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Next generation sequencing and the molecular tumor board from the point of view of oncologists. 从肿瘤学家的角度来看，下一代测序和分子肿瘤板。
Ceskoslovenska patologie Pub Date : 2021-01-01
Udmila Křížová, Luboš Petruželka
{"title":"Next generation sequencing and the molecular tumor board from the point of view of oncologists.","authors":"Udmila Křížová,&nbsp;Luboš Petruželka","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Molecular genetic methods have evolved dramatically in the last decade. In particular, sequencing of the new generation - NGS has become a financially and technically available examination. Thus, it begins to be used in the clinical practice of many specializations, including oncology. The proper use of these methods is a way to personalized oncology - treatment of the patient based on the occurrence of specific genetic aberrations, which are confirmed in his cancer, regardless of the histopathological type of tumor. This principle is completely new in oncology and raises number of questions and problems. The interpretation of the results of molecular genetic examinations is very complex and demanding, and therefore new multidisciplinary teams, so-called molecular tumor boards, are being created. The worldwide standardization of these boards is currently underway. Recommendations regarding the indication of NGS examinations in oncology patients are also being set.At the European level in the form of ESMO recommendations and at the national level also. Personalized oncology is the future of this field, which will lead to the best treatment response and minimize side effects.</p>","PeriodicalId":9861,"journal":{"name":"Ceskoslovenska patologie","volume":"57 3","pages":"144-146"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39439268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Secondary pulmonary hypoplasia associated with calcified Meckel´s diverticulum with osseous metaplasia. 继发性肺发育不全伴钙化梅克尔憩室伴骨化生。
Ceskoslovenska patologie Pub Date : 2021-01-01
Silvia Farkašová Iannaccone, Peter Švajdler, Marián Švajdler, Dorota Sopková, Ažbeta Ginelliová, Jana Šprláková, Miroslava Petrášová, Lucia Fröhlichová, Daniel Farkaš
{"title":"Secondary pulmonary hypoplasia associated with calcified Meckel´s diverticulum with osseous metaplasia.","authors":"Silvia Farkašová Iannaccone,&nbsp;Peter Švajdler,&nbsp;Marián Švajdler,&nbsp;Dorota Sopková,&nbsp;Ažbeta Ginelliová,&nbsp;Jana Šprláková,&nbsp;Miroslava Petrášová,&nbsp;Lucia Fröhlichová,&nbsp;Daniel Farkaš","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In this paper, we report autopsy findings of a 1-day old full-term mature female neonate with pulmonary hypoplasia diagnosed postnatally. Death was attributed to acute respiratory failure due to hyaline membrane disease. We describe pathological features of calcified Meckels diverticulum with osseous metaplasia and inflammatory changes in adjacent peritoneum. As far as we know, this case report documents the youngest patient ever diagnosed with calcified Meckels diverticulum with osseous metaplasia.</p>","PeriodicalId":9861,"journal":{"name":"Ceskoslovenska patologie","volume":"57 1","pages":"44-48"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38850267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Professor Jaroslav Hlava and his successors - a remembrance on the occasion of the 100th anniversary of the opening of the Hlava institute. 雅罗斯拉夫·赫拉瓦教授和他的继任者-赫拉瓦研究所成立100周年纪念活动。
Ceskoslovenska patologie Pub Date : 2021-01-01
Pavel Dundr, Ctibor Povýšil, Ludmila Hlaváčková, Karel Černý
{"title":"Professor Jaroslav Hlava and his successors - a remembrance on the occasion of the 100th anniversary of the opening of the Hlava institute.","authors":"Pavel Dundr,&nbsp;Ctibor Povýšil,&nbsp;Ludmila Hlaváčková,&nbsp;Karel Černý","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This year marks the 100th anniversary of the opening of the Hlava institute, which was ceremoniously held on April 18, 1921. The opening of the institute was the result of many years of Professor Hlava´s efforts to provide a dignified space for pathology at the Czech university. Hlava fundamentally influenced Czech pathology and was undoubtedly one of the most important personalities of not only Czech and European pathology, but the entire field of Czech medicine of the period. His influence on pathology and microbiology is indisputable and widely known, but he has also fundamentally influenced other fields, especially oncology. On the occasion of this important anniversary the following entry offers a look at the personality of Professor Jaroslav Hlava and provides an overview of his research activities, as well as a complete list of his publications. The successors of Professor Hlava in the position of the head of institute are also briefly listed.</p>","PeriodicalId":9861,"journal":{"name":"Ceskoslovenska patologie","volume":"57 4","pages":"233-243"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39831714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Renal involvement of a patient with Crohn´s disease: A case report. 克罗恩病患者肾脏受累1例报告。
