A systemic review on efficacy and safety of multi-oil fat emulsion injection in premature infant parenteral nutrition support based on the meta-analysis

Q4 Nursing

中华临床营养杂志 Pub Date : 2018-12-30 DOI:10.3760/CMA.J.ISSN.1674-635X.2018.06.006

Tian Zhang, Xueyang Wang, Q. Ni, Yi Ren

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Abstract

Objective To systemically analyze the efficacy and safety of multi-oil fat emulsion injection (SMOF) in the premature infant parenteral nutrition support. Methods Databases including EMbase, PubMed, Cochrane Library, CNKI, VIP and Wanfang, were searched from libraries establishment to November 2017 for randomized controlled trials (RCTs) focusing on the efficacy and safety of SMOF in the premature infant parenteral nutrition support. All the literatures were retrieved and screened according to inclusion and exclusion criteria by two researchers. The software RevMan 5.3 was used for meta-analysis after the evaluation of methodology of quality. Results A total of 7 articles including 7 RCTs were enrolled. Meta-analysis showed that there were no significant differences in body length (OR=-0.25, 95% CI=-1.80-1.30, P=0.75), weight(OR=-0.12, 95% CI=-0.20-0.04, P=0.14), head circumference(OR=0.07, 95% CI=-0.83-0.96, P=0.88), low-density lipoprotein, high-density lipoprotein, direct bilirubin, serum creatinine(OR=-0.16, 95% CI=-0.59-0.26, P=0.45) between the infants receiving SMOF or Intralipid. But compared with the infants receiving Intralipid, hemoglobin(OR=-0.75, 95% CI=-1.49-0.00, P=0.05), red blood cells(OR=-0.23, 95% CI=-0.45-0.00, P=0.05) decreased in the infants receiving SMOF, and white blood cells(OR=1.91, 95% CI=0.46-3.37, P=0.01) increased. Conclusions SMOF can control the hemoglobin content in serum, reduce the risk and degree of jaundice in premature infant, with better safety. Key words: Multi-oil fat emulsion injection; Premature infant; Meta-analysis; Randomized controlled trials; Efficacy; Safety

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基于荟萃分析的多油脂肪乳注射液用于早产儿肠外营养支持的疗效和安全性系统评价

目的系统分析多油脂肪乳注射液（SMOF）用于早产儿肠外营养支持的有效性和安全性。方法检索EMbase、PubMed、Cochrane Library、CNKI、VIP和万方等数据库，从图书馆建立到2017年11月，对SMOF在早产儿肠外营养支持中的疗效和安全性进行随机对照试验。所有文献均由两名研究人员根据纳入和排除标准进行检索和筛选。在对质量方法进行评估后，使用RevMan 5.3软件进行荟萃分析。结果共纳入7篇文章，包括7篇随机对照试验。荟萃分析显示，接受SMOF或Intralipid治疗的婴儿在体长（OR=0.25，95%CI=1.80-1.30，P=0.075）、体重（OR=0.12，95%CI=0.20-0.04，P=0.014）、头围（OR=0.07，95%CI=0.83-0.96，P=0.88）、低密度脂蛋白、高密度脂蛋白，直接胆红素、血清肌酐（OR=0.16，95%CI=0.59-0.26，P=0.45）方面无显著差异。但与接受Intralipid治疗的婴儿相比，接受SMOF治疗的婴儿血红蛋白（OR=0.75，95%CI=1.49-0.00，P=0.05）、红细胞（OR=0.23，95%CI=0.45-0.00，P=0.05）减少，白细胞（OR=1.91，95%CI0.46-3.37，P=0.01）增加。结论SMOF能有效控制血清血红蛋白含量，降低早产儿黄疸的风险和程度，安全性较好。关键词：多油脂肪乳注射液；早产儿；荟萃分析；随机对照试验；功效；安全

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来源期刊

中华临床营养杂志 Nursing-Nutrition and Dietetics

CiteScore

0.20

自引率

0.00%

发文量

2282

期刊介绍： The Chinese Journal of Clinical Nutrition was founded in 1993. It is the first professional academic journal (bimonthly) in my country co-sponsored by the Chinese Medical Association and the Chinese Academy of Medical Sciences to disseminate information on clinical nutrition support, nutrient metabolism, the impact of nutrition support on outcomes and "cost-effectiveness", as well as translational medicine and nutrition research. It is also a professional journal of the Chinese Medical Association's Parenteral and Enteral Nutrition Branch. The purpose of the Chinese Journal of Clinical Nutrition is to promote the rapid dissemination of knowledge on nutrient metabolism and the rational application of parenteral and enteral nutrition, focusing on the combination of multidisciplinary and multi-regional field investigations and clinical research. It mainly reports on nutritional risk screening related to the indications of parenteral and enteral nutrition support, "cost-effectiveness" research on nutritional drugs, consensus on clinical nutrition, guidelines, expert reviews, randomized controlled studies, cohort studies, glycoprotein and other nutrient metabolism research, systematic evaluation of clinical research, evidence-based case reports, special reviews, case reports and clinical experience exchanges, etc., and has a special column on new technologies related to the field of clinical nutrition and their clinical applications.