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The value of immunohistochemical methods in diagnosing mesenchymal tumours of the uterus. 免疫组织化学方法在子宫间质肿瘤诊断中的价值。
Ceskoslovenska patologie Pub Date : 2021-01-01
Pavel Dundr, Mária Gregová, Kristýna Němejcová, Michaela Bártů, Rosalie Jana Bennett, Ivana Stružinská
{"title":"The value of immunohistochemical methods in diagnosing mesenchymal tumours of the uterus.","authors":"Pavel Dundr,&nbsp;Mária Gregová,&nbsp;Kristýna Němejcová,&nbsp;Michaela Bártů,&nbsp;Rosalie Jana Bennett,&nbsp;Ivana Stružinská","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The goal of this manuscript is to provide a comprehensive overview of the use of immunohistochemical methods in diagnosing mesenchymal tumours of the uterus. The main points discussed include, especially, the issue of determining smooth muscle differentiation, the differential diagnosis between smooth muscle and endometrial stromal tumours, and the diagnosis of inflammatory myofibroblastic tumour. The role of immunohistochemical examination in the diagnosis of some of the only recently definedentities such as YWHAE-altered high grade endometrial stromal sarcoma (HG-ESS), BCOR-altered HG-ESS, tumours with NTRK fusion, and SMARCA4-deficient sarcomas is also discussed. The last aspect of this work is an analysis of the significance of immunohistochemical methods in the determination of the biological behaviour of leiomyocellular tumours. The issue of their molecular classification for those lesions associated with the presence of recurrent molecular aberrations is also discussed.</p>","PeriodicalId":9861,"journal":{"name":"Ceskoslovenska patologie","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39194808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vilém Dušan Lambl in the Imperial University of Kharkiv (Charkov) (1861-1871): biography outlines. 哈尔科夫帝国大学(Charkov)的vilsamim Du&#353;和Lambl(1861-1871):传记概要。
Ceskoslovenska patologie Pub Date : 2021-01-01
Igor Beloz Rov, Elena Protsenko, Maksym Kyrychenko, Natalia Remnyova
{"title":"Vilém Du&#353;an Lambl in the Imperial University of Kharkiv (Charkov) (1861-1871): biography outlines.","authors":"Igor Beloz Rov,&nbsp;Elena Protsenko,&nbsp;Maksym Kyrychenko,&nbsp;Natalia Remnyova","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This article focuses on the biography of the famous Czech pathologist Du&#353;an Lambl (1824-95), especially during his period of life in Kharkiv, Sloboda Ukraine (part of the Russian Empire). At the end of the 1850s, pursued by the authorities of the Austrian Empire as a politically compromised person (being a Czech patriot and slavophile, he took an active part in the so-called Spring of Nations in 1848), Du&#353;an Lambl was forced to seek refuge in the Russian Empire. He put forward his candidacy for the post of professor in the department of anatomy at the School of Medicine of Kharkiv University and was selected for this position. Being a professor of anatomy, Du&#353;an Lambl also actively developed other disciplines at the School of Medicine, particularly pathological anatomy and histology. Therefore, when in 1867 the departments of pathological anatomy and histology were established, Lambl was invited to become the head of any of them. Having chosen the former, Du&#353;an Lambl became the head of the first department of pathological anatomy in Sloboda Ukraine. Heading this department until 1871, Du&#353;an Lambl was able to raise the level of teaching of pathological anatomy at Kharkiv University to that of the best universities in Europe. This article considers the memoirs of Du&#353;an Lambl`s life in Kharkiv, left by his contemporaries. It focuses on information about his social activities, relations with colleagues and friends, and his work as a teacher and medical specialist.</p>","PeriodicalId":9861,"journal":{"name":"Ceskoslovenska patologie","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39194812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Next generation sequencing and the molecular tumor board from the point of view of oncologists. 从肿瘤学家的角度来看，下一代测序和分子肿瘤板。