Ceskoslovenska patologie Pub Date : 2021-01-01
Olga Snížková, Eva Jančová, Eva Honsová
{"title":"Renal involvement of a patient with Crohn´s disease: A case report.","authors":"Olga Snížková,&nbsp;Eva Jančová,&nbsp;Eva Honsová","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Inflammatory bowel disease (IBD) is a group of chronic relapsing intestinal inflammatory processes primarily represented by ulcerative colitis (UC) and Crohn´s disease (CD). Nearly half of IBD cases are followed by extraintestinal complications and renal involvement can occur independatly or along with other complications and are described with the patients sufferring from UC or CD. Most frequent renal involvement is nephrolithiasis, tubulointerstinal nephritis, different kinds of glomerulonephritis and AA amyloidosis. We are presenting an unusal form of renal involvement of a young female patient with a severe form of Crohn´s disease treated with recombinant monoclonal antibodies.</p>","PeriodicalId":9861,"journal":{"name":"Ceskoslovenska patologie","volume":"57 2","pages":"109-112"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39194811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular testing in endometrial carcinoma (Joint recommendation of Czech Oncological Society, Oncogynecological Section of the Czech Gynecological and Obstetrical Society, Society of Radiation Oncology, Biology and Physics, and the Society of Czech Pathologists). 子宫内膜癌的分子检测(捷克肿瘤学会、捷克妇产科学会妇科肿瘤科、捷克放射肿瘤学、生物学和物理学学会以及捷克病理学家学会联合推荐)。
Ceskoslovenska patologie Pub Date : 2021-01-01
Pavel Dundr, David Cibula, Martin Doležel, Pavel Fabian, Jindřich Fínek, Tomáš Jirásek, Radoslav Matěj, Luboš, Petruželka, Lukáš Rob, Aleš Ryška, Marián Švajdler, Vít Weinberger, Michal Zikán
{"title":"Molecular testing in endometrial carcinoma (Joint recommendation of Czech Oncological Society, Oncogynecological Section of the Czech Gynecological and Obstetrical Society, Society of Radiation Oncology, Biology and Physics, and the Society of Czech Pathologists).","authors":"Pavel Dundr,&nbsp;David Cibula,&nbsp;Martin Doležel,&nbsp;Pavel Fabian,&nbsp;Jindřich Fínek,&nbsp;Tomáš Jirásek,&nbsp;Radoslav Matěj,&nbsp;Luboš,&nbsp;Petruželka,&nbsp;Lukáš Rob,&nbsp;Aleš Ryška,&nbsp;Marián Švajdler,&nbsp;Vít Weinberger,&nbsp;Michal Zikán","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Molecular classification of endometrial carcinoma is becoming an important part of the diagnostic process with direct therapeutic implications. Recent international guidelines, including the joint ESGO-ESTRO-ESP recommendation, include the molecular classification into standard diagnostic algorithms. Molecular testing of endometrial carcinomas is also recommended in the latest (5th) edition of the WHO classification of Female Genital Tumors. Due to the need to implement these recommendations in practice, representatives of four professional societies of Czech Medical Association of J. E. Purkyn&#283; (Czech Oncological Society, Oncogynecological Section of the Czech Gynecological and Obstetrical Society, Society of Radiation Oncology, Biology and Physics, and the Society of Czech Pathologists) organized a meeting focused on this topic. The result of this meeting is a joint recommendation for molecular testing of endometrial carcinoma in routine diagnostic practice in the Czech Republic.</p>","PeriodicalId":9861,"journal":{"name":"Ceskoslovenska patologie","volume":"57 3","pages":"181-187"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39438687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A basic immunohistochemical panel for the diagnosis of soft tissue tumors. 软组织肿瘤的基本免疫组化诊断。
Ceskoslovenska patologie Pub Date : 2021-01-01
Michael Michal
{"title":"A basic immunohistochemical panel for the diagnosis of soft tissue tumors.","authors":"Michael Michal","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>There is no universal immunohistochemical panel which would be useful for the diagnosis of soft tissue tumors in all circumstances. Nevertheless, especially when faced with an uncharacteristic spindle cell neoplasm, a basic immunohistochemical panel can be recommended consisting of CD34, desmin, epithelial membrane antigen, broad-spectrum cytokeratins, S100 protein and smooth muscle actin. This review will address the utility and pitfalls of this panel. The use of MDM2 immunohistochemistry and fluorescence in situ hybridization in the diagnosis of lipomatous tumors will be discussed as well.</p>","PeriodicalId":9861,"journal":{"name":"Ceskoslovenska patologie","volume":"57 1","pages":"12-18"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38837872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Morphologic findings in placenta associated with SARS-CoV-2 infection. 与SARS-CoV-2感染相关的胎盘形态学发现。
Ceskoslovenska patologie Pub Date : 2021-01-01
Magdaléna Daumová, Šárka Hadravská, Andrea Straková Peteříková
