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News in WHO 2021 classification of tumours of the central nervous system. 世卫组织《2021年中枢神经系统肿瘤分类》新闻。
Ceskoslovenska patologie Pub Date : 2022-01-01
Tomáš Jirásek, Lenka Krsková, Iva Dolinová, Marián Švajdler, Aleš Vícha, Markéta Hermanová, Josef Zámečník
{"title":"News in WHO 2021 classification of tumours of the central nervous system.","authors":"Tomáš Jirásek,&nbsp;Lenka Krsková,&nbsp;Iva Dolinová,&nbsp;Marián Švajdler,&nbsp;Aleš Vícha,&nbsp;Markéta Hermanová,&nbsp;Josef Zámečník","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The aim of the presented communication is to clearly inform the general professional public about the newly approved modifications in this classification, including the newly approved types of tumours. A significant change is the new grading system for these tumours, including the innovative involvement of tumour profiling at the molecular level in the system for determining the degree of tumour differentiation and the application of the principle of integrated diagnostics, i. e. the synthesis of available histopathological and molecular findings in CNS tumors.</p>","PeriodicalId":9861,"journal":{"name":"Ceskoslovenska patologie","volume":"58 3","pages":"126-134"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33501316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cystic trophoblastic tumour of the testis: Case report. 睾丸囊性滋养细胞瘤1例。
Ceskoslovenska patologie Pub Date : 2022-01-01
Karol Kajo, Ján Benko, Katarína Kajová Macháleková, Miroslava Vallová, Dalibor Ondruš
{"title":"Cystic trophoblastic tumour of the testis: Case report.","authors":"Karol Kajo,&nbsp;Ján Benko,&nbsp;Katarína Kajová Macháleková,&nbsp;Miroslava Vallová,&nbsp;Dalibor Ondruš","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Cystic trophoblastic tumor (CTT) is a rare non-aggressive germinative neoplasm from the group of non-choriocarcinomatous trophoblastic tumors, which is presented by cystic spaces lined with mononuclear degenerative-looking trophoblastic cells. CTT has been most often described as a residual disease in dissected retroperitoneal lymph nodes of patients with metastatic germ cell testicular tumours after chemotherapy. There were published only sporadic cases of primary testicular mixed germ cell tumour with CTT component. Hereby, the authors present a case of a 22-year-old man with a mixed germ cell tumour composed of postpubertal teratoma, embryonal carcinoma and CTT. Immunohistochemically, the CTT tumour cells were positive for cytokeratins (AE1/AE3, CK8/18), GATA3, p63 and focally also for beta-hCG and alpha-inhibin. CTT may be presented as a rare component of primary testicular mixed germ cell tumour and it represents very likely an evolutionary intermediate stage of transition from choriocarcinoma into teratoma during the process of regression.</p>","PeriodicalId":9861,"journal":{"name":"Ceskoslovenska patologie","volume":"67 4","pages":"212-216"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10344381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Is obesity a risk factor for coronary atherosclerosis? 肥胖是冠状动脉粥样硬化的危险因素吗?
Ceskoslovenska patologie Pub Date : 2022-01-01
Ivo Šteiner, Lukáš Krbal
{"title":"Is obesity a risk factor for coronary atherosclerosis?","authors":"Ivo Šteiner,&nbsp;Lukáš Krbal","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A group of 279 adult autopsy patients (66 obese with BMI 30, versus 213 nonobese with BMI &lt; 30) was retrospectively studied for the relation between body weight and coronary artery atherosclerosis. In the obese group, there was slightly higher grade of coronary narrowing than in the nonobese (2.31/2.5 versus 2.12/2). With increasing BMI in the obese, there was a statistically significant trend for milder coronary atherosclerosis, with least involvement in the extremely obese (BMI &gt; 50). It seems that increased body weight by itself has little impact on coronary atherosclerosis, and extreme obesity may even by protective from it.</p>","PeriodicalId":9861,"journal":{"name":"Ceskoslovenska patologie","volume":"58 2","pages":"112-114"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40556051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Next generation sequencing - a science tool or routine pathology? 下一代测序——科学工具还是常规病理学?