Ceskoslovenska patologie Pub Date : 2021-01-01
Udmila Křížová, Luboš Petruželka
{"title":"Next generation sequencing and the molecular tumor board from the point of view of oncologists.","authors":"Udmila Křížová,&nbsp;Luboš Petruželka","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Molecular genetic methods have evolved dramatically in the last decade. In particular, sequencing of the new generation - NGS has become a financially and technically available examination. Thus, it begins to be used in the clinical practice of many specializations, including oncology. The proper use of these methods is a way to personalized oncology - treatment of the patient based on the occurrence of specific genetic aberrations, which are confirmed in his cancer, regardless of the histopathological type of tumor. This principle is completely new in oncology and raises number of questions and problems. The interpretation of the results of molecular genetic examinations is very complex and demanding, and therefore new multidisciplinary teams, so-called molecular tumor boards, are being created. The worldwide standardization of these boards is currently underway. Recommendations regarding the indication of NGS examinations in oncology patients are also being set.At the European level in the form of ESMO recommendations and at the national level also. Personalized oncology is the future of this field, which will lead to the best treatment response and minimize side effects.</p>","PeriodicalId":9861,"journal":{"name":"Ceskoslovenska patologie","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39439268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Secondary pulmonary hypoplasia associated with calcified Meckel´s diverticulum with osseous metaplasia. 继发性肺发育不全伴钙化梅克尔憩室伴骨化生。
Ceskoslovenska patologie Pub Date : 2021-01-01
Silvia Farkašová Iannaccone, Peter Švajdler, Marián Švajdler, Dorota Sopková, Ažbeta Ginelliová, Jana Šprláková, Miroslava Petrášová, Lucia Fröhlichová, Daniel Farkaš
{"title":"Secondary pulmonary hypoplasia associated with calcified Meckel´s diverticulum with osseous metaplasia.","authors":"Silvia Farkašová Iannaccone,&nbsp;Peter Švajdler,&nbsp;Marián Švajdler,&nbsp;Dorota Sopková,&nbsp;Ažbeta Ginelliová,&nbsp;Jana Šprláková,&nbsp;Miroslava Petrášová,&nbsp;Lucia Fröhlichová,&nbsp;Daniel Farkaš","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In this paper, we report autopsy findings of a 1-day old full-term mature female neonate with pulmonary hypoplasia diagnosed postnatally. Death was attributed to acute respiratory failure due to hyaline membrane disease. We describe pathological features of calcified Meckels diverticulum with osseous metaplasia and inflammatory changes in adjacent peritoneum. As far as we know, this case report documents the youngest patient ever diagnosed with calcified Meckels diverticulum with osseous metaplasia.</p>","PeriodicalId":9861,"journal":{"name":"Ceskoslovenska patologie","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38850267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Professor Jaroslav Hlava and his successors - a remembrance on the occasion of the 100th anniversary of the opening of the Hlava institute. 雅罗斯拉夫·赫拉瓦教授和他的继任者-赫拉瓦研究所成立100周年纪念活动。
Ceskoslovenska patologie Pub Date : 2021-01-01
Pavel Dundr, Ctibor Povýšil, Ludmila Hlaváčková, Karel Černý
{"title":"Professor Jaroslav Hlava and his successors - a remembrance on the occasion of the 100th anniversary of the opening of the Hlava institute.","authors":"Pavel Dundr,&nbsp;Ctibor Povýšil,&nbsp;Ludmila Hlaváčková,&nbsp;Karel Černý","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This year marks the 100th anniversary of the opening of the Hlava institute, which was ceremoniously held on April 18, 1921. The opening of the institute was the result of many years of Professor Hlava´s efforts to provide a dignified space for pathology at the Czech university. Hlava fundamentally influenced Czech pathology and was undoubtedly one of the most important personalities of not only Czech and European pathology, but the entire field of Czech medicine of the period. His influence on pathology and microbiology is indisputable and widely known, but he has also fundamentally influenced other fields, especially oncology. On the occasion of this important anniversary the following entry offers a look at the personality of Professor Jaroslav Hlava and provides an overview of his research activities, as well as a complete list of his publications. The successors of Professor Hlava in the position of the head of institute are also briefly listed.