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Potential roles of unmeasured spectra and light’s frequency-dependent neural modulation in daylight-mediated metabolic improvements 未测量光谱和光的频率依赖的神经调节在日光介导的代谢改善中的潜在作用
IF 29 1区 生物学
Cell metabolism Pub Date : 2026-02-12 DOI: 10.1016/j.cmet.2026.01.006
Chongyun Wu, Luodan Yang
{"title":"Potential roles of unmeasured spectra and light’s frequency-dependent neural modulation in daylight-mediated metabolic improvements","authors":"Chongyun Wu, Luodan Yang","doi":"10.1016/j.cmet.2026.01.006","DOIUrl":"https://doi.org/10.1016/j.cmet.2026.01.006","url":null,"abstract":"<h2>Section snippets</h2><section><section><h2>Main text</h2>We read with great interest the recent article by Harmsen et al. demonstrating that natural daylight during office hours improves glucose control and whole-body substrate metabolism in individuals with type 2 diabetes.<sup>1</sup> Harmsen et al.’s work provides valuable insights into the metabolic impacts of indoor lighting environments, but we wish to raise two complementary points that may extend mechanistic understanding and inform future study design considerations.First, the spectral analysis in</section></section><section><section><h2>Acknowledgments</h2>This study was supported by the <span>National Natural Science Foundation of China</span> (<!-- -->32300959<!-- -->), <span>Guangzhou Scientific Research Grant</span> (<!-- -->SL2024A04J00578<!-- -->), and the <span>SCNU Young Faculty Development Program</span> (<!-- -->22KJ04<!-- -->).</section></section><section><section><h2>Declaration of interests</h2>The authors declare no competing interests.</section></section>","PeriodicalId":9840,"journal":{"name":"Cell metabolism","volume":"147 1","pages":""},"PeriodicalIF":29.0,"publicationDate":"2026-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146160718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
NAMing the challenges and opportunities of new approach methodologies for studying cardiovascular metabolism 指出心血管代谢研究新方法的挑战和机遇
IF 29 1区 生物学
Cell metabolism Pub Date : 2026-02-11 DOI: 10.1016/j.cmet.2025.12.021
Arianne Caudal, Joseph C. Wu
{"title":"NAMing the challenges and opportunities of new approach methodologies for studying cardiovascular metabolism","authors":"Arianne Caudal, Joseph C. Wu","doi":"10.1016/j.cmet.2025.12.021","DOIUrl":"https://doi.org/10.1016/j.cmet.2025.12.021","url":null,"abstract":"","PeriodicalId":9840,"journal":{"name":"Cell metabolism","volume":"11 1","pages":""},"PeriodicalIF":29.0,"publicationDate":"2026-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146160720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New approach methodologies: Don’t throw the baby out with the bathwater 新方法：不要把婴儿连同洗澡水一起倒掉
IF 29 1区 生物学
Cell metabolism Pub Date : 2026-02-11 DOI: 10.1016/j.cmet.2026.01.009
Zoltan Arany
{"title":"New approach methodologies: Don’t throw the baby out with the bathwater","authors":"Zoltan Arany","doi":"10.1016/j.cmet.2026.01.009","DOIUrl":"https://doi.org/10.1016/j.cmet.2026.01.009","url":null,"abstract":"","PeriodicalId":9840,"journal":{"name":"Cell metabolism","volume":"28 1","pages":""},"PeriodicalIF":29.0,"publicationDate":"2026-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146160724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Semaglutide ameliorates osteoarthritis progression through a weight loss-independent metabolic restoration mechanism Semaglutide通过独立于体重减轻的代谢恢复机制改善骨关节炎的进展
IF 29 1区 生物学
Cell metabolism Pub Date : 2026-02-09 DOI: 10.1016/j.cmet.2026.01.008