{"title":"Morphologic findings in placenta associated with SARS-CoV-2 infection.","authors":"Magdaléna Daumová,&nbsp;Šárka Hadravská,&nbsp;Andrea Straková Peteříková","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>SARS-CoV-2 infection in pregnancy can cause a number of serious complications, including fetal growth restriction or intrauterine fetal death. It appears that transplacental transmission of infection is rare and the arising complications are due to damage of placental parenchyma. The aim of this article is to summarize the results of recent publications dealing with placental changes in COVID-19 disease, with special consideration to the morphology of the newly defined SARS-CoV-2 placentitis.</p>","PeriodicalId":9861,"journal":{"name":"Ceskoslovenska patologie","volume":"57 4","pages":"199-202"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39830282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Undiagnosed cryptococcal meningoencephalitis with extensive hypoxic-ischemic brain injury mimicking grade 3 diffuse axonal injury. 未确诊的隐球菌性脑膜脑炎伴大面积缺氧缺血性脑损伤，模拟3级弥漫性轴索损伤。
Ceskoslovenska patologie Pub Date : 2021-01-01
Daniel Farkaš, Anna Kružlíková, Jana Němcová, Vladimír Hrabovský, Silvia Farkašová Iannaccone, Alžbeta Ginelliová, Lucia Fröhlichová, Marián Švajdler
{"title":"Undiagnosed cryptococcal meningoencephalitis with extensive hypoxic-ischemic brain injury mimicking grade 3 diffuse axonal injury.","authors":"Daniel Farkaš,&nbsp;Anna Kružlíková,&nbsp;Jana Němcová,&nbsp;Vladimír Hrabovský,&nbsp;Silvia Farkašová Iannaccone,&nbsp;Alžbeta Ginelliová,&nbsp;Lucia Fröhlichová,&nbsp;Marián Švajdler","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In this article, we report the autopsy findings of a 50-year-old immunocompetent woman, who was hospitalized with an altered state of consciousness. Examinations, including cerebrospinal fluid analysis, carried out during hospitalization failed to identify the infectious agent causing progressive loss of consciousness and quadriparesis. The patient died within 8 days of admission to the hospital. Post-mortem microscopic and culture examination revealed Cryptococcus species. Death was attributed to cryptococcal meningoencephalitis. Histologic examination revealed accumulation of cryptococcus mimicking erythrocytes and extensive hemorrhage in hematoxylin and eosin-stained sections of the brain. Multifocal obliteration of the vascular bed by yeast was accompanied by hypoxic-ischemic brain injury mimicking traumatic diffuse axonal injury.</p>","PeriodicalId":9861,"journal":{"name":"Ceskoslovenska patologie","volume":"57 3","pages":"167-173"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39439273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
100th anniversary of the opening of the Hlava institute. 赫拉瓦学院成立100周年。
Ceskoslovenska patologie Pub Date : 2021-01-01
Ludmila Hlaváčková
{"title":"100th anniversary of the opening of the Hlava institute.","authors":"Ludmila Hlaváčková","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The paper comemmorates a centenary of construction of the current building for the Czech Institute for Pathological Anatomy (First Faculty of Medicine, Charles University in Prague) at Albertov, Prague. Project for the building was being developed since 1911, the construction works began three years later only to be interrupted by the onset of the WWI. The final inspection was carried out in 1921. The building served not just the Institute for Pathological Anatomy, but also Institute for Forensic Medicine as well as Institute for Microbiology and Serology. The Hlavas institute is considered to be an exceptional example of a modern interwar medical facility in the central Europe.</p>","PeriodicalId":9861,"journal":{"name":"Ceskoslovenska patologie","volume":"57 4","pages":"243-245"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39831715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fabry disease with cardiovascular manifestation in a patient with end-stage renal disease. 一名终末期肾病患者的法布里病伴心血管表现。
Ceskoslovenska patologie Pub Date : 2021-01-01
Hana Skopcová, Gabriela Dostálová, Tomáš Paleček, Aleš Linhart, Eva Honsová
{"title":"Fabry disease with cardiovascular manifestation in a patient with end-stage renal disease.","authors":"Hana Skopcová,&nbsp;Gabriela Dostálová,&nbsp;Tomáš Paleček,&nbsp;Aleš Linhart,&nbsp;Eva Honsová","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Fabry disease is a rare X-linked hereditary storage disease caused by a mutation of the gene encoding alpha-galactosidase A. The clinical manifestation of the classical disease form is variable depending on the degree of individual organs involvement, including especially kidney, myocardium, central nervous system (CNS) and skin. We report a case of a 51-year-old man whose diagnostic manifestation was cardiac involvement leading to endomyocardial biopsy, which significantly contributed to the diagnosis. Although at that time he was already 9 years dependent on dialysis with terminal renal failure.</p>","PeriodicalId":9861,"journal":{"name":"Ceskoslovenska patologie","volume":"57 1","pages":"49-52"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38850685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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