI, thus has the protective effect on nerves by inhibiting TBI-induced oxidative stress response, activating Nrf2 pathway and autophagy response. \u0000 \u0000 \u0000Key words: \u0000Traumatic brain injury; Glutamine; Oxidative stress; Nrf2 pathway; Autophagy","PeriodicalId":9877,"journal":{"name":"Chinese Journal of Clinical Nutrition","volume":"27 1","pages":"84-89"},"PeriodicalIF":0.0,"publicationDate":"2019-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45445832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of branched chain amino acid on apoptosis of neurons after focal cerebral ischemia in rats","authors":"F. Yan, Peng Sun, Huishou Zhao, Chong Huang, Xiong Guo, Xiaomeng Zhang","doi":"10.3760/CMA.J.ISSN.1674-635X.2019.02.010","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-635X.2019.02.010","url":null,"abstract":"Objective \u0000To investigate the regulatory effect of branched chain amino acids(BCAA) on the expression of apoptosis related proteins after cerebral ischemia reperfusion injury and the protective effects of BCAA on ischemic brain injury in rats. \u0000 \u0000 \u0000Methods \u000040 male SD rats were randomly divided into normal diet group(n=20)and branched chain amino acid (BCAA) group(n=20)according to the random number table, and each group was randomly divided into control group (n=6), sham operation group (n=6) and model group (n=8) which used suture method to make ischemia reperfusion model. After modeling, modified Neurological Severity Scores (mNSS) was used to access the neurological impairment degree of 2, 6, 24, 48 and 72 h in each group. The expression of apoptosis related proteins (Cleaved, Bax/Bcl-2) after 72 h was detected by the method of immune protein imprinting (Caspase3) and compared between normal diet group and BCAA group. \u0000 \u0000 \u0000Results \u0000Compared with the normal diet rats, the mNSS of BCAA diet rats after modeling at 2, 6, 24, 48, 72 h decreased(11.35±2.78 vs. 7.15±2.41, P=0.019; 9.35±1.75 vs. 5.82±1.17, P=0.002; 6.11±1.16 vs. 4.39±1.46, P=0.048; 5.87±1.32 vs. 3.55±1.94, P=0.036; 4.98±2.24 vs. 2.09±1.33, P=0.022). The expression of cleaved caspase3 protein and the ratio of Bax/Bcl-2 decreased in BCAA group. \u0000 \u0000 \u0000Conclusion \u0000BCAA can alleviate the apoptosis of rats after ischemia and reperfusion, reduce the damage of nerve function, and has a positive protective effect on ischemic brain injury. \u0000 \u0000 \u0000Key words: \u0000Branched chain amino acid; Cerebral ischemia reperfusion; Apoptosis","PeriodicalId":9877,"journal":{"name":"Chinese Journal of Clinical Nutrition","volume":"27 1","pages":"118-122"},"PeriodicalIF":0.0,"publicationDate":"2019-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45775698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A multicenter survey on changes in nutritional risk and malnutrition incidence of elderly patients in Chinese large hospitals during hospitalization","authors":"Jie Pan, H. Cui, Mingwei Zhu, Wei Chen, Xin Yang, Pian-hong Zhang, X. Liang, Jianqin Sun, Yan Shi, Hong-yu Zhang, Ya-Jie Gao, Sai-nan Zhu","doi":"10.3760/CMA.J.ISSN.1674-635X.2019.02.001","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-635X.2019.02.001","url":null,"abstract":"Objective \u0000To investigate the change of the nutritional status of elderly patients in Chinese major hospitals dynamically with nutritional risk screening 2002 (NRS 2002) and subjective global assessment (SGA) during hospitalization. \u0000 \u0000 \u0000Methods \u0000A prospective, multi-center survey was conducted on over 65 years old patients who were admitted in departments of gastroenterology, respiratory medicine, general surgery, geriatrics, thoracic surgery, neurology, orthopedics and medical oncology of 9 large hospitals in China for 7-30 days between June 2014 and September 2014. On admission and within 24 hours after discharge, the clinical data were recorded, physical indices were measured, and laboratory examination were conducted. NRS 2002 and SGA were used to make an evaluation. The nutritional supports and clinical outcomes were also recorded and then the correlation between nutritional status and clinical outcomes were analyzed. \u0000 \u0000 \u0000Results \u0000A total of 2558 patients above 65 years old were included into the study. Compared with their status on admission, their grip strength, upper arm circumference and crural circumference were reduced significantly at discharge (P<0.05). The total protein, albumin and hemoglobin levels were significantly lower than those on admission (P<0.05). The incidence of nutritional risk (NRS 2002 score≥3)and malnutrition (SGA B+ C) on admission were lower than those at discharge (51.1% vs 53.0%, 32.6% vs 35.6%). The hospitalization time and medical expenses were higher in patients with malnutrition on admission than in those with normal nutrition intakes. The nutritional status at discharge was negatively correlated with hospitalization time and medical expenses. 