Hongyu Qin, Jiamin Yu, Huan Yu, Chuqiao Zhou, Dongfeng Yuan, Ziling Wang, Zhenglin Zhu, Guizheng Wei, Peiyan Ou, Zhibin Li, Hua Jiang, Jie Shen, Guozhi Xiao, Xiaochun Bai, Huaiyu Wang, Huan-Tian Zhang, John R. Speakman, Di Chen, Liping Tong
{"title":"Semaglutide ameliorates osteoarthritis progression through a weight loss-independent metabolic restoration mechanism","authors":"Hongyu Qin, Jiamin Yu, Huan Yu, Chuqiao Zhou, Dongfeng Yuan, Ziling Wang, Zhenglin Zhu, Guizheng Wei, Peiyan Ou, Zhibin Li, Hua Jiang, Jie Shen, Guozhi Xiao, Xiaochun Bai, Huaiyu Wang, Huan-Tian Zhang, John R. Speakman, Di Chen, Liping Tong","doi":"10.1016/j.cmet.2026.01.008","DOIUrl":"https://doi.org/10.1016/j.cmet.2026.01.008","url":null,"abstract":"","PeriodicalId":9840,"journal":{"name":"Cell metabolism","volume":"23 1","pages":""},"PeriodicalIF":29.0,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146153266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Compartmentalized branched-chain amino acid metabolism orchestrates colorectal cancer dissemination via an UMP-vimentin axis 区隔化的支链氨基酸代谢通过UMP-vimentin轴协调结直肠癌的传播
IF 29 1区 生物学
Cell metabolism Pub Date : 2026-02-06 DOI: 10.1016/j.cmet.2026.01.007
Fenfen Ji, Pingmei Huang, Qiming Zhou, Lok Hin Ko, Qinyao Wei, Charis Cheuk-Lok Chan, Danyu Chen, Huarong Chen, Wei Kang, Alvin Ho-Kwan Cheung, Cillian H. Cheng, Jianming Shen, Yasi Pan, Ying Jiao, Lin Zhu, Tat Wai Chik, Peisi Xie, Xiao Liang, Onno Kranenburg, Zongwei Cai, Jun Yu, Chi Chun Wong
{"title":"Compartmentalized branched-chain amino acid metabolism orchestrates colorectal cancer dissemination via an UMP-vimentin axis","authors":"Fenfen Ji, Pingmei Huang, Qiming Zhou, Lok Hin Ko, Qinyao Wei, Charis Cheuk-Lok Chan, Danyu Chen, Huarong Chen, Wei Kang, Alvin Ho-Kwan Cheung, Cillian H. Cheng, Jianming Shen, Yasi Pan, Ying Jiao, Lin Zhu, Tat Wai Chik, Peisi Xie, Xiao Liang, Onno Kranenburg, Zongwei Cai, Jun Yu, Chi Chun Wong","doi":"10.1016/j.cmet.2026.01.007","DOIUrl":"https://doi.org/10.1016/j.cmet.2026.01.007","url":null,"abstract":"","PeriodicalId":9840,"journal":{"name":"Cell metabolism","volume":"15 1","pages":""},"PeriodicalIF":29.0,"publicationDate":"2026-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146134397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ketogenic diet alleviates septic lung injury via microbial gut-lung axis 生酮饮食通过微生物肠-肺轴减轻脓毒性肺损伤
IF 29 1区 生物学
Cell metabolism Pub Date : 2026-02-04 DOI: 10.1016/j.cmet.2026.01.005
Mingyuan Wei, Xinzhu Yi, Zhuandi Lin, Jingjing Cai, Shanze Chen, Fang Zhou, Hanqin Cai, Xinfeng Lu, Juan Tang, Yunfeng Shi, Liping Cui, Lei Yang, Xinru Jing, Yunong Zeng, Rong Wu, Tingting Shu, Yuanyuan Li, Fangyuan Yang, Yi He, Zhibin Zhao, Zhang Wang
{"title":"Ketogenic diet alleviates septic lung injury via microbial gut-lung axis","authors":"Mingyuan Wei, Xinzhu Yi, Zhuandi Lin, Jingjing Cai, Shanze Chen, Fang Zhou, Hanqin Cai, Xinfeng Lu, Juan Tang, Yunfeng Shi, Liping Cui, Lei Yang, Xinru Jing, Yunong Zeng, Rong Wu, Tingting Shu, Yuanyuan Li, Fangyuan Yang, Yi He, Zhibin Zhao, Zhang Wang","doi":"10.1016/j.cmet.2026.01.005","DOIUrl":"https://doi.org/10.1016/j.cmet.2026.01.005","url":null,"abstract":"Sepsis is characterized by impaired immunity to infection, leading to multi-organ dysfunction, with the lung being the most vulnerable organ. Here, we show that ketogenic diet (KD) alleviates sepsis-induced lung injury through a microbial-gut-lung axis. KD alters the gut microbiota in mice and humans, enriching <em>Limosilactobacillus reuteri</em> and <em>Lactiplantibacillus plantarum</em>. Specific strains of these species produce a flavin-dependent monooxygenase (FMO) that converts oleic acid in KD into