</p>","PeriodicalId":9861,"journal":{"name":"Ceskoslovenska patologie","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39831714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Renal involvement of a patient with Crohn´s disease: A case report. 克罗恩病患者肾脏受累1例报告。
Ceskoslovenska patologie Pub Date : 2021-01-01
Olga Snížková, Eva Jančová, Eva Honsová
{"title":"Renal involvement of a patient with Crohn´s disease: A case report.","authors":"Olga Snížková,&nbsp;Eva Jančová,&nbsp;Eva Honsová","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Inflammatory bowel disease (IBD) is a group of chronic relapsing intestinal inflammatory processes primarily represented by ulcerative colitis (UC) and Crohn´s disease (CD). Nearly half of IBD cases are followed by extraintestinal complications and renal involvement can occur independatly or along with other complications and are described with the patients sufferring from UC or CD. Most frequent renal involvement is nephrolithiasis, tubulointerstinal nephritis, different kinds of glomerulonephritis and AA amyloidosis. We are presenting an unusal form of renal involvement of a young female patient with a severe form of Crohn´s disease treated with recombinant monoclonal antibodies.</p>","PeriodicalId":9861,"journal":{"name":"Ceskoslovenska patologie","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39194811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular testing in endometrial carcinoma (Joint recommendation of Czech Oncological Society, Oncogynecological Section of the Czech Gynecological and Obstetrical Society, Society of Radiation Oncology, Biology and Physics, and the Society of Czech Pathologists). 子宫内膜癌的分子检测(捷克肿瘤学会、捷克妇产科学会妇科肿瘤科、捷克放射肿瘤学、生物学和物理学学会以及捷克病理学家学会联合推荐)。
Ceskoslovenska patologie Pub Date : 2021-01-01
Pavel Dundr, David Cibula, Martin Doležel, Pavel Fabian, Jindřich Fínek, Tomáš Jirásek, Radoslav Matěj, Luboš, Petruželka, Lukáš Rob, Aleš Ryška, Marián Švajdler, Vít Weinberger, Michal Zikán
{"title":"Molecular testing in endometrial carcinoma (Joint recommendation of Czech Oncological Society, Oncogynecological Section of the Czech Gynecological and Obstetrical Society, Society of Radiation Oncology, Biology and Physics, and the Society of Czech Pathologists).","authors":"Pavel Dundr,&nbsp;David Cibula,&nbsp;Martin Doležel,&nbsp;Pavel Fabian,&nbsp;Jindřich Fínek,&nbsp;Tomáš Jirásek,&nbsp;Radoslav Matěj,&nbsp;Luboš,&nbsp;Petruželka,&nbsp;Lukáš Rob,&nbsp;Aleš Ryška,&nbsp;Marián Švajdler,&nbsp;Vít Weinberger,&nbsp;Michal Zikán","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Molecular classification of endometrial carcinoma is becoming an important part of the diagnostic process with direct therapeutic implications. Recent international guidelines, including the joint ESGO-ESTRO-ESP recommendation, include the molecular classification into standard diagnostic algorithms. Molecular testing of endometrial carcinomas is also recommended in the latest (5th) edition of the WHO classification of Female Genital Tumors. Due to the need to implement these recommendations in practice, representatives of four professional societies of Czech Medical Association of J. E. Purkyn&#283; (Czech Oncological Society, Oncogynecological Section of the Czech Gynecological and Obstetrical Society, Society of Radiation Oncology, Biology and Physics, and the Society of Czech Pathologists) organized a meeting focused on this topic. The result of this meeting is a joint recommendation for molecular testing of endometrial carcinoma in routine diagnostic practice in the Czech Republic.</p>","PeriodicalId":9861,"journal":{"name":"Ceskoslovenska patologie","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39438687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A basic immunohistochemical panel for the diagnosis of soft tissue tumors. 软组织肿瘤的基本免疫组化诊断。