61.3% patients having nutritional risk did not take nutritional support during the hospital stay, while utilization rate of parenteral nutrition was higher than that of enteral nutrition in patients receiving nutritional support (19.6% vs 11.9%). \u0000 \u0000 \u0000Conclusion \u0000Elderly patients have higher possibilities of facing nutritional risk or malnutrition on admission, these are associated with poor clinical outcomes and their nutritional status will not improve significantly at discharge. Therefore, the screening and evaluation of nutritional status in elderly patients during hospitalization should be conducted and their nutritional intervention should be standardized so as to improve the clinical outcomes. \u0000 \u0000 \u0000Key words: \u0000Elderly patients; Dynamic nutrition survey; Nutritional status of discharged patients; Nutritional risk screening; Subjective global assessment; Length of hospital stay; Medical expenses","PeriodicalId":9877,"journal":{"name":"Chinese Journal of Clinical Nutrition","volume":"27 1","pages":"65-69"},"PeriodicalIF":0.0,"publicationDate":"2019-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43110703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protection effect of Lactobacillus rhamnosus GG supplied in early life on intestinal barrier in offspring","authors":"Ge Jin, Xiang Liu, Runxiang Xie, Zixuan Guo, Yue Sun, Tianyu Liu, Bangmao Wang","doi":"10.3760/CMA.J.ISSN.1674-635X.2019.02.007","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-635X.2019.02.007","url":null,"abstract":"Objective \u0000To investigate the effects of Lactobacillus rhamnosus GG (LGG) colonization in early life on intestinal barrier and intestinal development in offspring mice and its possible mechanism. \u0000 \u0000 \u0000Methods \u0000Six C57BL/6 pregnant mice with the same conception time of 6 weeks were selected and randomly divided into experiment group given 108 cfu/ml LGG live bacteria and control group given LGG inactivated bacteria by gavage from the 18th day of pregnancy until natural birth. The progeny mice in the two groups were continued to be gavaged with 107 cfu/ml of LGG live bacteria or LGG inactivated bacteria on days 1-5 of birth. The body weight changes of 3 week'progeny mice were recorded. The colonization of LGG bacteria in offspring mice was detected at 2nd and 3rd weeks. The mRNA of intestinal proinflammatory cytokines and tight junction molecules were evaluated by real-time PCR method. HE, immunohistochemistry, immunofluorescence staining and enzyme-linked immunosorbent assay were used to evaluate the intestinal barrier of 3-week old off spring mice. \u0000 \u0000 \u0000Results \u0000Compared with the control group, the progeny mice of the experiment group showed no significant difference in body weight at the first week, and the body weight increased at the second week and the third week [2nd week: (3.790±0.240)g vs.(4.326±0.140)g, t=3.707, P=0.006; 3rd week: (7.295±0.326)g vs. (8.040±0.370)g, t=3.130, P=0.011]. LGG colonization can be detected only in the feces of progeny mice in the experiment group. Intestinal colonization can promote the growth of small intestine villi and colon crypt depth[jejunum: (320.000±22.514)μm vs.(265.100±15.611)μm, t=8.258, P<0.001; ileum: (150.500±13.099)μm vs.(111.000±11.308)μm, t=9.958, P<0.001; colon: (295.000±15.209)μm vs.(233.100±6.678)μm, t=9.129, P<0.001]. Compared with the control group, the number of goblet cells in the colonic crypt of the experiment group increased(11.62±0.780 vs. 35.24 ±1.370, t=15.000, P<0.001), and the relative mRNA expression levels of pro-inflammatory factors as IFN-γ (1.280±0.232 vs. 0.512±0.206, t=4.970, P=0.001), IL-6(1.364±0.271 vs. 0.941±0.215, t=2.452, P=0.040), IL-10(1.341±0.320 vs. 0.744±0.294, t=2.762, P=0.025) and TNF-α(3.702±0.150 vs. 2.581±0.500, t=2.553, P=0.034) in the experiment group decreased; the expression levels of the intimate tight junction molecules (Claudin3)(1.283±0.152 vs. 1.881±0.172, t=4.932, P=0.001)and the atresia protein molecule (Occludin)( 1.164±0.342 vs. 0.812±0.224, t=3.67, P=0.016) significantly increased. \u0000 \u0000 \u0000Conclusion \u0000Early life LGG colonization protects the intestinal barrier by inhibiting low-grade intestinal inflammation. This study will lay the experimental foundation for the supplementation of probiotics in early life so as to prevent intestinal diseases. \u0000 \u0000 \u0000Key words: \u0000Early life; Lactobacillus rhamnosus GG; Low-grade inflammation; Intestinal barrier","PeriodicalId":9877,"journal":{"name":"Chinese Journal of Clinical Nutrition","volume":"27 