Ceskoslovenska patologie Pub Date : 2021-01-01
Lenka Krsková, Markéta Kalinová, Tereza Němečková, Barbora Šípalová, Marcela Mrhalová, Miroslav Koblížek, Jan Balko, Jaromír Háček, Daniela Nováková-Kodetová, Aleš Vícha, Petr Brož, Michal Zápotocký, Edita Kabíčková, Josef Zámečník
{"title":"Next generation sequencing - a science tool or routine pathology?","authors":"Lenka Krsková,&nbsp;Markéta Kalinová,&nbsp;Tereza Němečková,&nbsp;Barbora Šípalová,&nbsp;Marcela Mrhalová,&nbsp;Miroslav Koblížek,&nbsp;Jan Balko,&nbsp;Jaromír Háček,&nbsp;Daniela Nováková-Kodetová,&nbsp;Aleš Vícha,&nbsp;Petr Brož,&nbsp;Michal Zápotocký,&nbsp;Edita Kabíčková,&nbsp;Josef Zámečník","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Molecular assays for translocation detection in different tumors have gradually been incorporated into routine diagnostics. However, conventional methods such as fluorescence in situ hybridization (FISH) and reverse transcriptase-PCR come with several drawbacks. Next-generation sequencing (NGS) can provide in-depth detection of numerous gene alterations. The anchored multiplex PCR assay proved to be a fast and easy-to-analyze approach for routine diagnostics laboratories. Next-generation sequencing-based anchored multiplex PCR technique (Archer FusionPlex Panels) is beneficial in both diagnosis for patient care and in identification of a novel fusion breakpoint in tumors. NGS is useful in identifying targetable molecular changes (point mutations, fusion genes, etc.) in tumors that can serve as a rationale for inclusion of patients with advanced disease in ongoing clinical trials and allow for better risk stratification.</p>","PeriodicalId":9861,"journal":{"name":"Ceskoslovenska patologie","volume":"57 3","pages":"136-143"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39439267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An update on immunohistochemical and molecular genetic markers of selected soft tissue tumors. 软组织肿瘤免疫组织化学和分子遗传标记研究进展。
Ceskoslovenska patologie Pub Date : 2021-01-01
Michael Michal
{"title":"An update on immunohistochemical and molecular genetic markers of selected soft tissue tumors.","authors":"Michael Michal","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Recent years have brought an immense increase of knowledge regarding the molecular genetic background of mesenchymal tumors which in turn has significantly expanded the repertoire of molecular markers available for the routine diagnostic practice. This progress has also been followed by a rising number of available immunohistochemical markers useful for the diagnosis of soft tissue neoplasia. Both lineage specific and tumor-specific immunohistochemical antibodies have been discovered and subsequently tested in the surgical pathology practice. This article will review some of the immunohistochemical and molecular genetic markers useful in the diagnosis of vascular tumors, malignant peripheral nerve sheath tumors, low-grade fibromyxoid sarcomas/sclerosing epithelioid fibrosarcomas, solitary fibrous tumors, epithelioid sarcomas, rhabdomyosarcomas and other lesions showing skeletal muscle differentiation. The immunohistochemical and molecular genetic features of some recently characterized and clinically particularly important entities will be discussed as well.</p>","PeriodicalId":9861,"journal":{"name":"Ceskoslovenska patologie","volume":"57 1","pages":"19-29"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38837873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Consensus recommendations from the Czech Head and Neck Cancer Cooperative Group (2019): definition of surgical margins status, neck dissection reporting, and HPV/p16 status assessment. 捷克头颈癌合作小组(2019)的共识建议:手术边缘状态的定义、颈部解剖报告和HPV/p16状态评估。
Ceskoslovenska patologie Pub Date : 2021-01-01
Milan Vošmik, Jan Klozar, Jan Laco, Česká Kooperativní Skupina Pro Nádory Hlavy, Krku
{"title":"Consensus recommendations from the Czech Head and Neck Cancer Cooperative Group (2019): definition of surgical margins status, neck dissection reporting, and HPV/p16 status assessment.","authors":"Milan Vošmik,&nbsp;Jan Klozar,&nbsp;Jan Laco,&nbsp;Česká Kooperativní Skupina Pro Nádory Hlavy,&nbsp;Krku","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The Czech Head and Neck Cancer Cooperative Group (CHNCCG) held a meeting in Tabor on 11-12 October 2019 with the aim of reaching an interdisciplinary consensus on some controversial points where international unity is absent. The meeting resulted in recommendations on resection margin size terminology (definition of terms: negative margin, close margin and positive margin) and on the adoption of terminology for neck dissections reporting according to the International Recommendation of the International Head and Neck Scientific Group and on assessment of HPV/p16 status in head and neck tumors.</p>","PeriodicalId":9861,"journal":{"name":"Ceskoslovenska patologie","volume":"57 1","pages":"53-56"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38850686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Placental mesenchymal dysplasia - morphology and differential diagnosis. 胎盘间充质发育不良-形态学和鉴别诊断。
Ceskoslovenska patologie Pub Date : 2021-01-01
Magdaléna Daumová, Šárka Hadravská, Andrea Straková Peteříková, Marcel Hasch, Petr Martínek
{"title":"Placental mesenchymal dysplasia - morphology and differential diagnosis.","authors":"Magdaléna Daumová,&nbsp;Šárka Hadravská,&nbsp;Andrea Straková Peteříková,&nbsp;Marcel Hasch,&nbsp;Petr Martínek","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Placental mesenchymal dysplasia is a rare placental lesion characterized by placentomegaly, vascular abnormalities and formation of cystic structures in the placental parenchyma. It can be associated with various genetic abnormalities, fetal growth restriction or intrauterine fetal demise. Placental mesenchymal dysplasia needs to be distinguished from its main differential diagnosis, partial hydatidiform mole. The aim of this article is to provide readers with a basic overview of the morphology and differential diagnosis of this pathological entity.</p>","PeriodicalId":9861,"journal":{"name":"Ceskoslovenska patologie","volume":"57 4","pages":"203-207"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39830283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bone lesions - diagnostic approach using immunohistochemistry and molecular pathology. 骨病变-使用免疫组织化学和分子病理学诊断方法。