Ceskoslovenska patologie Pub Date : 2021-01-01
Michael Michal
{"title":"A basic immunohistochemical panel for the diagnosis of soft tissue tumors.","authors":"Michael Michal","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>There is no universal immunohistochemical panel which would be useful for the diagnosis of soft tissue tumors in all circumstances. Nevertheless, especially when faced with an uncharacteristic spindle cell neoplasm, a basic immunohistochemical panel can be recommended consisting of CD34, desmin, epithelial membrane antigen, broad-spectrum cytokeratins, S100 protein and smooth muscle actin. This review will address the utility and pitfalls of this panel. The use of MDM2 immunohistochemistry and fluorescence in situ hybridization in the diagnosis of lipomatous tumors will be discussed as well.</p>","PeriodicalId":9861,"journal":{"name":"Ceskoslovenska patologie","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38837872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Morphologic findings in placenta associated with SARS-CoV-2 infection. 与SARS-CoV-2感染相关的胎盘形态学发现。
Ceskoslovenska patologie Pub Date : 2021-01-01
Magdaléna Daumová, Šárka Hadravská, Andrea Straková Peteříková
{"title":"Morphologic findings in placenta associated with SARS-CoV-2 infection.","authors":"Magdaléna Daumová,&nbsp;Šárka Hadravská,&nbsp;Andrea Straková Peteříková","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>SARS-CoV-2 infection in pregnancy can cause a number of serious complications, including fetal growth restriction or intrauterine fetal death. It appears that transplacental transmission of infection is rare and the arising complications are due to damage of placental parenchyma. The aim of this article is to summarize the results of recent publications dealing with placental changes in COVID-19 disease, with special consideration to the morphology of the newly defined SARS-CoV-2 placentitis.</p>","PeriodicalId":9861,"journal":{"name":"Ceskoslovenska patologie","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39830282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Undiagnosed cryptococcal meningoencephalitis with extensive hypoxic-ischemic brain injury mimicking grade 3 diffuse axonal injury. 未确诊的隐球菌性脑膜脑炎伴大面积缺氧缺血性脑损伤，模拟3级弥漫性轴索损伤。
Ceskoslovenska patologie Pub Date : 2021-01-01
Daniel Farkaš, Anna Kružlíková, Jana Němcová, Vladimír Hrabovský, Silvia Farkašová Iannaccone, Alžbeta Ginelliová, Lucia Fröhlichová, Marián Švajdler
{"title":"Undiagnosed cryptococcal meningoencephalitis with extensive hypoxic-ischemic brain injury mimicking grade 3 diffuse axonal injury.","authors":"Daniel Farkaš,&nbsp;Anna Kružlíková,&nbsp;Jana Němcová,&nbsp;Vladimír Hrabovský,&nbsp;Silvia Farkašová Iannaccone,&nbsp;Alžbeta Ginelliová,&nbsp;Lucia Fröhlichová,&nbsp;Marián Švajdler","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In this article, we report the autopsy findings of a 50-year-old immunocompetent woman, who was hospitalized with an altered state of consciousness. Examinations, including cerebrospinal fluid analysis, carried out during hospitalization failed to identify the infectious agent causing progressive loss of consciousness and quadriparesis. The patient died within 8 days of admission to the hospital. Post-mortem microscopic and culture examination revealed Cryptococcus species. Death was attributed to cryptococcal meningoencephalitis. Histologic examination revealed accumulation of cryptococcus mimicking erythrocytes and extensive hemorrhage in hematoxylin and eosin-stained sections of the brain. Multifocal obliteration of the vascular bed by yeast was accompanied by hypoxic-ischemic brain injury mimicking traumatic diffuse axonal injury.</p>","PeriodicalId":9861,"journal":{"name":"Ceskoslovenska patologie","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39439273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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