1","pages":"101-106"},"PeriodicalIF":0.0,"publicationDate":"2019-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43501507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Explanation and analysis on GLIM consensus (2018) for malnutrition assessment (diagnosis)","authors":"Jian Yang, Zhuming Jiang, Kang Yu","doi":"10.3760/CMA.J.ISSN.1674-635X.2019.01.001","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-635X.2019.01.001","url":null,"abstract":"The criteria for malnutrition assessment (diagnosis) have been developed for years. Global Leadership Initiative on Malnutrition (GLIM) criteria for the diagnosis of malnutrition was issued in September 2018, which aims to build a global consensus around core diagnostic criteria for adult malnutrition in clinical settings. In this article, GLIM malnutrition assessment (diagnosis) consensus was reviewed and analyzed. \u0000 \u0000 \u0000Key words: \u0000Malnutrition; Nutritional screening; Nutritional risk screening; Nutrition support therapy","PeriodicalId":9877,"journal":{"name":"Chinese Journal of Clinical Nutrition","volume":"27 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2019-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47081273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fish oil fat emulsion nutritional support in the treatment of liver cirrhosis and portal hypertension in patients with pericardial devascularization with splenectomy: A randomized clinical trial","authors":"Ma Liya, Yue-ming He, Liu Quanyan, Zhang Zhonglin, Pan Dingyu, Yuan Yufeng, Liu Zhi-su","doi":"10.3760/CMA.J.ISSN.1674-635X.2019.01.003","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-635X.2019.01.003","url":null,"abstract":"Objective \u0000To explore the effect of fish oil fat emulsion as perioperative nutritional support on patients with liver cirrhosis and portal hypertension. \u0000 \u0000 \u0000Methods \u0000Randomized controlled clinical trial was performed between September 2011 and September 2017 in patients with liver cirrhosis and portal hypertension who underwent pericardial devascularization and splenectomy. Hypocaloric total parenteral nutritional support (TPN) started from the first day after the operation for 5 consecutive days. Patients were divided into experimental group and control group according to the type of fat emulsion used. 43 patients in experimental group were applied for fish oil fat emulsion injection (10% Omegaven) + medium long chain structure fat emulsion (20% STG) and 42 patients in control group were applied for medium long chain structure fat emulsion(20%STG). Liver function (total bilirubin and alanine aminotransferase), nutrition index (serum albumin and prealbumin), inflammatory mediators (TNF-ɑ, IL-6 and IL-10) were measured before and after the operation, and the clinical outcomes were observed. \u0000 \u0000 \u0000Results \u0000There was no statistically significant difference in liver function and nutritional indices between the experimental group and the control group (P>0.05). The inflammatory mediators like TNF-ɑ, IL-6 and IL-10 on the first day after surgery were significantly higher than those before surgery in both groups [experiment group: (225.54±54.78)vs.(61.49±16.47), (74.94±6.36)vs. (39.84±2.77), (77.53±11.4) vs. (46.05±6.13)ng/L ; control group: (229.26±62.15)vs.(63.48±13.76), (77.23±7.83) vs.(40.64±3.34), (73.89±7.97)vs.(44.88±5.72)ng/L ; P< 0.01]. With the progress of time, the proinflammatory factors like TNF-ɑ and IL-6 decreased after the operation and the range of decrease was higher in experiment group than in control group[d4-d1: (-56.88±31.63)vs.(-35.96±20.02), (-13.52±5.20)vs.(-6.38±2.84)ng/L; d7-d1: (-150.67±42.58)vs.(-132.79±53.35), (-27.04±8.97)vs.(-20.85±6.38)ng/L; P< 0.05]. The range of increase in anti-inflammatory media IL-10 was higher in experiment group than in the control group(d4-d1: (14.22±13.08)vs. (5.64±3.58)ng/L ; d7-d1: (17.78±5.58)vs. (-37.96±11.43)ng/L ; P<0.05). The incidence of grade Ⅲ complications and total complications (4.7% vs. 21.4%, 23.3% vs. 45.2%) and hospitalization time [(10.12 ±1.48) vs. (12.33±2.04) d] in the experimental group were significantly lower than those in the control group (P<0. 05). \u0000 \u0000 \u0000Conclusions \u0000In patients with liver cirrhosis and portal hypertension, perioperative nutritional support of fish oil fat emulsion can reduce systemic inflammatory response and operative complications and promote rapid recovery through its two-way regulation of inflammatory mediators. \u0000 \u0000 \u0000Key words: \u0000Fish oil fat emulsion; Inflammation mediators; Liver cirrhosis; Portal hypertension; Perioperative nutritional support","PeriodicalId":9877,"journal":{"name":"Chinese Journal of Clinical Nutrition","volume":"27 1","pages":"11-17"},"PeriodicalIF":0.0,"publicationDate":"2019-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46891338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}