Ceskoslovenska patologie Pub Date : 2021-01-01
Iva Staniczková Zambo, Tetiana Shatokhina
{"title":"Bone lesions - diagnostic approach using immunohistochemistry and molecular pathology.","authors":"Iva Staniczková Zambo,&nbsp;Tetiana Shatokhina","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Immunohistochemistry and molecular pathology play an essential role in the diagnosis of some focal bone lesions. These techniques may greatly help to distinguish primary bone tumors from metastatic diseases and allow a biologically important refinements in subclassification of round cell sarcomas. Recently, the diagnostic accuracy of organ and tumor specific antibodies has improved significantly. Knowledge of new type of antibodies and their meaningful use enables an accurate classification of the most undifferentiated carcinomas of unknown primary. However, the interpretation of immunohistochemical stains and molecular genetic analysis can be difficult in bone biopsies due to previous decalcification. This article summarizes the most important algorithmic approach to the diagnosis of bone tumors. It outlines the most frequently used tissue-specific antibodies. New advances in the understanding of bone tumorigenesis are also discussed.</p>","PeriodicalId":9861,"journal":{"name":"Ceskoslovenska patologie","volume":"57 1","pages":"30-39"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38850265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The value of immunohistochemical methods in diagnosing mesenchymal tumours of the uterus. 免疫组织化学方法在子宫间质肿瘤诊断中的价值。
Ceskoslovenska patologie Pub Date : 2021-01-01
Pavel Dundr, Mária Gregová, Kristýna Němejcová, Michaela Bártů, Rosalie Jana Bennett, Ivana Stružinská
{"title":"The value of immunohistochemical methods in diagnosing mesenchymal tumours of the uterus.","authors":"Pavel Dundr,&nbsp;Mária Gregová,&nbsp;Kristýna Němejcová,&nbsp;Michaela Bártů,&nbsp;Rosalie Jana Bennett,&nbsp;Ivana Stružinská","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The goal of this manuscript is to provide a comprehensive overview of the use of immunohistochemical methods in diagnosing mesenchymal tumours of the uterus. The main points discussed include, especially, the issue of determining smooth muscle differentiation, the differential diagnosis between smooth muscle and endometrial stromal tumours, and the diagnosis of inflammatory myofibroblastic tumour. The role of immunohistochemical examination in the diagnosis of some of the only recently definedentities such as YWHAE-altered high grade endometrial stromal sarcoma (HG-ESS), BCOR-altered HG-ESS, tumours with NTRK fusion, and SMARCA4-deficient sarcomas is also discussed. The last aspect of this work is an analysis of the significance of immunohistochemical methods in the determination of the biological behaviour of leiomyocellular tumours. The issue of their molecular classification for those lesions associated with the presence of recurrent molecular aberrations is also discussed.</p>","PeriodicalId":9861,"journal":{"name":"Ceskoslovenska patologie","volume":"57 2","pages":"86-95"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39194808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vilém Dušan Lambl in the Imperial University of Kharkiv (Charkov) (1861-1871): biography outlines. 哈尔科夫帝国大学(Charkov)的vilsamim Du&#353;和Lambl(1861-1871):传记概要。
Ceskoslovenska patologie Pub Date : 2021-01-01
Igor Beloz Rov, Elena Protsenko, Maksym Kyrychenko, Natalia Remnyova
{"title":"Vilém Du&#353;an Lambl in the Imperial University of Kharkiv (Charkov) (1861-1871): biography outlines.","authors":"Igor Beloz Rov,&nbsp;Elena Protsenko,&nbsp;Maksym Kyrychenko,&nbsp;Natalia Remnyova","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This article focuses on the biography of the famous Czech pathologist Du&#353;an Lambl (1824-95), especially during his period of life in Kharkiv, Sloboda Ukraine (part of the Russian Empire). At the end of the 1850s, pursued by the authorities of the Austrian Empire as a politically compromised person (being a Czech patriot and slavophile, he took an active part in the so-called Spring of Nations in 1848), Du&#353;an Lambl was forced to seek refuge in the Russian Empire. He put forward his candidacy for the post of professor in the department of anatomy at the School of Medicine of Kharkiv University and was selected for this position. Being a professor of anatomy, Du&#353;an Lambl also actively developed other disciplines at the School of Medicine, particularly pathological anatomy and histology. Therefore, when in 1867 the departments of pathological anatomy and histology were established, Lambl was invited to become the head of any of them. Having chosen the former, Du&#353;an Lambl became the head of the first department of pathological anatomy in Sloboda Ukraine. Heading this department until 1871, Du&#353;an Lambl was able to raise the level of teaching of pathological anatomy at Kharkiv University to that of the best universities in Europe. This article considers the memoirs of Du&#353;an Lambl`s life in Kharkiv, left by his contemporaries. It focuses on information about his social activities, relations with colleagues and friends, and his work as a teacher and medical specialist.</p>","PeriodicalId":9861,"journal":{"name":"Ceskoslovenska patologie","volume":"57 2","pages":"113-119"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39194812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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