azelaic acid (AZA). During sepsis, AZA translocates to the lung, where it promotes neutrophil apoptosis and expands MerTK<sup>+</sup> alveolar macrophages (AMs) via PPAR-γ activation, enhancing efferocytosis and resolution of lung injury. In patients with sepsis, elevated AZA correlates with improved clinical outcomes, including survival rates, ventilation-free days (VFDs), and pulmonary function, along with increased MerTK<sup>+</sup> AMs and apoptotic neutrophils in patient lungs. These findings uncover a pathway of gut-lung crosstalk mediated by diet-microbiome interactions, highlighting the therapeutic potential of KD and microbiome modulation in sepsis.","PeriodicalId":9840,"journal":{"name":"Cell metabolism","volume":"31 1","pages":""},"PeriodicalIF":29.0,"publicationDate":"2026-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146116220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metastasis gets a little help from immune cell mitochondria 转移得到免疫细胞线粒体的一点帮助
IF 29 1区 生物学
Cell metabolism Pub Date : 2026-02-03 DOI: 10.1016/j.cmet.2026.01.002
Michael V. Berridge, Renata Zobalova, Jiri Neuzil
{"title":"Metastasis gets a little help from immune cell mitochondria","authors":"Michael V. Berridge, Renata Zobalova, Jiri Neuzil","doi":"10.1016/j.cmet.2026.01.002","DOIUrl":"https://doi.org/10.1016/j.cmet.2026.01.002","url":null,"abstract":"","PeriodicalId":9840,"journal":{"name":"Cell metabolism","volume":"8 1","pages":""},"PeriodicalIF":29.0,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146110772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Back to basics: Bile acids in fat absorption 回到基础：脂肪吸收中的胆汁酸
IF 29 1区 生物学
Cell metabolism Pub Date : 2026-02-03 DOI: 10.1016/j.cmet.2025.12.010
Folkert Kuipers, Henkjan J. Verkade, Jan Freark de Boer
{"title":"Back to basics: Bile acids in fat absorption","authors":"Folkert Kuipers, Henkjan J. Verkade, Jan Freark de Boer","doi":"10.1016/j.cmet.2025.12.010","DOIUrl":"https://doi.org/10.1016/j.cmet.2025.12.010","url":null,"abstract":"","PeriodicalId":9840,"journal":{"name":"Cell metabolism","volume":"90 1","pages":""},"PeriodicalIF":29.0,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146110773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mitochondria at the membrane provide a route to inflammatory cell death 细胞膜上的线粒体为炎症细胞死亡提供了一条途径
IF 29 1区 生物学
Cell metabolism Pub Date : 2026-02-03 DOI: 10.1016/j.cmet.2025.12.019
Zezhao Chen, Daichao Xu
{"title":"Mitochondria at the membrane provide a route to inflammatory cell death","authors":"Zezhao Chen, Daichao Xu","doi":"10.1016/j.cmet.2025.12.019","DOIUrl":"https://doi.org/10.1016/j.cmet.2025.12.019","url":null,"abstract":"","PeriodicalId":9840,"journal":{"name":"Cell metabolism","volume":"79 1","pages":""},"PeriodicalIF":29.0,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146110536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lactate-driven mitochondrial pretenders hijack hippocampal function after excessive exercise 乳酸驱动的线粒体伪装者在过度运动后劫持海马功能
IF 29 1区 生物学
Cell metabolism Pub Date : 2026-02-03 DOI: 10.1016/j.cmet.2026.01.003
Filip J. Larsen
{"title":"Lactate-driven mitochondrial pretenders hijack hippocampal function after excessive exercise","authors":"Filip J. Larsen","doi":"10.1016/j.cmet.2026.01.003","DOIUrl":"https://doi.org/10.1016/j.cmet.2026.01.003","url":null,"abstract":"","PeriodicalId":9840,"journal":{"name":"Cell metabolism","volume":"18 1","pages":""},"PeriodicalIF":29.0,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146110538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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